Neurobiologia da doença de Alzheimer: marcadores de risco, prognóstico e resposta terapêutica

• Processo: 09/52825-8
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Data de Início da vigência: 01 de junho de 2010
• Data de Término da vigência: 31 de agosto de 2014
• Área do conhecimento: Ciências da Saúde - Medicina - Psiquiatria
• Pesquisador responsável: Wagner Farid Gattaz
• Beneficiário: Wagner Farid Gattaz
• Instituição Sede: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brasil
• Pesquisadores principais:( Últimos ): Emmanuel Dias-Neto
• Pesquisadores principais:( Antigos ): Orestes Vicente Forlenza
• Auxílio(s) vinculado(s): 12/06634-9 - Alzheimer's Association International Conference 2012, AR.EXT
• Bolsa(s) vinculada(s): 11/19892-3 - Efeitos do lítio sobre a expressão e atividade das enzimas Fosfolipase A2 e glicogênio sintase quinase 3B e sua relação com o estado de fosforilação da proteína Tau, BP.DR; 10/19471-5 - Neurobiologia da Doença de Alzheimer: marcadores de risco, prognóstico e resposta terapêutica, BP.TT
• Assunto(s): Neurobiologia Doença de Alzheimer Biomarcadores Lítio
• Palavra(s)-Chave do Pesquisador: Biomarcadores | Doenca De Alzheimer | Glicogenio Sintase Kinase | Litio | Neuroimagem | Pla2

Resumo

Por meio de dois projetos temáticos apoiados pela FAPESP desde 1997, nosso laboratório desenvolve pesquisa translacional aplicada à análise de anormalidades do metabolismo de fosfolípides de membrana, sua influência na homeostase cerebral e suas implicações em doenças neuropsiquiátricas. No presente projeto, avaliaremos múltiplos mecanismos biológicos relacionados à fisiopatologia da Doença de Alzheimer (DA), buscando os correlatos clínicos que determinam um maior risco de demência em pacientes idosos com transtornos cognitivos e do humor. Este projeto Temático é dividido em dois módulos. No módulo 1 (Estudos Clínicos, Laboratoriais e de Neuroimagem), determinaremos de forma integrada os marcadores biológicos que influenciam o risco, o curso clínico e a resposta terapêutica; avaliaremos polimorfismos genéticos, biomarcadores em líquor e sangue periférico, e parâmetros de imagem cerebral estrutural e funcional (MRS e PET). Nosso maior interesse é estabelecer o diagnóstico precoce da DA e avaliar a eficácia de intervenções farmacológicas e não farmacológicas sobre a atenuação das perdas cognitivas, almejando a prevenção da demência. No módulo 2 (Neuroquímica e Biologia Molecular), utilizaremos modelos experimentais in vitro (culturas primárias de neurônios) e in vivo (camundongos transgênicos que acumulam peptídeo beta-amilóide, Aβ) para estudar os mecanismos moleculares que inter-relacionam diferentes processos patogênicos. Avaliaremos a toxicidade do Aβ e seu impacto sobre a neurogênese, a atividade enzimática e a expressão gênica. Em modelos pré-clínicos, investigaremos a possibilidade de modificar estes processos pelo tratamento com lítio, dadas suas propriedades neurotróficas e neuroprotetoras, integrando assim as vertentes experimentais e clínicas deste projeto. (AU)

Publicações científicas

(55)

(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)

DE OLIVEIRA, ALEXANDRA MARTINI; RADANOVIC, MARCIA; HOMEM DE MELLO, PATRICIA COTTING; BUCHAIN, PATRICIA CARDOSO; BARBOSA VIZZOTTO, ADRIANA DIAS; CELESTINO, DIEGO L.; STELLA, FLORINDO; PIERSOL, CATHERINE V.; FORLENZA, ORESTES V.. Nonpharmacological Interventions to Reduce Behavioral and Psychological Symptoms of Dementia: A Systematic Review. BIOMED RESEARCH INTERNATIONAL, 2015. (09/52825-8)

