EMU concedido no processo CEPID 2013/07467-1 - nome do equipamento: sistema NanoLC...
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CeTICS - Centro de Toxinas, Imuno-Resposta e Sinalização Celular
Resumo
No Instituto Butantan toxinologia e regulação da resposta imune são, tradicionalmente, áreas conexas de pesquisa científica e desenvolvimento biotecnológico, através das quais o Instituto, historicamente, construiu sua reputação internacional de excelência. Na cultura do Instituto, venenos são misturas complexas de toxinas, selecionadas ao longo da evolução para sinergicamente exercerem efeitos biológicos sistêmicos, através de mecanismos bioquímicos, moleculares e celulares altamente específicos. Portanto, a análise química de venenos tem boas chances de levar à descoberta de novas moléculas de toxinas com potencial terapêutico. Essas premissas foram seguidas com sucesso por pesquisadores do Centro de Toxinologia Aplicada (CAT CEPID-FAPESP), projeto iniciado há 10 anos, que isolaram, caracterizaram quimicamente e patentearam diversas toxinas de natureza proteica, que se tornaram pontos de partida para desenvolvimento de inovação farmacêutica em parceria com indústrias locais. A ênfase em proteínas e peptídeos levou o CAT CEPID a instalar laboratórios no estado da arte para transcriptômica, proteômica, biologia molecular do DNA recombinante e síntese de peptídeos. Mais recentemente, estudos dos mecanismos de ação, bioquímicas, moleculares e celulares, dessas promissoras moléculas foram iniciados com o objetivo de estabelecer provas de conceito. Assim, o CAT estabeleceu, no Instituto Butantan, as condições iniciais para a criação de um centro de toxinas e resposta imune fundamentado nas abordagens atuais da biologia sistêmica. Por conseguinte, 10 pesquisadores, entre os mais competitivos do Instituto Butantan, propõem a criação do novo Centro de Toxinas, Resposta-imune e Sinalização Celular, com aspirações a centro de excelência de classe mundial, aproveitando a histórica reputação internacional do Butantan e o sucesso recente do CAT CEPID. O Plano de pesquisa do Centro Integra subprojetos voltados para a pesquisa científica com subprojetos de vocação para a inovação tecnológica. Um grande grupo de cientistas seniores do Instituto Butantan, de outras instituições brasileiras e de renomadas instituições estrangeiras serão colaboradores do Centro proposto. (AU)
Publicações científicas
(111)
(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)
DIAZ-ROA, ANDREA;
ESPINOZA-CULUPU, ABRAHAM;
TORRES-GARCIA, ORLANDO;
BORGES, MONAMARIS M.;
AVINO, IVAN N.;
ALVES, FLAVIO L.;
MIRANDA, ANTONIO;
PATARROYO, MANUEL A.;
DA SILVA, JR., PEDRO I.;
BELLO, FELIO J.
Sarconesin II, a New Antimicrobial Peptide Isolated from Sarconesiopsis magellanica Excretions and Secretions.
Molecules,
v. 24,
n. 11
JUN 1 2019.
Citações Web of Science: 0.
GREN, ERIC C. K.;
KITANO, EDUARDO S.;
ANDRADE-SILVA, DEBORA;
IWAI, LEO KEI;
REIS, MARCELO S.;
MENEZES, MILENE C.;
SERRANO, SOLANGE M. T.
Comparative analysis of the high molecular mass subproteomes of eight Bothrops snake venoms.
Comparative Biochemistry and Physiology D-Genomics & Proteomics,
v. 30,
p. 113-121,
JUN 2019.
Citações Web of Science: 0.
GONCALVES LUCHINI, LYGIA SAMARTIN;
PIDDE, GISELLE;
SQUAIELLA-BAPTISTAO, CARLA CRISTINA;
TAMBOURGI, DENISE V.
Complement System Inhibition Modulates the Pro-Inflammatory Effects of a Snake Venom Metalloproteinase.
