Mecanismos envolvidos na fisiopatologia da artrite reumatóide, dor e sepse

• Processo: 11/19670-0
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Vigência: 01 de maio de 2012 - 30 de junho de 2017
• Área do conhecimento: Ciências Biológicas - Farmacologia - Farmacologia Geral
• Pesquisador responsável: Fernando de Queiroz Cunha
• Beneficiário: Fernando de Queiroz Cunha
• Instituição Sede: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brasil
• Pesquisadores principais:( Últimos ): José Carlos Farias Alves Filho ; Paulo Louzada Junior ; Thiago Mattar Cunha
• Pesquisadores principais:( Antigos ): Sérgio Henrique Ferreira
• Auxílios(s) vinculado(s): 13/09434-3 - Moduladores imunofarmacológicos salivares de artrópodes hematófagos, AV.EXT
• Bolsa(s) vinculada(s): 15/22182-9 - Investigação do papel dos receptores de potencial transitório do tipo vanilóide 1 na hipersensibilidade nociceptiva herpética e pós-herpética, BP.IC; 15/15492-1 - "Mecanismos envolvidos na fisiopatologia da artrite reumatoide, dor e sepse"., BP.TT; 14/09008-7 - Investigação do papel do receptor de reconhecimento padrão do tipo toll 4 e seu ligante endógeno MRP14 na iniciação e manutenção da hipersensibilidade nociceptiva herpética e pós-herpética, BP.PD; + mais bolsas vinculadas 13/15316-3 - Investigação do papel protetor da Interleucina 27(IL-27) sobre a gênese e manutenção da dor neuropática, BP.DR; 13/04942-0 - Mecanismos moleculares envolvidos na potencialização da resposta Th17 pelo receptor de hidrocarbonetos arila (AHR) - correlação com artrite reumatoide, BP.DR; 13/07968-0 - Investigação do papel da enzima indoleamina 2,3-dioxigenase em estruturas supraespinais na indução e manutenção da dor neuropática, BP.MS; 13/03758-1 - Papel do receptor D6 no desenvolvimento e manutenção da dor crônica neuropática, BP.DR; 12/20330-2 - Mecanismos envolvidos na fisiopatologia da artrite reumatóide, dor e sepse, BP.TT; 12/04132-6 - Papel do receptor D6 no desenvolvimento da resposta inflamatória durante a sepse, BP.DR; 12/04076-9 - Papel do receptor de aril hidrocarboneto na patogênese da sepse, BP.PD; 11/13097-7 - Investigação do envolvimento da enzima indoleamina (2,3)-dioxigenase (IDO) na gênese e manutenção da dor neuropática, BP.PD - menos bolsas vinculadas
• Assunto(s): Inflamação Dor Sepse Artrite reumatoide
• Palavra(s)-Chave do Pesquisador: artrite reumatóide | Dor | Inflamação | Sepsis | Farmacologia da Inflamação e Imunofarmacologia

Resumo

Nos últimos 25 anos, nosso grupo de pesquisa vem desenvolvendo estudos na área de inflamação, visando o melhor entendimento dos mecanismos fisiopatológicos do processo inflamatório. Dando continuidade, no presente projeto pretendemos desenvolver investigação translacional na área de doenças inflamatórias, especificamente em artrite reumatóide, dor crônica e sepse. Para os três temas, pretendemos investigar de maneira integrada: 1) mecanismos envolvidos no reconhecimento dos agentes desencadeadores, com enfoque nos receptores de reconhecimento padrão (TLRs e NLRs) e seus ligantes endógenos e nas ativações das células de reconhecimento (células dendríticas, glia, mastócitos, sinoviócitos); 2) mecanismos efetores, especificamente papel de citocinas/quimiocinas e seus receptores e de células efetoras (neutrófilos, linfócitos e macrófagos); 3) sinalização intracelular, incluindo receptores intracelulares (AhR, PPARgama, LXR) e fatores de transcrição (NFkB, AP-1, CREB); e por fim 4) moduladores da resposta imune, com enfoque em adenosina, indoleamina 2,3-dioxigenase, eicosanóides e molécula co-estimulatória CD28. O desenvolvimento do projeto permitirá identificar novos alvos biológicos comuns para a maioria dos três temas supracitados, o que permitirá o desenvolvimento de novos marcadores biológicos e também novos tratamentos para estas doenças. (AU)

Publicações científicas

(77)

(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)

SONEGO, FABIANE; CASTANHEIRA, FERNANDA V. S.; HORTA, CATARINA V.; KANASHIRO, ALEXANDRE; CZAIKOSKI, PAULA G.; ZAMBONI, DARIO S.; ALVES-FILHO, JOSE CARLOS; CUNHA, FERNANDO Q.. The host control of a clinical isolate strain of P-aeruginosa infection is independent of Nod-1 but depends on MyD88. Inflammation Research, v. 67, n. 5, p. 435-443, MAY 2018. (08/11593-4, 11/19670-0)

SONEGO, FABIANE; CASTANHEIRA, FERNANDA V. S.; CZAIKOSKI, PAULA G.; KANASHIRO, ALEXANDRE; SOUTO, FABRICIO O.; FRANCA, RAFAEL O.; NASCIMENTO, DANIELE C.; FREITAS, ANDRESSA; SPILLER, FERNANDO; CUNHA, LARISSA D.; et al. MyD88-, but Not Nod1- and/or Nod2-Deficient Mice, Show Increased Susceptibility to Polymicrobial Sepsis due to Impaired Local Inflammatory Response. PLoS One, v. 9, n. 8, AUG 1 2014. (08/11593-4, 11/19670-0)

LOPES, ALEXANDRE H.; BRANDOLINI, LAURA; ARAMINI, ANDREA; BIANCHINI, GIANLUCA; SILVA, RANGEL L.; ZAPERLON, ANA C.; VERRI, JR., WALDICEU A.; ALVES-FILHO, JOSE C.; CUNHA, FERNANDO Q.; TEIXEIRA, MAURO M.; et al. DF2755A, a novel non-competitive allosteric inhibitor of CXCR1/2, reduces inflammatory and post-operative pain. PHARMACOLOGICAL RESEARCH, v. 103, p. 69-79, JAN 2016. (13/08216-2, 11/19670-0)

