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Wilner Martínez-López | Inst Investigaciones Biológicas Clemente Estable - Uruguai


It is proposed to study how the defect in TCR from Cockayne's Syndrome simile cells can interfere with the induction and Processing of UV-induced DNA lesions. Besides, it is foreseen to analyze the possible role of chromatin remodeling mechanisms in the induction and processing of UV-C-induced DNA lesions leading to an increase in the chromosomal aberration frequency and apoptosis in NER defective cells. DNA damage (basically pyrimidine dimers), after UV irradiation, and removal will be determined in CS (CHO) simile cells, in different conditions, in order to investigate what is the role of chromatin remodeling, in DNA repair and its relationship with the CS defect. (AU)