FRONTIERS IN IMMUNOLOGY,
v. 10,
MAY 22 2019.
Citações Web of Science: 1.
BORGES, ALYSSA R.;
TOLEDO, DANIEL A.;
FERMINO, BRUNO R.;
DE OLIVEIRA, JOSE CARLOS;
SILBER, ARIEL MARIANO;
ELIAS, MARIA CAROLINA;
D'AVILA, HELOISA;
SCOPEL, KEZIA K. G.
In Vitro Cellular Division of Trypanosoma abeli Reveals Two Pathways for Organelle Replication.
Journal of Eukaryotic Microbiology,
v. 66,
n. 3,
p. 385-392,
MAY-JUN 2019.
Citações Web of Science: 0.
DE ARAUJO, CHRISTIANE B.;
CALDERANO, SIMONE G.;
ELIAS, MARIA CAROLINA.
The Dynamics of Replication in Trypanosoma cruzi Parasites by Single-Molecule Analysis.
Journal of Eukaryotic Microbiology,
v. 66,
n. 3,
p. 514-518,
MAY-JUN 2019.
Citações Web of Science: 0.
DE ARAUJO, CHRISTIANE BEZERRA;
DE LIMA, LOYZE PAOLA;
CALDERANO, SIMONE GUEDES;
DAMASCENO, FLAVIA SILVA;
SILBER, ARIEL M.;
ELIAS, MARIA CAROLINA.
Pep5, a Fragment of Cyclin D2, Shows Antiparasitic Effects in Different Stages of the Trypanosoma cruzi Life Cycle and Blocks Parasite Infectivity.
Antimicrobial Agents and Chemotherapy,
v. 63,
n. 5
MAY 2019.
Citações Web of Science: 1.
DOS SANTOS, JULIANE MONTEIRO;
DOS SANTOS, JANAINA CARDOSO;
MARQUES, ELINEIDE EUGENIO;
DE ARAUJO, GESSI CARVALHO;
SEIBERT, CARLA SIMONE;
LOPES-FERREIRA, MONICA;
CARLA, LIMA.
Stingray (Potamotrygon rex) maturity is associated with inflammatory capacity of the venom.
Toxicon,
v. 163,
p. 74-83,
MAY 2019.
Citações Web of Science: 0.
MENEZES, MILENE C.;
KITANO, EDUARDO S.;
BAUER, VERENA C.;
OLIVEIRA, ANA K.;
CARARO-LOPES, EDUARDO;
NISHIYAMA, JR., MILTON Y.;
ZELANIS, ANDRE;
SERRANO, SOLANGE M. T.
Early response of C2C12 myotubes to a sub-cytotoxic dose of hemorrhagic metalloproteinase HF3 from Bothrops jararaca venom.
JOURNAL OF PROTEOMICS,
v. 198,
p. 163-176,
APR 30 2019.
Citações Web of Science: 0.
MENEGUELLO, LETICIA;
BARBOSA, NATALIA M.;
PEREIRA, KARINA D.;
PROENCA, ANDRE R. G.;
TAMBORLIN, LETICIA;
SIMABUCO, FERNANDO M.;
IWAI, LEO K.;
ZANELLI, CLESLEI F.;
VALENTINI, SANDRO R.;
LUCHESSI, AUGUSTO D.
The polyproline-motif of S6K2: eIF5A translational dependence and importance for protein-protein interactions.
Journal of Cellular Biochemistry,
v. 120,
n. 4,
p. 6015-6025,
APR 2019.
Citações Web of Science: 1.
DE LIMA, LOYZE P.;
CALDERANO, SIMONE G.;
DA SILVA, MARCELO S.;
DE ARAUJO, CHRISTIANE B.;
VASCONCELOS, ELTON J. R.;
IWAI, LEO K.;
PEREIRA, CLAUDIO A.;
FRAGOSO, STENIO P.;
CAROLINA ELIAS, M.
Ortholog of the polymerase theta helicase domain modulates DNA replication in Trypanosoma cruzi.
