Toxinas animais nativas e recombinantes: análise funcional, estrutural e molecular

• Processo: 11/23236-4
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Data de Início da vigência: 01 de fevereiro de 2014
• Data de Término da vigência: 30 de abril de 2019
• Área do conhecimento: Ciências da Saúde - Farmácia - Análise Toxicológica
• Pesquisador responsável: Suely Vilela
• Beneficiário: Suely Vilela
• Instituição Sede: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brasil
• Pesquisadores principais:( Últimos ): Antonio Cardozo dos Santos ; Eliane Candiani Arantes Braga
• Pesquisadores principais:( Antigos ): Fabíola Attié de Castro ; Maria Cristina Nonato
• Pesquisadores associados: Antonio José da Costa Filho ; Benedito Barraviera ; Carlos Henrique Tomich de Paula da Silva ; Catarina de Fatima Pereira Teixeira ; Fabiani Gai Frantz ; Fabíola Attié de Castro ; Hamilton Cabral ; José César Rosa ; Lúcia Helena Faccioli ; Luciana Simon Pereira Crott ; Lucilene Delazari dos Santos ; Lusânia Maria Greggi Antunes ; Maria Cristina Nonato ; Maria Regina Torqueti ; Rui Seabra Ferreira Junior ; Sergio Akira Uyemura
• Auxílio(s) vinculado(s): 18/23389-4 - EMU concedido no processo n. 2011/23236-4 : sistema de cromatografia Shimadzu prominence e acessórios, AP.EMU; 15/02506-4 - EMU concedido no processo n.° 2011/23236-4: sistema automático de sequenciamento de proteínas e peptídeos, modelo PPSQ-33A e acessórios, AP.EMU; 14/20212-5 - EMU concedido no processo 2011/23236-4: Labchip GXII touch 24 instrument, AP.EMU
• Bolsa(s) vinculada(s): 17/03580-9 - Avaliação bioquímica, estrutural e funcional de uma fosfodiesterase da peçonha de Crotalus durissus collilineatus, BP.DR; 16/04761-4 - Caracterização estrutural, funcional e análise da resposta imune in vivo de uma serinoprotease recombinante de Crotalus durissus collilineatus modificada por PEGlação, BP.DD; 16/17626-8 - Clonagem e expressão de toxinas com potencial aplicação biotecnológica presentes na peçonha de Crotalus durissus, BP.TT; + mais bolsas vinculadas 16/11578-1 - Estudo funcional de uma desintegrina da peçonha de Crotalus durissus collilineatus, BP.IC; 16/09711-5 - PURIFICAÇÃO E CARACTERIZAÇÃO ESTRUTURAL DE TOXINAS DE Lachesis muta E Crotalus durissus, BP.TT; 15/24701-3 - Estudo dos efeitos de uma fosfolipase a2 de veneno ofidico em células do tecido adiposo: adipogênese e resposta inflamatória, BP.PD; 16/04079-9 - Avaliação do potencial anti-inflamatório da crotoxina, uma fosfolipase A2 isolada da peçonha de Crotalus durissus terrificus, em modelo de endotoxemia, BP.IC; 15/26901-0 - Ação imunomoduladora e avaliação epigenética e transcricional de células natural killer submetidas à enzima L-aminoácido oxidase de Bothrops moojeni e a fosfolipase BthTX-I de Bothrops jararacussu, BP.PD; 15/26609-7 - Venômica da serpente Bothrops moojeni: aplicação de toxinas de interesse biotecnológico obtidas por técnicas ômicas, BP.PD; 15/25637-7 - Modulação epigenética da maquinaria apoptótica em células Bcr-Abl positivas pelas toxinas BmooLAAO-I e MjTX-I, BP.PD; 15/24808-2 - Avaliação do potencial neuroprotetor de um peptídeo sintético em doenças neurodegenerativas: avaliação da genotoxicidade e mutagenicidade, BP.PD; 15/24010-0 - Caracterização estrutural e biofísica de toxinas animais, BP.PD; 15/06290-6 - Avaliação do potencial anti-inflamatório da crotoxina, uma fosfolipase A2 isolada da peçonha de Crotalus durissus terrificus, em modelo de coagulação intravascular disseminada induzida por endotoxemia, BP.PD; 15/00740-0 - Avaliação do potencial terapêutico de L-aminoácido oxidases isoladas de peçonhas de serpentes como antitumoral: estudos de genotoxicidade e expressão gênica, BP.PD; 15/00847-9 - Avaliação do potencial genotóxico de uma L-aminoácido oxidase isolada da peçonha da serpente Calloselasma rhodostoma (CR-LAAO) sobre linhagens celulares humanas, BP.IC; 14/06170-8 - Caracterização bioquímica e avaliação in vitro da ativação de fibroblastos e do potencial leishmanicida de uma L-aminoácido oxidase (LAAO) da peçonha de Crotalus durissus terrificus, BP.MS; 14/16182-3 - Novas perspectivas funcionais de uma serinoprotease de Crotalus durissus collilineatus: ação sobre canais iônicos dependentes de voltagem, BP.PD; 14/19127-3 - Efeito da LAAO de Calloselasma rhodostoma e Bothrops moojeni na maquinaria apoptótica de linhagens JAK2V617F positivas de neoplasias mieloproliferativas, BP.IC; 14/13717-3 - Avaliação do potencial imunomodulador da peçonha bruta e de L-aminoácido oxidase de Calloselasma rhodostoma sobre o sistema complemento, BP.IC; 14/11266-4 - Caracterização estrutural e biofísica de toxinas animais, BP.PD; 12/11963-1 - Avaliação dos efeitos de uma metaloprotease e uma fosfolipase A2 ácida da peçonha de Bothrops atrox sobre o sistema complemento e o processo inflamatório, BP.PD; 12/21569-9 - ATIVIDADES ANTITROMBÓTICAS E TROMBOLÍTICAS DA BATROXASE, UMA METALOPROTEASE PURIFICADA DO VENENO DA COBRA Bothrops atrox, EM MODELOS EXPERIMENTAIS ANIMAIS., BP.PD - menos bolsas vinculadas
• Assunto(s): Toxicologia Hemostasia Clonagem Expressão gênica Venenos de origem animal Toxinas
• Palavra(s)-Chave do Pesquisador: Atividade Anti-tumoral | Caracterização estrutural | Caracterização Funcional | Clonagem e expressão | hemostasia | peçonhas de serpentes | Toxinologia

