CeTICS - Centro de Toxinas, Imuno-Resposta e Sinalização Celular

• Processo: 13/07467-1
• Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Vigência: 01 de julho de 2013 - 30 de junho de 2024
• Área do conhecimento: Ciências Biológicas - Bioquímica - Biologia Molecular
• Pesquisador responsável: Hugo Aguirre Armelin
• Beneficiário: Hugo Aguirre Armelin
• Instituição-sede: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brasil
• Pesquisadores principais:( Atuais ): Denise Vilarinho Tambourgi ; Gisele Picolo ; Inácio de Loiola Meirelles Junqueira de Azevedo ; Monica Valdyrce dos Anjos Lopes Ferreira ; Solange Maria de Toledo Serrano ; Wilmar Dias da Silva
• Pesquisadores principais:( Anteriores ): Ana Marisa Chudzinski-Tavassi ; Junior Barrera ; Maria Carolina Quartim Barbosa Elias Sabbaga ; Osvaldo Augusto Brazil Esteves Sant'Anna ; Yara Cury
• Pesq. associados: Adriana Mortara Almeida ; Alessandra Fernandes Bizerra ; Alexandre Keiji Tashima ; Aline Soriano Lopes ; Allan Mowat ; Ana Maria Moura da Silva ; Ana Marisa Chudzinski-Tavassi ; André Zelanis Palitot Pereira ; Ann Ager ; B. Paul Morgan ; Carla Cristina Squaiella ; Carla Lima da Silva ; Carmen W. Van Den Berg ; Daria Mochly-Rosen ; Denise Vilarinho Tambourgi ; Fabio Carlos Magnoli ; Fábio Nakano ; Fan Hui Wen ; Fernanda Calheta Vieira Portaro ; Fernanda Faria ; Fernanda Paiva Guimarães ; Gisele Picolo ; Giselle Pidde Marques Porto ; Inácio de Loiola Meirelles Junqueira de Azevedo ; Jay W. Fox ; Jesus Aparecido Ferro ; Jose Roberto Marcelino ; Jose Salvatore Leister Patane ; Julia Pinheiro Chagas da Cunha ; Katsuhiro Konno ; Kerly Fernanda Mesquita Pasqualoto ; Leo Kei Iwai ; Luc Pellerin ; Luciana Rodrigues Gomes ; Luiz Vicente Rizzo ; Marcella Barbosa Faria de Almeida Prado ; Marcelo da Silva Reis ; Marcelo de Franco ; Marcia Carvalho de Abreu Fantini ; Marcio Henrique Zaim ; Maria Carolina Quartim Barbosa Elias Sabbaga ; Maria Teresa Machini ; Marinilce Fagundes dos Santos ; Martha Marandino ; Miguel Allende ; Milton Yutaka Nishiyama Junior ; Mirta Schattner ; Miryam Paola Alvarez Flores ; Ovidiu Radulescu ; Paulo Lee Ho ; Paulo Sérgio Lacerda Beirão ; Pedro Ismael da Silva Junior ; Ricardo Jose Giordano ; Richard Mcculloch ; Robson Lopes de Melo ; Roger Chammas ; Ruy Gastaldoni Jaeger ; Sandra Coccuzzo Sampaio Vessoni ; Silvio Roberto de Azevedo Salinas ; Simone Guedes Calderano ; Sonia Aparecida de Andrade Chudzinski ; Tânia Tomé Martins de Castro ; Vanessa Olzon Zambelli ; Vanessa Rioli
• Auxílios(s) vinculado(s): 20/01360-4 - Evolução do veneno de serpentes avançadas da América do Sul: uma abordagem integrada comparando linhagens cis-/trans-andinas, AV.EXT; 22/10539-3 - EMU concedido no Processo Fapesp 2013/07467-1 : Nome do equipamento - QuantStudio 3 Real-Time PCR System, Applied Biosystems, AP.EMU; 19/23605-1 - Identificação de mecanismos moleculares de resistência a drogas e reparação de DNA em Trypanosomatidae, AP.R SPRINT; + mais auxílios vinculados 21/13951-0 - EMU concedido no processo 13/07467-1 : Citômetro de Fluxo BD FACSLyric e acessórios, AP.EMU; 21/13939-0 - EMU concedido no processo Fapesp 13/07467-1: Espectrômetro de Massas Orbitrap Exploris 480 e acessórios, AP.EMU; 19/07809-6 - ICOM CECA Conference 2019: Roles of Museum Education: Supporting Self and Society, AR.EXT; 18/26586-5 - 24o Congresso Mundial de Dermatologia, AR.EXT; 17/18281-7 - EMU concedido no processo CEPID 2013/07467-1 - nome do equipamento: sistema NanoLC EASY-nLCTM 1000 - thermo scientific, AP.EMU; 15/10413-6 - ICOM CECA Annual Conference 2015: Museum Education and Accessibility: Bridging the Gaps, AR.EXT; 15/07553-0 - EMU concedido no processo 2013/07467-1: sistema de ressonância plasmônica de superfície - Biacore T200, AP.EMU; 15/10037-4 - EMU concedido no processo 2013/07467-1: citômetro de fluxo, AP.EMU - menos auxílios vinculados
