CIBFar - Centro de Inovação em Biodiversidade e Fármacos

• Processo: 13/07600-3
• Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Vigência: 01 de julho de 2013 - 30 de junho de 2024
• Área do conhecimento: Ciências Biológicas - Biofísica
• Pesquisador responsável: Glaucius Oliva
• Beneficiário: Glaucius Oliva
• Instituição-sede: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brasil
• Pesquisadores principais: Adriano Defini Andricopulo ; Carlos Roque Duarte Correia ; Fernando Antonio Santos Coelho ; Leila Maria Beltramini ; Luiz Carlos Dias ; Maysa Furlan ; Paulo Cézar Vieira ; Vanderlan da Silva Bolzani
• Pesq. associados: Alberto José Cavalheiro ; Andre Luis Berteli Ambrosio ; Angela Regina Araújo ; Arlene Gonçalves Corrêa ; Dulce Helena Siqueira Silva ; Eduardo Maffud Cilli ; Fabio Cardoso Cruz ; Ian Castro-Gamboa ; Ilana Lopes Baratella da Cunha Camargo ; Marcia Nasser Lopes ; Márcia Regina Cominetti ; Mônica Tallarico Pupo ; Nelma Regina Segnini Bossolan ; Rafael Victorio Carvalho Guido
• Auxílios(s) vinculado(s): 22/04089-5 - EMU concedido no processo 2013/07600-3: Vitrobot e ELSA cryo-transfer holder, AP.EMU; 22/03494-3 - EMU concedido no processo 2013/07600-3: citometro, AP.EMU; 21/13118-6 - EMU concedido no processo 2013/07600-3: Cromatógrafo Líquido de Alta Eficiência, AP.EMU; + mais auxílios vinculados 20/04602-9 - Desenvolvimento de antivirais para o tratamento da COVID-19, AP.R; 19/13911-8 - 47th IUPAC World Chemistry Congress - 2019, AR.EXT; 19/07606-8 - EMU concedido no processo 13/07600-3: Omnilog Phenotypic Miroarray, AP.EMU; 19/07457-2 - EMU concedido no processo 2013/07600-3 "ROCKIMAGER 1000", AP.EMU; 17/17920-6 - 10th European Conference on Marine Natural Products - ECMNP 2017, AR.EXT; 17/05190-3 - Metabolomics 2017, AR.EXT; 16/23279-9 - 5th Annual Conference of AnalytiX-2017, AR.EXT; 16/13884-2 - EMU concedido no processo 2013/07600-3: MicroScale Thermophoresis (MST), AP.EMU; 16/50009-2 - Greening sample preparation of complex matrices by using natural deep eutectic solvents (NADES) together with porous polymeric adsorbents for subsequent analyses by liquid chromatography (LC) and nuclear magnetic resonance (NMR), AP.R SPRINT; 16/11312-1 - 9th Joint Natural Products Conference 2016, AR.EXT; 15/08181-0 - American Society of Pharmacognosy 2015 Annual Meeting, AR.EXT; 15/14968-2 - American Society of Pharmacognosy 2015 Annual Meeting, AR.EXT; 15/06751-3 - Antitrypanosomal acetylene fatty acid derivatives from the seeds of Porcelia macrocarpa (Annonaceae), PUB.ART; 14/50304-9 - Caracterização estereoquímica de ciclotideos de espécies do cerrado utilizando atividade óptica Raman, AP.R; 14/15579-7 - 55th Annual American Society of Pharmacognosy Meeting & 14th Annual Oxford International Conference on the Science of Botanicals, AR.EXT; 13/21599-8 - Estratégias para síntese de produtos naturais e análogos com atividade anti-cancerígena envolvendo reações multi-componentes organocatalisadas, AV.EXT; 13/18375-0 - 61st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), AR.EXT - menos auxílios vinculados