BERTOZZI, MARIANA M.; ROSSANEIS, ANA C.; FATTORI, VICTOR; LONGHI-BALBINOT, DANIELA T.; FREITAS, ANDRESSA; CUNHA, FERNANDO Q.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CASAGRANDE, RUBIA; VERRI, JR., WALDICEU A.. Diosmin reduces chronic constriction injury-induced neuropathic pain in mice. Chemico-Biological Interactions, v. 273, p. 180-189, AUG 1 2017. (13/08216-2, 11/19670-0)

PARRA, ROGERIO S.; LOPES, ALEXANDRE H.; CARREIRA, ELEONORA U.; FEITOSA, MARLEY R.; CUNHA, FERNANDO Q.; GARCIA, SERGIO B.; CUNHA, THIAGO M.; DA ROCHA, JOSE J. R.; FERES, OMAR. Hyperbaric oxygen therapy ameliorates TNBS-induced acute distal colitis in rats. MEDICAL GAS RESEARCH, v. 5, APR 16 2015. (11/19670-0)

SOUZA, GUILHERME R.; CUNHA, THIAGO M.; SILVA, RANGE L.; LOTUFO, CELINA M.; VERRI, JR., WALDICEU A.; FUNEZ, MANI I.; VILLARREAL, CHRISTIANE F.; TALBOT, JHIMMY; SOUSA, LIRLANDIA P.; PARADA, CARLOS A.; et al. Involvement of nuclear factor kappa B in the maintenance of persistent inflammatory hypernociception. Pharmacology Biochemistry and Behavior, v. 134, p. 49-56, JUL 2015. (13/08216-2, 11/19670-0)

TALBOT, JHIMMY; BIANCHINI, FRANCINE J.; NASCIMENTO, DANILELE C.; OLIVEIRA, RENE D. R.; SOUTO, FABRICIO O.; PINTO, LARISSA G.; PERES, RAPHAEL S.; SILVA, JAQUELINE R.; ALMEIDA, SERGIO C. L.; LOUZADA-JUNIOR, PAULO; et al. CCR2 Expression in Neutrophils Plays a Critical Role in Their Migration Into the Joints in Rheumatoid Arthritis. ARTHRITIS & RHEUMATOLOGY, v. 67, n. 7, p. 1751-1759, JUL 2015. (13/08216-2, 11/19670-0)

ZUCOLOTO, AMANDA Z.; MANCHOPE, MARILIA F.; STAURENGO-FERRARI, LARRISA; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; ANTUNES, MAISA M.; MENEZES, GUSTAVO B.; CUNHA, FERNANDO Q.; CASAGRANDE, RUBIA; VERRI, JR., WALDICEU A.. Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-kappa B activation and cytokine production without antioxidant effects. Inflammation Research, v. 66, n. 7, p. 591-602, JUL 2017. (13/08216-2, 11/19670-0)

TAMASHIRO, LETICIA FALEIROS; OLIVEIRA, RENE D. R.; OLIVEIRA, RODRIGO; COMINI FROTA, ELIZABETH REGINA; DONADI, EDUARDO ANTONIO; DEL-BEN, CRISTINA MARTA; TEIXEIRA, ANTONIO LUCIO; LOUZADA-JUNIOR, PAULO. Participation of the neutrophin brain-derived neurotrophic factor in neuropsychiatric systemic lupus erythematosus. RHEUMATOLOGY, v. 53, n. 12, p. 2182-2190, DEC 2014. (13/08216-2, 11/19670-0)

RUIZ-MIYAZAWA, KENJI W.; BORGHI, SERGIO M.; PINHO-RIBEIRO, FELIPE A.; STAURENGO-FERRARI, LARISSA; FATTORI, VICTOR; FERNANDES, GLAURA S. A.; CASELLA, ANTONIO M.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; et al. The citrus flavanone naringenin reduces gout-induced joint pain and inflammation in mice by inhibiting the activation of NF kappa B and macrophage release of IL-1 beta. Journal of Functional Foods, v. 48, p. 106-116, SEP 2018. (13/08216-2, 11/19670-0, 10/15014-9)

FERREIRA, RAPHAEL G.; RODRIGUES, LILIAN C.; NASCIMENTO, DANIELE C.; KANASHIRO, ALEXANDRE; MELO, PAULO H.; BORGES, VANESSA F.; GOZZI, ALINE; PRADO, DOUGLAS DA SILVA; BORGES, MARCOS C.; RAMALHO, FERNANDO S.; et al. Galectin-3 aggravates experimental polymicrobial sepsis by impairing neutrophil recruitment to the infectious focus. Journal of Infection, v. 77, n. 5, p. 391-397, NOV 2018. (13/08216-2, 11/19670-0)

PINTO, LARISSA G.; TALBOT, JHIMMY; PERES, RAPHAEL S.; FRANCA, RAFAEL F.; FERREIRA, SERGIO H.; RYFFEL, BERNHARD; AVES-FILHO, JOSE CARLOS F.; FIGUEIREDO, FLORENCIO; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.. Joint production of IL-22 participates in the initial phase of antigen-induced arthritis through IL-1 beta production. ARTHRITIS RESEARCH & THERAPY, v. 17, SEP 2 2015. (13/08216-2, 11/19670-0)

MORICONI, ALESSIO; CUNHA, THIAGO M.; SOUZA, GUILHERME R.; LOPES, ALEXANDRE H.; CUNHA, FERNANDO Q.; CARNEIRO, VICTOR L.; PINTO, LARISSA G.; BRANDOLINI, LAURA; ARAMINI, ANDREA; BIZZARRI, CINZIA; et al. Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 111, n. 47, p. 6-pg., 2014-11-25. (13/08216-2, 11/19670-0)

