INCT 2014: biodiversidade e produtos naturais

• Processo: 14/50926-0
• Linha de fomento: Auxílio à Pesquisa - Programa BIOTA - Temático
• Vigência: 01 de julho de 2017 - 30 de junho de 2023
• Área do conhecimento: Ciências Exatas e da Terra - Química
• Convênio/Acordo: CNPq - INCTs
• Pesquisador responsável: Vanderlan da Silva Bolzani
• Beneficiário: Vanderlan da Silva Bolzani
• Instituição-sede: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brasil
• Pesquisadores principais:( Atuais ): Alberto José Cavalheiro ; Leticia Veras Costa Lotufo
• Pesquisadores principais:( Anteriores ): Maria José Soares Mendes Giannini
• Auxílios(s) vinculado(s): 18/50025-3 - Green analytical chemistry applied to the investigation of agro industrial wastes generated in Brazil and Australia, AP.R SPRINT
• Assunto(s): Biodiversidade Produtos naturais Metabólitos secundários Pesquisa básica Desenvolvimento de produtos Sustentabilidade Micro-organismos
• Publicação FAPESP: https://media.fapesp.br/bv/uploads/pdfs/Brazilian_biodiversity...future_syWaC2Z_55_56.pdf

Resumo

O projeto delineado está centrado nos pilares de sustentação da Ciência, Tecnologia e Inovação, que norteiam as sociedades do conhecimento: (a) pesquisa básica e aplicada de excelência; (b) formação de recursos humanos em biodiversidade e produtos naturais; (c) colaboração com o setor empresarial para desenvolvimento tecnológico a partir das inovações em produtos naturais; (d) difusão do conhecimento sobre a biodiversidade e produtos naturais bioativos para o ensino médio e outros segmentos da sociedade; (e) contribuição nas ações de políticas públicas de conservação e uso sustentável da biodiversidade. Dentro destes fundamentos, o Instituto Nacional de Ciência & Tecnologia (INCTBioNat) foi criado para mapear e catalogar de forma organizada todas as informações sobre os metabólitos secundários detectados e/ou isolados de organismos de nossa rica biodiversidade, fundamental para o avanço de pesquisa em química de produtos naturais do Brasil. O conhecimento e uso sustentável da biodiversidade brasileira foi preconizado no documento Política Nacional da Biodiversidade, editado pela Secretaria de Biodiversidade e Florestas (SBF), Ministério do Meio Ambiente (MMA), em 2002 e tem prioridade para o desenvolvimento nacional. A criação de uma rede nacional de pesquisa para mapeamento químico e biológico das espécies terrestres, marinhas e de microrganismos da nossa biodiversidade constitui-se numa estratégia racional para a seleção de substâncias ativas mais promissoras para posterior estudos farmacológicos e toxicológicos visando moléculas protótipos. Para atingir tais metas, o ICNTBioNat reúne pesquisadores de excelência e pesquisadores jovens e talentosos que iniciam suas carreiras em universidades federais e estaduais de vários estados da federação, englobando todas as regiões do Brasil. Toda equipe atuará de forma colaborativa e multidisciplinar objetivando o fortalecimento de uma área de pesquisa e inovação estratégica para o Brasil, através de uma rede de laboratórios de excelência em produtos naturais para exploração e uso sustentável da rica biodiversidade brasileira. (AU)

Publicações científicas

(91)

(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)

DE SOUSA, IRAN DA LUZ; XIMENES, VALDECIR FARIAS; DE SOUZA, AGUINALDO ROBINSON; MORGON, NELSON HENRIQUE. Solvent-induced Stokes' shift in DCJTB: Experimental and theoretical results. Journal of Molecular Structure, v. 1192, p. 186-191, SEP 15 2019. (15/22338-9, 16/20549-5, 14/50926-0, 16/04963-6)

VALLI, MARILIA; RUSSO, HELENA MANNOCHIO; PILON, ALAN CESAR; FERREIRA PINTO, MERI EMILI; DIAS, NATHALIA B.; FREIRE, RAFAEL TEIXEIRA; CASTRO-GAMBOA, IAN; BOLZANI, VANDERLAN DA SILVA. Computational methods for NMR and MS for structure elucidation I: software for basic NMR. PHYSICAL SCIENCES REVIEWS, v. 4, n. 10, OCT 2019. (14/50926-0, 17/17098-4, 16/13292-8, 13/07600-3)

VENTURINI, DIEGO; DE SOUZA, AGUINALDO ROBINSON; CARACELLI, IGNEZ; MORGON, NELSON HENRIQUE; DA SILVA-FILHO, LUIZ CARLOS; XIMENES, VALDECIR FARIAS. Induction of axial chirality in divanillin by interaction with bovine serum albumin. PLoS One, v. 12, n. 6, JUN 2 2017. (14/50926-0, 15/22338-9)

SOUZA, FELIPE DE OLIVEIRA; SORBO, JULIANA MARIA; REGASINI, LUIS OCTAVIO; BOLZANI, VANDERLAN DA SILVA; ROSA, JOSE CESAR; CZERNYS, ERICA DA SILVA; VALENTE, VALERIA; MOREIRA, THAIS FERNANDA; NAVEGANTE, GEOVANA; FERNANDES, BARBARA COLATTO; et al. Nitensidine B affects proteins of the glycolytic pathway and induces apoptosis in cervical carcinoma cells immortalized by HPV16. Phytomedicine, v. 48, p. 179-186, SEP 15 2018. (14/50926-0)

