Estudo de filmes de carbono-tipo diamante contendo nanopartículas incorporadas para aplicações biomédicas

• Processo: 11/20345-7
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Vigência: 01 de junho de 2012 - 31 de maio de 2016
• Área do conhecimento: Engenharias - Engenharia de Materiais e Metalúrgica - Materiais Não-metálicos
• Pesquisador responsável: Fernanda Roberta Marciano
• Beneficiário: Fernanda Roberta Marciano
• Instituição Sede: Instituto de Pesquisa e Desenvolvimento (IP&D). Universidade do Vale do Paraíba (UNIVAP). São José dos Campos , SP, Brasil
• Pesquisadores associados: Airton Abrahao Martin ; Anderson de Oliveira Lobo ; Cristina Pacheco Soares ; Evaldo Jose Corat ; Leandro José Raniero ; Newton Soares da Silva ; Vladimir Jesus Trava-Airoldi
• Bolsa(s) vinculada(s): 16/00575-1 - Biomembranas funcionais a base de peptídeos e polímeros bottlebrush aplicados a engenharia de tecidos, BE.PQ; 16/01184-6 - Bioatividade de superfícies nanoestruturadas de titânio, BP.IC; 14/11491-8 - Estudo da biomineralização de filmes de carbono-tipo diamante contendo nanopartículas de dióxido de titânio incorporadas, BP.IC; + mais bolsas vinculadas 13/20825-4 - Estudo do processo de crescimento de filmes de carbono-tipo diamante contendo nanopartículas de dióxido de titânio incorporadas, BP.IC; 13/17415-9 - Estudo do processo de corrosão eletroquímica de filmes de carbono-tipo diamante contendo nanopartículas de diamante incorporadas, BP.IC; 12/21755-7 - Estudo do crescimento de filmes finos de carbono-tipo diamante contendo nanopartículas incorporadas em sua estrutura, BP.IC - menos bolsas vinculadas
• Assunto(s): Nanopartículas
• Palavra(s)-Chave do Pesquisador: atividade bactericida | biocompatibilidade | carbono-tipo diamante | Corrosão eletroquímica | Líquidos Biológicos | Nanopartículas | Biomateriais

Resumo

Este projeto tem caráter inovador e emergente na área biomédica por apresentar uma nova metodologia de obtenção de filmes finos de carbono-tipo diamante (DLC) com nanopartículas incorporadas em sua estrutura, visando o recobrimento de ligas ortopédicas. Para alcançar tal objetivo, este projeto propõe a criação de uma nova linha de pesquisa (Nanotecnologia Biomédica) em uma instituição com tradição consolidada em pesquisa na área de Engenharia Biomédica (IP&D/Univap). Os filmes finos de DLC serão produzidos a partir da técnica de deposição química da fase vapor assistida por plasma. Como nanopartículas de interesse biomédico, serão utilizadas: diamante cristalino (NDC), dióxido de titânio e ouro. A incorporação destas nanopartículas na estrutura dos filmes finos de DLC foi desenvolvida pela proponente deste projeto durante seu doutorado. Para isto, as nanopartículas de NCD e TiO2 serão funcionalizadas e as de ouro sintetizadas, para que as mesmas sejam homogeneamente dispersas em líquidos hidrocarbonetos utilizados como precursores do filme de DLC. Como substratos, serão utilizadas ligas comerciais biomédicas. As análises morfológicas e estruturais serão efetuadas por técnicas de microscopia eletrônica de varredura, microscopia eletrônica de transmissão, difractometria de raios-X e espectroscopia de espalhamento Raman. Os filmes produzidos serão caracterizados biologicamente in vitro utilizando: (i) linhagens de cultura de células permanentes (L-929) e osteoblastos humanos para avaliar a citotoxicidade, citocompatibilidade, bioatividade e biomineralização; (ii) cepas bacterianas para avaliar a atividade bacteriostática; e (iii) ensaios eletroquímicos para avaliar os efeitos anticorrosivos, utilizando simulados de fluidos humanos in vitro (SBF, solução de Ringer e líquido sinovial). Com isso, espera-se comprovar a biocompatibilidade e efeitos anticorrosivos para viabilizar a utilização dos filmes de DLC nas aplicações biomédicas. (AU)

Publicações científicas

(58)

(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)