DAVOLI-FERREIRA, MARCELA; DE LIMA, KALIL A.; FONSECA, MIRIAM M.; GUIMARAES, RAFAELA M.; GOMES, I, FRANCISCO; CAVALLINI, MARIA C.; QUADROS, ANDREZA U.; KUSUDA, RICARDO; CUNHA, FERNANDO Q.; ALVES-FILHO, JOSE C.; et al. Regulatory T cells counteract neuropathic pain through inhibition of the Th1 response at the site of peripheral nerve injury. Pain, v. 161, n. 8, p. 1730-1743, AUG 2020. (13/08216-2, 11/19670-0)

PINTO, LARISSA G.; SOUZA, GUILHERME R.; KUSUDA, RICARDO; LOPES, ALEXANDRE H.; SANT'ANNA, MORENA B.; CUNHA, FERNANDO Q.; FERREIRA, SERGIO H.; CUNHA, THIAGO M.. Non-Peptidergic Nociceptive Neurons Are Essential for Mechanical Inflammatory Hypersensitivity in Mice. Molecular Neurobiology, v. 56, n. 8, p. 5715-5728, AUG 2019. (13/08216-2, 10/04043-8, 11/19670-0)

COLON, DAVID F.; WANDERLEY, CARLOS W.; FRANCHIN, MARCELO; SILVA, CAMILA M.; HIROKI, CARLOS H.; CASTANHEIRA, FERNANDA V. S.; DONATE, PAULA B.; LOPES, ALEXANDRE H.; VOLPON, LEILA C.; KAVAGUTI, SILVIA K.; et al. Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis. CRITICAL CARE, v. 23, APR 8 2019. (13/08216-2, 11/19670-0)

LOURENCO-GONZALEZ, YURI; FATTORI, VICTOR; DOMICIANO, TALITA P.; ROSSANEIS, ANA C.; BORGHI, SERGIO M.; ZANINELLI, TIAGO H.; BERNARDY, CATIA C. F.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; et al. Repurposing of the Nootropic Drug Vinpocetine as an Analgesic and Anti-Inflammatory Agent: Evidence in a Mouse Model of Superoxide Anion-Triggered Inflammation. Mediators of Inflammation, 2019. (13/08216-2, 11/19670-0)

RUIZ-MIYAZAWA, KENJI W.; STAURENGO-FERRARI, LARISSA; PINHO-RIBEIRO, FELIPE A.; FATTORI, VICTOR; ZANINELLI, TIAGO H.; BADARO-GARCIA, STEPHANIE; BORGHI, SERGIO M.; ANDRADE, KETLEM C.; CLEMENTE-NAPIMOGA, JULIANA T.; ALVES-FILHO, JOSE C.; et al. 15d-PGJ(2)-loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive manner in mice. SCIENTIFIC REPORTS, v. 8, SEP 18 2018. (13/08216-2, 10/15014-9, 11/19670-0)

STAURENGO-FERRARI, LARISSA; RUIZ-MIYAZAWA, KENJI W.; PINHO-RIBEIRO, FELIPE A.; FATTORI, VICTOR; ZANINELLI, TIAGO H.; BADARO-GARCIA, STEPHANIE; BORGHI, SERGIO M.; CARVALHO, THACYANA T.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; et al. Trans-Chalcone Attenuates Pain and Inflammation in Experimental Acute Gout Arthritis in Mice. FRONTIERS IN PHARMACOLOGY, v. 9, OCT 2 2018. (13/08216-2, 11/19670-0)

FATTORI, VICTOR; ZARPELON, ANA C.; STAURENGO-FERRARI, LARISSA; BORGHI, SERGIO M.; ZANINELII, TIAGO H.; DA COSTA, FERNANDO B.; AIVES, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; CASAGRANDE, RUBIA; et al. Budlein A, a Sesquiterpene Lactone From Viguiera robusta, Alleviates Pain and Inflammation in a Model o Acute Gout Arthritis in Mice. FRONTIERS IN PHARMACOLOGY, v. 9, SEP 25 2018. (13/08216-2, 11/19670-0)

FONSECA, MIRIAM D.; CUNHA, FERNANDO Q.; KASHFI, KHOSROW; CUNHA, THIAGO M.. NOSH-aspirin (NBS-1120), a dual nitric oxide and hydrogen sulfide-releasing hybrid, reduces inflammatory pain. PHARMACOLOGY RESEARCH & PERSPECTIVES, v. 3, n. 3, JUN 2015. (13/08216-2, 11/19670-0)

FATTORI, VICTOR; SERAFIM, KARLA G. G.; ZARPELON, ANA C.; BORGHI, SERGIO M.; PINHO-RIBEIRO, FELIPE A.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; CASAGRANDE, RUBIA; VERRI, JR., WALDICEU A.. Differential regulation of oxidative stress and cytokine production by endothelin ETA and ETB receptors in superoxide anion-induced inflammation and pain in mice. Journal of Drug Targeting, v. 25, n. 3, p. 264-274, 2017. (13/08216-2, 11/19670-0)

SANT'ANNA, MORENA B.; KUSUDA, RICARDO; BOZZO, TIAGO A.; BASSI, GABRIEL S.; ALVES-FILHO, JOSE C.; CUNHA, FERNANDO Q.; FERREIRA, SERGIO H.; SOUZA, GUILHERME R.; CUNHA, THIAGO M.. Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization. SCIENTIFIC REPORTS, v. 6, MAY 27 2016. (13/08216-2, 11/19670-0)

VERAS, FLAVIO P.; PERES, RAPHAEL S.; SARAIVA, ANDRE L. L.; PINTO, LARISSA G.; LOUZADA-JUNIOR, PAULO; CUNHA, THIAGO M.; PASCHOAL, JONAS A. R.; CUNHA, FERNANDO Q.; ALVES-FILHO, JOSE C.. Fructose 1,6-bisphosphate, a high-energy intermediate of glycolysis, attenuates experimental arthritis by activating anti-inflammatory adenosinergic pathway. SCIENTIFIC REPORTS, v. 5, OCT 19 2015. (13/08216-2, 09/54014-7, 11/19670-0)

