CIBFar - Centro de Inovação em Biodiversidade e Fármacos

• Processo: 13/07600-3
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Vigência: 01 de julho de 2013 - 30 de junho de 2025
• Área do conhecimento: Ciências Biológicas - Biofísica
• Pesquisador responsável: Glaucius Oliva
• Beneficiário: Glaucius Oliva
• Instituição Sede: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brasil
• Pesquisadores principais: Adriano Defini Andricopulo ; Carlos Roque Duarte Correia ; Fernando Antonio Santos Coelho ; Leila Maria Beltramini ; Luiz Carlos Dias ; Maysa Furlan ; Paulo Cézar Vieira ; Vanderlan da Silva Bolzani
• Pesquisadores associados: ALBERTO JOSE CAVALHEIRO ; Andre Luis Berteli Ambrosio ; Angela Regina Araújo ; Arlene Gonçalves Corrêa ; Dulce Helena Siqueira Silva ; Eduardo Maffud Cilli ; Fabio Cardoso Cruz ; Ian Castro-Gamboa ; Ilana Lopes Baratella da Cunha Camargo ; Leonardo Luiz Gomes Ferreira ; Marcia Nasser Lopes ; Márcia Regina Cominetti ; Mônica Tallarico Pupo ; Nelma Regina Segnini Bossolan ; Rafael Victorio Carvalho Guido
• Auxílios(s) vinculado(s): 23/06024-0 - 266th ACS National Meeting & Exposition, AR.EXT; 23/01046-6 - Estruturação, organização e desenvolvimento de uma plataforma de busca de agentes antivirais contra os arbovírus causadores da febre Zika, febre Chikungunya e da febre Amarela utilizando os domínios enzimáticos de suas proteínas não-estruturais., AP.R; 22/04089-5 - EMU concedido no processo 2013/07600-3: Vitrobot e ELSA cryo-transfer holder, AP.EMU; + mais auxílios vinculados 22/03494-3 - EMU concedido no processo 2013/07600-3: citometro, AP.EMU; 21/13118-6 - EMU concedido no processo 2013/07600-3: Cromatógrafo Líquido de Alta Eficiência, AP.EMU; 20/04602-9 - Desenvolvimento de antivirais para o tratamento da COVID-19, AP.R; 19/13911-8 - 47th IUPAC World Chemistry Congress - 2019, AR.EXT; 19/07606-8 - EMU concedido no processo 13/07600-3: Omnilog Phenotypic Miroarray, AP.EMU; 19/07457-2 - EMU concedido no processo 2013/07600-3 "ROCKIMAGER 1000", AP.EMU; 17/17920-6 - 10th European Conference on Marine Natural Products - ECMNP 2017, AR.EXT; 17/05190-3 - Metabolomics 2017, AR.EXT; 16/23279-9 - 5th Annual Conference of AnalytiX-2017, AR.EXT; 16/13884-2 - EMU concedido no processo 2013/07600-3: MicroScale Thermophoresis (MST), AP.EMU; 16/50009-2 - Greening sample preparation of complex matrices by using natural deep eutectic solvents (NADES) together with porous polymeric adsorbents for subsequent analyses by liquid chromatography (LC) and nuclear magnetic resonance (NMR), AP.R SPRINT; 16/11312-1 - 9th Joint Natural Products Conference 2016, AR.EXT; 15/08181-0 - American Society of Pharmacognosy 2015 Annual Meeting, AR.EXT; 15/14968-2 - American Society of Pharmacognosy 2015 Annual Meeting, AR.EXT; 15/06751-3 - Antitrypanosomal acetylene fatty acid derivatives from the seeds of Porcelia macrocarpa (Annonaceae), PUB.ART; 14/50304-9 - Caracterização estereoquímica de ciclotideos de espécies do cerrado utilizando atividade óptica Raman, AP.R; 14/15579-7 - 55th Annual American Society of Pharmacognosy Meeting & 14th Annual Oxford International Conference on the Science of Botanicals, AR.EXT; 13/21599-8 - Estratégias para síntese de produtos naturais e análogos com atividade anti-cancerígena envolvendo reações multi-componentes organocatalisadas, AV.EXT; 13/18375-0 - 61st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), AR.EXT - menos auxílios vinculados
• Bolsa(s) vinculada(s): 23/10388-8 - Otimização de compostos da série piridil diazepano para o tratamento da malária, BP.IC; 23/09022-9 - Planejamento, síntese e avaliação biológica de novos compostos químicos para quimioterapia., BP.PD; 23/04660-7 - Caracterização funcional do complexo de replicação (DNA polimerase) do vírus Monkeypox, visando a busca por candidatos a fármacos antivirais, BP.MS; + mais bolsas vinculadas 23/00025-5 - Reações de Heck-Matsuda enantiosseletivas autossustentadas via sais de diazônio gerados in situ a partir de anilinas ou nitroaril derivados em uma estratégia "one-pot", BP.PD; 23/00874-2 - Acesso à quimiodiversidade de fungos: isolamento de inibidores de cisteíno proteases, BP.MS; 22/10835-1 - Frutos brasileiros comestíveis ricos em proteases e suas explorações microbianas para identificação de novos constituintes bioativos, BP.PD; 22/13110-8 - Otimização de Compostos Líderes para Tratamento de Doenças Parasitárias Tropicais em Colaboração com a Drugs for Neglected Diseases Initiative (DNDi), BP.IC; 22/15947-2 - Identificação e Otimização de Inibidores de Plasmodium falciparum como Candidatos a Fármacos para a Malaria, BP.PD; 23/00242-6 - Avaliação de Propriedades Biológicas e Farmacocinéticas de Candidatas a Fármacos, BP.PD; 22/16111-5 - Descoberta e desenvolvimento de candidatos antivirais contra a protease NS2B-NS3pro de Zika Vírus, BP.DD; 22/01266-3 - Construção e caracterização de um replicon de SARS-CoV-2 para a triagem de potenciais fármacos antivirais, BP.MS; 22/11106-3 - Busca por moléculas bioativas com ação inibitória na proteína não estrutural nsp13 de sars-cov-2, utilizando triagens enzimáticas e fragment screening, BP.PD; 22/07493-1 - Síntese de ligantes da enzima NS3 helicase do Vírus Zika baseado em fragmentos, BP.IC; 22/07984-5 - Centro de Pesquisa e Inovação em Biodiversidade e Fármacos, BP.TT; 21/03977-1 - Descoberta de inibidores a partir de plantas do Cerrado brasileiro como candidatos a compostos líderes para a Malária, BP.DR; 21/05646-2 - Engenharia metabólica aplicada à elucidação da via biossintética e produção sustentável de triterpenos quinonametídeos via expressão heteróloga em Saccharomyces cerevisiae, BP.DR; 21/13544-5 - Planejamento, síntese e avaliação biológica de novos agentes antiparasitários contendo o motivo 1,2,4-oxadiazol em suas estruturas, BP.DD; 21/14209-5 - Avaliação de Propriedades Farmacocinéticas e Biológicas de Candidatos a Fármacos, BP.PD; 21/06317-2 - Investigação de derivados de quinazolinas com