BOBEY, ANTONIO FERNANDEZ; FERREIRA PINTO, MERI EMILI; CILLI, EDUARDO MAFFUD; LOPES, NORBERTO PEPORINE; BOLZANI, VANDERLAN DA SILVA. A Cyclotide Isolated from Noisettia orchidiflora (Violaceae). Planta Medica, v. 84, n. 12-13, SI, p. 947+, AUG 2018. (14/50926-0, 17/17098-4, 13/07600-3)

CRISTIANO SOLEO FUNARI; ALBERTO JOSÉ CAVALHEIRO; RENATO LAJARIM CARNEIRO. Coupled monolithic columns as an alternative for the use of viscous ethanol–water mobile phases on chromatographic fingerprinting complex samples. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 28, n. 3, p. 261-266, 2018-06-00. (10/18840-7, 14/50926-0, 13/07600-3)

BERTOZO, LUIZA DE CARVALHO; PHILOT, ERIC ALLISON; LIMA, ANGELICA NAKAGAWA; DE RESENDE LARA, PEDRO TULIO; SCOTT, ANA LIGIA; XIMENES, VALDECIR FARIAS. Interaction between 1-pyrenesulfonic acid and albumin: Moving inside for the protein. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, v. 208, p. 243-254, FEB 5 2019. (14/50926-0, 16/22014-1, 16/20549-5)

MUSTEDANAGIC, JASMIN; XIMENES, VALDECIR FARIAS; NAGL, MARKUS. Microbicidal activity of N-chlorotaurine in combination with hydrogen peroxide. AMB EXPRESS, v. 7, MAY 23 2017. (14/50926-0)

REZENDE-TEIXEIRA, PAULA; DUSI, RENATA G.; JIMENEZ, PAULA C.; ESPINDOLA, LAILA S.; COSTA-LOTUFO, V, LETICIA. hat can we learn from commercial insecticides? Efficacy, toxicity, environmental impacts, and future development. Environmental Pollution, v. 300, MAY 1 2022. (17/09022-8, 14/50926-0, 15/17177-6, 17/17648-4)

GARCIA, MAYARA A. R.; THEODORO, REINALDO S.; SARDI, JANAINA C. O.; SANTOS, MARIANA B.; AYUSSO, GABRIELA M.; PAVAN, FERNANDO R.; COSTA, ALAN R.; SANTA CRUZ, LUCAS M.; ROSALEN, PEDRO L.; REGASINI, LUIS O.. Design, synthesis and antibacterial activity of chalcones against MSSA and MRSA planktonic cells and biofilms. BIOORGANIC CHEMISTRY, v. 116, NOV 2021. (18/15083-2, 14/50926-0, 09/53989-4, 14/18330-0)

BORGES, MAIARA S.; BIASETTO, CAROLINA R.; CHAPLA, VANESSA M.; EBRAHIMI, SAMAD N.; COSTA, MAYRA F.; BOLZANI, VANDERLAN S.; ARAUJO, ANGELA R.. Assessment of Novel C-4 Methylated Tetraketide by HPLC-SPE-TT in Saccharicola sp., an Endophytic Fungus in Eugenia jambolana Lam. Journal of the Brazilian Chemical Society, v. 30, n. 3, SI, p. 522-527, MAR 2019. (14/50926-0, 13/07600-3)

GOMES DO NASCIMENTO, MICHELLE NAUARA; MARTINS, MARIO MACHADO; SCALON CUNHA, LUIS CARLOS; SANTOS, PAULA DE SOUZA; GOULART, LUIZ RICARDO; SILVA, THAYNA DE SOUZA; GOMES MARTINS, CARLOS HENRIQUE; LEMOS DE MORAIS, SERGIO ANTONIO; PIVATTO, MARCOS. Antimicrobial and cytotoxic activities of Senna and Cassia species (Fabaceae) extracts. INDUSTRIAL CROPS AND PRODUCTS, v. 148, JUN 2020. (14/50926-0)

ALAN C. PILON; DENISE M. SELEGATO; RICHARD P. FERNANDES; PAULA C. P. BUENO; DANIELLE R. PINHO; FAUSTO CARNEVALE NETO; RAFAEL T. FREIRE; IAN CASTRO-GAMBOA; VANDERLAN S. BOLZANI; NORBERTO P. LOPES. METABOLÔMICA DE PLANTAS: MÉTODOS E DESAFIOS. Química Nova, v. 43, n. 3, p. 329-354, 2020-06-01. (16/13292-8, 15/50488-5, 13/07600-3, 17/17850-8, 14/50265-3, 14/05935-0, 19/15889-0, 17/19702-6, 19/08477-7, 14/50926-0)