RODRIGUES, BRUNO V. M.; LEITE, NELLY C. S.; CAVALCANTI, BRUNO DAS NEVES; DA SILVA, NEWTON S.; MARCIANO, FERNANDA R.; CORAT, EVALDO J.; WEBSTER, THOMAS J.; LOBO, ANDERSON O.. Graphene oxide/multi-walled carbon nanotubes as nanofeatured scaffolds for the assisted deposition of nanohydroxyapatite: characterization and biological evaluation. INTERNATIONAL JOURNAL OF NANOMEDICINE, v. 11, p. 2569-2585, 2016. (11/20345-7, 15/08523-8, 13/20054-8, 11/17877-7)

WACHESK, C. C.; TRAVA-AIROLDI, V. J.; DA-SILVA, N. S.; LOBO, A. O.; MARCIANO, F. R.. The Influence of Titanium Dioxide on Diamond-Like Carbon Biocompatibility for Dental Applications. Journal of Nanomaterials, 2016. (11/20345-7, 13/20054-8, 12/15857-1, 11/17877-7)

RAMOS, B. C.; SAITO, E.; TRAVA-AIROLDI, V. J.; LOBO, A. O.; MARCIANO, F. R.. Diamond-like carbon electrochemical corrosion resistance by addition of nanocrystalline diamond particles for biomedical applications. SURFACE & COATINGS TECHNOLOGY, v. 259, n. C, p. 732-736, NOV 25 2014. (11/20345-7, 11/17877-7)

LOBO, ANDERSON O.; ZANIN, HUDSON; SIQUEIRA, IDALIA A. W. B.; LEITE, NELLY C. S.; MARCIANO, FERNANDA R.; CORAT, EVALDO J.. Effect of ultrasound irradiation on the production of nHAp/MWCNT nanocomposites. Materials Science & Engineering C-Materials for Biological Applications, v. 33, n. 7, p. 4305-4312, OCT 1 2013. (11/20345-7, 11/17877-7)

ANTONIOLI, ELIANE; LOBO, ANDERSON O.; FERRETTI, MARIO; COHEN, MOISES; MARCIANO, FERNANDA R.; CORAT, EVALDO J.; TRAVA-AIROLDI, VLADIMIR J.. An evaluation of chondrocyte morphology and gene expression on superhydrophilic vertically-aligned multi-walled carbon nanotube films. Materials Science & Engineering C-Materials for Biological Applications, v. 33, n. 2, p. 641-647, MAR 1 2013. (11/20345-7, 11/17877-7)

NEVES, MARCELE FLORENCIO; SILVA, GISLENE RODRIGUES; BRAZIL, TAYRA RODRIGUES; MARCIANO, FERNANDA ROBERTA; PACHECO-SOARES, CRISTINA; LOBO, ANDERSON OLIVEIRA. Calcification in vitro of biomineralizated nanohydroxyapatite/superydrophilic vertically aligned multiwalled carbon nanotube scaffolds. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 16, n. 3, p. 614-618, MAY-JUN 2013. (11/20345-7, 12/02159-4, 11/17877-7)

NEVES, MARCELE FLORENCIO; BRAZIL, TAYRA RODRIGUES; SILVA SOARES, LUIS EDUARDO; CORAT, EVALDO JOSE; MARCIANO, FERNANDA ROBERTA; LOBO, ANDERSON OLIVEIRA. In vitro biomineralization of a novel hydroxyapatite/superhydrophilic multiwalled carbon nanotube nanocomposite using simulated body fluids. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 16, n. 3, p. 650-654, MAY-JUN 2013. (11/20345-7, 12/02159-4, 11/17877-7, 05/50811-9)

MACHADO, SUSANE MOREIRA; PACHECO-SOARES, CRISTINA; MARCIANO, FERNANDA ROBERTA; LOBO, ANDERSON OLIVEIRA; DA SILVA, NEWTON SOARES. Photodynamic therapy in the cattle protozoan Tritrichomonas foetus cultivated on superhydrophilic carbon nanotube. Materials Science & Engineering C-Materials for Biological Applications, v. 36, p. 180-186, MAR 1 2014. (11/20345-7, 08/06654-4, 11/17877-7)

LOBO, ANDERSON OLIVEIRA; SIQUEIRA, IDALIA A. W. B.; DAS NEVES, MARCELE F.; MARCIANO, FERNANDA ROBERTA; CORAT, EVALDO JOSE; CORAT, MARCUS ALEXANDRE F.. In vitro and in vivo studies of a novel nanohydroxyapatite/superhydrophilic vertically aligned carbon nanotube nanocomposites. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, v. 24, n. 7, p. 1723-1732, JUL 2013. (11/20345-7, 11/17877-7)