Resumo

As peçonhas animais constituem uma rica fonte de substâncias farmacologicamente ativas. Essas moléculas, denominadas toxinas, atuam de forma isolada ou sinérgica, podendo se ligar a diferentes receptores celulares e/ou interferir em vias metabólicas fundamentais para a viabilidade celular, causando danos locais, sistêmicos e até fatais na presa ou vítima. A exploração dos mecanismos de ação das toxinas tem se mostrado relevante, não só por fornecer a base molecular envolvida no mecanismo de toxicidade dessas moléculas, como também possibilitar a aplicação de toxinas no desenvolvimento de novas estratégias terapêuticas. Além disso, toxinas animais são valiosas ferramentas na elucidação de diversas vias e processos metabólicos envolvidos no sistema biológico. Dentro desse contexto, a presente proposta visa, por meio da aplicação de abordagens modernas de caracterização estrutural e funcional, contribuir para o mapeamento de novos componentes de diferentes peçonhas de serpentes, bem como o estudo de inibidores plasmáticos desses animais. Explorando peçonhas de diferentes serpentes, nossos estudos focarão a caracterização de moléculas (proteínas e peptídeos) que apresentarem ação sobre a hemostasia, apoptose celular, estabilidade genômica e processos inflamatórios, assim como seu envolvimento no efeito imunomodulatório, antiparasitário, neuroprotetor e antitumoral. A aplicação de ensaios biológicos bem estabelecidos, associada ao uso de ferramentas de biologia molecular e de caracterização bioquímica, biofísica e estrutural, será utilizada para a realização dos estudos de correlação de estrutura e função, visando não somente elucidar o mecanismo de toxicidade de novos componentes das peçonhas estudadas, como também possibilitar a exploração do potencial terapêutico das toxinas no desenvolvimento e produção de novos fármacos. (AU)

Publicações científicas

(85)

(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)

RAFHAELLA C. A. CEDRO; DANILO L. MENALDO; TÁSSIA R. COSTA; KARINA F. ZOCCAL; MARCO A. SARTIM; NORIVAL A. SANTOS-FILHO; LÚCIA H. FACCIOLI; SUELY V. SAMPAIO. Cytotoxic and inflammatory potential of a phospholipase A2 from Bothrops jararaca snake venom. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, 2018-12-17. (11/23236-4)

SANDRA MARA BURIN; MAIRA DA COSTA CACEMIRO; JUÇARA GASTALDI COMINAL; RONE APARECIDO DE GRANDIS; ANA RITA THOMAZELA MACHADO; FLAVIA SACILOTTO DONAIRES; ADELIA CRISTINA OLIVEIRA CINTRA; LUCIANA AMBROSIO; LUSÂNIA MARIA GREGGI ANTUNES; SUELY VILELA SAMPAIO; et al. Bothrops moojeni L-amino acid oxidase induces apoptosis and epigenetic modulation on Bcr-Abl+ cells. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 26, 2020-12-14. (18/01756-5, 15/25637-7, 11/23236-4)