WILKE, V, DIEGO; JIMENEZ, PAULA C.; BRANCO, PAOLA C.; REZENDE-TEIXEIRA, PAULA; TRINDADE-SILVA, AMARO E.; BAUERMEISTER, ANELIZE; LOPES, NORBERTO PEPORINE; COSTA-LOTUFO, V, LETICIA. Anticancer Potential of Compounds from the Brazilian Blue Amazon. Planta Medica, v. 87, n. 01/02, NOV 2020. (15/17177-6, 14/50926-0, 17/09022-8, 17/17648-4)

TEIXEIRA, THAIZ RODRIGUES; DOS SANTOS, GUSTAVO SOUZA; ARMSTRONG, LORENE; COLEPICOLO, PIO; DEBONSI, HOSANA MARIA. Antitumor Potential of Seaweed Derived-Endophytic Fungi. ANTIBIOTICS-BASEL, v. 8, n. 4, DEC 2019. (14/50926-0, 16/06931-4)

POLAQUINI, CARLOS R.; MARQUES, BEATRIZ C.; AYUSSO, GABRIELA M.; MORAO, LUANA G.; SARDI, JANAINA C. O.; CAMPOS, DEBORA L.; SILVA, ISABEL C.; CAVALCA, LUCIA B.; SCHEFFERS, DIRK-JAN; ROSALEN, PEDRO L.; et al. Antibacterial activity of a new monocarbonyl analog of curcumin MAC 4 is associated with divisome disruption. BIOORGANIC CHEMISTRY, v. 109, APR 2021. (15/50162-2, 18/00163-0, 14/50926-0, 14/18330-0, 18/15083-2, 13/50367-8, 17/50216-0, 14/50880-0, 09/53989-4)

DAYANE C. RIBEIRO; HELENA M. RUSSO; KARINA FRAIGE; MARIA L. ZERAIK; CLÁUDIO R. NOGUEIRA; PATRÍCIA B. DA SILVA; ANA C. CODO; GIOVANA M. F. CALIXTO; ALEXANDRA I. DE MEDEIROS; MARLUS CHORILLI; et al. Bioactive Bioflavonoids from Platonia insignis (Bacuri) Residues as Added Value Compounds. Journal of the Brazilian Chemical Society, v. 32, n. 4, p. 786-799, 2021-03-29. (17/19870-6, 13/07600-3, 16/16970-7, 17/18807-9, 14/50926-0)

ALVES DA SILVA, BRUNA TERRA; PELOI, KAREN ELAINE; XIMENES, VALDECIR FARIAS; NAKAMURA, CELSO VATARU; SILVA LAUTENSCHLAGER, SUELI DE OLIVEIRA. 2-acetylphenothiazine protects L929 fibroblasts against UVB-induced oxidative damage. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, v. 216, MAR 2021. (14/50926-0, 19/18445-5)

TEIXEIRA, THAIZ RODRIGUES; SANTOS, GUSTAVO SOUZA; CASANOVA TURATTI, IZABEL CRISTINA; PAZIANI, MARIO HENRIQUE; VON ZESKA KRESS, MARCIA REGINA; COLEPICOLO, PIO; DEBONSI, HOSANA MARIA. Characterization of the lipid profile of Antarctic brown seaweeds and their endophytic fungi by gas chromatography-mass spectrometry (GC-MS). POLAR BIOLOGY, v. 42, n. 8, p. 1431-1444, AUG 2019. (14/50926-0)

MEDINA, REBECA P.; ARAUJO, ANGELA R.; BATISTA JR, JOAO M.; CARDOSO, CARMEN L.; SEIDL, CLAUDIA; VILELA, ADRIANA F. L.; DOMINGOS, V, HELORI; COSTA-LOTUFO, V, LETICIA; ANDERSEN, RAYMOND J.; SILVA, DULCE H. S.. Botryane terpenoids produced by Nemania bipapillata, an endophytic fungus isolated from red alga Asparagopsis taxiformis - Falkenbergia stage. SCIENTIFIC REPORTS, v. 9, AUG 23 2019. (14/50926-0, 13/01710-1, 15/17177-6, 13/07600-3)

MARIACATERINA LIANZA; MARIA HELENA VERDAN; JEAN PAULO DE ANDRADE; FERRUCCIO POLI; LARISSA C. DE ALMEIDA; LETICIA V. COSTA-LOTUFO; ÁLVARO CUNHA NETO; SARAH C. C. OLIVEIRA; JAUME BASTIDA; ANDREA N. L. BATISTA; et al. Isolation, Absolute Configuration and Cytotoxic Activities of Alkaloids from Hippeastrum goianum (Ravenna) Meerow (Amaryllidaceae). Journal of the Brazilian Chemical Society, v. 31, n. 10, p. 2135-2145, Out. 2020. (14/25222-9, 15/17177-6, 14/50926-0, 18/17595-0)

DA SILVA, ALISON B.; SILVEIRA, EDILBERTO R.; WILKE, DIEGO V.; FERREIRA, ELHTON G.; COSTA-LOTUFO, LETICIA V.; TORRES, MARIA CONCEICAO M.; AYALA, ALEJANDRO PEDRO; COSTA, WENDELL S.; CANUTO, KIRLEY M.; DE ARAUJO-NOBRE, ALYNE R.; et al. Antibacterial Salinaphthoquinones from a Strain of the Bacterium Salinispora arenicola Recovered from the Marine Sediments of St. Peter and St. Paul Archipelago, Brazil. Journal of Natural Products, v. 82, n. 7, p. 1831-1838, JUL 2019. (14/50926-0, 15/17177-6)

