CeTICS - Centro de Toxinas, Imuno-Resposta e Sinalização Celular

• Processo: 13/07467-1
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Vigência: 01 de julho de 2013 - 30 de junho de 2024
• Área do conhecimento: Ciências Biológicas - Bioquímica - Biologia Molecular
• Pesquisador responsável: Hugo Aguirre Armelin
• Beneficiário: Hugo Aguirre Armelin
• Instituição Sede: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brasil
• Pesquisadores principais:( Atuais ): Denise Vilarinho Tambourgi ; Gisele Picolo ; Inácio de Loiola Meirelles Junqueira de Azevedo ; Monica Valdyrce dos Anjos Lopes Ferreira ; Solange Maria de Toledo Serrano ; Wilmar Dias da Silva
• Pesquisadores principais:( Anteriores ): Ana Marisa Chudzinski-Tavassi ; Junior Barrera ; Maria Carolina Quartim Barbosa Elias Sabbaga ; Osvaldo Augusto Brazil Esteves Sant'Anna ; Yara Cury
• Pesquisadores associados: Adriana Mortara Almeida ; Alessandra Fernandes Bizerra ; Alexandre Keiji Tashima ; Aline Soriano Lopes ; Allan Mowat ; Ana Maria Moura da Silva ; Ana Marisa Chudzinski-Tavassi ; André Zelanis Palitot Pereira ; Ann Ager ; B. Paul Morgan ; Carla Cristina Squaiella ; Carla Lima da Silva ; Carmen W. Van Den Berg ; Daria Mochly-Rosen ; Denise Vilarinho Tambourgi ; Fabio Carlos Magnoli ; Fábio Nakano ; Fan Hui Wen ; Fernanda Calheta Vieira Portaro ; Fernanda Faria ; Fernanda Paiva Guimarães ; Gisele Picolo ; Giselle Pidde Marques Porto ; Inácio de Loiola Meirelles Junqueira de Azevedo ; Jay W. Fox ; Jesus Aparecido Ferro ; Jose Roberto Marcelino ; Jose Salvatore Leister Patane ; Julia Pinheiro Chagas da Cunha ; Katsuhiro Konno ; Kerly Fernanda Mesquita Pasqualoto ; Leo Kei Iwai ; Luc Pellerin ; Luciana Rodrigues Gomes ; Luiz Vicente Rizzo ; Marcella Barbosa Faria de Almeida Prado ; Marcelo da Silva Reis ; Marcelo de Franco ; Marcia Carvalho de Abreu Fantini ; Marcio Henrique Zaim ; Maria Carolina Quartim Barbosa Elias Sabbaga ; Maria Teresa Machini ; Marinilce Fagundes dos Santos ; Martha Marandino ; Miguel Allende ; Milton Yutaka Nishiyama Junior ; Mirta Schattner ; Miryam Paola Alvarez Flores ; Ovidiu Radulescu ; Paulo Lee Ho ; Paulo Sérgio Lacerda Beirão ; Pedro Ismael da Silva Junior ; Ricardo Jose Giordano ; Richard Mcculloch ; Robson Lopes de Melo ; Roger Chammas ; Ruy Gastaldoni Jaeger ; Sandra Coccuzzo Sampaio Vessoni ; Silvio Roberto de Azevedo Salinas ; Simone Guedes Calderano ; Sonia Aparecida de Andrade Chudzinski ; Tânia Tomé Martins de Castro ; Vanessa Olzon Zambelli ; Vanessa Rioli
• Auxílios(s) vinculado(s): 20/01360-4 - Evolução do veneno de serpentes avançadas da América do Sul: uma abordagem integrada comparando linhagens cis-/trans-andinas, AV.EXT; 22/10539-3 - EMU concedido no processo FAPESP 2013/07467-1: nome do equipamento: QuantStudio 3 Real-Time PCR System, Applied Biosystems, AP.EMU; 19/23605-1 - Identificação de mecanismos moleculares de resistência a drogas e reparação de DNA em Trypanosomatidae, AP.R SPRINT; + mais auxílios vinculados 21/13951-0 - EMU concedido no processo 13/07467-1 : Citômetro de Fluxo BD FACSLyric e acessórios, AP.EMU; 21/13939-0 - EMU concedido no processo Fapesp 13/07467-1: Espectrômetro de Massas Orbitrap Exploris 480 e acessórios, AP.EMU; 19/07809-6 - ICOM CECA Conference 2019: Roles of Museum Education: Supporting Self and Society, AR.EXT; 18/26586-5 - 24o Congresso Mundial de Dermatologia, AR.EXT; 17/18281-7 - EMU concedido no processo CEPID 2013/07467-1 - nome do equipamento: sistema NanoLC EASY-nLCTM 1000 - thermo scientific, AP.EMU; 15/10413-6 - ICOM CECA Annual Conference 2015: Museum Education and Accessibility: Bridging the Gaps, AR.EXT; 15/07553-0 - EMU concedido no processo 2013/07467-1: sistema de ressonância plasmônica de superfície - Biacore T200, AP.EMU; 15/10037-4 - EMU concedido no processo 2013/07467-1: citômetro de fluxo, AP.EMU - menos auxílios vinculados
• Bolsa(s) vinculada(s): 22/16146-3 - Caracterização molecular dos efeitos do veneno de Bothrops jararaca: análise de células pulmonares em cultura e tecido pulmonar de camundongo por abordagens proteômica e imuno-histoquímica., BP.PD; 22/07209-1 - O veneno de Bothrops jararaca e a falência renal: bases moleculares da citotoxicidade em células mesangiais e do efeito sinérgico de produtos de degradação de proteínas plasmáticas., BP.MS; 22/10761-8 - Influência da tríade, grupo heme/sistema complemento/inflamação, na imunopatogênese do envenenamento por abelhas africanizadas, BP.TT; + mais bolsas vinculadas 21/10570-5 - Caracterização molecular dos efeitos in vivo do veneno da Bothrops jararaca: análises do tecido muscular e do plasma de camundongos, por abordagens