BARBOSA, MICHELLE C.; MESSMER, NIGEL R.; BRAZIL, TAYRA R.; MARCIANO, FERNANDA R.; LOBO, ANDERSON O.. The effect of ultrasonic irradiation on the crystallinity of nano-hydroxyapatite produced via the wet chemical method. Materials Science & Engineering C-Materials for Biological Applications, v. 33, n. 5, p. 2620-2625, JUL 1 2013. (11/20345-7, 11/17877-7)

LOPES, F. S.; OLIVEIRA, J. R.; MILANI, J.; OLIVEIRA, L. D.; MACHADO, J. P. B.; TRAVA-AIROLDI, V. J.; LOBO, A. O.; MARCIANO, F. R.. Biomineralized diamond-like carbon films with incorporated titanium dioxide nanoparticles improved bioactivity properties and reduced biofilm formation. Materials Science & Engineering C-Materials for Biological Applications, v. 81, p. 373-379, DEC 1 2017. (12/15857-1, 11/17877-7, 11/20345-7, 14/11491-8, 15/09697-0, 16/00575-1)

SILVA, ALINE DOS SANTOS; MANZOLLI RODRIGUES, BRUNO VINICIUS; OLIVEIRA, FRANCILIO CARVALHO; CARVALHO, JANCINEIDE OLIVEIRA; REIS DE VASCONCELLOS, LUANA MAROTTA; RIBEIRO DE ARAUJO, JULIANI CAROLINE; MARCIANO, FERNANDA ROBERTA; LOBO, ANDERSON OLIVEIRA. Characterization and in vitro and in vivo assessment of poly(butylene adipate-co-terephthalate)/nano-hydroxyapatite composites as scaffolds for bone tissue engineering. JOURNAL OF POLYMER RESEARCH, v. 26, n. 2, FEB 1 2019. (15/01259-3, 16/04618-7, 11/20345-7, 11/17877-7)

WACHESK, C. C.; SEABRA, S. H.; DOS SANTOS, T. A. T.; TRAVA-AIROLDI, V. J.; LOBO, A. O.; MARCIANO, F. R.. In vivo biocompatibility of diamond-like carbon films containing TiO2 nanoparticles for biomedical applications. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, v. 32, n. 9, SEP 2021. (11/20345-7, 12/15857-1)

PEREIRA, F. A. S.; SALLES, G. N.; RODRIGUES, B. V. M.; MARCIANO, F. R.; PACHECO-SOARES, C.; LOBO, A. O.. Diamond nanoparticles into poly(lactic acid) electrospun fibers: Cytocompatible and bioactive scaffolds with enhanced wettability and cell adhesion. Materials Letters, v. 183, p. 420-424, NOV 15 2016. (11/20345-7, 14/20561-0, 15/08523-8, 11/17877-7)

TONIATTO, T. V.; RODRIGUES, B. V. M.; MARSI, T. C. O.; RICCI, R.; MARCIANO, F. R.; WEBSTER, T. J.; LOBO, A. O.. Nanostructured poly (lactic acid) electrospun fiber with high loadings of TiO2 nanoparticles: Insights into bactericidal activity and cell viability. Materials Science & Engineering C-Materials for Biological Applications, v. 71, p. 381-385, FEB 1 2017. (11/17877-7, 15/08523-8, 13/08341-1, 11/20345-7, 14/16966-4)

ZOGBI, JR., M. M.; SAITO, E.; ZANIN, H.; MARCIANO, F. R.; LOBO, A. O.. Hydrothermal-electrochemical synthesis of nano-hydroxyapatite crystals on superhydrophilic vertically aligned carbon nanotubes. Materials Letters, v. 132, p. 70-74, OCT 1 2014. (11/20345-7, 12/15773-2, 11/17877-7)

RICCI, R.; LEITE, N. C. S.; DA-SILVA, N. S.; PACHECO-SOARES, C.; CANEVARI, R. A.; MARCIANO, F. R.; WEBSTER, T. J.; LOBO, A. O.. Graphene oxide nanoribbons as nanomaterial for bone regeneration: Effects on cytotoxicity, gene expression and bactericidal effect. Materials Science & Engineering C-Materials for Biological Applications, v. 78, p. 341-348, SEP 1 2017. (11/17877-7, 11/20345-7, 13/14464-9, 13/20054-8, 15/09697-0, 09/18440-1, 16/00575-1)