RUSSO, HELENA MANNOCHIO; GONCALVES NUNES, WILHAN DONIZETE; BOLZANI, VANDERLAN DA SILVA; IONASHIRO, MASSAO; CAIRES, FLAVIO JUNIOR. Thermoanalytical and spectroscopic characteristics of young and old leaves powder and methanolic extracts of Niedenzuella multiglandulosa. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, v. 132, n. 1, p. 771-776, APR 2018. (14/50926-0, 17/14936-9, 13/07600-3)

VALLI, MARILIA; RUSSO, HELENA MANNOCHIO; PILON, ALAN CESAR; FERREIRA PINTO, MERI EMILI; DIAS, NATHALIA B.; FREIRE, RAFAEL TEIXEIRA; CASTRO-GAMBOA, IAN; BOLZANI, VANDERLAN DA SILVA. Computational methods for NMR and MS for structure elucidation II: database resources and advanced methods. PHYSICAL SCIENCES REVIEWS, v. 4, n. 11, NOV 2019. (14/50926-0, 17/17098-4, 16/13292-8, 13/07600-3)

PASTRELLO, BRUNA; DOS SANTOS, GIOVANNY CARVALHO; DA SILVA-FILHO, LUIZ CARLOS; DE SOUZA, AGUINALDO ROBINSON; MORGON, NELSON HENRIQUE; XIMENES, VALDECIR FARIAS. Novel aminoquinoline-based solvatochromic fluorescence probe: Interaction with albumin, lysozyme and characterization of amyloid fibrils. DYES AND PIGMENTS, v. 173, FEB 2020. (15/22338-9, 14/50926-0, 15/00615-0, 18/14506-7, 16/20549-5)

PINTO, FRANCISCO C. L.; SILVEIRA, EDILBERTO R.; VASCONCELOS, ANA CAROLINE L.; FLORENCIO, KATHARINE G. D.; OLIVEIRA, FRANCISCA A. S.; SAHM, BIANCA B.; COSTA-LOTUFO, V, LETICIA; BAUERMEISTER, ANELIZE; LOPES, NORBERTO P.; WILKE, V, DIEGO; et al. Dextrorotatory Chromomycins from the Marine Streptomyces sp. Associated to Palythoa caribaeorum. Journal of the Brazilian Chemical Society, v. 31, n. 1, p. 143-152, JAN 2020. (14/50926-0, 17/17648-4, 15/17177-6)

LAMBERT MOREIRA, LETICIA GONDIM; LEITE FERREIRA, MARIA ELISA; SANTOS REGINALDO, FERNANDA PRISCILA; GUIMARAES LOURENCO, ESTELA MARIANA; SILVEIRA ZUANAZZI, JOSE ANGELO; BARBOSA, EUZEBIO GUIMARAES; FERREIRA, LEANDRO DE SANTIS; FETT-NETO, ARTHUR GERMANO; CAVALHEIRO, ALBERTO JOSE; LUCHIARI, ANA CAROLINA; et al. Erythroxylum pungens Tropane Alkaloids: GC-MS Analysis and the Bioactive Potential of 3-(2-methylbutyryloxy)tropan-6,7-diol in Zebrafish ( Danio rerio ). Planta Medica, v. 87, n. 01/02, p. 177-186, FEB 2021. (14/50926-0)

BORGES, MAIARA S.; ZANATTA, ANA C.; SOUZA, OTAVIO A.; PELISSARI, JOAO H.; CAMARGO, JULIO G. S.; CARNEIRO, RENATO L.; FUNARI, CRISTIANO S.; BOLZANI, VANDERLAN S.; RINALDO, DANIEL. A green and sustainable method for monitoring the chemical composition of soybean: an alternative for quality control. Phytochemical Analysis, v. 32, n. 4, p. 562-574, JUL 2021. (14/50926-0, 17/06216-6, 16/08179-8)

SOUZA, OTAVIO AGUIAR; FURLANI, RAFAEL PELEGRINO; RAMALHAO, VITORIA GIOVANNA DA SILVA; BORGES, MAIARA STEFANINI; FUNARI, CRISTIANO SOLEO; BOLZANI, VANDERLAN DA SILVA; RINALDO, DANIEL. Eco-friendly and inexpensive food grade bioethanol for Eugenia uniflora L. chromatographic fingerprinting: A trade-off between separation and sustainability. PHYTOCHEMISTRY LETTERS, v. 43, p. 200-207, JUN 2021. (14/50926-0, 16/08179-8)

POLITI, FLAVIO AUGUSTO SANCHES; BUENO, RENATA VIEIRA; ZEOLY, LUCAS ANDRE; FANTATTO, RAFAELA REGINA; ELOY, JOSIMAR DE OLIVEIRA; CHORILLI, MARLUS; COELHO, FERNANDO; GUIDO, RAFAEL VICTORIO CARVALHO; CHAGAS, ANA CAROLINA DE SOUZA; FURLAN, MAYSA. Anthelmintic activity of a nanoformulation based on thiophenes identified in Tagetes patula L. (Asteraceae) against the small ruminant nematode Haemonchus contortus. Acta Tropica, v. 219, JUL 2021. (14/50926-0, 13/04737-8, 13/03493-8, 11/08042-9)