• Bolsa(s) vinculada(s): 22/10835-1 - Frutos brasileiros comestíveis ricos em proteases e suas explorações microbianas para identificação de novos constituintes bioativos, BP.PD; 22/11106-3 - Busca por moléculas bioativas com ação inibitória na proteína não estrutural nsp13 de sars-cov-2, utilizando triagens enzimáticas e fragment screening, BP.PD; 22/07493-1 - Síntese de ligantes da enzima NS3 helicase do Vírus Zika baseado em fragmentos, BP.IC; + mais bolsas vinculadas 22/07984-5 - Centro de Pesquisa e Inovação em Biodiversidade e Fármacos, BP.TT; 21/03977-1 - Descoberta de inibidores a partir de plantas do Cerrado brasileiro como candidatos a compostos líderes para a Malária, BP.DR; 21/05646-2 - Engenharia metabólica aplicada à elucidação da via biossintética e produção sustentável de triterpenos quinonametídeos via expressão heteróloga em Saccharomyces cerevisiae, BP.DR; 21/13544-5 - Planejamento, síntese e avaliação biológica de novos agentes antiparasitários contendo o motivo 1,2,4-oxadiazol em suas estruturas, BP.DD; 21/14209-5 - Avaliação de Propriedades Farmacocinéticas e Biológicas de Candidatos a Fármacos, BP.PD; 21/06317-2 - Investigação de derivados de quinazolinas com propriedades anticâncerâncer, BP.IC; 21/06054-1 - Busca por candidatos a fármacos antivirais, tendo como alvo as RNA-polimerases dependentes de RNA (RdRp) do Alfavirus Chikungunya (NSP4) e do Betacoronavírus SARS-CoV-2 (NSP12), BP.PD; 21/02777-9 - Descoberta de fármacos para o tratamento da Doença de Chagas, BP.PD; 21/05629-0 - Centro de Pesquisa e Inovação em Biodiversidade e Farmácos - CIBFar, BP.TT; 21/01706-0 - Triagem de compostos para a identificação de fármacos contra o vírus Chikungunya utilizando sistema replicon subgenômico, BP.IC; 21/01686-0 - Triagem de compostos para a identificação de fármacos contra o vírus Zika utilizando sistema replicon subgenômico, BP.IC; 20/16787-3 - Estudo químico de micro-organismos endofíticos isolados de Malouetia tamaquarina (Apocynaceae) contra Doenças Tropicais Negligenciadas, BP.IC; 19/27790-8 - Desenvolvimento de ferramentas computacionais baseadas em aprendizado de máquina para a descoberta de novos candidatos a fármacos para a Malária, BP.PD; 19/23175-7 - Formulação com extratos e frações de Casearia sylvestris para controle de biofilme cariogênico, BP.DR; 19/24971-1 - Síntese, caracterização e avaliação da atividade de análogos do peptídeo (p-BthTX-I), BP.IC; 19/26679-6 - Avaliação da atividade de produtos naturais e outros compostos contra bactérias multirresistentes e seus biofilmes, BP.TT; 19/12632-8 - Sorocea bompladii: modelo vegetal para o isolamento de endófitos, visando a exploração racional da diversidade molecular, BP.IC; 19/09067-7 - Descobrindo o potencial dos metabólitos secundários de Malouetia tamaquarina (Apocynaceae) e seus endofíticos contra doenças tropicais neglegenciadas, BP.PD; 18/25289-7 - Descoberta de novos ligantes bioativos com propriedades anticâncer, BP.DR; 18/24344-4 - Otimização de compostos líderes para tratamento de doenças parasitárias tropicais em colaboração com a Drugs for Neglected Diseases Initiative (DNDi), BP.DR; 19/07603-9 - Exploração racional de Colletotrichum gloeosporiodes, visando à produção e isolamento de metabólitos bioativos e processos de scale-up, BP.IC; 19/06587-0 - Centro de Pesquisa e Inovação