QUADROS, ANDREZA U.; PINTO, LARISSA G.; FONSECA, MIRIAM M.; KUSUDA, RICARDO; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.. Dynamic weight bearing is an efficient and predictable method for evaluation of arthritic nociception and its pathophysiological mechanisms in mice. SCIENTIFIC REPORTS, v. 5, OCT 29 2015. (13/08216-2, 09/54014-7, 11/19670-0)

SISTI, FLAVIA; WANG, SOUJUAN; BRANDT, STEPHANIE L.; GLOSSON-BYERS, NICOLE; MAYO, LINDSEY D.; SON, YOUNG MIN; STURGEON, SARAH; FILGUEIRAS, LUCIANO; JANCAR, SONIA; WONG, HECTOR; et al. Nuclear PTEN enhances the maturation of a microRNA regulon to limit MyD88-dependent susceptibility to sepsis. SCIENCE SIGNALING, v. 11, n. 528, p. 14-pg., 2018-05-01. (13/08216-2, 11/19670-0)

GUIMARAESI, RAFAELA M.; DAVOLI-FERREIRA, MARCELA; FONSECA, MIRIAM M.; DAMASCENO, LUIS EDUARDO A.; SANTA-CECILIA, V, FLAVIA; KUSUDA, RICARDO; MENEZES, GUSTAVO B.; CUNHA, FERNANDO Q.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.. Frontline Science: Blood-circulating leukocytes fail to infiltrate the spinal cord parenchyma after spared nerve injury. Journal of Leukocyte Biology, v. 106, n. 3, SI, p. 541-551, SEP 2019. (13/08216-2, 11/19670-0)

PERES, RAPHAEL SANCHES; LIEW, FOO Y.; TALBOT, JHIMMY; CARREGARO, VANESSA; OLIVEIRA, RENE D.; ALMEIDA, SERGIO L.; FRANCA, RAFAEL F. O.; DONATE, PAULA B.; PINTO, LARISSA G.; FERREIRA, FLAVIA I. S.; et al. Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 112, n. 8, p. 6-pg., 2015-02-24. (13/08216-2, 11/19670-0)

LOURENCO-GONZALEZ, YURI; FATTORI, VICTOR; DOMICIANO, TALITA P.; ROSSANEIS, ANA C.; BORGHI, SERGIO M.; ZANINELLI, TIAGO H.; BERNARDY, CATIA C. F.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; et al. Repurposing of the Nootropic Drug Vinpocetine as an Analgesic and Anti-Inflammatory Agent: Evidence in a Mouse Model of Superoxide Anion-Triggered Inflammation. Mediators of Inflammation, v. 2019, p. 14-pg., 2019-01-01. (13/08216-2, 11/19670-0)

NASCIMENTO, DANIELE C.; MELO, PAULO H.; PINEROS, ANNIE R.; FERREIRA, RAPHAEL G.; COLON, DAVID F.; DONATE, PAULA B.; CASTANHEIRA, FERNANDA V.; GOZZI, ALINE; CZAIKOSKI, PAULA G.; NIEDBALA, WANDA; et al. IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population. NATURE COMMUNICATIONS, v. 8, APR 4 2017. (13/08216-2, 11/19670-0)

KANASHIRO, ALEXANDRE; SONEGO, FABIANE; FERREIRA, RAPHAEL G.; CASTANHEIRA, FERNANDA V. S.; LEITE, CAIO A.; BORGES, VANESSA F.; NASCIMENTO, DANIELE C.; COLON, DAVID F.; ALVES-FILHO, JOSE CARLOS; ULLOA, LUIS; et al. Therapeutic potential and limitations of cholinergic anti-inflammatory pathway in sepsis. PHARMACOLOGICAL RESEARCH, v. 117, p. 1-8, MAR 2017. (13/08216-2, 12/04237-2, 11/19670-0, 11/20343-4)

CZAIKOSKI, PAULA GISELLE; SEGUNDO CORREIA MOTA, JOSE MAURCIO; NASCIMENTO, DANIELE CARVALHO; SONEGO, FABIANE; VARGAS E SILVA CASTANHEIRA, FERNANDA; MELO, PAULO HENRIQUE; SCORTEGAGNA, GABRIELA TRENTIN; SILVA, RANGEL LEAL; BARROSO-SOUSA, ROMUALDO; SOUTO, FABRICIO OLIVEIRA; et al. Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis. PLoS One, v. 11, n. 2, FEB 5 2016. (13/08216-2, 11/19670-0)

SILVA, RANGEL L.; CASTANHEIRA, FERNANDA V.; FIGUEIREDO, JOZI G.; BASSI, GABRIEL S.; FERREIRA, SERGIO H.; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.; KANASHIRO, ALEXANDRE. Pharmacological Beta-Adrenergic Receptor Activation Attenuates Neutrophil Recruitment by a Mechanism Dependent on Nicotinic Receptor and the Spleen. Inflammation, v. 39, n. 4, p. 1405-1413, AUG 2016. (13/08216-2, 11/20343-4, 11/19670-0, 13/01466-3, 12/04237-2)

FRANCA, R. F. O.; VIEIRA, S. M.; TALBOT, J.; PERES, R. S.; PINTO, L. G.; ZAMBONI, D. S.; LOUZADA-JUNIOR, P.; CUNHA, F. Q.; CUNHA, T. M.. Expression and activity of NOD1 and NOD2/RIPK2 signalling in mononuclear cells from patients with rheumatoid arthritis. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, v. 45, n. 1, p. 8-12, JAN 2 2016. (10/19770-2, 13/08216-2, 11/19670-0)

PERES, RAPHAEL SANCHES; LIEW, FOO Y.; TALBOT, JHIMMY; CARREGARO, VANESSA; OLIVEIRA, RENE D.; ALMEIDA, SERGIO L.; FRANCA, RAFAEL F. O.; DONATE, PAULA B.; PINTO, LARISSA G.; FERREIRA, FLAVIA I. S.; et al. Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis. Proceedings of the National Academy of Sciences of the United States of America, v. 112, n. 8, p. 2509-2514, FEB 24 2015. (13/08216-2, 11/19670-0)