DOS SANTOS, WILLIAN HENRIQUE; YOGUIM, MAURICIO IKEDA; DARE, REGINA GOMES; DA SILVA-FILHO, LUIZ CARLOS; LAUTENSCHLAGER, SUELI OLIVEIRA SILVA; XIMENES, VALDECIR FARIAS. Development of a caffeic acid-phthalimide hybrid compound for NADPH oxidase inhibition. RSC ADVANCES, v. 11, n. 29, p. 17880-17890, MAY 27 2021. (19/18445-5, 16/20549-5, 14/50926-0)

RIBEIRO, IRISVAN S.; PONTES, FRANCISCO J. G.; CARNEIRO, MARIA J. M.; SOUSA, NAYARA A.; PINTO, VICENTE P. T.; RIBEIRO, FABIO O. S.; SILVA, DURCILENE A.; ARAUJO, GISELE S.; MARINHO FILHO, JOSE D. B.; ARAUJO, ANA J.; et al. Poly(epsilon-caprolactone) grafted cashew gum nanoparticles as an epirubicin delivery system. International Journal of Biological Macromolecules, v. 179, p. 314-323, MAY 15 2021. (14/50926-0)

DARE, REGINA G.; NAKAMURA, CELSO V.; XIMENES, VALDECIR F.; LAUTENSCHLAGER, SUELI O. S.. Tannic acid, a promising anti-photoaging agent: Evidences of its antioxidant and anti-wrinkle potentials, and its ability to prevent photodamage and MMP-1 expression in L929 fibroblasts exposed to UVB. Free Radical Biology and Medicine, v. 160, p. 342-355, NOV 20 2020. (14/50926-0)

DARE, REGINA G.; COSTA, ANA; NAKAMURA, V, CELSO; TRUITI, MARIA C. T.; XIMENES, VALDECIR F.; LAUTENSCHLAGER, SUELI O. S.; SARMENTO, BRUNO. Evaluation of lipid nanoparticles for topical delivery of protocatechuic acid and ethyl protocatechuate as a new photoprotection strategy. International Journal of Pharmaceutics, v. 582, MAY 30 2020. (14/50926-0)

QUEIROZ, SUZANA APARECIDA S.; PINTO, MERI EMILI F.; BOBEY, ANTONIO F.; RUSSO, HELENA M.; BATISTA, ANDREA N. L.; BATISTA, JR., JOAO M.; CODO, ANA C.; MEDEIROS, ALEXANDRA I.; BOLZANI, VANDERLAN S.. Diterpenoids with inhibitory activity of nitrite production from Croton floribundus. Journal of Ethnopharmacology, v. 249, MAR 1 2020. (19/04381-5, 13/07600-3, 14/25222-9, 17/19870-6, 17/18807-9, 14/50926-0, 17/17098-4)

TEIXEIRA, THAIZ RODRIGUES; RANGEL, KAREN CRISTINA; NAPOLEAO TAVARES, RENATA SPAGOLLA; KAWAKAMI, CAMILA MARTINS; DOS SANTOS, GUSTAVO SOUZA; MARIA-ENGLER, SILVYA STUCHI; COLEPICOLO, PIO; GASPAR, LORENA RIGO; DEBONSI, HOSANA MARIA. In Vitro Evaluation of the Photoprotective Potential of Quinolinic Alkaloids Isolated from the Antarctic Marine Fungus Penicillium echinulatum for Topical Use. MARINE BIOTECHNOLOGY, v. 23, n. 3, p. 357-372, JUN 2021. (14/50926-0, 17/03552-5)

SABINO FERRARI, ANNA BEATRIZ; DE OLIVEIRA, GEORGE AZEVEDO; RUSSO, HELENA MANNOCHIO; BERTOZO, LUIZA CARVALHO; BOLZANI, VANDERLAN DA SILVA; ZIED, DIEGO CUNHA; XIMENES, VALDECIR FARIAS; ZERAIK, MARIA LUIZA. PleurotusostreatusandAgaricus subrufescens: investigation of chemical composition and antioxidant properties of these mushrooms cultivated with different handmade and commercial supplements. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, v. 56, n. 1, JUL 2020. (16/16970-7, 14/50926-0, 15/15306-3, 13/07600-3)

LUZ RODRIGUES, RAIZA RAIANNE; LIMA NUNES, THAIS AMANDA; DE ARAUJO, ALYNE RODRIGUES; BARRETO MARINHO FILHO, JOSE DELANO; DA SILVA, MARCOS VINICIUS; DE AMORIM CARVALHO, FERNANDO AECIO; LOIOLA PESSOA, OTILIA DEUSDENIA; SILVA FREITAS, HOZANA PATRICIA; DA FRANCA RODRIGUES, KLINGER ANTONIO; ARAUJO, ANA JERSIA. Antileishmanial activity of cordiaquinone E towards Leishmania (Leishmania) amazonensis. International Immunopharmacology, v. 90, JAN 2021. (14/50926-0)