• Bolsa(s) vinculada(s): 22/10761-8 - Influência da tríade, grupo heme/sistema complemento/inflamação, na imunopatogênese do envenenamento por abelhas africanizadas, BP.TT; 21/10570-5 - Caracterização molecular dos efeitos in vivo do veneno da Bothrops jararaca: análises do tecido muscular e do plasma de camundongos, por abordagens de proteômica e imuno-histoquímica, BP.PD; 21/10344-5 - Identificação de peptídeos derivados da crotoxina com potencial antitumoral e imunomodulatório, BP.PD; + mais bolsas vinculadas 19/24580-2 - Seleção bayesiana de modelos dinâmicos de vias não isoladas de sinalização celular, BP.DD; 21/08891-8 - Avaliação dos mecanismos farmacológicos do peptídeo TnP isolado do veneno de Thalassophryne nattereri na terapêutica da Retinopatia Hipóxica em Zebrafish, BP.PD; 21/04355-4 - Implementações eficientes de métodos Bayesianos para seleção de modelos de vias de sinalização celular, BP.IC; 20/11468-7 - Gerenciamento e Implementação de Novas Ferramentas para a Plataforma CeTICSDB, BP.TT; 20/12317-2 - Análise proteômica dos efeitos sistêmicos do veneno da Bothrops jararaca em modelo murino., BP.PD; 19/27348-3 - Inibição do sistema complemento como meio para controlar a inflamação associada a envenenamentos, BP.PD; 20/03718-3 - Compreendendo as reações locais induzidas pelos venenos de Loxosceles e suas principais toxinas, BP.PD; 20/00770-4 - Síntese de derivados de benznidazol e óxido de grafeno e avaliação de suas atividades anti-chagásicas, BP.PD; 19/27677-7 - Estudo da indução de microRNAs regulatórios por TNP dependente da ativação do receptor de hidrocarboneto arílico (AhR), BP.PD; 19/20025-4 - Uma abordagem baseada em computação Bayesiana aproximada para resolver o problema da falta de isolamento na modelagem de vias de sinalização, BE.PQ; 19/18565-0 - Avaliação por hibridização in situ quantitativa dos níveis dos transcritos de natterina-like em zebrafish depletados com CRISPR/Cas-9, BP.IC; 19/10500-7 - Avaliação da necessidade da ativação do complexo inflamassoma na inflamação neutrofilica induzida pelas natterinas, toxinas formadoras de poros, BE.PQ; 19/05882-8 - Avaliação do papel da crotalfina na dinâmica do cílio primário de neurônios aferentes primários: novos caminhos para o estudo de compostos analgésicos, BP.PD; 19/13039-9 - Controle do Ciclo Celular em células normais e malignas, nova abordagem na terapia do câncer., BP.PD; 19/01895-8 - Função das nucleases MRE11, DNA2 e EXO1 na ressecção do DNA terminal e o reparo das quebras de dupla fita em Trypanosoma brucei, BP.PD; 19/02333-3 - Validação da importância funcional das natterinas na resposta imune inata em zebrafish por CRISPR-Cas9, um método de loss-of-function, BP.MS; 18/06751-1 - Caracterização molecular dos efeitos in vivo da metaloproteinase hemorrágica HF3: análises do proteoma do tecido muscular de camundongos, BP.MS; 18/12364-0 - Expressão, purificação e caracterização inicial de uma nova proteína RPA-like de Trypanosoma brucei, BP.IC; 17/07693-2 - Dinâmica funcional da proteína Orc1b durante o ciclo de vida de Trypanosoma, BP.DR; 18/08167-5 - Apoio bioinformático aos projetos de análise de expressão gênica diferencial do CeTICS, BP.TT; 18/06682-0 - Análise filogenética computacional de serpentes do gênero Bothrops a partir de proteomas de venenos, BP.IC; 17/06496-9 - Caracterização proteômica do efeito da peçonha de Bothrops jararaca sobre linhagens celulares de câncer versus linhagens celulares normais, BP.MS; 17/18344-9 - Proteômica quantitativa da cromatina frente ao tratamento com FGF2: análise da regulação transcricional e associação de cdc42, BP.DD; 17/20575-9 - Identificação de vias de sinalização celular baseada em repositórios de cinética de reações bioquímicas, BP.MS; 17/19252-0 - Análise proteômica dos efeitos de PA-BJ, uma serinoproteinase do veneno de Bothrops jararaca, sobre cultura de células endoteliais de sangue periférico, BP.PD; 17/19545-8 - Análise dos mecanismos moleculares subjacentes à inibição do ciclo celular por FGF2 em células Y1 adrenocorticais e tumorais de camundongo, dependentes de WT-Kras amplificado, BP.PD; 17/09929-3 - Venenos de serpentes do gênero Bothrops: impacto da glicosilação na complexidade dos proteomas e função de toxinas, BP.DD; 17/12199-7 - Loxoscelismo: da pesquisa básica ao desenvolvimento de novas terapias, BP.TT; 17/13681-7 - Análise e desenvolvimento de ferramentas de bioinformática aplicadas a estudos de genômica, transcriptômica e proteômica, BP.TT; 17/10853-1 - Desenvolvimento de ferramentas e análises para estudo das bases moleculares para a replicação do DNA e ciclo celular, BP.TT; 17/09648-4 - Expressão recombinante, e caracterização funcional dos domínios não catalíticos de uma metaloproteinase da classe P-III do veneno da serpente Bothrops jararaca, utilizando um sistema de expressão livre de célula, BP.IC; 16/25959-7 - Projeto de algoritmos baseados em florestas de posets para o problema de otimização U-curve, BP.IC; 16/22774-6 - Controle epigenético na analgesia dependente da ativação de receptores opióides: papel dos miRNAs e metilação do DNA no efeito antinociceptivo da crotalfina, BP.PD; 17/02225-0 - Loxoscelismo: da pesquisa básica ao desenvolvimento de novas terapias, BP.TT; 16/25661-8 - Desenvolvimento de infraestrutura e ferramentas de análise e integração de dados de genômica e transcriptômica para Bothrops jararaca no projeto CeTICS, BP.TT; 17/00715-0 - Enzimas proteolíticas de venenos de serpentes disparam cascatas de eventos moleculares ainda desconhecidos, BP.PD; 16/17775-3 - Desenho e simulação de modelos computacionais da dinâmica de replicação de DNA em Kinetoplastídeos, BP.IC; 16/22415-6 - Desenvolvimento de infraestrutura e ferramentas de análise e integração de dados de genômica e transcriptômica para Bothrops jararaca no projeto CeTICS, BP.TT; 16/16935-7 - Uma perspectiva sobre as modificações pós-traducionais em toxinas de venenos do gênero Bothrops: identificação proteômica de sítios específicos de N-glicanos e cisteínas., BP.DR; 15/12224-6 - Avaliação dos mecanismos envolvidos na sobrevivência de células de longa vida produtoras de anticorpos induzida pela IL-17 externalizada em NET (neutrophil extracellular traps), BE.PQ; 16/13469-5 - Desenvolvimento de