DE OLIVEIRA, ALEXANDRA MARTINI; RADANOVIC, MARCIA; HOMEM DE MELLO, PATRICIA COTTING; BUCHAIN, PATRICIA CARDOSO; VIZZOTTO, ADRIANA DIAS; HARDER, JANAINA; STELLA, FLORINDO; PIERSOL, CATHERINE VERRIER; GITLIN, LAURA N.; FORLENZA, ORESTES VICENTE. An intervention to reduce neuropsychiatric symptoms and caregiver burden in dementia: Preliminary results from a randomized trial of the tailored activity program-outpatient version. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, v. 34, n. 9, SI, p. 1301-1307, SEP 2019. (16/01302-9, 09/52825-8, 14/14211-6)

GLENDA DIAS SANTOS; PAULA VILLELA NUNES; FLORINDO STELLA; PAULA SCHIMIDT BRUM; MONICA SANCHES YASSUDA; LINDA MASSAKO UENO; WAGNER FARID GATTAZ; ORESTES VICENTE FORLENZA. Multidisciplinary rehabilitation program: effects of a multimodal intervention for patients with Alzheimer’s disease and cognitive impairment without dementia. ARCHIVES OF CLINICAL PSYCHIATRY, v. 42, n. 6, p. 153-156, 2015-12-00. (09/52825-8)

DORLI KAMKHAGI; ANA CAROLINA OLIVEIRA COSTA; SANDRA KUSMINSKY; DEBORAH SUPINO; BRENO SATLER DINIZ; WAGNER FARID GATTAZ; ORESTES VICENTE FORLENZA. Benefits of psychodynamic group therapy on depression, burden and quality of life of family caregivers to Alzheimer’s disease patients. ARCHIVES OF CLINICAL PSYCHIATRY, v. 42, n. 6, p. 157-160, 2015-12-00. (09/52825-8)

STELLA, FLORINDO; RADANOVIC, MARCIA; APRAHAMIAN, IVAN; CANINEU, PAULO RENATO; DE ANDRADE, LARISSA PIRES; FORLENZA, ORESTES VICENTE. Neurobiological Correlates of Apathy in Alzheimer's Disease and Mild Cognitive Impairment: A Critical Review. JOURNAL OF ALZHEIMER'S DISEASE, v. 39, n. 3, p. 633-648, 2014. (09/52825-8)

FORLENZA, O. V.; DE-PAULA, V. J. R.; DINIZ, B. S. O.. Neuroprotective Effects of Lithium: Implications for the Treatment of Alzheimer's Disease and Related Neurodegenerative Disorders. ACS Chemical Neuroscience, v. 5, n. 6, p. 443-450, JUN 2014. (09/52825-8)

CARDILLO, GIANCARLO DE MATTOS; RODRIGUES DE-PAULA, VANESSA DE JESUS; IKENAGA, ELIZA HIROMI; COSTA, LUCIANA RODRIGUES; CATANOZI, SERGIO; SCHAEFFER, EVELIN LISETE; GATTAZ, WAGNER FARID; KERR, DANIEL SHIKANAI; FORLENZA, ORESTES VICENTE. Chronic Lithium Treatment Increases Telomere Length in Parietal Cortex and Hippocampus of Triple-Transgenic Alzheimer's Disease Mice. JOURNAL OF ALZHEIMER'S DISEASE, v. 63, n. 1, p. 93-101, 2018. (14/14211-6, 09/52825-8, 16/01302-9)

DE-PAULA, VANESSA DE J. R.; FORLENZA, ANDREA S.; FORLENZA, ORESTES V.. Relevance of gutmicrobiota in cognition, behaviour and Alzheimer's disease. PHARMACOLOGICAL RESEARCH, v. 136, p. 29-34, OCT 2018. (16/01302-9, 13/20695-3, 09/52825-8)

STELLA, FLORINDO; FORLENZA, ORESTES VICENTE; LAKS, JERSON; DE ANDRADE, LARISSA PIRES; CACAO, JOAO DE CASTILHO; GOVONE, JOSE SILVIO; DE MEDEIROS, KATE; LYKETSOS, CONSTANTINE G.. Caregiver report versus clinician impression: disagreements in rating neuropsychiatric symptoms in Alzheimer's disease patients. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, v. 30, n. 12, p. 1230-1237, DEC 2015. (10/18999-6, 09/52825-8)