ZANIN, H.; CERAGIOLI, H. J.; PETERLEVITZ, A. C.; BARANAUSKAS, VITOR; MARCIANO, F. R.; LOBO, A. O.. Field emission properties of the graphenated carbon nanotube electrode. Applied Surface Science, v. 324, p. 174-178, JAN 1 2015. (11/20345-7, 14/02163-7, 11/17877-7)

MACHADO, M. M.; LOBO, A. O.; MARCIANO, F. R.; CORAT, E. J.; CORAT, M. A. F.. Analysis of cellular adhesion on superhydrophobic and superhydrophilic vertically aligned carbon nanotube scaffolds. Materials Science & Engineering C-Materials for Biological Applications, v. 48, p. 365-371, MAR 1 2015. (11/20345-7, 09/16986-7, 11/17877-7)

OLIVEIRA, C. A. G. S.; STEIN, M. F.; SAITO, E.; ZANIN, H.; VIEIRA, L. S.; RANIERO, L.; TRAVA-AIROLDI, V. J.; LOBO, A. O.; MARCIANO, F. R.. Effect of gold oxide incorporation on electrochemical corrosion resistance of diamond-like carbon. DIAMOND AND RELATED MATERIALS, v. 53, p. 40-44, MAR 2015. (11/20345-7, 14/02163-7, 11/17877-7)

SAITO, E.; ANTUNES, E. F.; ZANIN, H.; MARCIANO, F. R.; LOBO, A. O.; TRAVA-AIROLDI, V. J.; CORAT, E. J.. Oxygen Plasma Exfoliated Vertically-Aligned Carbon Nanotubes as Electrodes for Ultrasensitive Stripping Detection of Pb2+. Journal of the Electrochemical Society, v. 161, n. 5, p. H321-H325, 2014. (11/20345-7, 11/17877-7)

DE CASTRO, JUCARA G.; RODRIGUES, BRUNO V. M.; RICCI, RITCHELLI; COSTA, MAIRA M.; RIBEIRO, ANDRE F. C.; MARCIANO, FERNANDA R.; LOBO, ANDERSON O.. Designing a novel nanocomposite for bone tissue engineering using electrospun conductive PBAT/polypyrrole as a scaffold to direct nanohydroxyapatite electrodeposition. RSC ADVANCES, v. 6, n. 39, p. 32615-32623, 2016. (11/20345-7, 15/08523-8, 11/17877-7)

GRANATO, ALESSANDRO E. C.; RIBEIRO, ANDRE C.; MARCIANO, FERNANDA R.; RODRIGUES, BRUNO V. M.; LOBO, ANDERSON O.; PORCIONATTO, MARIMELIA. Polypyrrole increases branching and neurite extension by Neuro2A cells on PBAT ultrathin fibers. Nanomedicine-Nanotechnology Biology and Medicine, v. 14, n. 6, p. 1753-1763, AUG 2018. (11/20345-7, 12/00652-5, 11/17877-7)

DIAS, VANESSA; MACIEL, HOMERO; FRAGA, MARIANA; LOBO, ANDERSON O.; PESSOA, RODRIGO; MARCIANO, FERNANDA R.. Atomic Layer Deposited TiO2 and Al2O3 Thin Films as Coatings for Aluminum Food Packaging Application. MATERIALS, v. 12, n. 4, FEB 2 2019. (14/18139-8, 11/50773-0, 11/17877-7, 12/15857-1, 11/20345-7, 16/00575-1, 15/05956-0, 15/09697-0, 18/01265-1, 15/10876-6)

SILVA, EDMUNDO; REIS DE VASCONCELLOS, LUANA MAROTTA; RODRIGUES, BRUNO V. M.; DOS SANTOS, DANILO MARTINS; CAMPANA-FILHO, SERGIO P.; MARCIANO, FERNANDA ROBERTA; WEBSTER, THOMAS J.; LOBO, ANDERSON OLIVEIRA. PDLLA honeycomb-like scaffolds with a high loading of superhydrophilic graphene/multi-walled carbon nanotubes promote osteoblast in vitro functions and guided in vivo bone regeneration. Materials Science & Engineering C-Materials for Biological Applications, v. 73, p. 31-39, APR 1 2017. (11/17877-7, 11/20345-7, 15/09697-0, 15/08523-8, 16/00575-1)

RODRIGUES, BRUNO V. M.; LEITE, NELLY C. S.; CAVALCANTI, BRUNO DAS NEVES; DA SILVA, NEWTON S.; MARCIANO, FERNANDA R.; CORAT, EVALDO J.; WEBSTER, THOMAS J.; LOBO, ANDERSON O.. Graphene oxide/multi-walled carbon nanotubes as nanofeatured scaffolds for the assisted deposition of nanohydroxyapatite: characterization and biological evaluation. INTERNATIONAL JOURNAL OF NANOMEDICINE, v. 11, p. 17-pg., 2016-01-01. (15/08523-8, 11/20345-7, 13/20054-8, 11/17877-7)