BISCOLA, NATALIA PERUSSI; CARTAROZZI, LUCIANA POLITTI; FERREIRA JUNIOR, RUI SEABRA; BARRAVIERA, BENEDITO; RODRIGUES DE OLIVEIRA, ALEXANDRE LEITE. Long-Standing Motor and Sensory Recovery following Acute Fibrin Sealant Based Neonatal Sciatic Nerve Repair. NEURAL PLASTICITY, 2016. (12/08101-8, 14/06892-3, 11/23377-7, 11/23236-4, 09/53846-9)

BERNARDES, CAROLINA P.; MENALDO, DANILO L.; MAMEDE, CARLA C. N.; ZOCCAL, KARINA F.; CINTRA, ADELIA C. O.; FACCIOLI, LUCIA H.; STANZIOLA, LEONILDA; DE OLIVEIRA, FABIO; SAMPAIO, SUELY V.. Evaluation of the local inflammatory events induced by BpirMP, a metalloproteinase from Bothrops pirajai venom. Molecular Immunology, v. 68, n. 2, B, p. 456-464, 2015. (07/08361-1, 05/54855-0, 11/23236-4)

WIEZEL, GISELE A.; DOS SANTOS, PATTY K.; CORDEIRO, FRANCIELLE A.; BORDON, KARLA C. F.; SELISTRE-DE-ARAUJO, HELOISA S.; UEBERHEIDE, BEATRIX; ARANTES, ELIANE C.. Identification of hyaluronidase and phospholipase B in Lachesis muta rhombeata venom. Toxicon, v. 107, n. B, SI, p. 359-368, DEC 1 2015. (11/23236-4, 10/06199-5)

BOLDRINI-FRANCA, JOHARA; PINHEIRO-JUNIOR, ERNESTO LOPES; PEIGNEUR, STEVE; PUCCA, MANUELA BERTO; CERNI, FELIPE AUGUSTO; BORGES, RAFAEL JUNQUEIRA; COSTA, TASSIA RAFAELLA; IMAI CARONE, SANTE EMMANUEL; DE MATTOS FONTES, MARCOS ROBERTO; SAMPAIO, SUELY VILELA; et al. Beyond hemostasis: a snake venom serine protease with potassium channel blocking and potential antitumor activities. SCIENTIFIC REPORTS, v. 10, n. 1, MAR 11 2020. (15/18432-0, 15/00740-0, 18/14158-9, 16/24191-8, 15/16714-8, 17/13485-3, 11/23236-4, 17/14035-1, 16/04761-4, 14/16182-3, 15/17286-0)

DE OLIVEIRA, ISADORA SOUSA; PUCCA, MANUELA BERTO; WIEZEL, GISELE ADRIANO; CARDOSO, IARA AIME; FIGUEIREDO BORDON, KARLA DE CASTRO; SARTIM, MARCO AURELIO; KALOGEROPOULOS, KONSTANTINOS; AHMADI, SHIRIN; BAIWIR, DOMINIQUE; NONATO, MARIA CRISTINA; et al. Unraveling the structure and function of CdcPDE: A novel phosphodiesterase from Crotalus durissus collilineatus snake venom. International Journal of Biological Macromolecules, v. 178, p. 180-192, MAY 1 2021. (17/00586-6, 17/03580-9, 19/10173-6, 11/23236-4, 18/21233-7)

SARTIM, MARCO AURELIO; SOUZA, CAMILA O. S.; DINIZ, CASSIANO RICARDO A. F.; DA FONSECA, VANESSA M. B.; SOUSA, LUCAS O.; PETI, ANA PAULA F.; COSTA, TASSIA RAFAELLA; LOURENCO, ALAN G.; BORGES, MARCOS C.; SORGI, CARLOS A.; et al. Crotoxin-Induced Mice Lung Impairment: Role of Nicotinic Acetylcholine Receptors and COX-Derived Prostanoids. BIOMOLECULES, v. 10, n. 5, MAY 2020. (15/06290-6, 11/23236-4)

CORDEIRO, FRANCIELLE ALMEIDA; COUTINHO, BARBARA MARQUES; WIEZEL, GISELE ADRIANO; FIGUEIREDO BORDON, KARLA DE CASTRO; BREGGE-SILVA, CRISTIANE; ROSA-GARZON, NATHALIA GONSALES; CABRAL, HAMILTON; UEBERHEIDE, BEATRIX; ARANTES, ELIANE CANDIANI. Purification and enzymatic characterization of a novel metalloprotease from Lachesis muta rhombeata snake venom. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, NOV 22 2018. (14/23285-3, 16/09711-5, 11/23236-4)