propriedades anticâncerâncer, BP.IC; 21/06054-1 - Busca por candidatos a fármacos antivirais, tendo como alvo as RNA-polimerases dependentes de RNA (RdRp) do Alfavirus Chikungunya (NSP4) e do Betacoronavírus SARS-CoV-2 (NSP12), BP.PD; 21/02777-9 - Descoberta de fármacos para o tratamento da Doença de Chagas, BP.PD; 21/05629-0 - Centro de Pesquisa e Inovação em Biodiversidade e Farmácos - CIBFar, BP.TT; 21/01706-0 - Triagem de compostos para a identificação de fármacos contra o vírus Chikungunya utilizando sistema replicon subgenômico, BP.IC; 21/01686-0 - Triagem de compostos para a identificação de fármacos contra o vírus Zika utilizando sistema replicon subgenômico, BP.IC; 20/16787-3 - Estudo químico de micro-organismos endofíticos isolados de Malouetia tamaquarina (Apocynaceae) contra Doenças Tropicais Negligenciadas, BP.IC; 19/27790-8 - Desenvolvimento de ferramentas computacionais baseadas em aprendizado de máquina para a descoberta de novos candidatos a fármacos para a Malária, BP.PD; 19/23175-7 - Formulação com extratos e frações de Casearia sylvestris para controle de biofilme cariogênico, BP.DR; 19/24971-1 - Síntese, caracterização e avaliação da atividade de análogos do peptídeo (p-BthTX-I), BP.IC; 19/26679-6 - Avaliação da atividade de produtos naturais e outros compostos contra bactérias multirresistentes e seus biofilmes, BP.TT; 19/12632-8 - Sorocea bompladii: modelo vegetal para o isolamento de endófitos, visando a exploração racional da diversidade molecular, BP.IC; 18/24344-4 - Otimização de compostos líderes para tratamento de doenças parasitárias tropicais em colaboração com a Drugs for Neglected Diseases Initiative (DNDi), BP.DR; 19/09067-7 - Descobrindo o potencial dos metabólitos secundários de Malouetia tamaquarina (Apocynaceae) e seus endofíticos contra doenças tropicais neglegenciadas, BP.PD; 18/25289-7 - Descoberta de novos ligantes bioativos com propriedades anticâncer, BP.DR; 18/25600-4 - Descoberta e desenvolvimento de candidatos antivirais contra o vírus da Febre Amarela baseados na estrutura do complexo NS2B-NS3 protease, BP.DD; 19/07603-9 - Exploração racional de Colletotrichum gloeosporiodes, visando à produção e isolamento de metabólitos bioativos e processos de scale-up, BP.IC; 19/06587-0 - Centro de Pesquisa e Inovação em Biodiversidade e Fármacos (CIBFar), BP.TT; 18/14153-7 - Investigação de alterações moleculares em pequenos grupos neurais seletivamente ativados (neuronal ensembles) do núcleo acumbens, que medeiam a incubação da fissura a cocaína induzida pelo ambiente, BP.DR; 19/05967-3 - Compreensão da função biológica de produtos naturais de Bases de Dados para o planejamento de compostos ativos para o tratamento de doenças infecciosas, BP.PD; 18/23946-0 - Modelos preditivos para as fases dos fatores de estrutura de reflexões cêntricas em cristalografia de proteínas por aprendizado de máquina, BP.IC; 18/25773-6 - Descoberta de candidatos antivirais baseados na estrutura da enzima NS5 RNA polimerase RNA-dependente do vírus da febre amarela, BP.MS; 19/06034-0 - Avaliação farmacocinética e de propriedades biológicas de candidatos a fármacos, BP.PD; 19/01762-8 - Triagem de compostos naturais e sintéticos tendo como alvo proteínas de arbovírus, BP.TT; 19/04788-8 - Avaliação da atividade de produtos naturais e outros compostos contra bactérias multirresistentes e seus biofilmes, BP.TT; 18/23675-7 - Análise multiparamétrica do problema das fases em cristalografia de proteínas por aprendizagem profunda, BP.IC; 18/17095-8 - Caracterização estrutural da proteína NSP4 RNA polimerase RNA-dependente do Vírus Chikungunya e busca por agentes antivirais, BP.DR; 18/15887-4 - Otimização e elucidação da atividade antibacteriana de peptídeos catiônicos em patógenos multirresistentes, BP.DD; 18/19574-0 - Biologia estrutural e desenvolvimento de fármacos contra a proteína NS5 do Vírus Zika, BP.DD; 18/07287-7 - Descoberta de Derivados de Acridina e de Marinoquinolina como Inibidores de Plasmodium falciparum, BP.DR; 18/05130-3 - Construção e caracterização de um sistema replicon sub-genômico do ZIKV para a descoberta de agentes antivirais., BP.PD; 18/04896-2 - Estudo bioguiado de Talisia esculenta para a identificação de metabólitos secundários inibidores de glicação avançada, BP.IC; 17/26679-0 - Derivados 4-quinolinonas como candidatos a fármacos antimaláricos: caracterização da atividade Antiplasmodial in vitro, in vivo e de modo de ação, BP.MS; 17/16772-3 - Estudos estruturais e funcionais da enzima NS5 RNA-dependente RNA polimerase do vírus da febre amarela, BP.IC; 17/23778-8 - Estratégias em quimioinformática para uma série de compostos antichagásicos, BP.IC; 17/22661-0 - Estudos estruturais e funcionais do complexo NS2B-NS3 protease de febre amarela, BP.IC; 17/17098-4 - Emprego de imageamento MALDI-MSI em tecidos foliares nodulados e não nodulados de Psychotria e Hybanthus: Localização, análise de ciclotídeos e sua relação com bactérias endossimbiontes, BP.PD; 17/07229-4 - Caracterização estrutural das proteínas do vírus Chikungunya e busca por agentes antivirais, BP.PD; 17/15682-0 - Amidas de espécies de Piperaceae: estudos metabolômicos em matrizes naturais para bioprospecção de antimicrobianos, BP.IC; 17/12326-9 - Orbitídeos de Croton antisyphiliticus e C. sphaerogynus (Euphorbiaceae), caracterização química-biológica e síntese: prospecção racional de peptídeos de baixo peso molecular com potencial antitumoral, BP.MS; 17/01287-2 - Triagem de compostos candidatos a novos medicamentos antitumorais por cultura celular tridimensional, BP.PD; 17/04070-4 - Descoberta de derivados 4-quinolinonas como candidatos a composto líder para o desenvolvimento de novos antimaláricos, BP.IC; 16/24714-0 - Estruturação de um banco de dados metabólicos para Casearia sylvestris usando LC-DAD-CAD-MS, BP.IC; 16/24969-9 - Avaliação de compostos em patógenos bacterianos multirresistentes como parte do Centro de Pesquisa e Inovação em Biodiversidade e Fármacos - CIBFar, BP.IC; 16/19712-9 - Caracterização estrutural das proteínas do vírus Zika e busca por agentes antivirais, BP.PD; 16/17153-2 - Biologia estrutural e desenvolvimento de fármacos contra a proteína NS5 do vírus Zika, BP.DD; 16/09235-9 - Fingerprinting metabólico (perfil cromatográfico) por LC-DAD-MS para controle de qualidade de drogas vegetais de espécies de Erythrina: desenvolvimento e validação de método, BP.MS; 16/16402-9 - Centro de pesquisa e inovação em biodiversidade e fármacos., BP.TT; 16/09772-4 - Estudos de biologia estrutural e química medicinal para a descoberta de inibidores da enzima enolase de Plasmodium falciparum, BP.MS; 16/06499-5 - Estudos cristalográficos de complexos da enzima cruzaína de T.cruzi com inibidores, BP.IC; 16/04004-9 - Exploração do potencial químico e de biotransformação do fungo Rhinocladiella similis na busca por compostos de interesse biológico, BP.IC; 15/23244-8 - Desenvolvimento de novos peptídeos e bioconjugados com atividade contra infecção por Zika Vírus, BP.DR; 15/19495-5 - Síntese de compostos para o tratamento da Doença de Chagas no âmbito do CEPID/FAPESP/DNDi, BP.PD; 15/25175-3 - Clonagem e caracterização das oxidorredutases do tipo citocromo P450 de Maytenus ilicifolia e seu efeito no aumento da produção de triterpenos quinonametídeos por expressão heteróloga em Saccharomyces ceravisiae, BP.PD; 15/18192-9 - Descoberta e Desenvolvimento de Fármacos Antimaláricos: Biologia Estrutural, Química Medicinal e Parasitologia, BP.PD; 15/23095-2 - Síntese e caracterização de bioconjugados peptídicos com atividade antitumoral, BP.IC; 15/21272-4 - Estudos Computacionais da Enzima N-Miristoiltransferase de Plasmodium falciparum e seus Inibidores como Candidatos a Agentes Antimaláricos, BP.MS; 15/09533-7 - Ciclopeptídeos de Plantas de Ambientes Extremos (Bioma Caatinga): Caracterização, Função, Síntese e Avaliação do Potencial Antitumoral e Imunossupressor, BP.PD; 15/11339-4 - Análise comparativa de alquilresorcinóis em cultivares de cana-de-açúcar e avaliação de eventual efeito protetor frente a patógenos fúngicos, BP.IC; 14/26313-8 - Descoberta e Planejamento de Inibidores de Enolase de Plasmodium falciparum como Novos Agentes Antimaláricos, BP.PD; 14/15145-7 - Estudos estruturais da enzima topoisomerase II mitocondrial de tripanossomatídeos, BP.PD; 14/19362-2 - Aplicação da biotecnologia na avaliação da interação planta-microrganismo para a produção de metabólitos secundários em Peritassa campestris e seus endófitos, BP.PD; 14/21567-1 - Estudo de micro-organismos isolados da rizosfera de Senna spectabilis visando a detecção de metabólitos bioativos, BP.IC; 14/05538-1 - Síntese, caracterização, estudo do mecanismo de ação e análise de métodos de liberação do peptídeo pBthTX-I, nas formas monoméricas e diméricas, BP.PD; 14/14067-2 - Prospecção da rota de anabolismo dos congêneres quinonametídeo de Maytenus spp. (Celastraceae) em exemplares biogeograficamente distintos, BP.PD; 14/17931-0 - Avaliação da atividade de produtos naturais contra bactérias multirresistentes e seus biofilmes., BP.TT; 14/02282-6 - Estudo da relação estrutura-atividade de alcalóides derivados da Pilocarpus microphyllus (Rutaceae) com ação contra Schistosoma mansoni, BP.PD; 14/05935-0 - Co-cultura de micro-organismos isolados da rizosfera de Senna spectabilis visando a produção de metabólitos bioativos, BP.DD; 14/02738-0 - Documentação química de espécies do gênero Casearia (Salicaceae) de importância ecológica, econômica e medicinal, BP.IC; 13/25658-9 - Planejamento e Desenvolvimento de Candidatos a Fármacos para a Doença de Chagas, BP.PD; 13/24952-0 - Padrões da emergência de enterococci e staphylococci multiresistentes no Brasil e busca por novos fármacos, BP.PD; 14/00326-6 - Caracterização química de Ficus guaranítica (Moraceae): prospecção de compostos com interesse econômico e avaliação de atividades biológicas de interesse terapêutico, BP.IC; 13/15306-8 - Estudos sobre a biossíntese dos triterpenos quinonametídeos por engenharia metabólica: avaliação do fluxo metabólico micro- e macromolecular do sistema heterólogo por técnicas metabolômicas e proteômicas., BP.PD; 13/15086-8 - Aplicações da metabolômica e proteômica na busca por novas substâncias biologicamente ativas em espécies da família Malpighiaceae, BP.PD; 13/16807-0 - Síntese de Compostos para o Tratamento da Doença de Chagas no Âmbito do CEPID-FAPESP/DNDi, BP.PD; 13/18329-9 - "Avaliação In Vitro de Propriedades Citotóxicas e Farmacocinéticas de Compounds Bioativos de Origem Natural e Sintética", BP.TT; 13/10933-4 - Aplicação de ferramentas biotecnológicas em Streptomyces olindensis para a obtenção de novos produtos naturais com potencial farmacêutico, BP.PD; 13/03493-8 - Potencial de extratos brutos, óleo essencial e compostos isolados obtidos de Tagetes patula L. (Asteraceae) como antiparasitário botânico contra Rhipicephalus (Boophilus) microplus, Haemonchus contortus e Cimex lectularis, BP.PD; 11/01544-9 - Análise proteômica com enfoque na enzima oxidoredutase do tipo P450 em raízes de plantas jovens e adultas de Maytenus ilicifolia (Celastraceae), BP.PD; 11/10379-1 - CLONAGEM E CARACTERIZAÇÃO DE OXIDOESQUALENO CICLASES DE Maytenus ilicifolia Mart. ex Reissek, BP.PD; 11/01003-8 - Estudos proteômicos em Peperomia obtusifolia (Piperaceae), BP.PD; 11/03017-6 - Produtos naturais oriundos de plantas do Cerrado e Mata Atlântica, modelos potenciais e úteis para identificar protótipos com ação oxidante em neutrófilos e enzima mieloperoxidase (MPO), BP.PD - menos bolsas vinculadas
• Assunto(s): Biodiversidade Planejamento de fármacos Fármacos Produtos naturais Síntese orgânica Bioensaio Financiamento em saúde
• Palavra(s)-Chave do Pesquisador: Bioprospecção | Ensaio biológico | inibidor | Planejamento de Fármacos | Produtos Naturais | Síntese Orgânica | Outra Subárea Biofísica
• Publicação FAPESP: https://media.fapesp.br/bv/uploads/pdfs/Multidisciplinary_science_N0zamCM_16_17.pdf