Infraestrutura, ferramentas de análise e integração de dados de genômica e transcriptômica no projeto CeTICS, BP.TT; 16/10613-8 - Análise da ação do sistema complemento na expressão de micro RNAs no loxoscelismo sistêmico, BP.PD; 16/07802-3 - Concepção de antivenenos com base na sequência de aminoácidos das regiões determinantes de complementaridade (CDRs), BP.PD; 15/23691-4 - Ativ pró-inflamatória de proteinases de venenos de serpentes: i) obtenção de proteinases recombinantes em sistema livre de CEL; ii) geração de microvesículas por monócitos estimulados com proteinases nativas e recomb e sua interação com células endoteliais, BP.PD; 15/17053-5 - Estudo da ativação de inflamassomas, em queratinócitos humanos, por ação do veneno da aranha Loxosceles laeta e sua esfingomielinase D, BP.PD; 15/03509-7 - Sequenciamento genômico de serpentes brasileiras focado no estudo de toxinas, BP.PD; 15/17494-1 - Loxoscelism: from basic research to the proposal of new therapies, BP.PD; 15/01234-0 - Enzimas proteolíticas de venenos de serpentes disparam cascatas de eventos moleculares ainda desconhecidos, BP.PD; 14/24170-5 - Dinâmica da replicação do DNA em Trypanosoma cruzi: caracterização do licenciamento e da taxa de replicação, BP.PD; 15/04641-6 - Investigação da participação da dessensibilização de receptores no antagonismo das natterinas, BP.IC; 15/03953-4 - Modulação da expressão de integrinas em neutrófilos pelas Natterinas, BP.IC; 14/02978-0 - Análise funcional do complexo RPA em Trypanosoma cruzi e seu envolvimento com DNA telomérico, BP.DR; 14/23564-0 - Estudos de estruturas de dados eficientes para abordar o problema de otimização U-curve, BP.IC; 14/21557-6 - Analise funcional dos homólogos Ataxia-telangiectasia mutated (ATM) e a Ataxia-telangiectasia and RAD3-related (ATR) na sinalização de dano ao DNA em Trypanosoma cruzi, BP.IC; 14/18875-6 - Dor e analgesia: mecanismos moleculares de novas drogas terapêuticas e alvos, BP.PD; 14/13375-5 - Origens da replicação em tripanossomas, BP.PD; 14/01534-1 - Caracterização do potencial de inibição do receptor de colágeno receptor do domínio de Discoidina 2 por componentes de metaloproteinases de venenos de cobra, BE.PQ; 13/24212-7 - Bioinformática e modelagem, BP.PD; 13/50694-9 - Avaliação do papel dos NET de neutrófilos na diferenciação de células produtoras de anticorpos de longa vida na resposta crônica induzida pelo veneno de Thalassophryne nattereri, BP.PD; 13/07974-0 - Sequenciamento do genoma da serpente Bothrops jararaca para caracterização da estrutura gênica de toxinas e seus elementos regulatórios, BP.DR; 12/51135-0 - Verificação da indução pelas natterinas de mecanismos reguladores da cascata de sinalização de TLR, BP.PD; 12/20186-9 - Mecanismos moleculares da interação funcional entre Ras e ciclina D1 em células malignas dependentes de Ras, BP.PD; 11/09333-7 - Crotalfina: análogos fluorescentes e estudo de seu mecanismo de ação em culturas e co-culturas de neurônios e queratinócitos, BP.PD - menos bolsas vinculadas
• Assunto(s): Ciclo celular Homeostase Toxinas Genes de resposta imune Financiamento em saúde
• Palavra(s)-Chave do Pesquisador: biologia sistêmica | ciclo celular | homeostasia | resposta imune | sinalização celular | toxina | Biologia Molecular
• Publicação FAPESP: https://media.fapesp.br/bv/uploads/pdfs/Multidisciplinary_science_Ebmcxc8_18_19.pdf