CARONE, I, SANTE E.; MENALDO, DANILO L.; SARTIM, MARCO A.; BERNARDES, CAROLINA P.; CAETANO, RENATO C.; DA SILVA, RONIVALDO R.; CABRAL, HAMILTON; BARRAVIERA, BENEDITO; FERREIRA JUNIOR, RUI S.; SAMPAIO, V, SUELY. BjSP, a novel serine protease from Bothrops jararaca snake venom that degrades fibrinogen without forming fibrin clots. Toxicology and Applied Pharmacology, v. 357, p. 50-61, OCT 15 2018. (11/23236-4)

MACHADO, A. R. T.; AISSA, A. F.; RIBEIRO, D. L.; HERNANDES, L. C.; MACHADO, C. S.; BIANCHI, M. L. P.; SAMPAIO, S. V.; ANTUNES, L. M. G.. The toxin BjussuLAAO-II induces oxidative stress and DNA damage, upregulates the inflammatory cytokine genes TNF and IL6, and downregulates the apoptotic-related genes BAX, BCL2 and RELA in human Caco-2 cells. International Journal of Biological Macromolecules, v. 109, p. 212-219, APR 2018. (11/23236-4)

BRUNA TERADA GIMENEZ; GABRIEL NEVES CEZARETTE; ALINE DE SOUSA BOMFIM; WUELTON MARCELO MONTEIRO; ELISA MARIA DE SOUSA RUSSO; FABIANI GAI FRANTZ; SUELY VILELA SAMPAIO; MARCO AURELIO SARTIM. Role of crotoxin in coagulation: novel insights into anticoagulant mechanisms and impairment of inflammation-induced coagulation. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 26, 2020-11-27. (16/04079-9, 11/23236-4, 15/06290-6)

AMORIM, FERNANDA GOBBI; LONGHIM, HELOISA TAVONI; COLOGNA, CAMILA TAKENO; DEGUELDRE, MICHEL; DE PAUW, EDWIN; QUINTON, LOIC; ARANTES, ELIANE CANDIANI. Proteome of fraction from Tityus serrulatus venom reveals new enzymes and toxins. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 25, APR 18 2019. (14/07824-1, 15/17466-8, 12/14996-8, 13/26083-0, 11/23236-4, 14/22959-0, 13/26200-6)

BALDO, MATEUS AMARAL; SIQUEIRA CUNHA, ALEXANDRA OLIMPIO; GODOY, LIVEA DORNELA; LIBERATO, JOSE LUIZ; YONEDA, JULIANA SAKAMOTO; FORNARI-BALDO, ELISA CORREA; CIANCAGLINI, PIETRO; DOS SANTOS, WAGNER FERREIRA; ARANTES, ELIANE CANDIANI. Assessment of neuropharmacological potential of low molecular weight components extracted from Rhinella schneideri toad poison. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 25, APR 18 2019. (11/23236-4, 15/18432-0)

MENALDO, DANILO L.; BERNARDES, CAROLINA P.; JACOB-FERREIRA, ANNA L.; NOGUEIRA-SANTOS, CINTIA G.; CASARE-OGASAWARA, TANIA M.; PEREIRA-CROTT, LUCIANA S.; SAMPAIO, SUELY V.. Effects of Bothrops atrox venom and two isolated toxins on the human complement system: Modulation of pathways and generation of anaphylatoxins. Molecular Immunology, v. 80, p. 91-100, DEC 2016. (12/11963-1, 11/23236-4)

DE ANDRADE, CAMILA M.; REY, FERNANDA M.; CINTRA, ADELIA CRISTINA O.; SAMPAIO, SUELY V.; TORQUETI, MARIA REGINA. Effects of crotoxin, a neurotoxin from Crotalus durissus terrificus snake venom, on human endothelial cells. International Journal of Biological Macromolecules, v. 134, p. 613-621, AUG 1 2019. (11/23236-4)

DE ANDRADE, CAMILA M.; REY, FERNANDA M.; BIANCHINI, FRANCINE J.; SAMPAIO, SUELY V.; TORQUETI, MARIA REGINA. Crotoxin, a neurotoxin from Crotalus durissus terrificus snake venom, as a potential tool against thrombosis development. International Journal of Biological Macromolecules, v. 134, p. 653-659, AUG 1 2019. (11/23236-4)