SCIENTIFIC REPORTS,
v. 9,
FEB 27 2019.
Citações Web of Science: 0.
LIBERATO, TARCISIO;
FUKUSHIMA, ISABELLA;
KITANO, EDUARDO S.;
SERRANO, SOLANGE M. T.;
CHAMMAS, ROGER;
ZELANIS, ANDRE.
Proteomic profiling of the proteolytic events in the secretome of the transformed phenotype of melanocyte-derived cells using Terminal Amine Isotopic Labeling of Substrates.
JOURNAL OF PROTEOMICS,
v. 192,
p. 291-298,
FEB 10 2019.
Citações Web of Science: 1.
BOUFLEUR, PAMELA;
SCIANI, JULIANA MOZER;
GOLDFEDER, MAURICIO;
FARIA, FERNANDA;
BRANCO, VANIA;
CHUDZINSKI-TAVASSI, ANA MARISA.
Biodistribution and Pharmacokinetics of Amblyomin-X, a Novel Antitumour Protein Drug in Healthy Mice.
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS,
v. 44,
n. 1,
p. 111-120,
FEB 2019.
Citações Web of Science: 1.
EMILIO TAVERNELLI, LUIS;
MOTTA, MARIA CRISTINA M.;
SILVA GONCALVES, CAMILA;
DA SILVA, MARCELO SANTOS;
ELIAS, MARIA CAROLINA;
LUCIA ALONSO, VICTORIA;
SERRA, ESTEBAN;
CRIBB, PAMELA.
Overexpression of Trypanosoma cruzi High Mobility Group B protein (TcHMGB) alters the nuclear structure, impairs cytokinesis and reduces the parasite infectivity.
SCIENTIFIC REPORTS,
v. 9,
JAN 17 2019.
Citações Web of Science: 0.
LOPES, PRISCILA HESS;
MURAKAMI, MARIO T.;
PORTARO, V, FERNANDA C.;
MESQUITA PASQUALOTO, KERLY FERNANDA;
VAN DEN BERG, CARMEN;
TAMBOURGI, V, DENISE.
Targeting Loxosceles spider Sphingomyelinase D with small-molecule inhibitors as a potential therapeutic approach for loxoscelism.
Journal of Enzyme Inhibition and Medicinal Chemistry,
v. 34,
n. 1,
p. 310-321,
JAN 1 2019.
Citações Web of Science: 0.
ALVAREZ-FLORES, MILYAM P.;
HEBERT, AUDREY;
GOUELLE, CATHY;
GELLER, SARAH;
CHUDZINSKI-TAVASSI, ANA M.;
PELLERIN, LUC.
Neuroprotective effect of rLosac on supplement-deprived mouse cultured cortical neurons involves maintenance of monocarboxylate transporter MCT2 protein levels.
Journal of Neurochemistry,
v. 148,
n. 1,
p. 80-96,
JAN 2019.
Citações Web of Science: 0.
REIS, MARCELO S.;
ESTRELA, GUSTAVO;
FERREIRA, CARLOS EDUARDO;
BARRERA, JUNIOR.
Optimal Boolean lattice-based algorithms for the U-curve optimization problem.
INFORMATION SCIENCES,
v. 471,
p. 97-114,
JAN 2019.
Citações Web of Science: 0.
SILVA-DE-FRANCA, FELIPE;
VILLAS-BOAS, ISADORA MARIA;
DE TOLEDO SERRANO, SOLANGE MARIA;
COGLIATI, BRUNO;
DE ANDRADE CHUDZINSKI, SONIA APARECIDA;
LOPES, PRISCILA HESS;
KITANO, EDUARDO SHIGUEO;
OKAMOTO, CINTHYA KIMORI;
TAMBOURGI, DENISE V.
Naja annulifera Snake: New insights into the venom components and pathogenesis of envenomation.
PLoS Neglected Tropical Diseases,
v. 13,
n. 1
JAN 2019.