MIRANDEZ, ROBERTA M.; APRAHAMIAN, IVAN; TALIB, LEDA L.; FORLENZA, ORESTES V.; RADANOVIC, MARCIA. Multiple category verbal fluency in mild cognitive impairment and correlation with CSF biomarkers for Alzheimer's disease. INTERNATIONAL PSYCHOGERIATRICS, v. 29, n. 6, p. 949-958, JUN 2017. (09/52825-8)

MEMORIA, CLAUDIA M.; YASSUDA, MONICA S.; NAKANO, EDUARDO Y.; FORLENZA, ORESTES V.. Contributions of the Computer-Administered Neuropsychological Screen for Mild Cognitive Impairment (CANS-MCI) for the diagnosis of MCI in Brazil. INTERNATIONAL PSYCHOGERIATRICS, v. 26, n. 9, p. 1483-1491, SEP 2014. (09/52825-8)

TALIB, L. L.; HOTOTIAN, S. R.; JOAQUIM, H. P. G.; FORLENZA, O. V.; GATTAZ, W. F.. Increased iPLA2 activity and levels of phosphorylated GSK3B in platelets are associated with donepezil treatment in Alzheimer's disease patients. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, v. 265, n. 8, p. 701-706, DEC 2015. (02/13633-7, 09/52825-8)

TALIB, LEDA L.; VALENTE, KETTE D.; VINCENTIIS, SILVIA; GATTAZ, WAGNER F.. Correlation between platelet and brain PLA(2) activity. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, v. 89, n. 4, p. 265-268, SEP 2013. (09/52825-8)

TEIXEIRA, ANTONIO L.; DINIZ, BRENO S.; CAMPOS, ALLINE C.; MIRANDA, ALINE S.; ROCHA, NATALIA P.; TALIB, LEDA L.; GATTAZ, WAGNER F.; FORLENZA, ORESTES V.. Decreased Levels of Circulating Adiponectin in Mild Cognitive Impairment and Alzheimer's Disease. NEUROMOLECULAR MEDICINE, v. 15, n. 1, p. 115-121, MAR 2013. (09/52825-8)

ORESTES V. FORLENZA; BRENO S. DINIZ; FLORINDO STELLA; ANTONIO L. TEIXEIRA; WAGNER F. GATTAZ. Mild cognitive impairment (part 1): clinical characteristics and predictors of dementia. Revista Brasileira de Psiquiatria, v. 35, n. 2, p. 178-185, 2013-06-00. (09/52825-8)

DINIZ, BRENO S.; TEIXEIRA, ANTONIO L.; MACHADO-VIEIRA, RODRIGO; TALIB, LEDA L.; GATTAZ, WAGNER F.; FORIENZA, ORESTES V.. Reduced Serum Nerve Growth Factor in Patients With Late-Life Depression. AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, v. 21, n. 5, p. 493-496, MAY 2013. (09/52825-8)

FORLENZA, ORESTES VICENTE; MIRANDA, ALINE SILVA; BARBOSA, IZABELA GUIMARAES; TALIB, LEDA LEME; DINIZ, BRENO SATLER; GATTAZ, WAGNER FARID; TEIXEIRA, ANTONIO LUCIO. Decreased Neurotrophic Support is Associated with Cognitive Decline in Non-Demented Subjects. JOURNAL OF ALZHEIMER'S DISEASE, v. 46, n. 2, p. 423-429, 2015. (09/52825-8)

SCHAEFFER, EVELIN L.; CATANOZI, SERGIO; WEST, MARK J.; GATTAZ, WAGNER F.. Stereological investigation of the CA1 pyramidal cell layer in untreated and lithium-treated 3xTg-AD and wild-type mice. ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER, v. 209, p. 51-60, 2017. (09/52825-8)

KAMKHAGI, DORLI; OLIVEIRA COSTA, ANA CAROLINA; KUSMINSKY, SANDRA; SUPINO, DEBORAH; DINIZ, BRENO SATLER; GATTAZ, WAGNER FARID; FORLENZA, ORESTES VICENTE. Benefits of psychodynamic group therapy on depression, burden and quality of life of family caregivers to Alzheimer's disease patients. ARCHIVES OF CLINICAL PSYCHIATRY, v. 42, n. 6, p. 157-160, NOV-DEC 2015. (09/52825-8)