BURIN, SANDRA MARA; CACEMIRO, MAIRA COSTA; COMINAL, JUCARA GASTALDI; DE GRANDIS, RONE APARECIDO; THOMAZELA MACHADO, ANA RITA; DONAIRES, FLAVIA SACILOTTO; OLIVEIRA CINTRA, ADELIA CRISTINA; AMBROSIO, LUCIANA; GREGGI ANTUNES, LUSANIA MARIA; SAMPAIO, SUELY VILELA; et al. Bothrops moojeni L-amino acid oxidase induces apoptosis and epigenetic modulation on Bcr-Abl plus cells. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 26, DEC 14 2020. (15/25637-7, 11/23236-4, 18/01756-5)

LEIGUEZ, ELBIO; MOTTA, PRISCILA; MAIA MARQUES, RODRIGO; LOMONTE, BRUNO; SAMPAIO, SUELY VILELA; TEIXEIRA, CATARINA. A Representative GIIA Phospholipase A(2) Activates Preadipocytes to Produce Inflammatory Mediators Implicated in Obesity Development. BIOMOLECULES, v. 10, n. 12, DEC 2020. (11/23236-4, 15/24701-3)

CRISTIANE TAVARES; THAÍS MACIEL; SANDRA BURIN; LUCIANA AMBRÓSIO; SANDRO GHISLA; SUELY SAMPAIO; FABÍOLA CASTRO. l-Amino acid oxidase isolated from Calloselasma rhodostoma snake venom induces cytotoxicity and apoptosis in JAK2V617F-positive cell lines. Revista Brasileira de Hematologia e Hemoterapia, v. 38, n. 2, p. 128-134, 2016-06-00. (11/23236-4, 14/19127-3)

CARONE, SANTE E. I.; COSTA, TASSIA R.; BURIN, SANDRA M.; CINTRA, ADELIA C. O.; ZOCCAL, KARINA F.; BIANCHINI, FRANCINE J.; TUCCI, LUIZ F. F.; FRANCO, JOAO J.; TORQUETI, MARIA R.; FACCIOLI, LUCIA H.; et al. A new L-amino acid oxidase from Bothrops jararacussu snake venom: Isolation, partial characterization, and assessment of pro-apoptotic and antiprotozoal activities. International Journal of Biological Macromolecules, v. 103, p. 25-35, OCT 2017. (15/00740-0, 11/23236-4, 15/25637-7)

SARTIM, MARCO A.; CEZARETTE, GABRIEL N.; JACOB-FERREIRA, ANNA L.; FRANTZ, FABIANI G.; FACCIOLI, LUCIA H.; SAMPAIO, SUELY V.. Disseminated intravascular coagulation caused by moojenactivase, a procoagulant snake venom metalloprotease. International Journal of Biological Macromolecules, v. 103, p. 1077-1086, OCT 2017. (15/06290-6, 11/23236-4)

SANTOS-FILHO, NORIVAL A.; SOUSA, TIAGO S.; BOLDRINI-FRANCA, JOHARA; SANTOS-SILVA, LUDIER K.; MENALDO, DANILO L.; HENRIQUE-SILVA, FLAVIO; CINTRA, ADELIA C. O.; LAURE, HELEN J.; MAMEDE, CARLA C. N.; OLIVEIRA, FABIO; et al. rBaltMIP, a recombinant alpha-type myotoxin inhibitor from Bothrops alternatus (Rhinocerophis alternatus) snake, as a potential candidate to complement the antivenom therapy. Toxicon, v. 124, p. 53-62, DEC 15 2016. (11/23236-4, 08/10760-4)

AMORIM, FERNANDA GOBBI; MORANDI-FILHO, ROMUALDO; FUJIMURA, PATRICIA TIEME; UEIRA-VIEIRA, CARLOS; SAMPAIO, SUELY VILELA. New findings from the first transcriptome of the Bothrops moojeni snake venom gland. Toxicon, v. 140, p. 105-117, DEC 15 2017. (16/20641-9, 15/26609-7, 11/23236-4)

AMORIM, FERNANDA GOBBI; COSTA, TASSIA RAFAELA; BAIWIR, DOMINIQUE; DE PAUW, EDWIN; QUINTON, LOIC; SAMPAIO, SUELY VILELA. Proteopeptidomic, Functional and Immunoreactivity Characterization of Bothrops moojeni Snake Venom: Influence of Snake Gender on Venom Composition. TOXINS, v. 10, n. 5, MAY 2018. (15/00740-0, 15/26609-7, 16/20641-9, 11/23236-4)