de proteômica e imuno-histoquímica, BP.PD; 21/10344-5 - Identificação de peptídeos derivados da crotoxina com potencial antitumoral e imunomodulatório, BP.PD; 19/24580-2 - Seleção bayesiana de modelos dinâmicos de vias não isoladas de sinalização celular, BP.DD; 21/08891-8 - Avaliação dos mecanismos farmacológicos do peptídeo TnP isolado do veneno de Thalassophryne nattereri na terapêutica da Retinopatia Hipóxica em Zebrafish, BP.PD; 21/04355-4 - Implementações eficientes de métodos Bayesianos para seleção de modelos de vias de sinalização celular, BP.IC; 20/11468-7 - Gerenciamento e Implementação de Novas Ferramentas para a Plataforma CeTICSDB, BP.TT; 20/12317-2 - Análise proteômica dos efeitos sistêmicos do veneno da Bothrops jararaca em modelo murino., BP.PD; 19/27348-3 - Inibição do sistema complemento como meio para controlar a inflamação associada a envenenamentos, BP.PD; 20/03718-3 - Compreendendo as reações locais induzidas pelos venenos de Loxosceles e suas principais toxinas, BP.PD; 20/00770-4 - Síntese de derivados de benznidazol e óxido de grafeno e avaliação de suas atividades anti-chagásicas, BP.PD; 19/27677-7 - Estudo da indução de microRNAs regulatórios por TNP dependente da ativação do receptor de hidrocarboneto arílico (AhR), BP.PD; 19/20025-4 - Uma abordagem baseada em computação Bayesiana aproximada para resolver o problema da falta de isolamento na modelagem de vias de sinalização, BE.PQ; 19/18565-0 - Avaliação por hibridização in situ quantitativa dos níveis dos transcritos de natterina-like em zebrafish depletados com CRISPR/Cas-9, BP.IC; 19/10500-7 - Avaliação da necessidade da ativação do complexo inflamassoma na inflamação neutrofilica induzida pelas natterinas, toxinas formadoras de poros, BE.PQ; 19/05882-8 - Avaliação do papel da crotalfina na dinâmica do cílio primário de neurônios aferentes primários: novos caminhos para o estudo de compostos analgésicos, BP.PD; 19/13039-9 - Controle do Ciclo Celular em células normais e malignas, nova abordagem na terapia do câncer., BP.PD; 19/01895-8 - Função das nucleases MRE11, DNA2 e EXO1 na ressecção do DNA terminal e o reparo das quebras de dupla fita em Trypanosoma brucei, BP.PD; 19/02333-3 - Validação da importância funcional das natterinas na resposta imune inata em zebrafish por CRISPR-Cas9, um método de loss-of-function, BP.MS; 18/06751-1 - Caracterização molecular dos efeitos in vivo da metaloproteinase hemorrágica HF3: análises do proteoma do tecido muscular de camundongos, BP.MS; 18/12364-0 - Expressão, purificação e caracterização inicial de uma nova proteína RPA-like de Trypanosoma brucei, BP.IC; 17/07693-2 - Dinâmica funcional da proteína Orc1b durante o ciclo de vida de Trypanosoma, BP.DR; 18/08167-5 - Apoio bioinformático aos projetos de análise de expressão gênica diferencial do CeTICS, BP.TT; 18/06682-0 - Análise filogenética computacional de serpentes do gênero Bothrops a partir de proteomas de venenos, BP.IC; 17/06496-9 - Caracterização proteômica do efeito da peçonha de Bothrops jararaca sobre linhagens celulares de câncer versus linhagens celulares normais, BP.MS; 17/18344-9 - Proteômica quantitativa da cromatina frente ao tratamento com FGF2: análise da regulação transcricional e associação de cdc42, BP.DD; 17/20575-9 - Identificação de vias de sinalização celular baseada em repositórios de cinética de reações bioquímicas, BP.MS; 17/19252-0 - Análise proteômica dos efeitos de PA-BJ, uma serinoproteinase do veneno de Bothrops jararaca, sobre cultura de células endoteliais de sangue periférico, BP.PD; 17/19545-8 - Análise dos mecanismos moleculares subjacentes à inibição do ciclo celular por FGF2 em células Y1 adrenocorticais e tumorais de camundongo, dependentes de WT-Kras amplificado, BP.PD; 17/09929-3 - Venenos de serpentes do gênero Bothrops: impacto da glicosilação na complexidade dos proteomas e função de toxinas, BP.DD; 17/12199-7 - Loxoscelismo: da pesquisa básica ao desenvolvimento de novas terapias, BP.TT; 17/13681-7 - Análise e desenvolvimento de ferramentas de bioinformática aplicadas a estudos de genômica, transcriptômica e proteômica, BP.TT; 17/10853-1 - Desenvolvimento de ferramentas e análises para estudo das bases moleculares para a replicação do DNA e ciclo celular, BP.TT; 17/09648-4 - Expressão recombinante, e caracterização funcional dos domínios não catalíticos de uma metaloproteinase da classe P-III do veneno da serpente Bothrops jararaca, utilizando um sistema de expressão livre de célula, BP.IC; 16/25959-7 - Projeto de algoritmos baseados em florestas de posets para o problema de otimização U-curve, BP.IC; 16/22774-6 - Controle