RANGEL, KAREN CRISTINA; VILLELA, LEONARDO ZAMBOTTI; PEREIRA, KARINA DE CASTRO; COLEPICOLO, PIO; DEBONSI, HOSANA MARIA; GASPAR, LORENA RIGO. Assessment of the photoprotective potential and toxicity of Antarctic red macroalgae extracts from Curdiea racovitzae and Iridaea cordata for cosmetic use. ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS, v. 50, SEP 2020. (14/50926-0, 16/06931-4)

SILVA, MARIANA; PHILADELPHO, BIANE; SANTOS, JOHNNIE; SOUZA, VICTORIA; SOUZA, CAIO; SANTIAGO, VICTORIA; SILVA, JAFF; SOUZA, CAROLINA; AZEREDO, FRANCINE; CASTILHO, MARCELO; et al. IAF, QGF, and QDF Peptides Exhibit Cholesterol-Lowering Activity through a Statin-like HMG-CoA Reductase Regulation Mechanism: In Silico and In Vitro Approach. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 22, n. 20, OCT 2021. (14/50926-0, 13/07600-3)

DE CARVALHO BERTOZO, LUIZA; FERNANDES, ANA J. F. C.; YOGUIM, MAURICIO I.; BOLEAN, MAYTE; CIANCAGLINI, PIETRO; XIMENES, VALDECIR F.. Entropy-driven binding of octyl gallate in albumin: Failure in the application of temperature effect to distinguish dynamic and static fluorescence quenching. JOURNAL OF MOLECULAR RECOGNITION, v. 33, n. 7, MAR 2020. (14/50926-0, 16/20549-5, 16/22014-1)

DARE, REGINA G.; OLIVEIRA, MARIANA M.; TRUITI, MARIA C. T.; NAKAMURA, V, CELSO; XIMENES, VALDECIR F.; LAUTENSCHLAGER, SUELI O. S.. Abilities of protocatechuic acid and its alkyl esters, ethyl and heptyl protocatechuates, to counteract UVB-induced oxidative injuries and photoaging in fibroblasts L929 cell line. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, v. 203, JAN 2020. (14/50926-0)

MANNOCHIO-RUSSO, HELENA; BUENO, PAULA CAROLINA P.; BAUERMEISTER, ANELIZE; DE ALMEIDA, RAFAEL FELIPE; DORRESTEIN, PIETER C.; CAVALHEIRO, ALBERTO JOSE; BOLZANI, VANDERLAN S.. Can Statistical Evaluation Tools for Chromatographic Method Development Assist in the Natural Products Workflow? A Case Study on Selected Species of the Plant Family Malpighiaceae. Journal of Natural Products, v. 83, n. 11, p. 3239-3249, NOV 25 2020. (18/24865-4, 13/07600-3, 16/16970-7, 17/19702-6, 14/50926-0, 19/08477-7)

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DE ALMEIDA, LARISSA COSTA; BAUERMEISTER, ANELIZE; REZENDE-TEIXEIRA, PAULA; DOS SANTOS, EVELYNE ALVES; BERALDO DE MORAES, LUIZ ALBERTO; MACHADO-NETO, JOAO AGOSTINHO; COSTA-LOTUFO, LETICIA VERAS. Pradimicin-IRD exhibits antineoplastic effects by inducing DNA damage in colon cancer cells. Biochemical Pharmacology, v. 168, p. 38-47, OCT 2019. (18/17595-0, 15/17177-6, 17/17648-4, 14/50926-0, 17/24993-0)

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VIEIRA, NATALIA CAROLINA; CORTELO, PATRICIA CARDOSO; CASTRO-GAMBOA, IAN. Rapid qualitative profiling of metabolites present in Fusarium solani, a rhizospheric fungus derived from Senna spectabilis, using GC/MS and UPLC-QTOF/MSE techniques assisted by UNIFI information system. EUROPEAN JOURNAL OF MASS SPECTROMETRY, v. 26, n. 4, MAY 2020. (14/50926-0, 13/07600-3)

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DOS SANTOS, GUSTAVO SOUZA; TEIXEIRA, THAIZ RODRIGUES; COLEPICOLO, PIO; DEBONSI, HOSANA MARIA. Natural Products from the Poles: Structural Diversity and Biological Activities. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 31, n. 5, p. 531-560, OCT 2021. (14/50926-0)

MARQUES, BEATRIZ C.; SANTOS, MARIANA B.; ANSELMO, DAIANE B.; MONTEIRO, DIEGO A.; GOMES, ELENI; SAIKI, MARILIA F. C.; RAHAL, PAULA; ROSALEN, PEDRO L.; SARDI, JANAINA C. O.; REGASINI, LUIS O.. Methoxychalcones: Effect of Methoxyl Group on the Antifungal Antibacterial and Antiproliferative Activities. Medicinal Chemistry, v. 16, n. 7, p. 881-891, 2020. (14/18330-0, 17/09245-7, 14/18577-5, 09/53989-4, 18/15083-2, 16/08084-7, 14/50926-0)