SATO, TABATA P.; RODRIGUES, BRUNO V. M.; MELLO, DAPHNE C. R.; MUNCHOW, ELISEU A.; RIBEIRO, JULIANA S.; MACHADO, JOAO PAULO B.; VASCONCELLOS, LUANA M. R.; LOBO, ANDERSON O.; BOTTINO, MARCO C.; BORGES, ALEXANDRE L. S.. The role of nanohydroxyapatite on the morphological, physical, and biological properties of chitosan nanofibers. CLINICAL ORAL INVESTIGATIONS, v. 25, n. 5, p. 9-pg., 2020-10-13. (11/20345-7, 11/17877-7)

COSTA, R. P. C.; LIMA-OLIVEIRA, D. A.; MARCIANO, F. R.; LOBO, A. O.; CORAT, E. J.; TRAVA-AIROLDI, V. J.. Comparative study of the tribological behavior under hybrid lubrication of diamond-like carbon films with different adhesion interfaces. Applied Surface Science, v. 285, p. 4-pg., 2013-11-15. (11/20345-7, 11/17877-7)

RAMOS, B. C.; SAITO, E.; TRAVA-AIROLDI, V. J.; LOBO, A. O.; MARCIANO, F. R.. Diamond-like carbon electrochemical corrosion resistance by addition of nanocrystalline diamond particles for biomedical applications. SURFACE & COATINGS TECHNOLOGY, v. 259, p. 5-pg., 2014-11-25. (11/20345-7, 11/17877-7)

COSTA, R. P. C.; LIMA-OLIVEIRA, D. A.; MARCIANO, F. R.; LOBO, A. O.; CORAT, E. J.; TRAVA-AIROLDI, V. J.. Comparative study of the tribological behavior under hybrid lubrication of diamond-like carbon films with different adhesion interfaces. Applied Surface Science, v. 285, n. B, p. 645-648, NOV 15 2013. (11/20345-7, 11/17877-7)

ZANIN, HUDSON; SAITO, EDUARDO; MARCIANO, FERNANDA ROBERTA; CERAGIOLI, HELDER JOSE; CAMPOS GRANATO, ALESSANDRO EUSTAQUIO; PORCIONATTO, MARIMELIA; LOBO, ANDERSON OLIVEIRA. Fast preparation of nano-hydroxyapatite/superhydrophilic reduced graphene oxide composites for bioactive applications. JOURNAL OF MATERIALS CHEMISTRY B, v. 1, n. 38, p. 4947-4955, 2013. (11/20345-7, 11/17877-7)

ALMEIDA, C. N.; RAMOS, B. C.; DA-SILVA, N. S.; PACHECO-SOARES, C.; TRAVA-AIROLDI, V. J.; LOBO, A. O.; MARCIANO, F. R.. Morphological analysis and cell viability on diamond-like carbon films containing nanocrystalline diamond particles. Applied Surface Science, v. 275, p. 258-263, JUN 15 2013. (11/20345-7, 11/17877-7)

BRAZIL, TAYRA RODRIGUES; DAS NEVES, MARCELE FLORENCIO; REGIANI, INACIO; MARCIANO, FERNANDA ROBERTA; LOBO, ANDERSON OLIVEIRA. Proposed model for biomineralization of novel nanohydroxyapatite/vertically aligned multiwalled carbon nanotube scaffolds. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 16, n. 3, p. 661-667, MAY-JUN 2013. (11/20345-7, 12/02159-4, 11/17877-7)

ZAMPRONI, LAURA N.; GRINET, MARCO A. V. M.; MUNDIM, MAYARA T. V. V.; REIS, MARCELLA B. C.; GALINDO, LAYLA T.; MARCIANO, FERNANDA R.; LOBO, ANDERSON O.; PORCIONATTO, MARIMELIA. Rotary jet-spun porous microfibers as scaffolds for stem cells delivery to central nervous system injury. Nanomedicine-Nanotechnology Biology and Medicine, v. 15, n. 1, p. 98-107, JAN 2019. (12/00652-5, 09/05700-5, 11/20345-7, 11/17877-7)