JACOB-FERREIRA, ANNA L.; MENALDO, DANILO L.; SARTIM, MARCO A.; RIUL, THALITA B.; DIAS-BARUFFI, MARCELO; SAMPAIO, SUELY V.. Antithrombotic activity of Batroxase, a metalloprotease from Bothrops atrox venom, in a model of venous thrombosis. International Journal of Biological Macromolecules, v. 95, p. 263-267, FEB 2017. (11/23236-4, 12/21569-9)

SARTIM, MARCO A.; PINHEIRO, MATHEUS P.; DE PADUA, RICARDO A. P.; SAMPAIO, SUELY V.; CRISTINA NONATO, M.. Structural and binding studies of a C-type galactose-binding lectin from Bothrops jararacussu snake venom. Toxicon, v. 126, p. 59-69, FEB 2017. (11/23236-4, 14/19127-3, 14/11266-4)

BURIN, SANDRA MARA; BERZOTI-COELHO, MARIA GABRIELA; COMINAL, JUCARA GASTALDI; AMBROSIO, LUCIANA; TORQUETI, MARIA REGINA; SAMPAIO, SUELY VILELA; DE CASTRO, FABIOLA ATTIE. The L-amino acid oxidase from Calloselasma rhodostoma snake venom modulates apoptomiRs expression in Bcr-Abl-positive cell lines. Toxicon, v. 120, p. 9-14, SEP 15 2016. (15/23555-3, 15/25637-7, 11/23236-4)

BERNARDES, CAROLINA P.; SANTOS, NEIFE A. G.; SISTI, FLAVIA M.; FERREIRA, RAFAELA SCALCO; SANTOS-FILHO, NORIVAL A.; CINTRA, ADELIA C. O.; CILLI, EDUARDO M.; SAMPAIO, V, SUELY; SANTOS, ANTONIO C.. A synthetic snake-venom-based tripeptide (Glu-Val-Trp) protects PC12 cells from MPP+ toxicity by activating the NGF-signaling pathway. Peptides, v. 104, p. 24-34, JUN 2018. (11/23236-4, 13/07600-3)

BENATI, ROGERIO BODINI; COSTA, TASSIA RAFAELA; CACEMIRO, MAIRA DA COSTA; SAMPAIO, SUELY VILELA; DE CASTRO, FABIOLA ATTIE; BURIN, SANDRA MARA. Cytotoxic and pro-apoptotic action of MjTX-I, a phospholipase A2 isolated from Bothrops moojeni snake venom, towards leukemic cells. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, DEC 20 2018. (15/00740-0, 15/25637-7, 11/23236-4, 14/04234-9)

CASELLA-MARTINS, ANDREA; AYRES, LORENA R.; BURIN, SANDRA M.; MORAIS, FABIANA R.; PEREIRA, JULIANA C.; FACCIOLI, LUCIA H.; SAMPAIO, SUELY V.; ARANTES, ELIANE C.; CASTRO, FABIOLA A.; PEREIRA-CROTT, LUCIANA S.. Immunomodulatory activity of Tityus serrulatus scorpion venom on human T lymphocytes. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 21, NOV 11 2015. (11/23236-4)

DA-SILVA-FREITAS, DEBORA; BOLDRINI-FRANCA, JOHARA; ARANTES, ELIANE CANDIANI. PEGylation: A Successful Approach to Improve the Biopharmaceutical Potential of Snake Venom Thrombin-Like Serine Protease. PROTEIN AND PEPTIDE LETTERS, v. 22, n. 12, p. 1133-1139, 2015. (08/11688-5, 11/23236-4)

AMORIM, FERNANDA G.; MENALDO, DANILO L.; CARONE, SANTE E. I.; SILVA, THIAGO A.; SARTIM, MARCO A.; DE PAUW, EDWIN; QUINTON, LOIC; SAMPAIO, SUELY V.. New Insights on Moojase, a Thrombin-Like Serine Protease from Bothrops moojeni Snake Venom. TOXINS, v. 10, n. 12, DEC 2018. (11/23236-4, 16/20641-9, 15/26609-7)

SARTIM, MARCO A.; COSTA, TASSIA R.; LAURE, HELEN J.; ESPINDOLA, MILENA S.; FRANTZ, FABIANI G.; SORGI, CARLOS A.; CINTRA, ADELIA C. O.; ARANTES, ELIANE C.; FACCIOLI, LUCIA H.; ROSA, JOSE C.; et al. Moojenactivase, a novel pro-coagulant PIIId metalloprotease isolated from Bothrops moojeni snake venom, activates coagulation factors II and X and induces tissue factor up-regulation in leukocytes. ARCHIVES OF TOXICOLOGY, v. 90, n. 5, p. 1261-1278, MAY 2016. (11/23236-4)