em Biodiversidade e Fármacos (CIBFar), BP.TT; 18/14153-7 - Investigação de alterações moleculares em pequenos grupos neurais seletivamente ativados (neuronal ensembles) do núcleo acumbens, que medeiam a incubação da fissura a cocaína induzida pelo ambiente, BP.DR; 18/25600-4 - Descoberta e desenvolvimento de candidatos antivirais contra o vírus da Febre Amarela baseados na estrutura do complexo NS2B-NS3 protease, BP.DD; 19/05967-3 - Compreensão da função biológica de produtos naturais de Bases de Dados para o planejamento de compostos ativos para o tratamento de doenças infecciosas, BP.PD; 18/23946-0 - Modelos preditivos para as fases dos fatores de estrutura de reflexões cêntricas em cristalografia de proteínas por aprendizado de máquina, BP.IC; 18/25773-6 - Descoberta de candidatos antivirais baseados na estrutura da enzima NS5 RNA polimerase RNA-dependente do vírus da febre amarela, BP.MS; 19/06034-0 - Avaliação farmacocinética e de propriedades biológicas de candidatos a fármacos, BP.PD; 19/01762-8 - Triagem de compostos naturais e sintéticos tendo como alvo proteínas de arbovírus, BP.TT; 19/04788-8 - Avaliação da atividade de produtos naturais e outros compostos contra bactérias multirresistentes e seus biofilmes, BP.TT; 18/23675-7 - Análise multiparamétrica do problema das fases em cristalografia de proteínas por aprendizagem profunda, BP.IC; 18/17095-8 - Caracterização estrutural da proteína NSP4 RNA polimerase RNA-dependente do Vírus Chikungunya e busca por agentes antivirais, BP.DR; 18/15887-4 - Otimização e elucidação da atividade antibacteriana de peptídeos catiônicos em patógenos multirresistentes, BP.DD; 18/19574-0 - Biologia estrutural e desenvolvimento de fármacos contra a proteína NS5 do Vírus Zika, BP.DD; 18/07287-7 - Descoberta de Derivados de Acridina e de Marinoquinolina como Inibidores de Plasmodium falciparum, BP.DR; 18/05130-3 - Construção e caracterização de um sistema replicon sub-genômico do ZIKV para a descoberta de agentes antivirais., BP.PD; 18/04896-2 - Estudo bioguiado de Talisia esculenta para a identificação de metabólitos secundários inibidores de glicação avançada, BP.IC; 17/26679-0 - Derivados 4-quinolinonas como candidatos a fármacos antimaláricos: caracterização da atividade Antiplasmodial in vitro, in vivo e de modo de ação, BP.MS; 17/16772-3 - Estudos estruturais e funcionais da enzima NS5 RNA-dependente RNA polimerase do vírus da febre amarela, BP.IC; 17/23778-8 - Estratégias em quimioinformática para uma série de compostos antichagásicos, BP.IC; 17/22661-0 - Estudos estruturais e funcionais do complexo NS2B-NS3 protease de febre amarela, BP.IC; 17/17098-4 - Emprego de imageamento MALDI-MSI em tecidos foliares nodulados e não nodulados de Psychotria e Hybanthus: Localização, análise de ciclotídeos e sua relação com bactérias endossimbiontes, BP.PD; 17/07229-4 - Caracterização estrutural das proteínas do vírus Chikungunya e busca por agentes antivirais, BP.PD; 17/12326-9 - Orbitídeos de Croton antisyphiliticus e C. sphaerogynus (Euphorbiaceae), caracterização química-biológica e síntese: prospecção racional de peptídeos de baixo peso molecular com potencial antitumoral, BP.MS; 17/15682-0 - Amidas de espécies de