Resumo

No Instituto Butantan toxinologia e regulação da resposta imune são, tradicionalmente, áreas conexas de pesquisa científica e desenvolvimento biotecnológico, através das quais o Instituto, historicamente, construiu sua reputação internacional de excelência. Na cultura do Instituto, venenos são misturas complexas de toxinas, selecionadas ao longo da evolução para sinergicamente exercerem efeitos biológicos sistêmicos, através de mecanismos bioquímicos, moleculares e celulares altamente específicos. Portanto, a análise química de venenos tem boas chances de levar à descoberta de novas moléculas de toxinas com potencial terapêutico. Essas premissas foram seguidas com sucesso por pesquisadores do Centro de Toxinologia Aplicada (CAT CEPID-FAPESP), projeto iniciado há 10 anos, que isolaram, caracterizaram quimicamente e patentearam diversas toxinas de natureza proteica, que se tornaram pontos de partida para desenvolvimento de inovação farmacêutica em parceria com indústrias locais. A ênfase em proteínas e peptídeos levou o CAT CEPID a instalar laboratórios no estado da arte para transcriptômica, proteômica, biologia molecular do DNA recombinante e síntese de peptídeos. Mais recentemente, estudos dos mecanismos de ação, bioquímicas, moleculares e celulares, dessas promissoras moléculas foram iniciados com o objetivo de estabelecer provas de conceito. Assim, o CAT estabeleceu, no Instituto Butantan, as condições iniciais para a criação de um centro de toxinas e resposta imune fundamentado nas abordagens atuais da biologia sistêmica. Por conseguinte, 10 pesquisadores, entre os mais competitivos do Instituto Butantan, propõem a criação do novo Centro de Toxinas, Resposta-imune e Sinalização Celular, com aspirações a centro de excelência de classe mundial, aproveitando a histórica reputação internacional do Butantan e o sucesso recente do CAT CEPID. O Plano de pesquisa do Centro Integra subprojetos voltados para a pesquisa científica com subprojetos de vocação para a inovação tecnológica. Um grande grupo de cientistas seniores do Instituto Butantan, de outras instituições brasileiras e de renomadas instituições estrangeiras serão colaboradores do Centro proposto. (AU)

Publicações científicas

(206)

(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)

AOUNALLAH, HAJER; BENSAOUD, CHAIMA; M'GHIRBI, YOUMNA; FARIA, FERNANDA; CHMELAR, JINDRICH; KOTSYFAKIS, MICHAIL. Tick Salivary Compounds for Targeted Immunomodulatory Therapy. FRONTIERS IN IMMUNOLOGY, v. 11, SEP 23 2020. (13/07467-1)

ESPINOZA-CULUPU, ABRAHAM; VAZQUEZ-RAMIREZ, RICARDO; FARFAN-LOPEZ, MARIELLA; MENDES, ELIZABETH; NOTOMI SATO, MARIA; DA SILVA JUNIOR, PEDRO ISMAEL; BORGES, MONAMARIS MARQUES. Acylpolyamine Mygalin as a TLR4 Antagonist Based on Molecular Docking and In Vitro Analyses. BIOMOLECULES, v. 10, n. 12, DEC 2020. (13/11212-9, 13/07467-1)

TANAKA, GABRIELA D.; SANT'ANNA, OSVALDO AUGUSTO; MARCELINO, JOSE ROBERTO; LUSTOZA DA LUZ, ANA CRISTINA; TEIXEIRA DA ROCHA, MARISA MARIA; TAMBOURGI, DENISE V.. Micrurus snake species: Venom immunogenicity, antiserum cross-reactivity and neutralization potential. Toxicon, v. 117, p. 59-68, JUL 2016. (13/07467-1)