epigenético na analgesia dependente da ativação de receptores opióides: papel dos miRNAs e metilação do DNA no efeito antinociceptivo da crotalfina, BP.PD; 17/02225-0 - Loxoscelismo: da pesquisa básica ao desenvolvimento de novas terapias, BP.TT; 16/25661-8 - Desenvolvimento de infraestrutura e ferramentas de análise e integração de dados de genômica e transcriptômica para Bothrops jararaca no projeto CeTICS, BP.TT; 17/00715-0 - Enzimas proteolíticas de venenos de serpentes disparam cascatas de eventos moleculares ainda desconhecidos, BP.PD; 16/17775-3 - Desenho e simulação de modelos computacionais da dinâmica de replicação de DNA em Kinetoplastídeos, BP.IC; 16/22415-6 - Desenvolvimento de infraestrutura e ferramentas de análise e integração de dados de genômica e transcriptômica para Bothrops jararaca no projeto CeTICS, BP.TT; 16/16935-7 - Uma perspectiva sobre as modificações pós-traducionais em toxinas de venenos do gênero Bothrops: identificação proteômica de sítios específicos de N-glicanos e cisteínas., BP.DR; 15/12224-6 - Avaliação dos mecanismos envolvidos na sobrevivência de células de longa vida produtoras de anticorpos induzida pela IL-17 externalizada em NET (neutrophil extracellular traps), BE.PQ; 16/13469-5 - Desenvolvimento de Infraestrutura, ferramentas de análise e integração de dados de genômica e transcriptômica no projeto CeTICS, BP.TT; 16/10613-8 - Análise da ação do sistema complemento na expressão de micro RNAs no loxoscelismo sistêmico, BP.PD; 16/07802-3 - Concepção de antivenenos com base na sequência de aminoácidos das regiões determinantes de complementaridade (CDRs), BP.PD; 15/23691-4 - Ativ pró-inflamatória de proteinases de venenos de serpentes: i) obtenção de proteinases recombinantes em sistema livre de CEL; ii) geração de microvesículas por monócitos estimulados com proteinases nativas e recomb e sua interação com células endoteliais, BP.PD; 15/17053-5 - Estudo da ativação de inflamassomas, em queratinócitos humanos, por ação do veneno da aranha Loxosceles laeta e sua esfingomielinase D, BP.PD; 15/03509-7 - Sequenciamento genômico de serpentes brasileiras focado no estudo de toxinas, BP.PD; 15/17494-1 - Loxoscelism: from basic research to the proposal of new therapies, BP.PD; 15/01234-0 - Enzimas proteolíticas de venenos de serpentes disparam cascatas de eventos moleculares ainda desconhecidos, BP.PD; 14/24170-5 - Dinâmica da replicação do DNA em Trypanosoma cruzi: caracterização do licenciamento e da taxa de replicação, BP.PD; 15/04641-6 - Investigação da participação da dessensibilização de receptores no antagonismo das natterinas, BP.IC; 15/03953-4 - Modulação da expressão de integrinas em neutrófilos pelas Natterinas, BP.IC; 14/02978-0 - Análise funcional do complexo RPA em Trypanosoma cruzi e seu envolvimento com DNA telomérico, BP.DR; 14/23564-0 - Estudos de estruturas de dados eficientes para abordar o problema de otimização U-curve, BP.IC; 14/21557-6 - Analise funcional dos homólogos Ataxia-telangiectasia mutated (ATM) e a Ataxia-telangiectasia and RAD3-related (ATR) na sinalização de dano ao DNA em Trypanosoma cruzi, BP.IC; 14/18875-6 - Dor e analgesia: mecanismos moleculares de novas drogas terapêuticas e alvos, BP.PD; 14/13375-5 - Origens da replicação em tripanossomas, BP.PD; 14/01534-1 - Caracterização do potencial de inibição do receptor de colágeno receptor do domínio de Discoidina 2 por componentes de metaloproteinases de venenos de cobra, BE.PQ; 13/24212-7 - Bioinformática e modelagem, BP.PD; 13/50694-9 - Avaliação do papel dos NET de neutrófilos na diferenciação de células produtoras de anticorpos de longa vida na resposta crônica induzida pelo veneno de Thalassophryne nattereri, BP.PD; 13/07974-0 - Sequenciamento do genoma da serpente Bothrops jararaca para caracterização da estrutura gênica de toxinas e seus elementos regulatórios, BP.DR; 12/51135-0 - Verificação da indução pelas natterinas de mecanismos reguladores da cascata de sinalização de TLR, BP.PD; 12/20186-9 - Mecanismos moleculares da interação funcional entre Ras e ciclina D1 em células malignas dependentes de Ras, BP.PD; 11/09333-7 - Crotalfina: análogos fluorescentes e estudo de seu mecanismo de ação em culturas e co-culturas de neurônios e queratinócitos, BP.PD - menos bolsas vinculadas
• Assunto(s): Ciclo celular Homeostase Toxinas Genes de resposta imune Financiamento em saúde
• Palavra(s)-Chave do Pesquisador: biologia sistêmica | ciclo celular | homeostasia | resposta imune | sinalização celular | toxina | Biologia Molecular
• Publicação FAPESP: https://media.fapesp.br/bv/uploads/pdfs/Multidisciplinary_science_Ebmcxc8_18_19.pdf