Piperaceae: estudos metabolômicos em matrizes naturais para bioprospecção de antimicrobianos, BP.IC; 17/01287-2 - Triagem de compostos candidatos a novos medicamentos antitumorais por cultura celular tridimensional, BP.PD; 17/04070-4 - Descoberta de derivados 4-quinolinonas como candidatos a composto líder para o desenvolvimento de novos antimaláricos, BP.IC; 16/24714-0 - Estruturação de um banco de dados metabólicos para Casearia sylvestris usando LC-DAD-CAD-MS, BP.IC; 16/24969-9 - Avaliação de compostos em patógenos bacterianos multirresistentes como parte do Centro de Pesquisa e Inovação em Biodiversidade e Fármacos - CIBFar, BP.IC; 16/19712-9 - Caracterização estrutural das proteínas do vírus Zika e busca por agentes antivirais, BP.PD; 16/09235-9 - Fingerprinting metabólico (perfil cromatográfico) por LC-DAD-MS para controle de qualidade de drogas vegetais de espécies de Erythrina: desenvolvimento e validação de método, BP.MS; 16/17153-2 - Biologia estrutural e desenvolvimento de fármacos contra a proteína NS5 do vírus Zika, BP.DD; 16/16402-9 - Centro de pesquisa e inovação em biodiversidade e fármacos., BP.TT; 16/09772-4 - Estudos de biologia estrutural e química medicinal para a descoberta de inibidores da enzima enolase de Plasmodium falciparum, BP.MS; 16/06499-5 - Estudos cristalográficos de complexos da enzima cruzaína de T.cruzi com inibidores, BP.IC; 16/04004-9 - Exploração do potencial químico e de biotransformação do fungo Rhinocladiella similis na busca por compostos de interesse biológico, BP.IC; 15/23244-8 - Desenvolvimento de novos peptídeos e bioconjugados com atividade contra infecção por Zika Vírus, BP.DR; 15/19495-5 - Síntese de compostos para o tratamento da Doença de Chagas no âmbito do CEPID/FAPESP/DNDi, BP.PD; 15/25175-3 - Clonagem e caracterização das oxidorredutases do tipo citocromo P450 de Maytenus ilicifolia e seu efeito no aumento da produção de triterpenos quinonametídeos por expressão heteróloga em Saccharomyces ceravisiae, BP.PD; 15/23095-2 - Síntese e caracterização de bioconjugados peptídicos com atividade antitumoral, BP.IC; 15/21272-4 - Estudos Computacionais da Enzima N-Miristoiltransferase de Plasmodium falciparum e seus Inibidores como Candidatos a Agentes Antimaláricos, BP.MS; 15/18192-9 - Descoberta e Desenvolvimento de Fármacos Antimaláricos: Biologia Estrutural, Química Medicinal e Parasitologia, BP.PD; 15/09533-7 - Ciclopeptídeos de Plantas de Ambientes Extremos (Bioma Caatinga): Caracterização, Função, Síntese e Avaliação do Potencial Antitumoral e Imunossupressor, BP.PD; 15/11339-4 - Análise comparativa de alquilresorcinóis em cultivares de cana-de-açúcar e avaliação de eventual efeito protetor frente a patógenos fúngicos, BP.IC; 14/26313-8 - Descoberta e Planejamento de Inibidores de Enolase de Plasmodium falciparum como Novos Agentes Antimaláricos, BP.PD; 14/15145-7 - Estudos estruturais da enzima topoisomerase II mitocondrial de tripanossomatídeos, BP.PD; 14/19362-2 - Aplicação da biotecnologia na avaliação da interação planta-microrganismo para a produção de metabólitos secundários em Peritassa campestris e seus endófitos, BP.PD; 14/21567-1 - Estudo de micro-organismos isolados da rizosfera de Senna