LOPES, ALEXANDRE H.; TALBOT, JHIMMY; SILVA, RANGEL L.; LIMA, JONILSON B.; FRANCA, RAFAEL O.; VERRI, JR., WALDICEU A.; MASCARENHAS, DANIELLE P.; RYFFEL, BERNHARD; CUNHA, FERNANDO Q.; ZAMBONI, DARIO S.; et al. Peripheral NLCR4 inflammasome participates in the genesis of acute inflammatory pain. Pain, v. 156, n. 3, p. 451-459, MAR 2015. (13/08216-2, 11/19670-0)

TREVELIN, SILVIA CELLONE; DOS SANTOS, CELIO XAVIER; FERREIRA, RAPHAEL GOMES; LIMA, LARISSA DE SA; SILVA, RANGEL LEAL; SCAVONE, CRISTOFORO; CURI, RUI; CARLOS ALVES-FILHO, JOSE; CUNHA, THIAGO MATTAR; ROXO-JUNIOR, PERSIO; et al. Apocynin and Nox2 regulate NF-kappa B by modifying thioredoxin-1 redox-state. SCIENTIFIC REPORTS, v. 6, OCT 4 2016. (12/24677-7, 09/54764-6, 13/08216-2, 13/03520-5, 11/19670-0, 11/03293-3, 13/07937-8)

FATTORI, VICTOR; PINHO-RIBEIRO, FELIPE A.; BORGHI, SERGIO M.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; CASAGRANDE, RUBIA; VERRI, JR., WALDICEU A.. Curcumin inhibits superoxide anion-induced pain-like behavior and leukocyte recruitment by increasing Nrf2 expression and reducing NF-kappa B activation. Inflammation Research, v. 64, n. 12, p. 993-1003, DEC 2015. (13/08216-2, 11/19670-0)

VIEIRA, SILVIO MANFREDO; SILVA, RANGEL LEAL; LEMOS, HENRIQUE PAULA; DAS NEVES AMORIM, RODRIGO CESAR; COSTA SILVA, ELLEN CRISTINA; REINACH, PETER SOL; CUNHA, FERNANDO QUEIROZ; POHLIT, ADRIAN MARTIN; CUNHA, THIAGO MATTAR. Gastro-protective effects of isobrucein B, a quassinoid isolated from Picrolemma sprucei. Fitoterapia, v. 95, p. 8-15, JUN 2014. (11/19670-0)

CALIL, IGOR L.; ZARPELON, ANA C.; GUERRERO, ANA T. G.; ALVES-FILHO, JOSE C.; FERREIRA, SERGIO H.; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.; VERRI, JR., WALDICEU A.. Lipopolysaccharide Induces Inflammatory Hyperalgesia Triggering a TLR4/MyD88-Dependent Cytokine Cascade in the Mice Paw. PLoS One, v. 9, n. 3, MAR 3 2014. (11/19670-0)

CECILIO, NERRY T.; SOUZA, GUILHERME R.; ALVES-FILHO, JOSE C.; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.. The PI3K gamma/AKT signaling pathway mediates peripheral antinociceptive action of dipyrone. FUNDAMENTAL & CLINICAL PHARMACOLOGY, v. 35, n. 2, p. 364-370, APR 2021. (13/08216-2, 11/19670-0)

HIROKI, CARLOS H.; TOLLER-KAWAHISA, JULIANA E.; FUMAGALLI, MARCILIO J.; COLON, DAVID F.; FIGUEIREDO, LUIZ T. M.; FONSECA, BENDITO A. L. D.; FRANCA, RAFAEL F. O.; CUNHA, FERNANDO Q.. Neutrophil Extracellular Traps Effectively Control Acute Chikungunya Virus Infection. FRONTIERS IN IMMUNOLOGY, v. 10, JAN 31 2020. (13/08216-2, 11/19670-0)

SILVA, CASSIA R.; MELO, BRUNO M. S.; SILVA, JAQUELINE R.; LOPES, ALEXANDRE H.; PEREIRA, JANAINA A.; CECILIO, NERRY T.; BERLINK, JONILSON; SOUZA, GIOVANI G.; LUCAS, GUILHERME; VOGL, THOMAS; et al. S100A9 plays a pivotal role in a mouse model of herpetic neuralgia via TLR4/TNF pathway. BRAIN BEHAVIOR AND IMMUNITY, v. 88, p. 353-362, AUG 2020. (13/08216-2, 11/19670-0)

SILVA CASTANHEIRA, FERNANDA V. E; BORGES, VANESSA; SONEGO, FABIANE; KANASHIRO, ALEXANDRE; DONATE, PAULA B.; MELO, PAULO H.; PALLAS, KENNETH; RUSSO, REMO C.; AMARAL, FLAVIO A.; TEIXEIRA, MAURO M.; et al. THE ATYPICAL CHEMOKINE RECEPTOR ACKR2 IS PROTECTIVE AGAINST SEPSIS. Shock, v. 49, n. 6, p. 682-689, JUN 2018. (13/08216-2, 11/19670-0)

HUANG, LEI; OU, RONG; DE SOUZA, GUILHERME RABELO; CUNHA, THIAGO M.; LEMOS, HENRIQUE; MOHAMED, ESLAM; LI, LINGQIAN; PACHOLCZYK, GABRIELA; RANDALL, JANICE; MUNN, DAVID H.; et al. Virus Infections Incite Pain Hypersensitivity by Inducing Indoleamine 2,3 Dioxygenase. PLOS PATHOGENS, v. 12, n. 5, MAY 2016. (13/08216-2, 11/19670-0)

BASSI, GABRIEL S.; MALVAR, DAVID DO C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; KANASHIRO, ALEXANDRE. Spinal GABA-B receptor modulates neutrophil recruitment to the knee joint in zymosan-induced arthritis. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, v. 389, n. 8, p. 851-861, AUG 2016. (13/08216-2, 12/04237-2, 11/19670-0, 11/20343-4)