Resumo

O Centro de Inovação em Biodiversidade e Fármacos (CIBFar) é uma iniciativa resultante de projetos de pesquisa colaborativos, envolvendo: (i) Laboratório de Química Medicinal e Computacional (LQMC) e Biofísica Molecular - IFSC - USP, (II) Núcleo de Bioensaios, Biossíntese e Eco Fisiologia de Produtos Naturais (NUBBE) – IQ - UNESP, (III) Laboratórios de Síntese Orgânica - IQ - UNICAMP, (iv) Laboratórios de Produtos Naturais e Síntese Orgânica - DQ - UFSCar, e (v) Laboratório de Produtos Naturais - FCFRP - USP. O objetivo principal desse Centro é a realização de ciência básica e aplicada, bem como o desenvolvimento tecnológico em todas as áreas de biodiversidade e de descoberta de fármacos com base em pesquisas que utilizam o estado da arte da química de produtos naturais, química orgânica sintética, biologia molecular e estrutural, bioquímica, química medicinal, planejamento de fármacos e ensaios farmacológicos. Os objetivos específicos são a bioprospecção da flora brasileira para a identificação de compostos com um amplo espectro de atividades biológicas (antiparasitária, antibacteriana, anticâncer); seleção de compostos bioativos promissores para síntese orgânica e estudos das relações entre a estrutura e atividade (SAR, QSAR); uso de estratégias de planejamento de fármacos baseado na estrutura do receptor e do ligante (SBDD e LBDD, respectivamente); abordagens para otimização de compostos-líderes; estudos pré-clínicos in vitro e in vivo para a avaliação e otimização de compostos-líderes, e estudos de toxicologia e farmacocinética. O objetivo final é o desenvolvimento de novos candidatos a fármacos com elevado potencial de inovação para desenvolvimento clínico. Para tanto, o CIBFar se baseia não apenas nas competências e conhecimentos científicos sólidos em todas as áreas de interesse, mas também em uma estrutura organizada para a integração das abordagens modernas em biodiversidade e descoberta de fármacos. O CIBFar tem como principal característica a infraestrutura bem estabelecida em termos de competências para o apoio técnico, financeiro, educação tecnológica e gestão executiva (adquirida nos últimos 11 anos como um dos CEPID-FAPESP). A integração máxima com o setor produtivo será realizada para identificação de oportunidades e definição de metas. No aspecto educacional, o Centro conta com a significativa experiência adquirida ao longo de uma década, em educação e disseminação do conhecimento realizada no CEPID-FAPESP. (AU)

Publicações científicas

(297)

(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)

SUELEM D. RAMALHO; MERI EMILI F. PINTO; RENATA K. ANDRICOPULO; PAULO R. S. SANCHES; EDILBERTO R. SILVEIRA; EDUARDO M. CILLI; ADRIANO D. ANDRICOPULO; VANDERLAN S. BOLZANI. Linear Peptide Analogues from Jatropha’s Orbitides Promote Migration of Human Neonatal Foreskin Fibroblasts in vitro and Collagen Deposition. Journal of the Brazilian Chemical Society, v. 30, n. 10, p. 2153-2161, 2019-10-21. (17/17098-4, 15/09533-7, 10/52327-5, 13/07600-3)

MAIARA S. BORGES; CAROLINA R. BIASETTO; VANESSA M. CHAPLA; SAMAD N. EBRAHIMI; MAYRA F. COSTA; VANDERLAN S. BOLZANI; ANGELA R. ARAUJO. Assessment of Novel C-4 Methylated Tetraketide by HPLC-SPE-TT in Saccharicola sp., an Endophytic Fungus in Eugenia jambolana Lam.. Journal of the Brazilian Chemical Society, v. 30, n. 3, p. 522-527, 2019-03-00. (14/50926-0, 13/07600-3)

JULIANA R. GUBIANI; HELDER L. TELES; GERALDO H. SILVA; MARIA CLÁUDIA M. YOUNG; JOSÉ O. PEREIRA; VANDERLAN S. BOLZANI; ANGELA R. ARAUJO. CYCLO-(TRP-PHE) DIKETOPIPERAZINES FROM THE ENDOPHYTIC FUNGUS Aspergillus versicolor ISOLATED FROM Piper aduncum#. Química Nova, v. 40, n. 2, p. 138-142, Fev. 2017. (13/07600-3)

DANIELE RODRIGUES DE LIMA; MARIA GLEIZIANE DE ARAÚJO FRANCA; FÁTIMA DE CÁSSIA EVANGELISTA DE OLIVEIRA; CLÁUDIA DO Ó PESSOA; ALBERTO JOSÉ CAVALHEIRO; MARIA GORETTI DE VASCONCELOS SILVA. METABOLIC PROFILING AND CYTOTOXIC ACTIVITY OF METHANOL EXTRACTS FROM CHAMAECRISTA DUCKEANA (P. BEZERRA & A. FERN.) H. S. IRWIN & BARNEBY (LEGUMINOSAE, CAESALPINIOIDEAE). Química Nova, v. 45, n. 7, p. 803-806, 2022-09-26. (13/07600-3, 14/50926-0)

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RAMALHO, SUELEM D.; PINTO, MERI EMILI F.; ANDRICOPULO, RENATA K.; SANCHES, PAULO R. S.; SILVEIRA, EDILBERTO R.; CILLI, EDUARDO M.; ANDRICOPULO, ADRIANO D.; BOLZANI, VANDERLAN S.. Linear Peptide Analogues from Jatropha's Orbitides Promote Migration of Human Neonatal Foreskin Fibroblasts in vitro and Collagen Deposition. Journal of the Brazilian Chemical Society, v. 30, n. 10, SI, p. 2153-2161, OCT 2019. (15/09533-7, 17/17098-4, 13/07600-3, 10/52327-5)

ORTEGA, HUMBERTO E.; FERREIRA, LEONARDO L. G.; MELO, WEILAN G. P.; OLIVEIRA, ANA LIGIA L.; RAMOS ALVARENGA, RENE F.; LOPES, NORBERTO P.; BUGNI, TIM S.; ANDRICOPULO, ADRIANO D.; PUPO, MONICA T.. Antifungal compounds from Streptomyces associated with attine ants also inhibit Leishmania donovani. PLoS Neglected Tropical Diseases, v. 13, n. 8, AUG 2019. (13/07600-3, 13/50954-0, 15/01001-6, 14/14095-6, 16/15872-1, 16/20154-0)

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CORNELIO, VIVIAN E.; MALUF, FERNANDO V.; FERNANDES, JOAO B.; DA SILVA, MARIA FATIMA G. F.; OLIVA, GLAUCIUS; GUIDO, RAFAEL V. C.; VIEIRA, PAULO C.. Isolation of Tiliroside from Spiranthera odoratissima as Inhibitor of Trypanosoma cruzi Glyceraldehyde-3-phosphate Dehydrogenase by Using Bioactivity-Guided Fractionation. Journal of the Brazilian Chemical Society, v. 28, n. 3, SI, p. 512-519, MAR 2017. (09/17538-8, 13/07600-3)

CHAGAS, FERNANDA OLIVEIRA; PESSOTTI, RITA DE CASSIA; CARABALLO-RODRIGUEZ, ANDRES MAURICIO; PUPO, MONICA TALLARICO. Chemical signaling involved in plant-microbe interactions. CHEMICAL SOCIETY REVIEWS, v. 47, n. 5, p. 1652-1704, MAR 7 2018. (11/12910-6, 08/09540-0, 13/07600-3, 13/50954-0, 12/21803-1)

SALDIVAR-GONZALEZ, FERNANDA I.; VALLI, MARILIA; ANDRICOPULO, ADRIANO D.; BOLZANI, VANDERLAN DA SILVA; MEDINA-FRANCO, JOSE L.. Chemical Space and Diversity of the NuBBE Database: A Chemoinformatic Characterization. JOURNAL OF CHEMICAL INFORMATION AND MODELING, v. 59, n. 1, p. 74-85, JAN 2019. (14/50926-0, 13/07600-3)