Citações Web of Science: 0.
DA SILVA, MARCELO S.;
MARINI, PAULA A.;
REPOLES, BRUNO M.;
ELIAS, MARIA C.;
MACHADO, CARLOS R.
Analysis of DNA Exchange Using Thymidine Analogs (ADExTA) in Trypanosoma cruzi.
BIO-PROTOCOL,
v. 8,
n. 24
DEC 20 2018.
Citações Web of Science: 0.
AMADEU MEGALE, ANGELA ALICE;
MAGNOLI, FABIO CARLOS;
KUNIYOSHI, ALEXANDRE KAZUO;
IWAI, LEO KEI;
TAMBOURGI, DENISE V.;
PORTARO, FERNANDA C. V.;
DA SILVA, WILMAR DIAS.
Kn-Ba: a novel serine protease isolated from Bitis arietans snake venom with fibrinogenolytic and kinin-releasing activities.
Journal of Venomous Animals and Toxins including Tropical Diseases,
v. 24,
DEC 13 2018.
Citações Web of Science: 0.
SEGURA-RAMIREZ, PAULA J.;
SILVA JUNIOR, PEDRO I.
Loxosceles gaucho Spider Venom: An Untapped Source of Antimicrobial Agents.
TOXINS,
v. 10,
n. 12
DEC 2018.
Citações Web of Science: 1.
DA SILVA, MARCELO SANTOS;
HOVEL-MINER, GALADRIEL A.;
BRIGGS, EMMA M.;
ELIAS, MARIA CAROLINA;
MCCULLOCH, RICHARD.
Evaluation of mechanisms that may generate DNA lesions triggering antigenic variation in African trypanosomes.
PLOS PATHOGENS,
v. 14,
n. 11
NOV 2018.
Citações Web of Science: 1.
OLIVEIRA, DANIELLE B. L.;
DURIGON, GIULIANA S.;
MENDES, ERICA A.;
LADNER, JASON T.;
ANDREATA-SANTOS, ROBERT;
ARAUJO, DANIELLE B.;
BOTOSSO, VIVIANE F.;
PAOLA, NICHOLAS D.;
NETO, DANIEL F. L.;
CUNHA, MARIELTON P.;
BRACONI, CARLA T.;
ALVES, RUBENS P. S.;
JESUS, MONICA R.;
PEREIRA, LENNON R.;
MELO, STELLA R.;
MESQUITA, FLAVIO S.;
SILVEIRA, VANESSA B.;
THOMAZELLI, LUCIANO M.;
FAVORETTO, SILVANA R.;
ALMONFREY, FRANCIANE B.;
ABDULKADER, REGINA C. R. M.;
GABRILI, JOEL M.;
TAMBOURGI, DENISE V.;
OLIVEIRA, SERGIO F.;
PRIETO, KARLA;
WILEY, MICHAEL R.;
FERREIRA, LUIS C. S.;
SILVA, MARCOS V.;
PALACIOS, GUSTAVO F.;
ZANOTTO, PAOLO M. A.;
DURIGON, EDISON L.
Persistence and Intra-Host Genetic Evolution of Zika Virus Infection in Symptomatic Adults: A Special View in the Male Reproductive System.
Viruses-Basel,
v. 10,
n. 11
NOV 2018.
Citações Web of Science: 1.
TORRES-BONILLA, KRISTIAN A.;
ANDRADE-SILVA, DEBORA;
SERRANO, SOLANGE M. T.;
HYSLOP, STEPHEN.
Biochemical characterization of venom from Pseudoboa neuwiedii (Neuwied's false boa; Xenodontinae; Pseudoboini).
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,
v. 213,
p. 27-38,
NOV 2018.
Citações Web of Science: 1.
LIMA DINIZ, LAURA CRISTINA;
MIRANDA, ANTONIO;
DA SILVA, JR., PEDRO ISMAEL.