FATTORI, VICTOR; HOHMANN, MIRIAM S. N.; ROSSANEIS, ANA C.; MANCHOPE, MARILIA F.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; VERRI, JR., WALDICEU A.. Targeting IL-33/ST2 signaling: regulation of immune function and analgesia. EXPERT OPINION ON THERAPEUTIC TARGETS, v. 21, n. 12, p. 1141-1152, 2017. (13/08216-2, 11/19670-0)

SANTA-CECILIA, V, FLAVIA; FERREIRA, DAVID W.; GUIMARAES, RAFAELA M.; CECILIO, NERRY T.; FONSECA, MIRIAM M.; LOPES, ALEXANDRE H.; DAVOLI-FERREIRA, MARCELA; KUSUDA, RICARDO; SOUZA, GUILHERME R.; NACHBUR, UELI; et al. The NOD2 signaling in peripheral macrophages contributes to neuropathic pain development. Pain, v. 160, n. 1, p. 102-116, JAN 2019. (13/08216-2, 11/19670-0)

MEDEIROS, PRISCILA; DOS SANTOS, IEDA REGINA; MATIAS JUNIOR, IVAIR; PALAZZO, ENZA; DA SILVA, JOSE APARECIDO; MACHADO, HELIO RUBENS; FERREIRA, SERGIO HENRIQUE; MAIONE, SABATINO; COIMBRA, NORBERTO CYSNE; DE FREITAS, RENATO LEONARDO. An Adapted Chronic Constriction Injury of the Sciatic Nerve Produces Sensory, Affective, and Cognitive Impairments: A Peripheral Mononeuropathy Model for the Study of Comorbid Neuropsychiatric Disorders Associated with Neuropathic Pain in Rats. PAIN MEDICINE, v. 22, n. 2, p. 338-351, FEB 2021. (11/19670-0, 13/08216-2, 13/12916-0, 17/13560-5, 14/11869-0, 12/25167-2, 14/07902-2, 01/03752-6, 09/17258-5, 03/05256-1)

MEDEIROS, PRISCILA; NEGRINI-FERRARI, SYLMARA ESTHER; PALAZZO, ENZA; MAIONE, SABATINO; FERREIRA, SERGIO HENRIQUE; DE FREITAS, RENATO LEONARDO; COIMBRA, NORBERTO CYSNE. N-methyl-d-aspartate Receptors in the Prelimbic Cortex are Critical for the Maintenance of Neuropathic Pain. Neurochemical Research, v. 44, n. 9, p. 2068-2080, SEP 2019. (14/11869-0, 03/05256-1, 01/03752-6, 12/25167-2, 13/08216-2, 13/12916-0, 11/19670-0, 02/01497-1, 17/13560-5, 09/17258-5, 14/07902-2)

YAMACITA-BORIN, FABIANE Y.; ZARPELON, ANA C.; PINHO-RIBEIRO, FELIPE A.; FATTORI, VICTOR; ALVES-FILHO, JOSE C.; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.; CASAGRANDE, RUBIA; VERRI, JR., WALDICEU A.. Superoxide anion-induced pain and inflammation depends on TNF alpha/TNFR1 signaling in mice. Neuroscience Letters, v. 605, p. 53-58, SEP 25 2015. (13/08216-2, 11/19670-0)

BARRAGAN-IGLESIAS, PAULINO; ROCHA-GONZALEZ, HECTOR I.; BARUCH PINEDA-FARIAS, JORGE; MURBARTIAN, JANET; GODINEZ-CHAPARRO, BEATRIZ; REINACH, PETER S.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; GRANADOS-SOTO, VINICIO. Inhibition of peripheral anion exchanger 3 decreases formalin-induced pain. European Journal of Pharmacology, v. 738, p. 91-100, SEP 5 2014. (11/19670-0)

SONEGO, FABIANE; ALVES-FILHO, JOSE CARLOS; CUNHA, FERNANDO QUEIROZ. Targeting neutrophils in sepsis. EXPERT REVIEW OF CLINICAL IMMUNOLOGY, v. 10, n. 8, p. 1019-1028, AUG 2014. (13/08216-2, 11/19670-0)

ZARPELON, ANA C.; FATTORI, VICTOR; SOUTO, FABRICIO O.; PINTO, LARISSA G.; PINHO-RIBEIRO, FELIPE A.; RUIZ-MIYAZAWA, KENJI W.; TURATO, WALTER M.; CUNHA, THIAGO M.; DA COSTA, FERNANDO B.; CUNHA, FERNANDO Q.; et al. The Sesquiterpene Lactone, Budlein A, Inhibits Antigen-Induced Arthritis in Mice: Role of NF-kappa B and Cytokines. Inflammation, v. 40, n. 6, p. 2020-2032, DEC 2017. (13/08216-2, 11/19670-0)

SANTA-CECILIA, FLAVIA V.; SOCIAS, BENJAMIN; OUIDJA, MOHAND O.; SEPULVEDA-DIAZ, JULIA E.; ACUNA, LEONARDO; SILVA, RANGEL L.; MICHEL, PATRICK P.; DEL-BEL, ELAINE; CUNHA, THIAGO M.; RAISMAN-VOZARI, RITA. Doxycycline Suppresses Microglial Activation by Inhibiting the p38 MAPK and NF-kB Signaling Pathways. NEUROTOXICITY RESEARCH, v. 29, n. 4, p. 447-459, MAY 2016. (13/08216-2, 11/19670-0)

ZARPELON, ANA C.; RODRIGUES, FRANCIELLE C.; LOPES, ALEXANDRE H.; SOUZA, GUILHERME R.; CARVALHO, THACYANA T.; PINTO, LARISSA G.; XU, DAMO; FERREIRA, SERGIO H.; ALVES-FILHO, JOSE C.; MCINNES, IAIN B.; et al. Spinal cord oligodendrocyte-derived alarmin IL-33 mediates neuropathic pain. FASEB JOURNAL, v. 30, n. 1, p. 54-65, JAN 2016. (13/08216-2, 11/19670-0)