FRAIGE, KARINA; ARRUA, R. DARIO; SUTTON, ADAM T.; FUNARI, CRISTIANO SOLEO; CAVALHEIRO, ALBERTO JOSE; HILDER, EMILY F.; BOLZANI, VANDERLAN DA SILVA. Using natural deep eutectic solvents for the extraction of metabolites in Byrsonima intermedia leaves. JOURNAL OF SEPARATION SCIENCE, v. 42, n. 2, p. 591-597, JAN 2019. (13/15086-8, 13/07600-3, 16/50009-2)

CHAPLA, VANESSA M.; HONORIO, ALANA E.; GUBIANI, JULIANA R.; VILELA, ADRIANA F. L.; YOUNG, MARIA C. M.; CARDOSO, CARMEN L.; PAVAN, FERNANDO R.; CICARELLI, REGINA M.; PINHEIRO FERREIRA, PAULO MICHEL; BOLZANI, VANDERLAN DA S.; et al. Acetylcholinesterase inhibition and antifungal activity of cyclohexanoids from the endophytic fungus Saccharicola sp.. PHYTOCHEMISTRY LETTERS, v. 39, p. 116-123, OCT 2020. (13/07600-3, 17/06014-4)

FREITAS, JOLINDO A.; SORRECHIA, RODRIGO; POLITI, FLAVIO A. S.; SANTOS, ANDRE G.; RODRIGUES, EDVANIO R.; SANTOS, LOURDES C.; FUSCO-ALMEIDA, ANA M.; OLIVEIRA, ANDREW A.; GUIDO, RAFAEL V. C.; PIETRO, ROSEMEIRE C. L. R.. In vitro bioassay guided anti-dermatophyte and cytotoxic activities from Piper umbellatum L. Miq. led to 4-nerolidylcatechol. NATURAL PRODUCT RESEARCH, v. 34, n. 23, p. 3423-3427, DEC 1 2020. (13/10578-0, 13/25243-3, 13/07600-3)

QUESNAY, JOSE EDWIN NECIOSUP; POLLOCK, NAOMI L.; NAGAMPALLI, RAGHAVENDRA SASHI KRISHNA; LEE, SARAH C.; BALAKRISHNAN, VIJAYAKUMAR; DIAS, SANDRA MARTHA GOMES; MORAES, ISABEL; DAFFORN, TIM R.; AMBROSIO, ANDRE LUIS BERTELI. Insights on the Quest for the Structure-Function Relationship of the Mitochondrial Pyruvate Carrier. BIOLOGY-BASEL, v. 9, n. 11, NOV 2020. (14/20673-2, 17/11766-5, 19/02261-2, 13/07600-3, 14/06954-9, 18/00492-4, 17/02391-8, 15/02734-7)

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RODRIGUES JR, MANOEL T.; SANTOS, HUGO; ZEOLY, LUCAS A.; SIMONI, DEBORAH A.; MOYANO, ALBERT; COELHO, FERNANDO. Preparation of tetrahydro-1H-xanthen-1-one and chromen-1-one derivatives via a Morita-Baylis-Hillman/oxa-Michael/elimination cascade. ARKIVOC, n. 2, p. 77+, 2020. (13/07600-3, 15/09205-0, 18/02611-0, 17/02364-0)

NUNES, WILHAN DONIZETE GONCALVES; RUSSO, HELENA MANNOCHIO; BOLZANI, VANDERLAN DA SILVA; CAIRES, FLAVIO JUNIOR. Thermal characterization and compounds identification of commercialStevia rebaudianaBertoni sweeteners and thermal degradation products at high temperatures by TG-DSC, IR and LC-MS/MS. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, AUG 2020. (18/24378-6, 14/50926-0, 13/07600-3, 16/16970-7)

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PICCOLI, JULIA P.; SOARES, ANDREY C.; OLIVEIRA, JR., OSVALDO N.; CILLI, EDUARDO M.. Nanostructured functional peptide films and their application in C-reactive protein immunosensors. BIOELECTROCHEMISTRY, v. 138, APR 2021. (18/22214-6, 13/07600-3, 18/18953-8, 17/24839-0, 18/18231-2)

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SILVA, ALLAN R.; POLO, ELLEN C.; MARTINS, NELSON C.; CORREIA, CARLOS ROQUE D.. Enantioselective Oxy-Heck-Matsuda Arylations: Expeditious Synthesis of Dihydrobenzofuran Systems and Total Synthesis of the Neolignan (-)-Conocarpan. ADVANCED SYNTHESIS & CATALYSIS, v. 360, n. 2, p. 346-365, JAN 17 2018. (13/25886-1, 13/17083-6, 13/07600-3, 14/25770-6)

FERREIRA, LEONARDO G.; OLIVA, GLAUCIUS; ANDRICOPULO, ADRIANO D.. From Medicinal Chemistry to Human Health: Current Approaches to Drug Discovery for Cancer and Neglected Tropical Diseases. Anais da Academia Brasileira de Ciências, v. 90, n. 1, 1, p. 645-661, 2018. (13/07600-3, 13/25658-9)

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ALVES, THAIS B.; SOUZA-MOREIRA, TATIANA M.; VALENTINI, SANDRO R.; ZANELLI, CLESLEI E.; FURLAN, MAYSA. Friedelin in Maytenus ilicifolia Is Produced by Friedelin Synthase Isoforms. Molecules, v. 23, n. 3, MAR 2018. (14/03819-3, 13/07600-3, 11/10379-1)

BERNARDES, CAROLINA P.; SANTOS, NEIFE A. G.; SISTI, FLAVIA M.; FERREIRA, RAFAELA SCALCO; SANTOS-FILHO, NORIVAL A.; CINTRA, ADELIA C. O.; CILLI, EDUARDO M.; SAMPAIO, V, SUELY; SANTOS, ANTONIO C.. A synthetic snake-venom-based tripeptide (Glu-Val-Trp) protects PC12 cells from MPP+ toxicity by activating the NGF-signaling pathway. Peptides, v. 104, p. 24-34, JUN 2018. (11/23236-4, 13/07600-3)

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CHAGAS, FERNANDA O.; DIAS, LUIS G.; PUPO, MONICA T.. New perylenequinone derivatives from the endophytic fungus Alternaria tenuissima SS77. Tetrahedron Letters, v. 57, n. 29, p. 3185-3189, JUL 20 2016. (08/09540-0, 09/17695-6, 13/07600-3, 13/08166-5)

FROTA, CARLISE; POLO, ELLEN CHRISTINE; ESTEVES, HENRIQUE; DUARTE CORREIA, CARLOS ROQUE. Regioselective and Stereoselective Heck Matsuda Arylations of Trisubstituted Allylic Alkenols and Their Silyl and Methyl Ether Derivatives To Access Two Contiguous Stereogenic Centers: Expanding the Redox-Relay Process and Application in the Total Synthesis of meso-Hexestrol. Journal of Organic Chemistry, v. 83, n. 4, p. 2198-2209, FEB 16 2018. (13/10639-9, 14/25770-6, 13/07600-3, 16/18061-4)

PILON, ALAN CESAR; NETO, FAUSTO CARNEVALE; FREIRE, RAFAEL TEIXEIRA; CARDOSO, PATRICIA; CARNEIRO, RENATO LAJARIM; BOLZANI, VANDERLAN DA SILVA; CASTRO-GAMBOA, IAN. Partial least squares model and design of experiments toward the analysis of the metabolome of Jatropha gossypifolia leaves: Extraction and chromatographic fingerprint optimization. JOURNAL OF SEPARATION SCIENCE, v. 39, n. 6, p. 1023-1030, MAR 2016. (10/17935-4, 13/07600-3, 11/50816-1)