KERR, DANIEL SHIKANAI; STELLA, FLORINDO; RADANOVIC, MARCIA; APRAHAMIAN, IVAN; FERREIRA BERTOLLUCCI, PAULO HENRIQUE; FORLENZA, ORESTES VICENTE. Apolipoprotein E genotype is not associated with cognitive impairment in older adults with bipolar disorder. BIPOLAR DISORDERS, v. 18, n. 1, p. 71-77, FEB 2016. (13/01352-8, 09/52825-8)

DUITS, FLORA H.; MARTINEZ-LAGE, PABLO; PAQUET, CLAIRE; ENGELBORGHS, SEBASTIAAN; LLEO, ALBERTO; HAUSNER, LUCREZIA; MOLINUEVO, JOSE L.; STOMRUD, ERIK; FAROTTI, LUCIA; RAMAKERS, INEZ H. G. B.; et al. Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study. ALZHEIMERS & DEMENTIA, v. 12, n. 2, p. 154-163, FEB 2016. (09/52825-8)

RADANOVIC, MARCIA; OSHIRO, CARLOS A.; FREITAS, THIAGO Q.; TALIB, LEDA L.; FORLENZA, ORESTES V.. Correlation between CSF biomarkers of Alzheimer's disease and global cognition in a psychogeriatric clinic cohort. Revista Brasileira de Psiquiatria, v. 41, n. 6, p. 479-484, NOV-DEC 2019. (09/52825-8, 16/01302-9, 14/14211-6)

DINIZ, BRENO S.; TEIXEIRA, ANTONIO L.; TALIB, LEDA L.; GATTAZ, WAGNER F.; FORLENZA, ORESTES V.. Circulating Nerve Growth Factor in elderly subjects: state marker of depression?. AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, v. 20, n. 3, p. 2-pg., 2012-03-01. (09/52825-8)

DE OLIVEIRA, ALEXANDRA MARTINI; RADANOVIC, MARCIA; HOMEM DE MELLO, PATRICIA COTTING; BUCHAIN, PATRICIA CARDOSO; BARBOSA VIZZOTTO, ADRIANA DIAS; CELESTINO, DIEGO L.; STELLA, FLORINDO; PIERSOL, CATHERINE V.; FORLENZA, ORESTES V.. Nonpharmacological Interventions to Reduce Behavioral and Psychological Symptoms of Dementia: A Systematic Review. BIOMED RESEARCH INTERNATIONAL, v. 2015, p. 9-pg., 2015-01-01. (09/52825-8)

VACAS, SARA M.; STELLA, FLORINDO; LOUREIRO, JULIA C.; DO COUTO, FREDERICO SIMOES; OLIVEIRA-MAIA, ALBINO J.; FORLENZA, ORESTES V.. Noninvasive brain stimulation for behavioural and psychological symptoms of dementia: A systematic review and meta-analysis. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, v. 34, n. 9, p. 9-pg., 2019-09-01. (16/01302-9, 14/14211-6, 09/52825-8)

ROCHA, NICOLE KEMBERLY R.; THEMOTEO, RAFAEL; BRENTANI, HELENA; FORLENZA, ORESTES V.; DE PAULA, VANESSA DE JESUS RODRIGUES. Neuronal-Glial Interaction in a Triple-Transgenic Mouse Model of Alzheimer's Disease: Gene Ontology and Lithium Pathways. FRONTIERS IN NEUROSCIENCE, v. 14, DEC 1 2020. (17/14418-8, 11/19892-3, 16/01302-9, 09/52825-8, 18/08621-8, 14/50873-3)