Human Antimicrobial Peptide Isolated From Triatoma infestans Haemolymph, Trypanosoma cruzi-Transmitting Vector.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,
v. 8,
OCT 30 2018.
Citações Web of Science: 0.
SILVA, MAKSWELL ALMEIDA;
LOPES, DAIANA SILVA;
TEIXEIRA, SAMUEL COTA;
CIRILO GIMENES, SARAH NATALIE;
VASCONCELOS AZEVEDO, FERNANDA VAN PETTEN;
POLLONI, LORENA;
BORGES, BRUNA CRISTINA;
DA SILVA, MARCELO SANTOS;
BARBOSA, MARCELO JOSE;
DE OLIVEIRA JUNIOR, ROBSON JOSE;
ELIAS, MARIA CAROLINA;
DA SILVA, CLAUDIO VIEIRA;
GERALDO YONEYAMA, KELLY APARECIDA;
RODRIGUES, VERIDIANA DE MELO;
RODRIGUES, RENATA SANTOS.
Genotoxic effects of BnSP-6, a Lys-49 phospholipase A(2) (PLA(2)) homologue from Bothrops pauloensis snake venom, on MDA-MB-231 breast cancer cells.
International Journal of Biological Macromolecules,
v. 118,
n. A,
p. 311-319,
OCT 15 2018.
Citações Web of Science: 2.
DIAZ-ROA, ANDREA;
PATARROYO, MANUEL A.;
BELLO, FELIO J.;
DA SILVA, JR., PEDRO I.
Sarconesin: Sarconesiopsis magellanica Blowfly Larval Excretions and Secretions With Antibacterial Properties.
FRONTIERS IN MICROBIOLOGY,
v. 9,
SEP 28 2018.
Citações Web of Science: 3.
ALVES, CERES LUCIANA;
REPOLES, BRUNO MARCAL;
DA SILVA, MARCELO SANTOS;
MENDES, ISABELA CECILIA;
MARIN, PAULA ANDREA;
NASCIMENTO AGUIAR, PEDRO HENRIQUE;
SANTOS, SELMA DA SILVA;
FRANCO, GLORIA REGINA;
MACEDO, ANDREA MARA;
JUNHO PENA, SERGIO DANILO;
ANDRADE, LUCIANA DE OLIVEIRA;
GUARNERI, ALESSANDRA APARECIDA;
TAHARA, ERICH BIRELLI;
ELIAS, MARIA CAROLINA;
MACHADO, CARLOS RENATO.
The recombinase Rad51 plays a key role in events of genetic exchange in Trypanosoma cruzi.
SCIENTIFIC REPORTS,
v. 8,
SEP 6 2018.
Citações Web of Science: 2.
DE LUNA VITORINO, FRANCISCA NATHALIA;
MONTONI, FABIO;
MORENO, JAQUELINE NEVES;
DE SOUZA, BRUNO FERREIRA;
LOPES, MARIANA DE CAMARGO;
CORDEIRO, BARBARA;
FONSECA, CECILIA SELLA;
GILMORE, JOSHUA M.;
SARDIU, MIHAELA I.;
REIS, MARCELO SILVA;
FLORENS, LAURENCE A.;
WASHBURN, MICHAEL P.;
ARMELIN, HUGO AGUIRRE;
CHAGAS DA CUNHA, JULIA PINHEIRO.
FGF2 Antiproliferative Stimulation Induces Proteomic Dynamic Changes and High Expression of FOSB and JUNB in K-Ras-Driven Mouse Tumor Cells.
PROTEOMICS,
v. 18,
n. 17
SEP 2018.
Citações Web of Science: 0.
DINIZ, V, MARCELO R.;
PAIVA, ANA L. B.;
GUERRA-DUARTE, CLARA;
NISHIYAMA JR, MILTON Y.;
MUDADU, MAURICIO A.;
DE OLIVEIRA, URSULA;
BORGES, MARCIA H.;
YATES, JOHN R.;
JUNQUEIRA-DE-AZEVEDO, INACIO DE L.