PINHO-RIBEIRO, FELIPE A.; FATTORI, VICTOR; ZARPELON, ANA C.; BORGHI, SERGIO M.; STAURENGO-FERRARI, LARISSA; CARVALHO, THACYANA T.; ALVES, JOSE C.; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.; CASAGRANDE, RUBIA; et al. Pyrrolidine dithiocarbamate inhibits superoxide anion-induced pain and inflammation in the paw skin and spinal cord by targeting NF-kappa B and oxidative stress. INFLAMMOPHARMACOLOGY, v. 24, n. 2-3, p. 97-107, JUN 2016. (13/08216-2, 11/19670-0)

PINHO-RIBEIRO, FELIPE A.; ZARPELON, ANA C.; MIZOKAMI, SANDRA S.; BORGHI, SERGIO M.; BORDIGNON, JULIANO; SILVA, RANGEL L.; CUNHA, THIAGO M.; ALVES-FILHO, JOSE C.; CUNHA, FERNANDO Q.; CASAGRANDE, RUBIA; et al. The citrus flavonone naringenin reduces lipopolysaccharide-induced inflammatory pain and leukocyte recruitment by inhibiting NF-kappa B activation. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v. 33, p. 8-14, JUL 2016. (13/08216-2, 11/19670-0)

FRANCA, RAFAEL F. O.; COSTA, RENATA S.; SILVA, JAQUELINE R.; PERES, RAPHAEL S.; MENDONCA, LEILA R.; COLON, DAVID F.; ALVES-FILHO, JOSE CARLOS; CUNHA, FERNANDO Q.. IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system. JOURNAL OF NEUROINFLAMMATION, v. 13, JUN 22 2016. (10/19770-2, 13/08216-2, 11/19670-0)

SISTI, FLAVIA; WANG, SOUJUAN; BRANDT, STEPHANIE L.; GLOSSON-BYERS, NICOLE; MAYO, LINDSEY D.; SON, YOUNG MIN; STURGEON, SARAH; FILGUEIRAS, LUCIANO; JANCAR, SONIA; WONG, HECTOR; et al. Nuclear PTEN enhances the maturation of a microRNA regulon to limit MyD88-dependent susceptibility to sepsis. Science Signaling, v. 11, n. 528, MAY 1 2018. (13/08216-2, 11/19670-0)

STAURENGO-FERRARI, LARISSA; TREVELIN, SILVIA C.; FATTORI, VICTOR; NASCIMENTO, DANIELE C.; DE LIMA, KALIL A.; PELAYO, JACINTA S.; FIGUEIREDO, FLORENCIO; CASAGRANDE, RUBIA; FUKADA, SANDRA Y.; TEIXEIRA, MAURO M.; et al. Interleukin-33 Receptor (ST2) Deficiency Improves the Outcome of Staphylococcus aureus-lnduced Septic Arthritis. FRONTIERS IN IMMUNOLOGY, v. 9, MAY 16 2018. (13/08216-2, 11/19670-0)

SILVA, JAQUELINE R.; LOPES, ALEXANDRE H.; TALBOT, JHIMMY; CECILIO, NERRY T.; ROSSATO, MATEUS F.; SILVA, RANGEL L.; SOUZA, GUILHERME R.; SILVA, CASSIA R.; LUCAS, GUILHERME; FONSECA, BENEDITO A.; et al. Neuroimmune-Glia Interactions in the Sensory Ganglia Account for the Development of Acute Herpetic Neuralgia. JOURNAL OF NEUROSCIENCE, v. 37, n. 27, p. 6408-6422, JUL 5 2017. (10/12309-8, 13/08216-2, 11/19670-0)

PINEROS ALVAREZ, ANNIE ROCIO; GLOSSON-BYERS, NICOLE; BRANDT, STEPHANIE; WANG, SOUJUAN; WONG, HECTOR; STURGEON, SARAH; MCCARTHY, BRIAN PAUL; TERRITO, PAUL R.; ALVES-FILHO, JOSE CARLOS; HENRIQUE SEREZANI, C.. SOCS1 is a negative regulator of metabolic reprogramming during sepsis. JCI INSIGHT, v. 2, n. 13, JUL 6 2017. (13/08216-2, 11/19670-0)

ALVES-FILHO, JOSE C.; PALSSON-MCDERMOTT, EVA M.. Pyruvate Kinase M2: A Potential Target for Regulating inflammation. FRONTIERS IN IMMUNOLOGY, v. 7, APR 21 2016. (13/08216-2, 11/19670-0)

SONEGO, FABIANE; CASTANHEIRA, FERNANDA VARGAS E SILVA; FERREIRA, RAPHAEL GOMES; KANASHIRO, ALEXANDRE; VITORINO GONCALVES LEITE, CAIO ABNER; NASCIMENTO, DANIELE CARVALHO; COLON, DAVID FERNANDO; BORGES, VANESSA DE FATIMA; ALVES-FILHO, JOSE CARLOS; CUNHA, FERNANDO QUEIROZ. Paradoxical Roles of the neutrophil in Sepsis: Protective and Deleterious. FRONTIERS IN IMMUNOLOGY, v. 7, APR 26 2016. (08/11593-4, 11/19670-0)

SARAIVA, ANDRE L.; VERAS, FLAVIO P.; PERES, RAPHAEL S.; TALBOT, JHIMMY; DE LIMA, KALIL A.; LUIZ, JOAO P.; CARBALLIDO, JOSE M.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; RYFFEL, BERNHARD; et al. Succinate receptor deficiency attenuates arthritis by reducing dendritic cell traffic and expansion of T(h)17 cells in the lymph nodes. FASEB JOURNAL, v. 32, n. 12, p. 6550-6558, DEC 2018. (13/08216-2, 11/19670-0)

MANCHOPE, MARILIA F.; ARTERO, NAYARA A.; FATTORI, VICTOR; MIZOKAMI, SANDRA S.; PITOL, DIMITRIUS L.; ISSA, JOAO P. M.; FUKADA, SANDRA Y.; CUNHA, THIAGO M.; ALVES-FILHO, JOSE C.; CUNHA, FERNANDO Q.; et al. Naringenin mitigates titanium dioxide (TiO2)-induced chronic arthritis in mice: role of oxidative stress, cytokines, and NF kappa B. Inflammation Research, v. 67, n. 11-12, p. 997-1012, DEC 2018. (13/08216-2, 11/19670-0)