spectabilis visando a detecção de metabólitos bioativos, BP.IC; 14/14067-2 - Prospecção da rota de anabolismo dos congêneres quinonametídeo de Maytenus spp. (Celastraceae) em exemplares biogeograficamente distintos, BP.PD; 14/05538-1 - Síntese, caracterização, estudo do mecanismo de ação e análise de métodos de liberação do peptídeo pBthTX-I, nas formas monoméricas e diméricas, BP.PD; 14/17931-0 - Avaliação da atividade de produtos naturais contra bactérias multirresistentes e seus biofilmes., BP.TT; 14/02282-6 - Estudo da relação estrutura-atividade de alcalóides derivados da Pilocarpus microphyllus (Rutaceae) com ação contra Schistosoma mansoni, BP.PD; 14/05935-0 - Co-cultura de micro-organismos isolados da rizosfera de Senna spectabilis visando a produção de metabólitos bioativos, BP.DD; 14/02738-0 - Documentação química de espécies do gênero Casearia (Salicaceae) de importância ecológica, econômica e medicinal, BP.IC; 13/25658-9 - Planejamento e Desenvolvimento de Candidatos a Fármacos para a Doença de Chagas, BP.PD; 13/24952-0 - Padrões da emergência de enterococci e staphylococci multiresistentes no Brasil e busca por novos fármacos, BP.PD; 14/00326-6 - Caracterização química de Ficus guaranítica (Moraceae): prospecção de compostos com interesse econômico e avaliação de atividades biológicas de interesse terapêutico, BP.IC; 13/15306-8 - Estudos sobre a biossíntese dos triterpenos quinonametídeos por engenharia metabólica: avaliação do fluxo metabólico micro- e macromolecular do sistema heterólogo por técnicas metabolômicas e proteômicas., BP.PD; 13/15086-8 - Aplicações da metabolômica e proteômica na busca por novas substâncias biologicamente ativas em espécies da família Malpighiaceae, BP.PD; 13/16807-0 - Síntese de Compostos para o Tratamento da Doença de Chagas no Âmbito do CEPID-FAPESP/DNDi, BP.PD; 13/18329-9 - "Avaliação In Vitro de Propriedades Citotóxicas e Farmacocinéticas de Compounds Bioativos de Origem Natural e Sintética", BP.TT; 13/10933-4 - Aplicação de ferramentas biotecnológicas em Streptomyces olindensis para a obtenção de novos produtos naturais com potencial farmacêutico, BP.PD; 13/03493-8 - Potencial de extratos brutos, óleo essencial e compostos isolados obtidos de Tagetes patula L. (Asteraceae) como antiparasitário botânico contra Rhipicephalus (Boophilus) microplus, Haemonchus contortus e Cimex lectularis, BP.PD; 11/01544-9 - Análise proteômica com enfoque na enzima oxidoredutase do tipo P450 em raízes de plantas jovens e adultas de Maytenus ilicifolia (Celastraceae), BP.PD; 11/10379-1 - CLONAGEM E CARACTERIZAÇÃO DE OXIDOESQUALENO CICLASES DE Maytenus ilicifolia Mart. ex Reissek, BP.PD; 11/01003-8 - Estudos proteômicos em Peperomia obtusifolia (Piperaceae), BP.PD; 11/03017-6 - Produtos naturais oriundos de plantas do Cerrado e Mata Atlântica, modelos potenciais e úteis para identificar protótipos com ação oxidante em neutrófilos e enzima mieloperoxidase (MPO), BP.PD - menos bolsas vinculadas
• Assunto(s): Biodiversidade Planejamento de fármacos Fármacos Produtos naturais Síntese orgânica Bioensaio Financiamento em saúde
• Publicação FAPESP: https://media.fapesp.br/bv/uploads/pdfs/Multidisciplinary_science_N0zamCM_16_17.pdf