An overview of Phoneutria nigriventer spider venom using combined transcriptomic and proteomic approaches.
PLoS One,
v. 13,
n. 8
AUG 1 2018.
Citações Web of Science: 2.
ANDRADE-SILVA, DEBORA;
ASHLINE, DAVID;
TRAN, THUY;
LOPES, ALINE SORIANO;
TRAVAGLIA CARDOSO, SILVIA REGINA;
REIS, MARCELO DA SILVA;
ZELANIS, ANDRE;
SERRANO, SOLANGE M. T.;
REINHOLD, VERNON.
Structures of N-Glycans of Bothrops Venoms Revealed as Molecular Signatures that Contribute to Venom Phenotype in Viperid Snakes.
MOLECULAR & CELLULAR PROTEOMICS,
v. 17,
n. 7,
p. 1261-1284,
JUL 2018.
Citações Web of Science: 1.
PAVANI, RAPHAEL SOUZA;
VITARELLI, MARCELA O.;
FERNANDES, CARLOS A. H.;
MATTIOLI, FABIO F.;
MORONE, MARIANA;
MENEZES, MILENE C.;
FONTES, MARCOS R. M.;
CANO, MARIA ISABEL N.;
ELIAS, MARIA CAROLINA.
Replication Protein A-1 Has a Preference for the Telomeric G-rich Sequence in Trypanosoma cruzi.
Journal of Eukaryotic Microbiology,
v. 65,
n. 3,
p. 345-356,
MAY-JUN 2018.
Citações Web of Science: 1.
RIBEIRO, KLEBER SILVA;
VASCONCELLOS, CAMILLA IOSHIDA;
SOARES, RODRIGO PEDRO;
MENDES, MARIA TAYS;
ELLIS, CAMERON C.;
AGUILERA-FLORES, MARCELA;
DE ALMEIDA, IGOR CORREIA;
SCHENKMAN, SERGIO;
IWAI, LEO KEI;
TORRECILHAS, ANA CLAUDIA.
Proteomic analysis reveals different composition of extracellular vesicles released by two Trypanosoma cruzi strains associated with their distinct interaction with host cells.
JOURNAL OF EXTRACELLULAR VESICLES,
v. 7,
n. 1
APR 17 2018.
Citações Web of Science: 4.
VALENTE, RICHARD HEMMI;
LUNA, MILENE SCHMIDT;
DE OLIVEIRA, URSULA CASTRO;
NISHIYAMA-JUNIOR, MILTON YUTAKA;
JUNQUEIRA-DE-AZEVEDO, INACIO DE LOIOLA;
PORTES-JUNIOR, JOSE ANTONIO;
CLISSA, PATRICIA BIANCA;
VIANA, LUCIANA GODOY;
SANCHES, LEONARDO;
MOURA-DA-SILVA, ANA MARIA;
PERALES, JONAS;
YAMANOUYE, NORMA.
Bothrops jararaca accessory venom gland is an ancillary source of toxins to the snake.
JOURNAL OF PROTEOMICS,
v. 177,
p. 137-147,
APR 15 2018.
Citações Web of Science: 0.
MARIN, PAULA ANDREA;
DA SILVA, MARCELO SANTOS;
PAVANI, RAPHAEL SOUZA;
MACHADO, CARLOS RENATO;
ELIAS, MARIA CAROLINA.
Recruitment kinetics of the homologous recombination pathway in procyclic forms of Trypanosoma brucei after ionizing radiation treatment.
SCIENTIFIC REPORTS,
v. 8,
MAR 29 2018.
Citações Web of Science: 2.
DE OLIVEIRA, URSULA CASTRO;
NISHIYAMA, JR., MILTON YUTAKA;
VIANA DOS SANTOS, MARIA BEATRIZ;
SANTOS-DA-SILVA, ANDRIA DE PAULA;
CHALKIDIS, HIPOCRATES DE MENEZES;
SOUZA-IMBERG, ANDREIA;
CANDIDO, DENISE MARIA;
YAMANOUYE, NORMA;
CORONADO DORCE, VALQUIRIA ABRAO;
MEIRELLES JUNQUEIRA-DE-AZEVEDO, INACIO DE LOIOLA.