Resumo

No Instituto Butantan toxinologia e regulação da resposta imune são, tradicionalmente, áreas conexas de pesquisa científica e desenvolvimento biotecnológico, através das quais o Instituto, historicamente, construiu sua reputação internacional de excelência. Na cultura do Instituto, venenos são misturas complexas de toxinas, selecionadas ao longo da evolução para sinergicamente exercerem efeitos biológicos sistêmicos, através de mecanismos bioquímicos, moleculares e celulares altamente específicos. Portanto, a análise química de venenos tem boas chances de levar à descoberta de novas moléculas de toxinas com potencial terapêutico. Essas premissas foram seguidas com sucesso por pesquisadores do Centro de Toxinologia Aplicada (CAT CEPID-FAPESP), projeto iniciado há 10 anos, que isolaram, caracterizaram quimicamente e patentearam diversas toxinas de natureza proteica, que se tornaram pontos de partida para desenvolvimento de inovação farmacêutica em parceria com indústrias locais. A ênfase em proteínas e peptídeos levou o CAT CEPID a instalar laboratórios no estado da arte para transcriptômica, proteômica, biologia molecular do DNA recombinante e síntese de peptídeos. Mais recentemente, estudos dos mecanismos de ação, bioquímicas, moleculares e celulares, dessas promissoras moléculas foram iniciados com o objetivo de estabelecer provas de conceito. Assim, o CAT estabeleceu, no Instituto Butantan, as condições iniciais para a criação de um centro de toxinas e resposta imune fundamentado nas abordagens atuais da biologia sistêmica. Por conseguinte, 10 pesquisadores, entre os mais competitivos do Instituto Butantan, propõem a criação do novo Centro de Toxinas, Resposta-imune e Sinalização Celular, com aspirações a centro de excelência de classe mundial, aproveitando a histórica reputação internacional do Butantan e o sucesso recente do CAT CEPID. O Plano de pesquisa do Centro Integra subprojetos voltados para a pesquisa científica com subprojetos de vocação para a inovação tecnológica. Um grande grupo de cientistas seniores do Instituto Butantan, de outras instituições brasileiras e de renomadas instituições estrangeiras serão colaboradores do Centro proposto. (AU)

Publicações científicas

(206)

(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)

IQBAL, ASIF; GOLDFEDER, MAURICIO BARBUGIANI; MARQUES-PORTO, RAFAEL; ASIF, HUMA; DE SOUZA, JEAN GABRIEL; FARIA, FERNANDA; CHUDZINSKI-TAVASSI, ANA MARISA. Revisiting antithrombotic therapeutics; sculptin, a novel specific, competitive, reversible, scissile and tight binding inhibitor of thrombin. SCIENTIFIC REPORTS, v. 7, MAY 3 2017. (13/07467-1, 15/50040-4)

ALMEIDA, DIEGO DANTAS; KITAJIMA, JOAO PAULO; NISHIYAMA, JR., MILTON YUTAKA; CONDOMITTI, GEORGE WILLIAN; DE OLIVEIRA, URSULA CASTRO; SETUBAL, JOAO CARLOS; JUNQUEIRA-DE-AZEVEDO, INACIO L. M.. The complete mitochondrial genome of Bothrops jararaca (Reptilia, Serpentes, Viperidae). MITOCHONDRIAL DNA PART B-RESOURCES, v. 1, p. 907-908, 2016. (13/07467-1, 13/07974-0, 12/00177-5)

ATASHPAZ-GARGARI, ESMAEIL; REIS, MARCELO S.; BRAGA-NETO, ULISSES M.; BARRERA, JUNIOR; DOUGHERTY, EDWARD R.. A fast Branch-and-Bound algorithm for U-curve feature selection. PATTERN RECOGNITION, v. 73, p. 172-188, JAN 2018. (13/07467-1, 15/01587-0)

CHUDZINSKI-TAVASSI, ANA MARISA; MORAIS, KATIA L. P.; FERNANDES PACHECO, MARIO THIEGO; MESQUITA PASQUALOTO, KERLY FERNANDA; DE SOUZA, JEAN GABRIEL. Tick salivary gland as potential natural source for the discovery of promising antitumor drug candidates. BIOMEDICINE & PHARMACOTHERAPY, v. 77, p. 14-19, FEB 2016. (13/07467-1, 10/52669-3, 11/05969-4, 98/14307-9, 10/07958-7)

MYAMOTO, DANIELA TIEMI; PIDDE-QUEIROZ, GISELLE; GONCALVES-DE-ANDRADE, RUTE MARIA; PEDROSO, AURELIO; VAN DEN BERG, CARMEN W.; TAMBOURGI, DENISE V.. Characterization of a Gene Coding for the Complement System Component FB from Loxosceles laeta Spider Venom Glands. PLoS One, v. 11, n. 1, JAN 15 2016. (13/07467-1)

ELIAS, M. CAROLINA; FLOETER-WINTER, LUCILE M.; MENA-CHALCO, JESUS P.. The dynamics of Brazilian protozoology over the past century. Memórias do Instituto Oswaldo Cruz, v. 111, n. 1, p. 67+, JAN 2016. (13/07467-1)