OLIVEIRA, ALEXANDRA MARTINI; RADANOVIC, MARCIA; HOMEM DE MELLO, PATRICIA COTTING; BUCHAIN, PATRICIA CARDOSO; BARBOSA VIZZOTTO, ADRIANA DIAS; HARDER, JANAINA; STELLA, FLORINDO; GITLIN, LAURA N.; PIERSOL, CATHERINE VERRIER; VALIENGO, LEANDRO L. C.; et al. Adjunctive Therapy to Manage Neuropsychiatric Symptoms in Moderate and Severe Dementia: Randomized Clinical Trial Using an Outpatient Version of Tailored Activity Program. JOURNAL OF ALZHEIMER'S DISEASE, v. 83, n. 1, p. 475-486, 2021. (14/14211-6, 16/01302-9, 09/52825-8)

MÁRCIA RADANOVIC; CARLOS A. OSHIRO; THIAGO Q. FREITAS; LEDA L. TALIB; ORESTES V. FORLENZA. Correlation between CSF biomarkers of Alzheimer’s disease and global cognition in a psychogeriatric clinic cohort. Revista Brasileira de Psiquiatria, n. ahead, p. -, 2019. (09/52825-8, 16/01302-9, 14/14211-6)

DE-PAULA, VANESSA J.; GATTAZ, WAGNER F.; FORLENZA, ORESTES V.. Long-term lithium treatment increases intracellular and extracellular brain-derived neurotrophic factor (BDNF) in cortical and hippocampal neurons at subtherapeutic concentrations. BIPOLAR DISORDERS, v. 18, n. 8, p. 692-695, DEC 2016. (09/52825-8, 11/19892-3, 16/01302-9)

FORLENZA, ORESTES V.; LOUREIRO, JULIA CUNHA; PAIS, MARCOS VASCONCELOS; STELLA, FLORINDO. Recent advances in the management of neuropsychiatric symptoms in dementia. CURRENT OPINION IN PSYCHIATRY, v. 30, n. 2, p. 151-158, MAR 2017. (09/52825-8)

STELLA, FLORINDO; RADANOVIC, MARCIA; CANINEU, PAULO RENATO; DE PAULA, VANESSA J. R.; FORLENZA, ORESTES V.. Anti-dementia medications: current prescriptions in clinical practice and new agents in progress. THERAPEUTIC ADVANCES IN DRUG SAFETY, v. 6, n. 4, p. 151-165, AUG 2015. (09/52825-8)

RADANOVIC, MARCIA; FACCO, GIULIANA; FORLENZA, ORESTES V.. Sensitivity and specificity of a briefer version of the Cambridge Cognitive Examination (CAMCog-Short) in the detection of cognitive decline in the elderly: An exploratory study. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, v. 33, n. 5, p. 769-778, MAY 2018. (09/52825-8, 13/20695-3)

IBARRA, ROMEL; RADANOVIC, MARCIA; PAIS, V, MARCOS; TALIB, LEDA L.; FORLENZA, V, ORESTES. AD-Related CSF Biomarkers Across Distinct Levels of Cognitive Impairment: Correlations With Global Cognitive State. JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY, v. 34, n. 6, SI, p. 659-667, NOV 2021. (09/52825-8, 16/01302-9, 14/14211-6)

MÁRCIA RADANOVIC; CARLOS A. OSHIRO; THIAGO Q. FREITAS; LEDA L. TALIB; ORESTES V. FORLENZA. Correlation between CSF biomarkers of Alzheimer’s disease and global cognition in a psychogeriatric clinic cohort. Revista Brasileira de Psiquiatria, v. 41, n. 6, p. 479-484, 2019-05-30. (14/14211-6, 16/01302-9, 09/52825-8)

IBARRA, ROMEL; RADANOVIC, MARCIA; PAIS, V, MARCOS; TALIB, LEDA L.; FORLENZA, V, ORESTES. AD-Related CSF Biomarkers Across Distinct Levels of Cognitive Impairment: Correlations With Global Cognitive State. JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY, AUG 2020. (09/52825-8, 16/01302-9, 14/14211-6)

VACAS, SARA M.; STELLA, FLORINDO; LOUREIRO, JULIA C.; DO COUTO, FREDERICO SIMOES; OLIVEIRA-MAIA, ALBINO J.; FORLENZA, ORESTES V.. Noninvasive brain stimulation for behavioural and psychological symptoms of dementia: A systematic review and meta-analysis. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, v. 34, n. 9, SI, p. 1336-1344, SEP 2019. (16/01302-9, 09/52825-8, 14/14211-6)