BORDON, KARLA C. F.; WIEZEL, GISELE A.; AMORIM, FERNANDA G.; ARANTES, ELIANE C.. Arthropod venom Hyaluronidases: biochemical properties and potential applications in medicine and biotechnology. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 21, OCT 22 2015. (11/12317-3, 14/06170-8, 11/23236-4)

BORDON, KARLA C. F.; WIEZEL, GISELE A.; CABRAL, HAMILTON; ARANTES, ELIANE C.. Bordonein-L, a new L-amino acid oxidase from Crotalus durissus terrificus snake venom: isolation, preliminary characterization and enzyme stability. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 21, AUG 13 2015. (14/06170-8, 11/23236-4)

AYRES, LORENA ROCHA; RECIO, ALEX DOS REIS; BURIN, SANDRA MARA; PEREIRA, JULIANA CAMPOS; MARTINS, ANDREA CASELLA; SAMPAIO, SUELY VILELA; DE CASTRO, FABIOLA ATTIE; PEREIRA-CROTT, LUCIANA SIMON. Bothrops snake venoms and their isolated toxins, an L-amino acid oxidase and a serine protease, modulate human complement system pathways. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 21, AUG 13 2015. (11/23236-4)

MENALDO, DANILO L.; JACOB-FERREIRA, ANNA L.; BERNARDES, CAROLINA P.; CINTRA, ADELIA C. O.; SAMPAIO, SUELY V.. Purification procedure for the isolation of a P-I metalloprotease and an acidic phospholipase A(2) from Bothrops atrox snake venom. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 21, AUG 13 2015. (12/21569-9, 11/23236-4, 12/11963-1)

COSTA, TASSIA R.; MENALDO, DANILO L.; DA SILVA, CASSIO PRINHOLATO; SORRECHIA, RODRIGO; DE ALBUQUERQUE, SERGIO; PIETRO, ROSEMEIRE C. L. R.; GHISLA, SANDRO; ANTUNES, LUSANIA M. GREGGI; SAMPAIO, SUELY V.. Evaluating the microbicidal, antiparasitic and antitumor effects of CR-LAAO from Calloselasma rhodostoma venom. International Journal of Biological Macromolecules, v. 80, p. 489-497, SEP 2015. (11/23236-4, 11/02645-3)

SARTIM, MARCO A.; SAMPAIO, SUELY V.. Snake venom galactoside-binding lectins: a structural and functional overview. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 21, SEP 24 2015. (11/23236-4)

SANTOS-FILHO, NORIVAL A.; BOLDRINI-FRANCA, JOHARA; SANTOS-SILVA, LUDIER K.; MENALDO, DANILO L.; HENRIQUE-SILVA, FLAVIO; SOUSA, TIAGO S.; CINTRA, ADELIA C. O.; MAMEDE, CARLA C. N.; OLIVEIRA, FABIO; ARANTES, ELIANE C.; et al. Heterologous expression and biochemical and functional characterization of a recombinant alpha-type myotoxin inhibitor from Bothrops alternatus snake. Biochimie, v. 105, p. 119-128, OCT 2014. (11/23236-4, 08/10760-4)

CARTAROZZI, LUCIANA P.; SPEJO, ALINE B.; FERREIRA, JR., RUI S.; BARRAVIERA, BENEDITO; DUEK, ELIANA; CARVALHO, JULIANA L.; GOES, ALFREDO M.; OLIVEIRA, ALEXANDRE L. R.. Mesenchymal stem cells engrafted in a fibrin scaffold stimulate Schwann cell reactivity and axonal regeneration following sciatic nerve tubulization. Brain Research Bulletin, v. 112, p. 14-24, MAR 2015. (14/06892-3, 12/08101-8, 11/23236-4, 09/53846-9)

CEZARETTE, G. N.; SARTIM, M. A.; SAMPAIO, S. V.. Inflammation and coagulation crosstalk induced by BJcuL, a galactose-binding lectin isolated from Bothrops jararacussu snake venom. International Journal of Biological Macromolecules, v. 144, p. 9-pg., 2020-02-01. (11/23236-4, 15/06290-6, 16/04079-9)

BERNARDES, CAROLINA P.; SANTOS, NEIFE A. G.; COSTA, TASSIA R.; MENALDO, DANILO L.; SISTI, FLAVIA M.; AMSTALDEN, MARTIN K.; RIBEIRO, DIEGO L.; ANTUNES, LUSANIA M. G.; SAMPAIO, SUELY V.; SANTOS, ANTONIO C.. Effects of C-Terminal-Ethyl-Esterification in a Snake-Venom-Based Peptide Against the Neurotoxicity of Acrolein in PC12 Cells. INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, v. 29, n. 3, p. 16-pg., 2023-04-03. (11/23236-4)