MENEZES, MILENE C.; IMBERT, LIONEL; KITANO, EDUARDO S.; VERNET, THIERRY; SERRANO, SOLANGE M. T.. Recombinant expression of the precursor of the hemorrhagic metalloproteinase HF3 and its non-catalytic domains using a cell-free synthesis system. Amino Acids, v. 48, n. 9, p. 2205-2214, SEP 2016. (13/07467-1)

SILVA, THAIOMARA A.; SMUCZEK, BASILIO; VALADAO, IURI C.; DZIK, LUCIANA M.; IGLESIA, REBECA P.; CRUZ, MARIO C.; ZELANIS, ANDRE; DE SIQUEIRA, ADRIANE S.; SERRANO, SOLANGE M. T.; GOLDBERG, GARY S.; et al. AHNAK enables mammary carcinoma cells to produce extracellular vesicles that increase neighboring fibroblast cell motility. ONCOTARGET, v. 7, n. 31, p. 49998-50016, AUG 2 2016. (13/07467-1, 11/09472-7, 15/00544-6, 10/07699-1)

CAMPOS, POLLYANNA FERNANDES; ANDRADE-SILVA, DEBORA; ZELANIS, ANDRE; PAES LEME, ADRIANA FRANCO; TEIXEIRA ROCHA, MARISA MARIA; MENEZES, MILENE CRISTINA; SERRANO, SOLANGE M. T.; MEIRELLES JUNQUEIRA-DE-AZEVE, INACIO DE LOIOLA. Trends in the Evolution of Snake Toxins Underscored by an Integrative Omics Approach to Profile the Venom of the Colubrid Phalotris mertensi. GENOME BIOLOGY AND EVOLUTION, v. 8, n. 8, p. 2266-2287, AUG 2016. (13/07467-1)

JUNQUEIRA-DE-AZEVEDO, INACIO L. M.; CAMPOS, POLLYANNA F.; CHING, ANA T. C.; MACKESSY, STEPHEN P.. Colubrid Venom Composition: An -Omics Perspective. TOXINS, v. 8, n. 8, AUG 2016. (13/07467-1, 12/00177-5)

ANDRADE-SILVA, DEBORA; ZELANIS, ANDRE; KITANO, EDUARDO S.; JUNQUEIRA-DE-AZEVEDO, INACIO L. M.; REIS, MARCELO S.; LOPES, ALINE S.; SERRANO, SOLANGE M. T.. Proteomic and Glycoproteomic Profilings Reveal That Post- translational Modifications of Toxins Contribute to Venom Phenotype in Snakes. JOURNAL OF PROTEOME RESEARCH, v. 15, n. 8, p. 2658-2675, AUG 2016. (13/07467-1, 13/13548-4)

LIBERATO, TARCISIO; PAOLO TRONCONE, LANFRANCO RANIERI; YAMASHIRO, EDSON T.; SERRANO, SOLANGE M. T.; ZELANIS, ANDRE. High-resolution proteomic profiling of spider venom: expanding the toxin diversity of Phoneutria nigriventer venom. Amino Acids, v. 48, n. 3, p. 901-906, MAR 2016. (13/07467-1, 11/08514-8, 02/04545-7)

CHAVES, ALISON F. A.; CASTILHO, DANIELE G.; NAVARRO, MARINA V.; OLIVEIRA, ANA K.; SERRANO, SOLANGE M. T.; TASHIMA, ALEXANDRE K.; BATISTA, WAGNER L.. Phosphosite-specific regulation of the oxidative-stress response of Paracoccidioides brasiliensis: a shotgun phosphoproteomic analysis. Microbes and Infection, v. 19, n. 1, p. 34-46, JAN 2017. (14/13961-1, 11/14392-2, 13/07467-1, 12/19321-9, 12/17530-0)

ZAMBELLI, VANESSA O.; PICOLO, GISELE; FERNANDES, CARLOS A. H.; FONTES, MARCOS R. M.; CURY, YARA. Secreted Phospholipases A(2) from Animal Venoms in Pain and Analgesia. TOXINS, v. 9, n. 12, DEC 2017. (13/07467-1, 15/01254-1, 11/17974-2)

CRISPIM, MARCELL; DAMASCENO, FLAVIA SILVA; HERNANDEZ, AGUSTINO; BARISON, MARIA JULIA; SAUTER, ISMAEL PRETTO; PAVANI, RAPHAEL SOUZA; MOURA, ALEXANDRE SANTOS; FURUSHO PRAL, ELIZABETH MIEKO; CORTEZ, MAURO; ELIAS, MARIA CAROLINA; et al. The glutamine synthetase of Trypanosoma cruzi is required for its resistance to ammonium accumulation and evasion of the parasitophorous vacuole during host-cell infection. PLoS Neglected Tropical Diseases, v. 12, n. 1, JAN 2018. (13/07467-1, 16/06034-2, 15/10580-0, 14/10443-0, 16/50050-2)

FERREIRA JUNIOR, WILSON ALVES; ZAHARENKO, ANDRE JUNQUEIRA; KAZUMA, KOHEI; PICOLO, GISELE; GUTIERREZ, VANESSA PACCIARI; DE FREITAS, JOSE CARLOS; KONNO, KATSUHIRO; CURY, YARA. Peripheral 5-HT3 Receptors Are Involved in the Antinociceptive Effect of Bunodosine 391. TOXINS, v. 10, n. 1, JAN 2018. (13/07467-1, 11/01183-6, 09/08089-5)