ORESTES V. FORLENZA; BRENO S. DINIZ; ANTONIO L. TEIXEIRA; FLORINDO STELLA; WAGNER GATTAZ. Mild cognitive impairment (part 2): biological markers for diagnosis and prediction of dementia in Alzheimer's disease. Revista Brasileira de Psiquiatria, v. 35, n. 3, p. 284-294, 2013-09-00. (09/52825-8)

BRAM, JESSYKA MARIA DE FRANCA; TALIB, LEDA LEME; JOAQUIM, HELENA PASSARELLI GIROUD; SARNO, TAMIRES ALVES; GATTAZ, WAGNER FARID; FORLENZA, ORESTES VICENTE. Protein levels of ADAM10, BACE1, and PSEN1 in platelets and leukocytes of Alzheimer's disease patients. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, v. 269, n. 8, p. 963-972, DEC 2019. (13/20695-3, 09/52825-8)

DE-PAULA, VANESSA J.; DOS SANTOS, CARLA CRISTINE C.; LUQUE, MARIA CAROLINA A.; ALI, TACCYANA M.; KALIL, JORGE E.; FORLENZA, ORESTES V.; CUNHA-NETO, EDECIO. Acute and chronic lithium treatment increases Wnt/beta-catenin transcripts in cortical and hippocampal tissue at therapeutic concentrations in mice. METABOLIC BRAIN DISEASE, v. 36, n. 1, NOV 2020. (14/50890-5, 11/19892-3, 09/52825-8, 16/01302-9)

STELLA, FLORINDO; LOUREIRO, JULIA C.; PAIS, MARCOS V.; CANINEU, PAULO R.; FORLENZA, ORESTES V.. Safety Limits of Antidepressant Use Plus Combinations: Focus on Cardiovascular Function. CURRENT DRUG METABOLISM, v. 19, n. 8, p. 641-652, 2018. (09/52825-8)

LOUREIRO, JULIA C.; PAIS, MARCOS V.; STELLA, FLORINDO; RADANOVIC, MARCIA; TEIXEIRA, ANTONIO LUCIO; FORLENZA, ORESTES V.; DE SOUZA, LEONARDO CRUZ. Passive antiamyloid immunotherapy for Alzheimer's disease. CURRENT OPINION IN PSYCHIATRY, v. 33, n. 3, p. 284-291, MAY 2020. (09/52825-8)

SANTOS, GLENDA DIAS; NUNES, PAULA VILLELA; STELLA, FLORINDO; BRUM, PAULA SCHIMIDT; YASSUDA, MONICA SANCHES; UENO, LINDA MASSAKO; GATTAZ, WAGNER FARID; FORLENZA, ORESTES VICENTE. Multidisciplinary rehabilitation program: effects of a multimodal intervention for patients with Alzheimer's disease and cognitive impairment without dementia. ARCHIVES OF CLINICAL PSYCHIATRY, v. 42, n. 6, p. 153-156, NOV-DEC 2015. (09/52825-8)

FORLENZA, ORESTES V.; APRAHAMIAN, IVAN; RADANOVIC, MARCIA; TALIB, LEDA L.; CAMARGO, MARINA Z. A.; STELLA, FLORINDO; MACHADO-VIEIRA, RODRIGO; GATTAZ, WAGNER F.. Cognitive impairment in late-life bipolar disorder is not associated with Alzheimer's disease pathological signature in the cerebrospinal fluid. BIPOLAR DISORDERS, v. 18, n. 1, p. 63-70, FEB 2016. (09/52825-8)

SARNO, TAMIRES ALVES; TALIB, LEDA LEME; GIROUD JOAQUIM, HELENA PASSARELLI; DE FRANCA BRAM, JESSYKA MARIA; GATTAZ, WAGNER FARID; FORLENZA, ORESTES VICENTE. Protein Expression of BACE1 is Downregulated by Donepezil in Alzheimer's Disease Platelets. JOURNAL OF ALZHEIMER'S DISEASE, v. 55, n. 4, p. 1445-1451, 2017. (13/20695-3, 09/52825-8)