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DANILO L. MENALDO; ANNA L. JACOB-FERREIRA; CAROLINA P. BERNARDES; ADÉLIA C. O. CINTRA; SUELY V. SAMPAIO. Purification procedure for the isolation of a P-I metalloprotease and an acidic phospholipase A 2 fromBothrops atrox snake venom. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 21, p. 0-0, 2015-09-29. (12/21569-9, 12/11963-1, 11/23236-4)

DE OLIVEIRA, ISADORA SOUSA; CARDOSO, IARA AIME; FIGUEIREDO BORDON, KARLA DE CASTRO; IMAI CARONE, SANTE EMMANUEL; BOLDRINI-FRANCA, JOHARA; PUCCA, MANUELA BERTO; ZOCCAL, KARMA FURLANI; FACCIOLI, LUCIA HELENA; SAMPAIO, SUELY VILELA; ROSA, JOSE CESAR; et al. Global proteomic and functional analysis of Crotalus durissus collilineatus individual venom variation and its impact on envenoming. JOURNAL OF PROTEOMICS, v. 191, n. SI, p. 153-165, JAN 16 2019. (14/16182-3, 11/23236-4, 14/03332-7)

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CEZARETTE, G. N.; SARTIM, M. A.; SAMPAIO, S. V.. Inflammation and coagulation crosstalk induced by BJcuL, a galactose-binding lectin isolated from Bothrops jararacussu snake venom. International Journal of Biological Macromolecules, v. 144, p. 296-304, FEB 1 2020. (11/23236-4, 15/06290-6, 16/04079-9)

BARBIZAN, ROBERTA; CASTRO, MATEUS V.; FERREIRA, JR., RUI SEABRA; BARRAVIERA, BENEDITO; OLIVEIRA, ALEXANDRE L. R.. Long-Term Spinal Ventral Root Reimplantation, but not Bone Marrow Mononuclear Cell Treatment, Positively Influences Ultrastructural Synapse Recovery and Motor Axonal Regrowth. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 15, n. 11, p. 19535-19551, NOV 2014. (14/06892-3, 12/08101-8, 11/23236-4, 09/53846-9)

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WIEZEL, GISELE A.; RUSTIGUEL, JOANE K.; MORGENSTERN, DAVID; ZOCCAL, KARINA E.; FACCIOLI, LUCIA H.; CRISTINA NONATO, M.; UEBERHEIDE, BEATRIX; ARANTES, ELIANE C.. Insights into the structure, function and stability of bordonein-L, the first L-amino acid oxidase from Crotalus durissus terrificus snake venom. Biochimie, v. 163, p. 33-49, AUG 2019. (14/03332-7, 11/23236-4, 15/24010-0, 14/23285-3, 14/06170-8, 14/07125-6)

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MACHADO, A. R. T.; AISSA, A. F.; RIBEIRO, D. L.; COSTA, T. R.; FERREIRA, JR., R. S.; SAMPAIO, S. V.; ANTUNES, L. M. G.. Cytotoxic, genotoxic, and oxidative stress-inducing effect of an L-amino acid oxidase isolated from Bothrops jararacussu venom in a co-culture model of HepG2 and HUVEC cells. International Journal of Biological Macromolecules, v. 127, p. 425-432, APR 15 2019. (11/23236-4)

WIEZEL, GISELE A.; BORDON, KARLA C. F.; SILVA, RONIVALDO R.; GOMES, MARIO S. R.; CABRAL, HAMILTON; RODRIGUES, VERIDIANA M.; UEBERHEIDE, BEATRIX; ARANTES, ELIANE C.. Subproteome of Lachesis muta rhombeata venom and preliminary studies on LmrSP-4, a novel snake venom serine proteinase. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 25, APR 15 2019. (10/06199-5, 14/23285-3, 15/18432-0, 11/23236-4)

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COSTA, TASSIA R.; AMSTALDEN, MARTIN K.; RIBEIRO, DIEGO L.; MENALDO, DANILO L.; SARTIM, MARCO A.; AISSA, ALEXANDRE F.; ANTUNES, LUSANIA M. G.; SAMPAIO, V, SUELY. CR-LAAO causes genotoxic damage in HepG2 tumor cells by oxidative stress. Toxicology, v. 404, p. 42-48, JUL 1 2018. (15/00740-0, 11/23236-4, 15/00847-9)

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