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SOUSA, IRAN DA L.; HEERDT, GABRIEL; XIMENES, VALDECIR F.; DE SOUZA, AGUINALDO R.; MORGON, NELSON H.. TD-DFT Analysis of the Dissymmetry Factor in Camphor. Journal of the Brazilian Chemical Society, v. 31, n. 3, p. 613-618, MAR 2020. (14/50926-0, 16/20549-5, 15/22338-9, 16/04963-6, 19/12294-5)

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BIASETTO, CAROLINA R.; SOMENSI, ANDRESSA; SORDI, RENATA; CHAPLA, VANESSA M.; EBRAHIMI, SAMAD N.; SILVA, GERALDO H.; TELES, HELDER L.; BOLZANI, VANDERLAN DA S.; YOUNG, MARIA CLAUDIA M.; PFENNING, LUDWIG H.; et al. The new koninginins T-U from Phomopsis stipata, an endophytic fungus isolated from Styrax camporum Pohl. PHYTOCHEMISTRY LETTERS, v. 36, p. 106-110, APR 2020. (14/50926-0, 13/07600-3, 03/02176-7)

VALLI, MARILIA; ATANAZIO, LETICIA CRISTINA VIEIRA; MONTEIRO, GUSTAVO CLARO; COELHO, ROBERTA RAMOS; DEMARQUE, DANIEL PECORARO; ANDRICOPULO, ADRIANO DEFINI; ESPINDOLA, LAILA SALMEN; BOLZANI, VANDERLAN DA SILVA. The Potential of Biologically Active Brazilian Plant Species as a Strategy to Search for Molecular Models for Mosquito Control. Planta Medica, v. 87, n. 01/02, p. 6-23, FEB 2021. (14/50926-0, 13/07600-3, 19/05967-3)

SANTOS REGINALDO, FERNANDA PRISCILA; PIRES BUENO, PAULA CAROLINA; DE MATOS COSTA, ISABELLY CRISTINA; ROQUE, ALAN DE ARAUJO; FETT-NETO, ARTHUR GERMANO; CAVALHEIRO, ALBERTO JOSE; GIORDANI, RAQUEL BRANDT. Molecular Networking Discloses the Chemical Diversity of Flavonoids and Selaginellins in Selaginella convoluta. Planta Medica, v. 87, n. 01/02, p. 113-123, FEB 2021. (14/50926-0, 19/08477-7, 17/19702-6)

NUNES, WILHAN DONIZETE GONCALVES; RUSSO, HELENA MANNOCHIO; BOLZANI, VANDERLAN DA SILVA; CAIRES, FLAVIO JUNIOR. Thermal characterization and compounds identification of commercialStevia rebaudianaBertoni sweeteners and thermal degradation products at high temperatures by TG-DSC, IR and LC-MS/MS. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, v. 146, n. 3, p. 1149-1155, NOV 2021. (13/07600-3, 18/24378-6, 16/16970-7, 14/50926-0)

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TORREZAN, GUILHERME SILVA; POLAQUINI, CARLOS ROBERTO; LIMA, MARCELO FREITAS; REGASINI, LUIS OCTAVIO. Use of glycerol, waste glycerol from biodiesel production and other protic solvents in bioactive alpha, beta-unsaturated ketones synthesis. SUSTAINABLE CHEMISTRY AND PHARMACY, v. 16, JUN 2020. (18/15083-2, 09/53989-4, 14/50926-0, 14/18330-0)

REGINALDO, FERNANDA P. SANTOS; FREIRE, RAFAEL; COSTA, ISABELLY C. M.; DA SILVA, IVANICE BEZERRA; ROQUE, ALAN DE ARAUJO; HALLWASS, FERNANDO; CASTRO-GAMBOA, IAN; FETT-NETO, ARTHUR GERMANO; CAVALHEIRO, ALBERTO J.; GIORDANI, RAQUEL B.. NMR-based metabolite profiling of Selaginella convoluta in different hydration states and the unprecedented occurrence of anabasine in lycophytes. PHYTOCHEMISTRY LETTERS, v. 43, p. 75-79, JUN 2021. (14/50926-0)

ASSIRATI, JULIA; RINALDO, DANIEL; RABELO, SARITA CANDIDA; BOLZANI, VANDERLAN DA SILVA; HILDER, EMILY FRANCES; FUNARI, CRISTIANO SOLEO. A green, simplified, and efficient experimental setup for a high-throughput screening of agri-food by-products - From polar to nonpolar metabolites in sugarcane solid residues. Journal of Chromatography A, v. 1634, DEC 20 2020. (18/09886-5, 14/50926-0, 18/01786-1, 17/06216-6, 18/50025-3)

DE TOLEDO, LUCIANI GASPAR; DOS SANTOS RAMOS, MATHEUS APARECIDO; DA SILVA, PATRICIA BENTO; RODERO, CAMILA FERNANDA; GOMES, VERIDIANA DE SA; DA SILVA, ANDERSON NORONHA; PAVAN, FERNANDO ROGERIO; DA SILVA, ISABEL CRISTIANE; ODA, FERNANDO BOMBARDA; FLUMIGNAN, DANILO LUIS; et al. Improved in vitro and in vivo Anti-Candida albicans Activity of Cymbopogon nardus Essential Oil by Its Incorporation into a Microemulsion System. INTERNATIONAL JOURNAL OF NANOMEDICINE, v. 15, p. 10481-10497, 2020. (20/13057-4, 16/08559-5, 14/50926-0, 15/23959-7)