Resumo

O Centro de Inovação em Biodiversidade e Fármacos (CIBFar) é uma iniciativa resultante de projetos de pesquisa colaborativos, envolvendo: (i) Laboratório de Química Medicinal e Computacional (LQMC) e Biofísica Molecular - IFSC - USP, (II) Núcleo de Bioensaios, Biossíntese e Eco Fisiologia de Produtos Naturais (NUBBE) – IQ - UNESP, (III) Laboratórios de Síntese Orgânica - IQ - UNICAMP, (iv) Laboratórios de Produtos Naturais e Síntese Orgânica - DQ - UFSCar, e (v) Laboratório de Produtos Naturais - FCFRP - USP. O objetivo principal desse Centro é a realização de ciência básica e aplicada, bem como o desenvolvimento tecnológico em todas as áreas de biodiversidade e de descoberta de fármacos com base em pesquisas que utilizam o estado da arte da química de produtos naturais, química orgânica sintética, biologia molecular e estrutural, bioquímica, química medicinal, planejamento de fármacos e ensaios farmacológicos. Os objetivos específicos são a bioprospecção da flora brasileira para a identificação de compostos com um amplo espectro de atividades biológicas (antiparasitária, antibacteriana, anticâncer); seleção de compostos bioativos promissores para síntese orgânica e estudos das relações entre a estrutura e atividade (SAR, QSAR); uso de estratégias de planejamento de fármacos baseado na estrutura do receptor e do ligante (SBDD e LBDD, respectivamente); abordagens para otimização de compostos-líderes; estudos pré-clínicos in vitro e in vivo para a avaliação e otimização de compostos-líderes, e estudos de toxicologia e farmacocinética. O objetivo final é o desenvolvimento de novos candidatos a fármacos com elevado potencial de inovação para desenvolvimento clínico. Para tanto, o CIBFar se baseia não apenas nas competências e conhecimentos científicos sólidos em todas as áreas de interesse, mas também em uma estrutura organizada para a integração das abordagens modernas em biodiversidade e descoberta de fármacos. O CIBFar tem como principal característica a infraestrutura bem estabelecida em termos de competências para o apoio técnico, financeiro, educação tecnológica e gestão executiva (adquirida nos últimos 11 anos como um dos CEPID-FAPESP). A integração máxima com o setor produtivo será realizada para identificação de oportunidades e definição de metas. No aspecto educacional, o Centro conta com a significativa experiência adquirida ao longo de uma década, em educação e disseminação do conhecimento realizada no CEPID-FAPESP. (AU)

Publicações científicas

(285)

(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)

CRISTIANO SOLEO FUNARI; ALBERTO JOSÉ CAVALHEIRO; RENATO LAJARIM CARNEIRO. Coupled monolithic columns as an alternative for the use of viscous ethanol–water mobile phases on chromatographic fingerprinting complex samples. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 28, n. 3, p. 261-266, 2018-06-00. (10/18840-7, 14/50926-0, 13/07600-3)

DAYANE C. RIBEIRO; HELENA M. RUSSO; KARINA FRAIGE; MARIA L. ZERAIK; CLÁUDIO R. NOGUEIRA; PATRÍCIA B. DA SILVA; ANA C. CODO; GIOVANA M. F. CALIXTO; ALEXANDRA I. DE MEDEIROS; MARLUS CHORILLI; et al. Bioactive Bioflavonoids from Platonia insignis (Bacuri) Residues as Added Value Compounds. Journal of the Brazilian Chemical Society, v. 32, n. 4, p. 786-799, 2021-03-29. (17/19870-6, 13/07600-3, 16/16970-7, 17/18807-9, 14/50926-0)

CARBALLEIRA, NESTOR M.; BWALYA, ANGELA GONO; ITOE, MAURICE AYAMBA; ANDRICOPULO, ADRIANO D.; CORDERO-MALDONADO, MARIA LORENA; KAISER, MARCEL; MOTA, MARIA M.; CRAWFORD, ALEXANDER D.; GUIDO, RAFAEL V. C.; TASDEMIR, DENIZ. 2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes. Bioorganic & Medicinal Chemistry Letters, v. 24, n. 17, p. 4151-4157, SEP 1 2014. (13/07600-3)

KHAN, ISMAT ULLAH; KATTELA, SHIVASHANKAR; HASSAN, ABBAS; CORREIA, CARLOS ROQUE DUARTE. Enantioselective total synthesis of the highly selective sphingosine-1-receptor VPC01091 by the Heck desymmetrization of a non-activated cyclopentene-fused spiro-pyrrolidinone. ORGANIC & BIOMOLECULAR CHEMISTRY, v. 14, n. 40, p. 9476-9480, OCT 28 2016. (14/05407-4, 14/25770-6, 13/07600-3)

MAGALHAES, LUMA G.; MARQUES, FERNANDO B.; DA FONSECA, MARINA B.; ROGERIO, KAMILLA R.; GRAEBIN, CEDRIC S.; ANDRICOPULO, ADRIANO D.. Discovery of a Series of Acridinones as Mechanism-Based Tubulin Assembly Inhibitors with Anticancer Activity. PLoS One, v. 11, n. 8, AUG 10 2016. (13/07600-3)