REIS, MARCELO S.; ESTRELA, GUSTAVO; FERREIRA, CARLOS EDUARDO; BARRERA, JUNIOR. featsel: A framework for benchmarking of feature selection algorithms and cost functions. SOFTWAREX, v. 6, p. 193-197, 2017. (15/01587-0, 16/25959-7, 13/03447-6, 13/07467-1)

MANZONI-DE-ALMEIDA, DANIEL; SQUAIELLA-BAPTISTAO, CARLA CRISTINA; LOPES, PRISCILA HESS; VAN DEN BERG, CARMEN W.; TAMBOURGI, DENISE V.. Loxosceles venom Sphingomyelinase D activates human blood leukocytes: Role of the complement system. Molecular Immunology, v. 94, p. 45-53, FEB 2018. (13/07467-1, 15/17053-5)

VALENTE, RICHARD HEMMI; LUNA, MILENE SCHMIDT; DE OLIVEIRA, URSULA CASTRO; NISHIYAMA-JUNIOR, MILTON YUTAKA; JUNQUEIRA-DE-AZEVEDO, INACIO DE LOIOLA; PORTES-JUNIOR, JOSE ANTONIO; CLISSA, PATRICIA BIANCA; VIANA, LUCIANA GODOY; SANCHES, LEONARDO; MOURA-DA-SILVA, ANA MARIA; et al. Bothrops jararaca accessory venom gland is an ancillary source of toxins to the snake. JOURNAL OF PROTEOMICS, v. 177, p. 137-147, APR 15 2018. (13/07467-1, 07/50083-9, 14/26058-8, 16/50127-5)

GLORIA MARIA DA SILVA; DANIEL HENRIQUE BERTO DE SOUZA; KAROLINE B. WAITMAN; MATTEO CELANO EBRAM; MELISSA R. FESSEL; IULIU CEZAR ZAINESCU; FERNANDA C. PORTARO; MONTSE HERAS; SONIA A. DE ANDRADE. Design, synthesis, and evaluation of Bothrops venom serine protease peptidic inhibitors. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 27, 2021-01-15. (13/07467-1, 17/04321-7)

SILVA DE FRANCA, FELIPE; GABRILI, JOEL JOSE MEGALE; MATHIEU, LAURENCE; BURGHER, FRANCOIS; BLOMET, JOEL; TAMBOURGI, DENISE V.. Bothrops lanceolatus snake (Fer-de-lance) venom triggers inflammatory mediators' storm in human blood. ARCHIVES OF TOXICOLOGY, JAN 2021. (13/07467-1)

BUENO, THAIS CAVENATTI; COLLACO, RITA DE CASSIA; CARDOSO, BIANCA APARECIDA; BREDARIOL, RAFAEL FUMACHI; ESCOBAR, MARILIA LEAL; CAJADO, ISABELA BUBENIK; GRACIA, MARTA; ANTUNES, EDSON; ZAMBELLI, VANESSA O.; PICOLO, GISELE; et al. Neurotoxicity of Olindias sambaquiensis and Chiropsalmus quadrumanus extracts in sympathetic nervous system. Toxicon, v. 199, p. 127-138, AUG 2021. (11/50242-5, 13/07467-1)

DISNER, GEONILDO R.; FALCAO, MARIA A. P.; LIMA, CARLA; LOPES-FERREIRA, MONICA. In Silico Target Prediction of Overexpressed microRNAs from LPS-Challenged Zebrafish (Danio rerio) Treated with the Novel Anti-Inflammatory Peptide TnP. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 22, n. 13, JUL 2021. (13/07467-1, 19/27677-7)

GREN, ERIC C. K.; KITANO, EDUARDO S.; ANDRADE-SILVA, DEBORA; IWAI, LEO KEI; REIS, MARCELO S.; MENEZES, MILENE C.; SERRANO, SOLANGE M. T.. Comparative analysis of the high molecular mass subproteomes of eight Bothrops snake venoms. Comparative Biochemistry and Physiology D-Genomics & Proteomics, v. 30, p. 113-121, JUN 2019. (13/07467-1, 15/01234-0, 13/13548-4)