SILVA SOARES, LUIS EDUARDO; MAGALHAES, JUAREZ DA SILVA; MARCIANO, FERNANDA ROBERTA; LOBO, ANDERSON OLIVEIRA. Surface characteristics of a modified acidulated phosphate fluoride gel with nano-hydroxyapatite coating applied on bovine enamel subjected to an erosive environment. MICROSCOPY RESEARCH AND TECHNIQUE, v. 81, n. 12, p. 1456-1466, DEC 2018. (11/17877-7, 11/20345-7, 13/14464-9, 07/07984-5, 05/50811-9, 09/18440-1)

SANTANA-MELO, GABRIELA F.; RODRIGUES, BRUNO V. M.; DA SILVA, EDMUNDO; RICCI, RITCHELLI; MARCIANO, FERNANDA R.; WEBSTER, THOMAS J.; VASCONCELLOS, LUANA M. R.; LOBO, ANDERSON O.. Electrospun ultrathin PBAT/nHAp fibers influenced the in vitro and in vivo osteogenesis and improved the mechanical properties of neoformed bone. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 155, p. 544-552, JUL 1 2017. (11/17877-7, 11/20345-7, 15/09697-0, 15/08523-8, 16/00575-1)

NAHORNY, SIDNEI; ZANIN, HUDSON; CHRISTINO, VINIE ABREU; MARCIANO, FERNANDA ROBERTA; OLIVEIRA LOBO, ANDERSON; SILVA SOARES, LUIS EDUARDO. Multi-walled carbon nanotubes/graphene oxide hybrid and nanohydroxyapatite composite: A novel coating to prevent dentin erosion. Materials Science & Engineering C-Materials for Biological Applications, v. 79, p. 199-208, OCT 1 2017. (14/21587-2, 01/14384-8, 11/17877-7, 11/20345-7, 15/50093-0, 13/20825-4, 14/02163-7, 15/09697-0, 13/11192-8, 16/00575-1)

MACHADO-PAULA, M. M.; CORAT, M. A. F.; LANCELLOTTI, M.; MI, G.; MARCIANO, F. R.; VEGA, M. L.; HIDALGO, A. A.; WEBSTER, T. J.; LOBO, A. O.. A comparison between electrospinning and rotary-jet spinning to produce PCL fibers with low bacteria colonization. Materials Science & Engineering C-Materials for Biological Applications, v. 111, JUN 2020. (11/20345-7, 15/08523-8, 11/17877-7, 14/50869-6, 14/16295-2, 15/09697-0)

RICCI, RITCHELLI; LOBO, ANDERSON OLIVEIRA; MARCIANO, FERNANDA ROBERTA. In Vitro Osteogenesis Stimulation via Nano-Hydroxyapatite/Carbon Nanotube Thin Films on Biomedical Stainless Steel. MATERIALS, v. 11, n. 9, SEP 2018. (11/20345-7, 18/12383-5, 11/17877-7)

REIS DE VASCONCELLOS, LUANA MAROTTA; DO PRADO, RENATA FALCHETE; SARTORI, ELISA MATTIAS; SILVEIRA MENDONCA, DANIELA BACCELLI; MENDONCA, GUSTAVO; MARCIANO, FERNANDA ROBERTA; LOBO, ANDERSON OLIVEIRA. In vitro osteogenesis process induced by hybrid nanohydroxyapatite/graphene nanoribbons composites. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, v. 30, n. 7, JUL 2019. (11/20345-7, 11/17877-7)

GONCALVES, NATALIA I.; MUNCHOW, ELISEU A.; SANTOS, JESSICA D.; SATO, TABATA P.; DE OLIVEIRA, LETICIA R.; DE ARRUDA PAES-JUNIOR, TARCISIO J.; BOTTINO, MARCO C.; BORGES, ALEXANDRE L. S.. The role of polymeric nanofibers on the mechanical behavior of polymethyl methacrylate resin. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, v. 112, DEC 2020. (11/17877-7, 11/20345-7)

SILVA SOARES, LUIS EDUARDO; NAHORNY, SIDNEI; BRAGA, VIVIAN DE FARIA; MARCIANO, FERNANDA ROBERTA; BHATTACHARJEE, TANMOY T.; LOBO, ANDERSON OLIVEIRA. Raman spectroscopy-multivariate analysis related to morphological surface features on nanomaterials applied for dentin coverage. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, v. 228, MAR 5 2020. (11/20345-7, 11/17877-7, 16/00575-1, 13/11192-8, 14/21587-2, 15/09697-0, 14/02163-7, 01/14384-8)