PAZ, TIAGO ANTUNES; DOS SANTOS, VANIA A. F. F. M.; INACIO, MARIELLE CASCAES; DIAS, NATHALIA BATISTA; PALMA, MARIO SERGIO; SOARES PEREIRA, ANA MARIA; FURLAN, MAYSA. Proteome profiling reveals insights into secondary metabolism in Maytenus ilicifolia (Celastraceae) cell cultures producing quinonemethide triterpenes. PLANT CELL TISSUE AND ORGAN CULTURE, v. 130, n. 2, p. 405-416, AUG 2017. (14/19362-2, 11/01544-9, 13/07600-3)

CORREIA, JOSE TIAGO M.; ACCONCIA, LAIS V.; COELHO, FERNANDO. Studies on Pumiliotoxin A Alkaloids: An Approach to Preparing the Indolizidinic Core by Intramolecular Diastereoselective N-Heterocyclic Carbene Catalyzed Benzoin Reaction. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, n. 11, p. 1972-1976, APR 2016. (13/24386-5, 13/10449-5, 12/21809-0, 13/07600-3)

BERNARDINO, K.; PINTO, M. E. F.; BOLZANI, V. S.; DE MOURA, A. F.; BATISTA JUNIOR, J. M.. Pinpointing disulfide connectivities in cysteine-rich proteins. CHEMICAL COMMUNICATIONS, v. 53, n. 53, p. 7337-7340, JUL 7 2017. (15/07089-2, 13/07600-3, 14/25222-9, 14/50304-9, 13/07296-2, 12/15147-4)

FERREIRA, LEONARDO G.; ANDRICOPULO, ADRIANO D.. From Protein Structure to Small-Molecules: Recent Advances and Applications to Fragment-Based Drug Discovery. CURRENT TOPICS IN MEDICINAL CHEMISTRY, v. 17, n. 20, p. 2260-2270, 2017. (13/07600-3, 13/25658-9)

FRANCESCHINI SARRIA, ANDRE LUCIO; LOPES VILELA, ADRIANA FERREIRA; FRUGERI, BARBARA MAMMANA; FERNANDES, JOAO BATISTA; CARLOS, ROSE MARIA; DAS GRACAS FERNANDES DA SILVA, MARIA FATIMA; CASS, QUEZIA BEZERRA; CARDOSO, CARMEN LUCIA. Copper (II) and zinc (II) complexes with flavanone derivatives: Identification of potential cholinesterase inhibitors by on-flow assays. Journal of Inorganic Biochemistry, v. 164, p. 141-149, NOV 2016. (13/07600-3, 06/58043-3, 09/01847-1)

MAFUD, ANA C.; FERREIRA, LEONARDO G.; MASCARENHAS, YVONNE P.; ANDRICOPULO, ADRIANO D.; DE MORAES, JOSUE. Discovery of Novel Antischistosomal Agents by Molecular Modeling Approaches. Trends in Parasitology, v. 32, n. 11, p. 874-886, NOV 2016. (14/02282-6, 13/25658-9, 13/07600-3)

ARDILA, JORGE ARMANDO; FUNARI, CRISTIANO SOLEO; ANDRADE, ANDRE MARQUES; CAVALHEIRO, ALBERTO JOSE; CARNEIRO, RENATO LAJARIM. Cluster analysis of commercial samples of Bauhinia spp. using HPLC-UV/PDA and MCR-ALS/PCA without peak alignment procedure. Phytochemical Analysis, v. 26, n. 5, p. 367-373, SEP-OCT 2015. (10/52327-5, 13/07600-3, 12/15844-7, 10/16520-5)

BATISTA, JR., JOAO M.; BLANCH, EWAN W.; BOLZANI, VANDERLAN DA SILVA. Recent advances in the use of vibrational chiroptical spectroscopic methods for stereochemical characterization of natural products. NATURAL PRODUCT REPORTS, v. 32, n. 9, p. 1280-1302, 2015. (11/22339-4, 13/07600-3, 14/25222-9, 14/50304-9)

BATISTA, ANDREA N. L.; DOS SANTOS-PINTO, JOSE ROBERTO A.; BATISTA, JR., JOAO M.; SOUZA-MOREIRA, TATIANA M.; SANTONI, MARIANA M.; ZANELLI, CLESLEI F.; KATO, MASSUO J.; LOPEZ, SILVIA N.; PALMA, MARIO S.; FURLAN, MAYSA. The Combined Use of Proteomics and Transcriptomics Reveals a Complex Secondary Metabolite Network in Peperomia obtusifolia. Journal of Natural Products, v. 80, n. 5, p. 1275-1286, MAY 2017. (13/07600-3, 11/51684-1, 14/25222-9, 11/01003-8)

PAULI, IVANI; FERREIRA, LEONARDO G.; DE SOUZA, MARIANA L.; OLIVA, GLAUCIUS; FERREIRA, RAFAELA S.; DESSOY, MARCO A.; SLAFER, BRIAN W.; DIAS, LUIZ C.; ANDRICOPULO, ADRIANO D.. Molecular modeling and structure-activity relationships for a series of benzimidazole derivatives as cruzain inhibitors. Future Medicinal Chemistry, v. 9, n. 7, p. 641-657, MAY 2017. (11/13789-6, 13/07600-3, 13/25658-9)

DE SOUZA, ANACLETO S.; DE OLIVEIRA, MARCELO T.; ANDRICOPULO, ADRIANO D.. Development of a pharmacophore for cruzain using oxadiazoles as virtual molecular probes: quantitative structure-activity relationship studies. Journal of Computer-Aided Molecular Design, v. 31, n. 9, p. 801-816, SEP 2017. (13/07600-3)

PIRES BUENO, PAULA CAROLINA; PASSARELI, FERNANDO; ANHESINE, NAIRA BUZZO; TORRES, ROSELI BUZANELLI; CAVALHEIRO, ALBERTO JOSE. Flavonoids from Casearia sylvestris Swartz variety lingua (Salicaceae). Biochemical Systematics and Ecology, v. 68, p. 23-26, OCT 2016. (11/21440-3, 13/07600-3)

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ZERAIK, MARIA LUIZA; QUEIROZ, EMERSON FERREIRA; MARCOURT, LAURENCE; CICLET, OLIVIER; CASTRO-GAMBOA, IAN; SIQUEIRA SILVA, DULCE HELENA; CUENDET, MURIEL; BOLZANI, VANDERLAN DA SILVA; WOLFENDER, JEAN-LUC. Antioxidants, quinone reductase inducers and acetylcholinesterase inhibitors from Spondias tuberosa fruits. Journal of Functional Foods, v. 21, p. 396-405, MAR 2016. (10/52327-5, 13/07600-3, 11/03017-6)

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BATISTA, ANDREA N. L.; BATISTA, JR., JOAO M.; ASHTON, LORNA; BOLZANI, VANDERLAN S.; FURLAN, MAYSA; BLANCH, EWAN W.. Investigation of DMSO-Induced Conformational Transitions in Human Serum Albumin Using Two-Dimensional Raman Optical Activity Spectroscopy. Chirality, v. 26, n. 9, SI, p. 497-501, SEP 2014. (12/16484-4, 12/13739-1, 13/07600-3)