TALBOT, JHIMMY; PERES, RAPHAEL S.; PINTO, LARISSA G.; OLIVEIRA, RENE D. R.; LIMA, KALIL A.; DONATE, PAULA B.; SILVA, JAQUELINE R.; RYFFEL, BERNARD; CUNHA, THIAGO M.; ALVES-FILHO, JOSE C.; et al. Smoking-induced aggravation of experimental arthritis is dependent of aryl hydrocarbon receptor activation in Th17 cells. ARTHRITIS RESEARCH & THERAPY, v. 20, JUN 8 2018. (13/08216-2, 11/19670-0)

TREVELIN, SILVIA C.; CARLOS, DANIELA; BERETTA, MATTEO; DA SILVA, JOAO S.; CUNHA, FERNANDO Q.. Diabetes Mellitus and Sepsis: A Challenging Association. Shock, v. 47, n. 3, p. 276-287, MAR 2017. (13/08216-2, 11/03293-3, 11/19670-0, 09/54764-6)

MORICONI, ALESSIO; CUNHA, THIAGO M.; SOUZA, GUILHERME R.; LOPES, ALEXANDRE H.; CUNHA, FERNANDO Q.; CARNEIRO, VICTOR L.; PINTO, LARISSA G.; BRANDOLINI, LAURA; ARAMINI, ANDREA; BIZZARRI, CINZIA; et al. Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief. Proceedings of the National Academy of Sciences of the United States of America, v. 111, n. 47, p. 16937-16942, NOV 25 2014. (13/08216-2, 11/19670-0)

FREITAS, CRISTINA S.; ROVEDA, ANTONIO C.; TRUZZI, JR., DANIELA R.; GARCIA, ANDRE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; FRANCO, DOUGLAS W.. Anti-inflammatory and Anti-nociceptive Activity of Ruthenium Complexes with Isonicotinic and Nicotinic Acids (Niacin) as Ligands. Journal of Medicinal Chemistry, v. 58, n. 11, p. 4439-4448, JUN 11 2015. (12/23651-4, 13/08216-2, 11/19670-0)

P. MEDEIROS; I.R. DOS SANTOS; A.C. MEDEIROS; J.A. DA SILVA; S.H. FERREIRA; R.L. DE FREITAS; N.C. COIMBRA. Indomethacin attenuates mechanical allodynia during the organization but not the maintenance of the peripheral neuropathic pain induced by nervus ischiadicus chronic constriction injury. Brazilian Journal of Medical and Biological Research, v. 53, n. 5, 2020-04-27. (13/08216-2, 14/07902-2, 11/19670-0, 09/17258-5, 01/03752-6, 17/13560-5, 03/05256-1, 02/01497-1, 12/25167-2, 13/12916-0, 14/11869-0)

KANASHIRO, ALEXANDRE; HIROKI, CARLOS HIROJI; DA FONSECA, DENISE MORAIS; BIRBRAIR, ALEXANDER; FERREIRA, RAPHAEL GOMES; BASSI, GABRIEL SHIMIZU; FONSECA, MIRIAN D.; KUSUDA, RICARDO; MARTELOSSI CEBINELLI, GUILHERME CESAR; DA SILVA, KATIUSSIA PINHO; et al. The role of neutrophils in neuro-immune modulation. PHARMACOLOGICAL RESEARCH, v. 151, JAN 2020. (16/08385-7, 13/08216-2, 11/20343-4, 11/19670-0, 12/04237-2)

FONSECA, MIRIAM M.; DAVOLI-FERREIRA, MARCELA; SANTA-CECILIA, FLAVIA; GUIMARAES, RAFAELA M.; OLIVEIRA, FRANCISCO F. B.; KUSUDA, RICARDO; FERREIRA, DAVID W.; ALVES-FILHO, JOSE C.; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.. IL-27 Counteracts Neuropathic Pain Development Through Induction of IL-10. FRONTIERS IN IMMUNOLOGY, v. 10, p. 14-pg., 2020-01-28. (13/08216-2, 11/19670-0)

MAGANIN, ALEXANDRE G.; SOUZA, GUILHERME R.; FONSECA, MIRIAM D.; LOPES, ALEXANDRE H.; GUIMARAES, RAFAELA M.; DAGOSTIN, ANDRE; CECILIO, NERRY T.; MENDES, ATLANTE S.; GONCALVES, WILLIAM A.; SILVA, CONCEICAO E. A.; et al. Meningeal dendritic cells drive neuropathic pain through elevation of the kynurenine metabolic pathway in mice. Journal of Clinical Investigation, v. 132, n. 23, p. 17-pg., 2022-12-01. (13/08216-2, 11/19670-0)

LOPES, ALEXANDRE H.; SILVA, RANGEL L.; FONSECA, MIRIAM D.; GOMES, FRANCISCO I.; MAGANIN, ALEXANDRE G.; RIBEIRO, LUCAS S.; MARQUES, LUCAS MACIEL MAURIZ; CUNHA, FERNANDO Q.; ALVES-FILHO, JOSE C.; ZAMBONI, DARIO S.; et al. Molecular basis of carrageenan-induced cytokines production in macrophages. CELL COMMUNICATION AND SIGNALING, v. 18, n. 1, p. 17-pg., 2020-09-07. (13/08216-2, 11/19670-0)

COLON, DAVID F.; WANDERLEY, CARLOS W.; FRANCHIN, MARCELO; SILVA, CAMILA M.; HIROKI, CARLOS H.; CASTANHEIRA, FERNANDA V. S.; DONATE, PAULA B.; LOPES, ALEXANDRE H.; VOLPON, LEILA C.; KAVAGUTI, SILVIA K.; et al. Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis. Critical Care, v. 23, p. 13-pg., 2019-04-08. (13/08216-2, 11/19670-0)

Patente(s) depositada(s) como resultado deste projeto de pesquisa