STOCCO, T. D.; RODRIGUES, B. V. M.; MARCIANO, F. R.; LOBO, A. O.. Design of a novel electrospinning setup for the fabrication of biomimetic scaffolds for meniscus tissue engineering applications. Materials Letters, v. 196, p. 221-224, JUN 1 2017. (11/17877-7, 15/08523-8, 11/20345-7, 16/00575-1, 15/09697-0)

SIQUEIRA, IDALIA A. W. B.; OLIVEIRA, CILIANA A. G. S.; ZANIN, HUDSON; GRINET, MARCO A. V. M.; GRANATO, ALESSANDRO E. C.; PORCIONATTO, MARIMELIA A.; MARCIANO, FERNANDA R.; LOBO, ANDERSON O.. Bioactivity behaviour of nano-hydroxyapatite/freestanding aligned carbon nanotube oxide composite. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, v. 26, n. 2, FEB 2015. (11/20345-7, 14/02163-7, 13/07696-0, 11/17877-7)

RODRIGUES, BRUNO V. M.; SILVA, ALINE S.; MELO, GABRIELA F. S.; VASCONSCELLOS, LUANA M. R.; MARCIANO, FERNANDA R.; LOBO, ANDERSON O.. Influence of low contents of superhydrophilic MWCNT on the properties and cell viability of electrospun poly (butylene adipate-co-terephthalate) fibers. Materials Science & Engineering C-Materials for Biological Applications, v. 59, p. 782-791, FEB 1 2016. (15/01259-3, 15/08523-8, 11/20345-7, 11/17877-7)

PESSOA, R. S.; DOS SANTOS, V. P.; CARDOSO, S. B.; DORIA, A. C. O. C.; FIGUEIRA, F. R.; RODRIGUES, B. V. M.; TESTONI, G. E.; FRAGA, M. A.; MARCIANO, F. R.; LOBO, A. O.; et al. TiO2 coatings via atomic layer deposition on polyurethane and polydimethylsiloxane substrates: Properties and effects on C. albicans growth and inactivation process. Applied Surface Science, v. 422, p. 73-84, NOV 15 2017. (11/50773-0, 12/15857-1, 11/17877-7, 11/20345-7, 15/10876-6, 15/09697-0, 15/08523-8, 16/00575-1, 15/05956-0)

SALLES, GEISA NOGUEIRA; DOS SANTOS PEREIRA, FERNANDA APARECIDA; PACHECO-SOARES, CRISTINA; MARCIANO, FERNANDA ROBERTA; HOLSCHER, CHRISTIAN; WEBSTER, THOMAS J.; LOBO, ANDERSON OLIVEIRA. A Novel Bioresorbable Device as a Controlled Release System for Protecting Cells from Oxidative Stress from Alzheimer's Disease. Molecular Neurobiology, v. 54, n. 9, p. 6827-6838, NOV 2017. (11/17877-7, 11/20345-7, 15/09697-0, 14/20561-0, 16/00575-1)

SIQUEIRA, IDALIA A. W. B.; CORAT, MARCUS ALEXANDRE F.; CAVALCANTI, BRUNO DAS NEVES; RIBEIRO NETO, WILSON ALVES; MARTIN, AIRTON ABRAHAO; SUMAN BRETAS, ROSARIO ELIDA; MARCIANO, FERNANDA ROBERTA; LOBO, ANDERSON OLIVEIRA. In Vitro and in Vivo Studies of Novel Poly(D,L-lactic acid), Superhydrophilic Carbon Nanotubes, and Nanohydroxyapatite Scaffolds for Bone Regeneration. ACS APPLIED MATERIALS & INTERFACES, v. 7, n. 18, p. 9385-9398, MAY 13 2015. (11/20345-7, 12/02159-4, 11/17877-7)

ZANIN, H.; ROSA, C. M. R.; ELIAZ, N.; MAY, P. W.; MARCIANO, F. R.; LOBO, A. O.. Assisted deposition of nano-hydroxyapatite onto exfoliated carbon nanotube oxide scaffolds. NANOSCALE, v. 7, n. 22, p. 10218-10232, 2015. (11/20345-7, 14/02163-7, 11/17877-7)

GRINET, MARCO A. V. M.; ZANIN, HUDSON; CAMPOS GRANATA, ALESSANDRO EUSTAQUIO; PORCIONATTO, MARIMELIA; MARCIANO, FERNANDA ROBERTA; LOBO, ANDERSON OLIVEIRA. Fast preparation of free-standing nanohydroxyapatite-vertically aligned carbon nanotube scaffolds. JOURNAL OF MATERIALS CHEMISTRY B, v. 2, n. 9, p. 1196-1204, MAR 7 2014. (11/20345-7, 13/07696-0, 11/17877-7)