GONCALVES, MARIANA TORRENTE; SQUAIELLA-BAPTISTAO, CARLA CRISTINA; PIDDE, GISELLE; LOPES, PRISCILA HESS; DA SILVA NUNES, ISEU; TAMBOURGI, DENISE V.. P-MAPA, a Fungi-Derived Immunomodulatory Compound, Induces a Proinflammatory Response in a Human Whole Blood Model. Mediators of Inflammation, v. 2020, NOV 24 2020. (13/07467-1, 12/05306-8)

SOARES-SCHANOSKI, ALESSANDRA; BAPTISTA CRUZ, NATALIA; DE CASTRO-JORGE, LUIZA ANTUNES; HOMEM DE CARVALHO, RENAN VILLANOVA; DOS SANTOS, CLIOMAR ALVES; DA ROS, NANCY; OLIVEIRA, URSULA; COSTA, DANUZA DUARTE; SIMOES DOS SANTOS, CECILIA LUIZA; CUNHA, MARIELTON DOS PASSOS; et al. Systems analysis of subjects acutely infected with the Chikungunya virus. PLOS PATHOGENS, v. 15, n. 6, JUN 2019. (12/19278-6, 13/07467-1, 15/25055-8, 13/08216-2, 16/08204-2, 17/50137-3)

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CEOLIN MARIANO, DOUGLAS OSCAR; MESSIAS, MARCELA DI GIACOMO; SPENCER, PATRICK JACK; PIMENTA, DANIEL CARVALHO. Protein identification from the parotoid macrogland secretion of Duttaphrynus melanostictus. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 25, AUG 19 2019. (13/07467-1)

CEOLIN MARIANO, DOUGLAS OSCAR; DE OLIVEIRA, URSULA CASTRO; ZAHARENKO, ANDRE JUNQUEIRA; PIMENTA, DANIEL CARVALHO; RADIS-BAPTISTA, GANDHI; DE BRANDAO PRIETO-DA-SILVA, ALVARO ROSSAN. Bottom-Up Proteomic Analysis of Polypeptide Venom Components of the Giant Ant Dinoponera Quadriceps. TOXINS, v. 11, n. 8, AUG 2019. (13/07467-1)

ZELANIS, ANDRE; OLIVEIRA, ANA K.; PRUDOVA, ANNA; HUESGEN, PITTER F.; TASHIMA, ALEXANDRE K.; KIZHAKKEDATHU, JAYACHANDRAN; OVERALL, CHRISTOPHER M.; SERRANO, SOLANGE M. T.. Deep Profiling of the Cleavage Specificity and Human Substrates of Snake Venom Metalloprotease HF3 by Proteomic Identification of Cleavage Site Specificity (PICS) Using Proteome Derived Peptide Libraries and Terminal Amine Isotopic Labeling of Substrates (TAILS) N-Terminomics. JOURNAL OF PROTEOME RESEARCH, v. 18, n. 9, p. 3419-3428, SEP 2019. (13/07467-1, 11/23403-8, 11/08514-8, 10/17328-0)

KIMURA, LOUISE F.; SANT'ANNA, MORENA B.; ANDRADE, SONIA A.; EBRAM, MATTEO C.; LIMA, CRISTIANE F. G.; CELANO, ROSA M. G.; VIEGAS, RUY F. M.; PICOLO, GISELE. COVID-19 induces proatherogenic alterations in moderate to severe non-comorbid patients: A single-center observational study. BLOOD CELLS MOLECULES AND DISEASES, v. 92, DEC 2021. (19/05882-8, 13/07467-1)

HAYASHIDA, PATRICIA YUMI; DA SILVA JUNIOR, PEDRO ISMAEL. Insights into Antimicrobial Peptides from Limacus flavus Mucus. Current Microbiology, v. 78, n. 8, p. 2970-2979, AUG 2021. (13/07467-1)

SILVA DE FRANCA, FELIPE; VILLAS-BOAS, ISADORA MARIA; COGLIATI, BRUNO; WOODRUFF, TRENT M.; REIS, EDIMARA DA SILVA; LAMBRIS, JOHN D.; TAMBOURGI, DENISE V.. C5a-C5aR1 Axis Activation Drives Envenomation Immunopathology by the Snake Naja annulifera. FRONTIERS IN IMMUNOLOGY, v. 12, APR 15 2021. (13/07467-1)

ANDRADE-SILVA, DEBORA; NISHIYAMA JR, MILTON Y.; STUGINSKI, DANIEL R.; ZELANIS, ANDRE; SERRANO, SOLANGE M. T.. The distinct N-terminomes of Bothrops jararaca newborn and adult venoms. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, v. 1869, n. 7, JUL 2021. (16/16935-7, 13/07467-1, 13/14651-3)

SEGURA-RAMIREZ, PAULA J.; DE GODOY, PEDRO MACHADO; AVINO, IVAN N.; SILVA JUNIOR, PEDRO I.. Encrypted antimicrobial peptides from proteins present in the plasma of the millipede Rhinocricus sp.. JOURNAL OF PROTEOMICS, v. 242, JUN 30 2021. (13/07467-1)