ZERAIK, MARIA LUIZA; PETRONIO, MAICON S.; COELHO, DYOVANI; REGASINI, LUIS OCTAVIO; SILVA, DULCE H. S.; DA FONSECA, LUIZ MARCOS; MACHADO, SERGIO A. S.; BOLZANI, VANDERLAN S.; XIMENES, VALDECIR F.. Improvement of Pro-Oxidant Capacity of Protocatechuic Acid by Esterification. PLoS One, v. 9, n. 10, OCT 23 2014. (11/03017-6, 10/52327-5, 13/07600-3, 13/08784-0)

TUICHE, MAYRA VENDRAMINI; LOPES, ADRIANA APARECIDA; SILVA, DENISE BRENTAN; LOPES, NORBERTO PEPORINE; PUPO, MONICA TALLARICO. Direct MALDI-TOF/TOF analyses of unnatural beauvericins produced by the endophytic fungus Fusarium oxysporum SS46. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 24, n. 4, p. 433-438, JUL-AUG 2014. (08/09540-0, 13/07600-3)

PIVATTO, MARCOS; BACCINI, LUCIENE R.; SHARMA, ABHINAY; NAKABASHI, MYNA; DANUELLO, AMANDA; VIEGAS JUNIOR, CLAUDIO; GARCIA, CELIA R. S.; BOLZANI, VANDERLAN S.. Antimalarial activity of piperidine alkaloids from Senna spectabilis and semisynthetic derivatives. Journal of the Brazilian Chemical Society, v. 25, n. 10, p. 1900+, OCT 2014. (09/53640-1, 03/02176-7, 13/07600-3)

MONTEIRO, AFIF F.; BATISTA, JR., JOAO M.; MACHADO, MICHELLE A.; SEVERINO, RICHELE P.; BLANCH, EWAN W.; BOLZANI, VANDERLAN S.; VIEIRA, PAULO C.; SEVERINO, VANESSA G. P.. Structure and Absolute Configuration of Diterpenoids from Hymenaea stigonocarpa. Journal of Natural Products, v. 78, n. 6, p. 1451-1455, JUN 2015. (10/52326-9, 13/07600-3, 14/50304-9)

VENTURINI, DIEGO; PASTRELLO, BRUNA; ZERAIK, MARIA LUIZA; PAULI, IVANI; ANDRICOPULO, ADRIANO DEFINI; SILVA-FILHO, LUIZ CARLOS; BOLZANI, V. S.; MORGON, NELSON HENRIQUE; DA SOUZA, A. R.; XIMENES, VALDECIR FARIAS. Experimental, DFT and docking simulations of the binding of diapocynin to human serum albumin: induced circular dichroism. RSC ADVANCES, v. 5, n. 76, p. 62220-62228, 2015. (11/03017-6, 10/52327-5, 13/07600-3, 13/08784-0)

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GUIDOTTI, BRUNO B.; COELHO, FERNANDO. Sequential Morita-Baylis-Hillman/Achmatowicz reactions: an expeditious access to pyran-3(6H)-ones with a unique substitution pattern. Tetrahedron Letters, v. 56, n. 46, p. 6356-6359, NOV 18 2015. (13/10449-5, 13/07600-3)

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OLIVEIRA, CAIO C.; DUARTE CORREIA, CARLOS ROQUE. Enantioselective Heck-Matsuda Reactions: From Curiosity to a Game-Changing Methodology. CHEMICAL RECORD, JUN 2021. (13/07600-3, 14/25770-6, 18/01669-5)

SILVA, THIAGO S.; COELHO, FERNANDO. Methodologies for the synthesis of quaternary carbon centers via hydroalkylation of unactivated olefins: twenty years of advances. Beilstein Journal of Organic Chemistry, v. 17, p. 1565-1590, JUL 7 2021. (13/07600-3, 18/02611-0)

DAYANE C. RIBEIRO; HELENA M. RUSSO; KARINA FRAIGE; MARIA L. ZERAIK; CLÁUDIO R. NOGUEIRA; PATRÍCIA B. DA SILVA; ANA C. CODO; GIOVANA M. F. CALIXTO; ALEXANDRA I. DE MEDEIROS; MARLUS CHORILLI; et al. Bioactive Bioflavonoids from Platonia insignis (Bacuri) Residues as Added Value Compounds. Journal of the Brazilian Chemical Society, v. 32, n. 4, p. 786-799, 2021-03-29. (17/19870-6, 13/07600-3, 16/16970-7, 17/18807-9, 14/50926-0)

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KHAN, ISMAT ULLAH; KATTELA, SHIVASHANKAR; HASSAN, ABBAS; CORREIA, CARLOS ROQUE DUARTE. Enantioselective total synthesis of the highly selective sphingosine-1-receptor VPC01091 by the Heck desymmetrization of a non-activated cyclopentene-fused spiro-pyrrolidinone. ORGANIC & BIOMOLECULAR CHEMISTRY, v. 14, n. 40, p. 9476-9480, OCT 28 2016. (14/05407-4, 14/25770-6, 13/07600-3)

MAGALHAES, LUMA G.; MARQUES, FERNANDO B.; DA FONSECA, MARINA B.; ROGERIO, KAMILLA R.; GRAEBIN, CEDRIC S.; ANDRICOPULO, ADRIANO D.. Discovery of a Series of Acridinones as Mechanism-Based Tubulin Assembly Inhibitors with Anticancer Activity. PLoS One, v. 11, n. 8, AUG 10 2016. (13/07600-3)

VIEIRA, LUCAS C. C.; MATSUO, BIANCA T.; MARTELLI, LORENA S. R.; GALL, MAYARA; PAIXAO, MARCIO W.; CORREA, ARLENE G.. Asymmetric synthesis of new gamma-butenolides via organocatalyzed epoxidation of chalcones. ORGANIC & BIOMOLECULAR CHEMISTRY, v. 15, n. 29, p. 6098-6103, AUG 7 2017. (15/17141-1, 14/50249-8, 13/07600-3)

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CARBALLEIRA, NESTOR M.; BWALYA, ANGELA GONO; ITOE, MAURICE AYAMBA; ANDRICOPULO, ADRIANO D.; CORDERO-MALDONADO, MARIA LORENA; KAISER, MARCEL; MOTA, MARIA M.; CRAWFORD, ALEXANDER D.; GUIDO, RAFAEL V. C.; TASDEMIR, DENIZ. 2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes. Bioorganic & Medicinal Chemistry Letters, v. 24, n. 17, p. 4151-4157, SEP 1 2014. (13/07600-3)

DE AZAMBUJA, FRANCISCO; CARMONA, RAFAELA C.; CHORRO, TOMAZ H. D.; HEERDT, GABRIEL; CORREIA, CARLOS ROQUE D.. Noncovalent Substrate-Directed Enantioselective Heck Reactions: Synthesis of S- and P-Stereogenic Heterocycles. CHEMISTRY-A EUROPEAN JOURNAL, v. 22, n. 32, p. 11205-11209, AUG 1 2016. (13/10183-5, 14/25770-6, 14/26055-9, 13/07600-3)