ZANIN, H.; MARGRAF-FERREIRA, A.; DA SILVA, N. S.; MARCIANO, F. R.; CORAT, E. J.; LOBO, A. O.. Graphene and carbon nanotube composite enabling a new prospective treatment for trichomoniasis disease. Materials Science & Engineering C-Materials for Biological Applications, v. 41, p. 65-69, AUG 1 2014. (11/20345-7, 08/06654-4, 11/17877-7)

METOKI, N.; ROSA, C. M. R.; ZANIN, H.; MARCIANO, F. R.; ELIAZ, N.; LOBO, A. O.. Electrodeposition and biomineralization of nano-beta-tricalcium phosphate on graphenated carbon nanotubes. SURFACE & COATINGS TECHNOLOGY, v. 297, p. 51-57, JUL 15 2016. (11/20345-7, 13/09684-0, 11/17877-7)

ZANIN, HUDSON; MANZOLLI RODRIGUES, BRUNO VINICIUS; RIBEIRO NETO, WILSON ALVES; SUMAN BRETAS, ROSARIO ELIDA; DA-SILVA, NEWTON SOARES; MARCIANO, FERNANDA ROBERTA; LOBO, ANDERSON OLIVEIRA. High loading of graphene oxide/multi-walled carbon nanotubes into PDLLA: A route towards the design of osteoconductive, bactericidal and non-immunogenic 3D porous scaffolds. Materials Chemistry and Physics, v. 177, p. 56-66, JUL 1 2016. (11/17877-7, 11/20345-7, 15/01259-3, 13/20054-8, 14/02163-7, 15/08523-8)

GRANATO, ALESSANDRO E. C.; RODRIGUES, BRUNO V. M.; RODRIGUES-JUNIOR, DORIVAL M.; MARCIANO, FERNANDA R.; LOBO, ANDERSON O.; PORCIONATTO, MARIMELIA A.. Magnetic super-hydrophilic carbon nanotubes/graphene oxide composite as nanocarriers of mesenchymal stem cells: Insights into the time and dose dependences. Materials Science & Engineering C-Materials for Biological Applications, v. 67, p. 694-701, OCT 1 2016. (11/20345-7, 12/00652-5, 15/08523-8, 11/17877-7)

WACHESK, C. C.; PIRES, C. A. F.; RAMOS, B. C.; TRAVA-AIROLDI, V. J.; LOBO, A. O.; PACHECO-SOARES, C.; MARCIANO, F. R.; DA-SILVA, N. S.. Cell viability and adhesion on diamond-like carbon films containing titanium dioxide nanoparticles. Applied Surface Science, v. 266, p. 176-181, FEB 1 2013. (11/20345-7, 11/17877-7)

RODRIGUES, BRUNO V. M.; DIAS, VANESSA M.; FRAGA, MARIANA A.; DA SILVA SOBRINHO, ARGEMIRO S.; LOBO, ANDERSON O.; MACIEL, HOMERO S.; PESSOA, RODRIGO S.. Atomic layer deposition of TiO2 thin films on electrospun poly (butylene adipate-co-terephthalate) fibers: Freestanding TiO2 nanostructures via polymer carbonization. MATERIALS TODAY-PROCEEDINGS, v. 14, p. 7-pg., 2019-01-01. (15/10876-6, 17/18826-3, 15/09697-0, 11/50773-0, 12/15857-1, 11/20345-7, 16/00575-1, 15/05956-0, 18/01265-1)

WACHESK, C. C.; TRAVA-AIROLDI, V. J.; DA-SILVA, N. S.; LOBO, A. O.; MARCIANO, F. R.. The Influence of Titanium Dioxide on Diamond-Like Carbon Biocompatibility for Dental Applications. Journal of Nanomaterials, v. 2016, p. 7-pg., 2016-01-01. (12/15857-1, 11/20345-7, 13/20054-8, 11/17877-7)

ANDRADE, P. O.; SANTO, A. M. E.; COSTA, M. M.; LOBO, A. O.; BEAUREPAIRE, E; PAVONE, FS; SO, PTC. Production of rotary jet spun ultrathin fibers of poly-butylene adipate-co- terephthalate (PBAT) filled with nanocomposites. ADVANCES IN MICROSCOPIC IMAGING, v. 10414, p. 7-pg., 2017-01-01. (11/20345-7, 13/20054-8, 11/17877-7)