Proteomic endorsed transcriptomic profiles of venom glands from Tityus obscurus and T. serrulatus scorpions.
PLoS One,
v. 13,
n. 3
MAR 21 2018.
Citações Web of Science: 7.
DE FARIAS, IASMIM BAPTISTA;
DE MORAIS-ZANI, KAREN;
SERINO-SILVA, CAROLINE;
SANT'ANNA, SAVIO S.;
DA ROCHA, MARISA M. T.;
GREGO, KATHLEEN F.;
ANDRADE-SILVA, DEBORA;
SERRANO, SOLANGE M. T.;
TANAKA-AZEVEDO, ANITA M.
Functional and proteomic comparison of Bothrops jararaca venom from captive specimens and the Brazilian Bothropic Reference Venom.
JOURNAL OF PROTEOMICS,
v. 174,
p. 36-46,
MAR 1 2018.
Citações Web of Science: 3.
LIBERATO, TARCISIO;
PESSOTTI, DAYELLE S.;
FUKUSHIMA, ISABELLA;
KITANO, EDUARDO S.;
SERRANO, SOLANGE M. T.;
ZELANIS, ANDRE.
Signatures of protein expression revealed by secretome analyses of cancer associated fibroblasts and melanoma cell lines.
JOURNAL OF PROTEOMICS,
v. 174,
p. 1-8,
MAR 1 2018.
Citações Web of Science: 2.
MANZONI-DE-ALMEIDA, DANIEL;
SQUAIELLA-BAPTISTAO, CARLA CRISTINA;
LOPES, PRISCILA HESS;
VAN DEN BERG, CARMEN W.;
TAMBOURGI, DENISE V.
Loxosceles venom Sphingomyelinase D activates human blood leukocytes: Role of the complement system.
Molecular Immunology,
v. 94,
p. 45-53,
FEB 2018.
Citações Web of Science: 5.
ATASHPAZ-GARGARI, ESMAEIL;
REIS, MARCELO S.;
BRAGA-NETO, ULISSES M.;
BARRERA, JUNIOR;
DOUGHERTY, EDWARD R.
A fast Branch-and-Bound algorithm for U-curve feature selection.
PATTERN RECOGNITION,
v. 73,
p. 172-188,
JAN 2018.
Citações Web of Science: 3.
CRISPIM, MARCELL;
DAMASCENO, FLAVIA SILVA;
HERNANDEZ, AGUSTINO;
BARISON, MARIA JULIA;
SAUTER, ISMAEL PRETTO;
PAVANI, RAPHAEL SOUZA;
MOURA, ALEXANDRE SANTOS;
FURUSHO PRAL, ELIZABETH MIEKO;
CORTEZ, MAURO;
ELIAS, MARIA CAROLINA;
SILBER, ARIEL MARIANO.
The glutamine synthetase of Trypanosoma cruzi is required for its resistance to ammonium accumulation and evasion of the parasitophorous vacuole during host-cell infection.
PLoS Neglected Tropical Diseases,
v. 12,
n. 1
JAN 2018.
Citações Web of Science: 4.
FERREIRA JUNIOR, WILSON ALVES;
ZAHARENKO, ANDRE JUNQUEIRA;
KAZUMA, KOHEI;
PICOLO, GISELE;
GUTIERREZ, VANESSA PACCIARI;
DE FREITAS, JOSE CARLOS;
KONNO, KATSUHIRO;
CURY, YARA.
Peripheral 5-HT3 Receptors Are Involved in the Antinociceptive Effect of Bunodosine 391.
TOXINS,
v. 10,
n. 1
JAN 2018.
Citações Web of Science: 1.
ZAMBELLI, VANESSA O.;
PICOLO, GISELE;
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