LUND, PEDER J.; LOPES, MARIANA; SIDOLI, SIMONE; CORADIN, MARIEL; DE LUNA VITORINO, FRANCISCA NATHALIA; CHAGAS DA CUNHA, JULIA PINHEIRO; GARCIA, BENJAMIN A.. FGF-2 induces a failure of cell cycle progression in cells harboring amplified K-Ras, revealing new insights into oncogene-induced senescence. MOLECULAR OMICS, JUN 2021. (11/22619-7, 16/24881-4, 17/15835-1, 18/15553-9, 15/04867-4, 17/18344-9, 13/07467-1)

KISAKI, CAROLINA YUKIKO; ARCOS, STEPHANIE SANTOS SUEHIRO; MONTONI, FABIO; DA SILVA SANTOS, WELLINGTON; CALACINA, HAMIDA MACEDO; LIMA, ISMAEL FEITOSA; CAJADO-CARVALHO, DANIELA; FERRO, EMER SUAVINHO; NISHIYAMA-JR, MILTON YUTAKA; IWAI, LEO KEI. Bothrops Jararaca Snake Venom Modulates Key Cancer-Related Proteins in Breast Tumor Cell Lines. TOXINS, v. 13, n. 8, AUG 2021. (17/06496-9, 13/07467-1, 16/04000-3, 17/17943-6)

THOMAZINI, CAMILA MARTOS; SACHETTO, ANA TERESA AZEVEDO; DE ALBUQUERQUE, CYNTHIA ZACCANINI; DE MOURA MATTARAIA, VANIA GOMES; DE OLIVEIRA, ANA KARINA; SERRANO, SOLANGE MARIA DE TOLEDO; LEBRUN, IVO; BARBARO, KATIA CRISTINA; SANTORO, MARCELO LARAMI. Involvement of von Willebrand factor and botrocetin in the thrombocytopenia induced by Bothrops jararaca snake venom. PLoS Neglected Tropical Diseases, v. 15, n. 9, SEP 2021. (13/07467-1, 18/26015-8, 13/20239-8, 19/07618-6, 13/25177-0)

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ROSON, JULIANA NUNES; VITARELLI, MARCELA DE OLIVEIRA J.; COSTA-SILVA, HELLIDA MARINA; PEREIRA, KAMILLE SCHMITT; PIRES, DAVID DA SILVA; LOPES, LETICIA DE SOUSA; CORDEIRO, BARBARA; KRAUS, AMELIE; CRUZ, KARIN NAVARRO TOZZI; CALDERANO, SIMONE GUEDES; et al. 2B.V demarcates divergent strand-switch regions, some tDNA loci, and genome compartments in Trypanosoma cruzi and affects parasite differentiation and host cell invasio. PLOS PATHOGENS, v. 18, n. 2, FEB 2022. (18/15553-9, 16/50050-2, 17/06104-3, 19/04483-2, 19/16033-1, 13/07467-1, 19/19834-5)

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A. LILLO; F. CARVAJAL-CAICONTE; W. VITAL; P. I. SILVA JUNIOR; E. J. PAREDES-GAMERO; M. ALVEAR; A. MIRANDA. Propriedades bioativas de extratos de folhas e frutos de Persea lingue Ness (Lauraceae). Brazilian Journal of Biology, v. 83, 2021-09-06. (13/07467-1)

ROBERTO TADASHI KODAMA; ALEXANDRE KAZUO KUNIYOSHI; CRISTIANE CASTILHO FERNANDES DA SILVA; DANIELA CAJADO-CARVALHO; BRUNO DUZZI; DOUGLAS CEOLIN MARIANO; DANIEL C. PIMENTA; RAFAEL BORGES; WILMAR DIAS DA SILVA; FERNANDA CALHETA VIEIRA PORTARO. A Kunitz-type peptide from Dendroaspis polylepis venom as a simultaneous inhibitor of serine and cysteine proteases. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 26, 2020-10-07. (13/07467-1, 11/02061-1, 15/15364-3, 15/13124-5, 13/15344-7)

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FRANCISQUINI, RODRIGO; BERTON, RAFAEL; SOARES, SANDRO GOMES; PESSOTTI, DAYELLE S.; CAMACHO, MAURICIO F.; ANDRADE-SILVA, DEBORA; BARCICK, UILLA; SERRANO, SOLANGE M. T.; CHAMMAS, ROGER; NASCIMENTO, MARIA C. V.; et al. Community-based network analyses reveal emerging connectivity patterns of protein-protein interactions in murine melanoma secretome. JOURNAL OF PROTEOMICS, v. 232, FEB 10 2021. (17/22330-3, 15/21660-4, 13/07375-0, 17/24185-0, 14/06579-3, 19/10817-0, 13/07467-1)

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LIMA, CARLA; FALCAO, MARIA ALICE PIMENTEL; ANDRADE-BARROS, ALINE INGRID; SENI-SILVA, ANA CAROLINA; GRUND, LIDIANE ZITO; BALOGH, ENIKO; CONCEICAO, KATIA; QUENIAUX, VALERIE F.; RYFFEL, BERNHARD; LOPES-FERREIRA, MONICA. Natterin an aerolysin-like fish toxin drives IL-1 beta-dependent neutrophilic inflammation mediated by caspase-1 and caspase-11 activated by the inflammasome sensor NLRP6. International Immunopharmacology, v. 91, FEB 2021. (18/17413-0, 19/10500-7, 13/07467-1)