FORLENZA, ORESTES V.; APRAHAMIAN, IVAN; DE PAULA, VANESSA J.; HAJEK, TOMAS. Lithium, a Therapy for AD: Current Evidence from Clinical Trials of Neurodegenerative Disorders. Current Alzheimer Research, v. 13, n. 8, p. 879-886, 2016. (09/52825-8)

DE-PAULA, VANESSA DE JESUS; KERR, DANIEL SHIKANAI; FABIANO DE CARVALHO, MARILIA PALMA; SCHAEFFER, EVELIN LISETE; TALIB, LEDA LEME; GATTAZ, WAGNER FARID; FORLENZA, ORESTES VICENTE. Long-Term Lithium Treatment Increases cPLA(2) and iPLA(2) Activity in Cultured Cortical and Hippocampal Neurons. Molecules, v. 20, n. 11, p. 19878-19885, NOV 2015. (11/19892-3, 09/52825-8)

MURY, FABIO B.; DA SILVA, WEBER C.; BARBOSA, NADIA R.; MENDES, CAMILA T.; BONINI, JULIANA S.; SOUZA SARKIS, JORGE EDUARDO; CAMMAROTA, MARTIN; IZQUIERDO, IVAN; GATTAZ, WAGNER F.; DIAS-NETO, EMMANUEL. Lithium activates brain phospholipase A2 and improves memory in rats: implications for Alzheimer's disease. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, v. 266, n. 7, p. 607-618, OCT 2016. (04/01478-2, 04/02165-8, 09/52825-8)

DINIZ, BRENO S.; TEIXEIRA, ANTONIO L.; MACHADO-VIEIRA, RODRIGO; TALIB, LEDA L.; RADANOVIC, MARCIA; GATTAZ, WAGNER F.; FORLENZA, ORESTES V.. Reduced Cerebrospinal Fluid Levels of Brain-Derived Neurotrophic Factor Is Associated With Cognitive Impairment in Late-Life Major Depression. JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES, v. 69, n. 6, p. 845-851, NOV 2014. (09/52825-8)

SCHAEFFER, EVELIN L.; CERULLI, FABIANA G.; SOUZA, HELIO O. X.; CATANOZI, SERGIO; GATTAZ, WAGNER F.. Synergistic and additive effects of enriched environment and lithium on the generation of new cells in adult mouse hippocampus. JOURNAL OF NEURAL TRANSMISSION, v. 121, n. 7, p. 695-706, JUL 2014. (11/24022-8, 09/52825-8, 09/53008-3, 11/23039-4)

FORLENZA, ORESTES V.; NOVAES COUTINHO, ARTUR MARTINS; APRAHAMIAN, IVAN; PRANDO, SILVANA; MENDES, LUCIANA LUCAS; DINIZ, BRENO S.; GATTAZ, WAGNER F.; BUCHPIGUEL, CARLOS A.. Long-Term Lithium Treatment Reduces Glucose Metabolism in the Cerebellum and Hippocampus of Nondemented Older Adults: An [F-18]FDG-PET Study. ACS Chemical Neuroscience, v. 5, n. 6, p. 484-489, JUN 2014. (09/52825-8)

MÁRCIA RADANOVIC; FLORINDO STELLA; LIS GOMES SILVA; LEDA L. TALIB; ORESTES V. FORLENZA. AUMENTO DOS NÍVEIS DE CSF DE TAU TOTAL EM PACIENTES COM PATOLOGIA SUBCUTÂNEA CEREBROVASCULAR E COMPROMETIMENTO COGNITIVO. Dement. Neuropsychol., v. 11, n. 4, p. 419-425, 2017-12-00. (09/52825-8)

SCHAEFFER, EVELIN L.; GATTAZ, WAGNER F.. Chronic inhibition of brain phospholipase A(2) in adult rats impairs the survival of newborn mature neurons in the hippocampus. JOURNAL OF NEURAL TRANSMISSION, v. 122, n. 5, p. 619-628, MAY 2015. (09/52825-8, 09/53008-3, 10/05442-3)

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