FERREIRA, LEONARDO G.; ANDRICOPULO, ADRIANO D.. Fragment-Based QSAR and Structural Analysis of a Series of Hydroxyethylamine Derivatives as HIV-1 Protease Inhibitors. COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, v. 18, n. 5, p. 464-475, 2015. (13/25658-9, 13/07600-3)

RODRIGUES, MARILI V. N.; BARBOSA, ALEXANDRE F.; DA SILVA, JULIA F.; DOS SANTOS, DEBORAH A.; VANZOLINI, KENIA L.; DE MORAES, MARCELA C.; CORREA, ARLENE G.; CASS, QUEZIA B.. 9-Benzoyl 9-deazaguanines as potent xanthine oxidase inhibitors. Bioorganic & Medicinal Chemistry, v. 24, n. 2, p. 226-231, JAN 15 2016. (13/01710-1, 13/50680-8, 13/07600-3)

SANTOS, GABRIELA B.; KROGH, RENATA; MAGALHAES, LUMA G.; ANDRICOPULO, ADRIANO D.; PUPO, MONICA T.; EMERY, FLAVIO S.. Semisynthesis of new aphidicolin derivatives with high activity against Trypanosoma cruzi. Bioorganic & Medicinal Chemistry Letters, v. 26, n. 4, p. 1205-1208, FEB 15 2016. (09/14184-0, 13/07600-3)

DIAS, LUIZ C.; DE LUCCA, JR., EMILIO C.. Total Synthesis of the Oxopolyene Macrolide (-)-Marinisporolide C. ORGANIC LETTERS, v. 17, n. 24, p. 6278-6281, DEC 18 2015. (11/06721-6, 12/02230-0, 13/07600-3)

OLIVEIRA, CAIO C.; MARQUES, MARCELO V.; GODOI, MARLA N.; REGIANI, THAIS; SANTOS, VANESSA G.; DOS SANTOS, EMERSON A. F.; EBERLIN, MARCOS N.; SA, MARCUS M.; CORREIA, CARLOS R. D.. Chemo-, Regio- and Stereoselective Heck Arylation of Allylated Malonates: Mechanistic Insights by ESI-MS and Synthetic Application toward 5-Arylmethyl-gamma-lactones. ORGANIC LETTERS, v. 16, n. 19, p. 5180-5183, OCT 3 2014. (13/07600-3, 11/23832-6)

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GOMES, RALPH C.; BARCELOS, ROSIMEIRE C.; RODRIGUES, JR., MANOEL T.; SANTOS, HUGO; COELHO, FERNANDO. Intermolecular Stetter Reactions on Morita-Baylis-Hillman Adducts: an Approach to Highly Functionalized 1,4-Dicarbonyl Compounds. CHEMISTRYSELECT, v. 2, n. 3, p. 926-930, JAN 2017. (15/09205-0, 13/10449-5, 13/07600-3)

PARACATU, LUANA C.; ZERAIK, MARIA L.; BERTOZO, LUIZA DE CARVALHO; BARTOLOMEU, ALOISIO DE ANDRADE; DA SILVA FILHO, LUIZ C.; DA FONSECA, LUIZ M.; XIMENES, VALDECIR F.. Synthesis, Antioxidant and Anti-inflammatory Properties of an Apocynin- Derived Dihydrocoumarin. Medicinal Chemistry, v. 13, n. 1, p. 93-100, 2017. (10/52327-5, 13/08784-0, 13/07600-3)

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LORENZON, ESTEBAN N.; PICCOLI, JULIA P.; SANTOS-FILHO, NORIVAL A.; CILLI, EDUARDO M.. Dimerizatiori of Antimicrobial Peptides: A Promising Strategy to Enhance Antimicrobial Peptide Activity. PROTEIN AND PEPTIDE LETTERS, v. 26, n. 2, p. 98-107, 2019. (12/15346-7, 13/07600-3)

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