LOPES, PRISCILA HESS; SQUAIELLA-BAPTISTAO, CARLA CRISTINA; MARQUES, MARIO OCTAVIO THA; TAMBOURGI, DENISE V.. Clinical aspects, diagnosis and management of Loxosceles spider envenomation: literature and case review. ARCHIVES OF TOXICOLOGY, v. 94, n. 5, MAR 2020. (13/07467-1, 15/17053-5)

SILVA, NORTON FELIPE DOS SANTOS; WILLEMART, RODRIGO HIRATA; DA SILVA, JOSE ROBERTO MACHADO CUNHA; DA SILVA JUNIOR, PEDRO ISMAEL. rotein Components of the Arthrodial Membrane Gland in a Neotropical Harvestman (Arachnida, Opiliones. ACS OMEGA, DEC 2021. (13/07467-1, 20/05158-5)

CAETANO, LHIRI HANNA DE LUCCA; NISHIYAMA-JR, MILTON YUTAKA; TAVORA, BIANCA DE CARVALHO LINS FERNANDES; DE OLIVEIRA, URSULA CASTRO; JUNQUEIRA-DE-AZEVEDO, INACIO DE LOIOLA MEIRELLES; FAQUIM-MAURO, ELIANA L.; MAGALHAES, GERALDO SANTANA. Recombinant Production and Characterization of a New Toxin from Cryptops iheringi Centipede Venom Revealed by Proteome and Transcriptome Analysis. TOXINS, v. 13, n. 12, DEC 2021. (17/13812-4, 17/16999-8, 13/07467-1)

HAUZMAN, EINAT; PIEROTTI, MICHELE E. R.; BHATTACHARYYA, NIHAR; TASHIRO, JULIANA H.; YOVANOVICH, CAROLA A. M.; CAMPOS, POLLYANNA F.; VENTURA, DORA F.; CHANG, BELINDA S. W.. imultaneous Expression of UV and Violet SWS1 Opsins Expands the Visual Palette in a Group of Freshwater Snake. Molecular Biology and Evolution, v. 38, n. 12, p. 5225-5240, DEC 2021. (18/11502-0, 14/26818-2, 18/13910-9, 14/25743-9, 18/09321-8, 13/07467-1, 15/14857-6)

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SANT'ANNA, MORENA BRAZIL; GIARDINI, ALINE C.; RIBEIRO, MARCIO A. C.; LOPES, FLAVIA S. R.; TEIXEIRA, NATHALIA B.; KIMURA, LOUISE F.; BUFALO, MICHELLE C.; RIBEIRO, ORLANDO G.; BORREGO, ANDREA; CABRERA, WAFA H. K.; et al. The Crotoxin:SBA-15 Complex Down-Regulates the Incidence and Intensity of Experimental Autoimmune Encephalomyelitis Through Peripheral and Central Actions. FRONTIERS IN IMMUNOLOGY, v. 11, OCT 28 2020. (17/17844-8, 15/01254-1, 14/19397-0, 13/07467-1)

MEGALE, ANGELA ALICE AMADEU; PORTARO, FERNANDA CALHETA; DA SILVA, WILMAR DIAS. Bitis arietans Snake Venom Induces an Inflammatory Response Which Is Partially Dependent on Lipid Mediators. TOXINS, v. 12, n. 9, SEP 2020. (13/07467-1)

CALDERANO, SIMONE GUEDES; NISHIYAMA JUNIOR, MILTON YUTAKA; MARINI, MARJORIE; NUNES, NATHAN DE OLIVEIRA; REIS, MARCELO DA SILVA; PATANE, JOSE SALVATORE LEISTER; DA SILVEIRA, JOSE FRANCO; DA CUNHA, JULIA PINHEIRO CHAGAS; ELIAS, MARIA CAROLINA. Identification of Novel Interspersed DNA Repetitive Elements in the Trypanosoma cruzi Genome Associated with the 3 ` UTRs of Surface Multigenic Families. GENES, v. 11, n. 10, OCT 2020. (13/07467-1, 16/50050-2)

PAVANI, RAPHAEL S.; DE LIMA, LOYZE P.; LIMA, ANDRE A.; FERNANDES, CARLOS A. H.; FRAGOSO, STENIO P.; CALDERANO, SIMONE G.; ELIAS, MARIA CAROLINA. Nuclear export of replication protein A in the nonreplicative infective forms of Trypanosoma cruzi. FEBS Letters, v. 594, n. 10, p. 1596-1607, MAY 2020. (16/50050-2, 14/02978-0, 18/14432-3, 18/21785-0, 13/07467-1)

LIMA, GUILHERME M.; MENEZES, MILENE C.; COSTA, IRIS M.; SERRANO, SOLANGE M. T.; MONTEIRO, GISELE. Development of a cell-free protein synthesis protocol to rapidly screen L-asparaginase proteoforms by enzymatic activity. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, v. 96, n. 9, p. 2659-2666, SEP 2021. (18/15041-8, 13/08617-7, 13/07467-1, 18/15104-0, 16/25896-5)

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KATO, ELLEN EMI; PIMENTA, LUCIANA ARAUJO; SOARES DE ALMEIDA, MAIRA ESTANISLAU; ZAMBELLI, VANESSA OLZON; DOS SANTOS, MARINILCE FAGUNDES; SAMPAIO, SANDRA COCCUZZO. rotoxin Inhibits Endothelial Cell Functions in Two- and Three-dimensional Tumor Microenvironmen. FRONTIERS IN PHARMACOLOGY, v. 12, AUG 4 2021. (13/07467-1, 12/51241-5)