FUNARI, CRISTIANO SOLEO; CARNEIRO, RENATO LAJARIM; CREESE, MARI EGENESS; LEME, GABRIEL MAZZI; CAYALHEIRO, ALBERTO JOSE; HILDER, EMILY FRANCES. On Track for a Truly Green Propolis-Fingerprinting Propolis Samples from Seven Countries by Means of a Fully Green Approach. ACS SUSTAINABLE CHEMISTRY & ENGINEERING, v. 4, n. 12, p. 7110-7117, DEC 2016. (10/18840-7, 13/07600-3, 12/15844-7, 10/16520-5)

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FERREIRA, LEONARDO G.; ANDRICOPULO, ADRIANO D.. Fragment-Based QSAR and Structural Analysis of a Series of Hydroxyethylamine Derivatives as HIV-1 Protease Inhibitors. COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, v. 18, n. 5, p. 464-475, 2015. (13/07600-3, 13/25658-9)

PEDROSO, MARIELE MUCIO; FOGUEL, MARCOS VINICIUS; SIQUEIRA SILVA, DULCE HELENA; TABOADA SOTOMAYOR, MARIA DEL PILAR; YAMANAKA, HIDEKO. Electrochemical sensor for dodecyl gallate determination based on electropolymerized molecularly imprinted polymer. SENSORS AND ACTUATORS B-CHEMICAL, v. 253, p. 180-186, DEC 2017. (14/25264-3, 13/07600-3, 13/05448-0)

DA SILVA, ERICA C.; YAMAKAWA, NATHALIA C. G.; DOS SANTOS, ALCINDO A.; COELHO, FERNANDO. Short and Diastereoselective Total Synthesis of the Polyhydroxylated Pyrrolidine LAB-1: A Potent -Glycosidase Inhibitor. SYNTHESIS-STUTTGART, v. 49, n. 21, p. 4869-4875, NOV 2017. (13/10449-5, 13/06757-6, 16/09579-0, 13/07600-3)

CHAGAS, FERNANDA OLIVEIRA; CARABALLO-RODRIGUEZ, ANDRES MAURICIO; DORRESTEIN, PIETER C.; PUPO, MONICA TALLARICO. Expanding the Chemical Repertoire of the Endophyte Streptomyces albospinus RLe7 Reveals Amphotericin B as an Inducer of a Fungal Phenotype. Journal of Natural Products, v. 80, n. 5, p. 1302-1309, MAY 2017. (08/09540-0, 13/07600-3, 14/01651-8, 09/17695-6, 12/21803-1)

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MENEZES CORREIA, JOSE TIAGO; LIST, BENJAMIN; COELHO, FERNANDO. Catalytic Asymmetric Conjugate Addition of Indolizines to alpha,beta-Unsaturated Ketones. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v. 56, n. 27, p. 7967-7970, JUN 26 2017. (13/10449-5, 14/02062-6, 13/07600-3)

OLIVEIRA, CAIO C.; PFALTZ, ANDREAS; DUARTE CORREIA, CARLOS ROQUE. Quaternary Stereogenic Centers through Enantioselective Heck Arylation of Acyclic Olefins with Aryldiazonium Salts: Application in a Concise Synthesis of (R)-Verapamil. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v. 54, n. 47, p. 14036-14039, NOV 16 2015. (14/00588-0, 13/07600-3)

ALVES, EDUARDO; MALUF, FERNANDO V.; BUENO, VANIA B.; GUIDO, RAFAEL V. C.; OLIVA, GLAUCIUS; SINGH, MANEESH; SCARPELLI, PEDRO; COSTA, FAHYME; SARTORELLO, ROBSON; CATALANI, LUIZ H.; et al. Biliverdin targets enolase and eukaryotic initiation factor 2 (eIF2 alpha) to reduce the growth of intraerythrocytic development of the malaria parasite Plasmodium falciparum. SCIENTIFIC REPORTS, v. 6, FEB 26 2016. (11/51295-5, 11/21442-6, 13/07600-3)

RODRIGUES, MARILI V. N.; BARBOSA, ALEXANDRE F.; DA SILVA, JULIA F.; DOS SANTOS, DEBORAH A.; VANZOLINI, KENIA L.; DE MORAES, MARCELA C.; CORREA, ARLENE G.; CASS, QUEZIA B.. 9-Benzoyl 9-deazaguanines as potent xanthine oxidase inhibitors. Bioorganic & Medicinal Chemistry, v. 24, n. 2, p. 226-231, JAN 15 2016. (13/01710-1, 13/50680-8, 13/07600-3)

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DIAS, LUIZ C.; DE LUCCA, JR., EMILIO C.. Total Synthesis of the Oxopolyene Macrolide (-)-Marinisporolide C. ORGANIC LETTERS, v. 17, n. 24, p. 6278-6281, DEC 18 2015. (11/06721-6, 12/02230-0, 13/07600-3)

PINTO, MERI EMILI F.; BATISTA, JR., JOAO M.; KOEHBACH, JOHANNES; GAUR, PRATIBHA; SHARMA, ABHINAY; NAKABASHI, MYNA; CILLI, EDUARDO MAFFUD; GIESEL, GUILHERME M.; VERLI, HUGO; GRUBER, CHRISTIAN W.; et al. Ribifolin, an Orbitide from Jatropha ribifolia, and Its Potential Antimalarial Activity. Journal of Natural Products, v. 78, n. 3, p. 374-380, MAR 2015. (11/22339-4, 10/52327-5, 13/07600-3, 12/13739-1)

DIAS, L. C.; KUROISHI, P. K.; DE LUCCA, JR., E. C.. The total synthesis of (-)-cryptocaryol A. ORGANIC & BIOMOLECULAR CHEMISTRY, v. 13, n. 12, p. 3575-3584, 2015. (12/02230-0, 13/07600-3)

FERREIRA, RAFAELA S.; DESSOY, MARCO A.; PAULI, IVANI; SOUZA, MARIANA L.; KROGH, RENATA; SALES, ANA I. L.; OLIVA, GLAUCIUS; DIAS, LUIZ C.; ANDRICOPULO, ADRIANO D.. Synthesis, Biological Evaluation, and Structure-Activity Relationships of Potent Noncovalent and Nonpeptidic Cruzain Inhibitors as Anti-Trypanosoma cruzi Agents. Journal of Medicinal Chemistry, v. 57, n. 6, p. 2380-2392, MAR 27 2014. (12/02230-0, 10/16778-2, 13/07600-3)

VALLI, MARILIA; BETTI, ANDRESA HEEMANN; DANUELLO, AMANDA; PIVATTO, MARCOS; CENTURIAO, FERNANDA; ANTONIO, CAMILA BOQUE; KUZE RATES, STELA MARIS; BOLZANI, VANDERLAN DA SILVA. Pyridinic analog of the natural product (-)-spectaline as potential adjuvant for the treatment of central nervous system disorders. Bioorganic & Medicinal Chemistry Letters, v. 25, n. 10, p. 2247-2250, MAY 15 2015. (03/02176-7, 10/52327-5, 13/07600-3)

FUNARI, CRISTIANO SOLEO; CARNEIRO, RENATO LAJARIM; KHANDAGALE, MANISH M.; CAVALHEIRO, ALBERTO JOSE; HILDER, EMILY F.. Acetone as a greener alternative to acetonitrile in liquid chromatographic fingerprinting. JOURNAL OF SEPARATION SCIENCE, v. 38, n. 9, p. 1458-1465, MAY 2015. (13/07600-3, 12/15844-7)

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