FRANCA, MARIA G. A.; CAVALHEIRO, ALBERTO J.; SILVA, MARIA G. V.. A Comprehensive LC-DAD-QTOF-MS Method for Dereplication of Bioactive Compounds in Senna Extracts. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 31, n. 1, p. 32-39, FEB 2021. (13/07600-3, 14/50926-0)

FERRARI, ANNA BEATRIZ SABINO; MARCHEAFAVE, GUSTAVO GALO; MANNOCHIO-RUSSO, HELENA; BOLZANI, VANDERLAN DA SILVA; ZIED, DIEGO CUNHA; SCARMINIO, IEDA SPACINO; ZERAIK, MARIA LUIZA. Chemical composition and chromatographic fingerprint of three strains of Agaricus subrufescens cultivated with handmade and commercial supplements. Food Chemistry, v. 363, NOV 30 2021. (14/50926-0, 13/07600-3)

DA SILVA, GISELLE LOPES; CAMPIDELI, MARIANA BORDIN; SABINO FERRARI, ANNA BEATRIZ; MANNOCHIO-RUSSO, HELENA; FRAIGE, KARINA; DAMETTO, ALESSANDRA CRISTINA; BOLZANI, VANDERLAN DA SILVA; ZERAIK, MARIA LUIZA. In vitro antiglycation and antioxidant properties of Eugenia pyriformis leaves and fruits. NATURAL PRODUCT RESEARCH, NOV 2021. (13/07600-3, 14/50926-0)

DA SILVA, JAFF RIBEIRO; DE CERQUEIRA E SILVA, MARIANA BARROS; PHILADELPHO, BIANE OLIVEIRA; DE SOUZA, VICTORIA CRUZ; MACHADO DOS SANTOS, JOHNNIE ELTON; CASTILHO, MARCELO SANTOS; FERREIRA, EDERLAN DE SOUZA; CILLI, EDUARDO MAFFUD. PyrGF and GSTLN peptides enhance pravastatin's inhibition of 3-hydroxy-3-methyl-glutaryl coenzyme. FOOD BIOSCIENCE, v. 44, n. B, DEC 2021. (13/07600-3, 14/50926-0)

MAZZEU, BRUNA F.; SOUZA-MOREIRA, TATIANA M.; OLIVEIRA, ANDREW A.; REMLINGER, MELISSA; FELIPPE, LIDIANE G.; VALENTINI, SANDRO R.; GUIDO, RAFAEL V. C.; ZANELLI, CLESLEI F.; FURLAN, MAYSA. The Methionine 549 and Leucine 552 Residues of Friedelin Synthase from Maytenus ilicifolia Are Important for Substrate Binding Specificity. Molecules, v. 26, n. 22, NOV 2021. (13/07600-3, 11/10379-1, 14/25705-0, 14/50926-0)

BIM-JUNIOR, ODAIR; GAGLIERI, CAROLINE; BEDRAN-RUSSO, ANA K.; BUENO-SILVA, BRUNO; BANNACH, GILBERT; FREM, REGINA; XIMENES, VALDECIR FARIAS; LISBOA-FILHO, PAULO N.. MOF-Based Erodible System for On-Demand Release of Bioactive Flavonoid at the Polymer-Tissue Interface. ACS BIOMATERIALS SCIENCE & ENGINEERING, v. 6, n. 8, p. 4539-4550, AUG 2020. (17/08820-8, 14/50926-0, 18/02186-8)

PRINCIPE, SILAS C.; ACOSTA, ANDRE L.; ANDRADE, JOAO E.; LOTUFO, TITO M. C.. Predicted Shifts in the Distributions of Atlantic Reef-Building Corals in the Face of Climate Change. FRONTIERS IN MARINE SCIENCE, v. 8, JUL 19 2021. (17/11948-6, 14/50926-0, 15/17177-6)

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WOLF, VANESSA GONCALVES; BONACORSI, CIBELE; GONCALVES RADDI, MARIA STELLA; DA FONSECA, LUIZ MARCOS; XIMENES, VALDECIR FARIAS. Octyl gallate, a food additive with potential beneficial properties to treat Helicobacter pylori infection. FOOD & FUNCTION, v. 8, n. 7, p. 2500-2511, JUL 1 2017. (14/50926-0, 15/21693-0)

XIMENES, VALDECIR FARIAS; MORGON, NELSON HENRIQUE; DE SOUZA, AGUINALDO ROBINSON. Solvent-dependent inversion of circular dichroism signal in naproxen: An unusual effect!. CHIRALITY, v. 30, n. 9, p. 1049-1053, SEP 2018. (14/50926-0, 15/22338-9, 16/20549-5)

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BERTOZO, LUIZA DE CARVALHO; NETO, ERNESTO TAVARES; DE OLIVEIRA, LEANDRO CRISTANTE; XIMENES, VALDECIR FARIAS. Oxidative Alteration of Trp-214 and Lys-199 in Human Serum Albumin Increases Binding Affinity with Phenylbutazone: A Combined Experimental and Computational Investigation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 19, n. 10, OCT 2018. (14/50926-0, 16/20549-5, 16/22014-1)