DIAZ-ROA, ANDREA; ESPINOZA-CULUPU, ABRAHAM; TORRES-GARCIA, ORLANDO; BORGES, MONAMARIS M.; AVINO, IVAN N.; ALVES, FLAVIO L.; MIRANDA, ANTONIO; PATARROYO, MANUEL A.; DA SILVA, JR., PEDRO I.; BELLO, FELIO J.. Sarconesin II, a New Antimicrobial Peptide Isolated from Sarconesiopsis magellanica Excretions and Secretions. Molecules, v. 24, n. 11, JUN 1 2019. (13/07467-1)

DE ARAUJO, CHRISTIANE BEZERRA; CHAGAS DA CUNHA, JULIA PINHEIRO; INADA, DAVI TOSHIO; DAMASCENO, JEZIEL; JERONIMO LIMA, ALEX RANIERI; HIRAIWA, PRISCILA; MARQUES, CATARINA; GONCALVES, EVONNILDO; NISHIYAMA-JUNIOR, MILTON YUTAKA; MCCULLOCH, RICHARD; et al. Replication origin location might contribute to genetic variability in Trypanosoma cruzi. BMC Genomics, v. 21, n. 1, JUN 22 2020. (13/07467-1, 14/24170-5, 16/50050-2, 14/13375-5)

DA SILVA, MARCELO S.; VITARELLI, MARCELA O.; SOUZA, BRUNO F.; ELIAS, MARIA CAROLINA. Comparative Analysis of the Minimum Number of Replication Origins in Trypanosomatids and Yeasts. GENES, v. 11, n. 5, MAY 2020. (13/07467-1, 14/24170-5, 16/50050-2, 17/18719-2, 17/07693-2)

MOURA-DA-SILVA, ANA MARIA; CONTRERAS-BERNAL, JORGE CARLOS; GIMENES, SARAH NATALIE CIRILO; FREITAS-DE-SOUSA, LUCIANA APARECIDA; PORTES-JUNIOR, JOSE ANTONIO; PEIXOTO, PEDRO DA SILVA; IWAI, LEO KEI; DE MOURA, VALERIA MOURAO; BISNETO, PEDRO FERREIRA; LACERDA, MARCUS; et al. The relationship between clinics and the venom of the causative Amazon pit viper (Bothrops atrox). PLoS Neglected Tropical Diseases, v. 14, n. 6, JUN 2020. (13/07467-1, 18/13108-8, 18/25749-8, 17/24546-3)

LOPES, PRISCILA HESS; VAN DEN BERG, CARMEN W.; TAMBOURGI, V, DENISE. Sphingomyelinases D From Loxosceles Spider Venoms and Cell Membranes: Action on Lipid Rafts and Activation of Endogenous Metalloproteinases. FRONTIERS IN PHARMACOLOGY, v. 11, MAY 13 2020. (13/07467-1, 15/17053-5)

REIS, MARCELO S.; ESTRELA, GUSTAVO; FERREIRA, CARLOS EDUARDO; BARRERA, JUNIOR. Optimal Boolean lattice-based algorithms for the U-curve optimization problem. INFORMATION SCIENCES, v. 471, p. 97-114, JAN 2019. (13/07467-1, 11/50761-2, 14/23564-0)

DIAZ-ROA, ANDREA; PATARROYO, MANUEL A.; BELLO, FELIO J.; DA SILVA, JR., PEDRO I.. Sarconesin: Sarconesiopsis magellanica Blowfly Larval Excretions and Secretions With Antibacterial Properties. FRONTIERS IN MICROBIOLOGY, v. 9, SEP 28 2018. (13/07467-1)

DA SILVA, MARCELO S.; MARINI, PAULA A.; REPOLES, BRUNO M.; ELIAS, MARIA C.; MACHADO, CARLOS R.. Analysis of DNA Exchange Using Thymidine Analogs (ADExTA) in Trypanosoma cruzi. BIO-PROTOCOL, v. 8, n. 24, DEC 20 2018. (13/07467-1, 14/24170-5, 17/18719-2)

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