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International joint research on the development and application of electroretinographic and psychophysical methods for the assessment of postreceptoral on-and off-mechanisms in both chromatic and luminance retinal visual pathways in Duchenne muscular dystrophy and in Diabetes mellitus

Processo: 12/51299-3
Linha de fomento:Auxílio à Pesquisa - Regular
Vigência: 01 de fevereiro de 2013 - 31 de janeiro de 2015
Área do conhecimento:Ciências Humanas - Psicologia - Psicologia Experimental
Convênio/Acordo: BAYLAT/StMBW - Bavarian Academic Center for Latin America and Bavarian State Ministry of Science and the Arts
Pesquisador responsável:Dora Selma Fix Ventura
Beneficiário:Dora Selma Fix Ventura
Pesq. responsável no exterior: Jan Kremers
Instituição no exterior: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Alemanha
Instituição-sede: Instituto de Psicologia (IP). Universidade de São Paulo (USP). São Paulo , SP, Brasil
Assunto(s):Distrofia muscular de Duchenne  Diabetes mellitus  Eletrorretinografia  Retina 

Resumo

Diabetes mellitus and Duchenne muscular dystrophy are diseases that affect many organ systems in the body, including the retina. The objective of the proposed project is to obtain a more comprehensive and detailed understanding of the pathophysiological mechanisms in the human retina associated with these two important diseases. Our approach will be to use modern electrophysiological and psychophysical techniques that selectively reflect the activity of post-receptoral retinal mechanisms. The techniques are designed to specifically tap post-receptoral mechanisms associated with distinct retino-geniculate pathways that subserve different sensory-perceptual features: spatiotemporal luminance (achromatic) and chromatic vision. The results of the project will quantify the alterations caused by these diseases in these visual pathways, clarify the nature and locus of alterations in the underlying retinal neural substrate and bring the data in a context that is relevant for visual perception. (AU)

Publicações científicas (4)
(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)
HUCHZERMEYER, CORD; MARTINS, CRISTIANE M. G.; NAGY, BALAZS; BARBONI, MIRELLA T. S.; VENTURA, DORA F.; COSTA, MARCELO F.; KREMERS, JAN. Photoreceptor-specific light adaptation of critical flicker frequency in trichromat and dichromat observers. JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, v. 35, n. 4, p. B106-B113, APR 1 2018. Citações Web of Science: 2.
TSAI, TINA I.; SALGUEIRO BARBONI, MIRELLA TELLES; NAGY, BALAZS VINCE; ROUX, MICHEL J.; RENDON, ALVARO; VENTURA, DORA FIX; KREMERS, JAN. Asymmetrical Functional Deficits of ON and OFF Retinal Processing in the mdx(3Cv) Mouse Model of Duchenne Muscular Dystrophy. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 57, n. 13, p. 5788-5798, OCT 2016. Citações Web of Science: 3.
SALGUEIRO BARBONI, MIRELLA TELLES; GOMES MARTINS, CRISTIANE MARIA; NAGY, BALAZS VINCE; TSAI, TINA; DAMICO, FRANCISCO MAX; DA COSTA, MARCELO FERNANDES; PAVANELLO, RITA DE CASSIA M.; VILACA LOURENCO, NAILA CRISTINA; PEREIRADE CERQUEIRA, ANTONIA MARIA; ZATZ, MAYANA; KREMERS, JAN; VENTURA, DORA FIX. Dystrophin Is Required for Proper Functioning of Luminance and Red-Green Cone Opponent Mechanisms in the Human Retina. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 57, n. 8, p. 3581-3587, JUL 2016. Citações Web of Science: 1.
NAGY, BALAZS VINCE; SALGUEIRO BARBONI, MIRELLA TELLES; GOMES MARTINS, CRISTIANE MARIA; DA COSTA, MARCELO FERNANDES; KREMERS, JAN; VENTURA, DORA FIX. Human flicker electroretinography using different temporal modulations at mesopic and photopic luminance levels. DOCUMENTA OPHTHALMOLOGICA, v. 129, n. 2, p. 129-138, OCT 2014. Citações Web of Science: 4.

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