INCT 2014: Nanotecnologia Farmacêutica: uma abordagem transdisciplinar

• Processo: 14/50928-2
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Data de Início da vigência: 01 de julho de 2017
• Data de Término da vigência: 31 de dezembro de 2025
• Área do conhecimento: Ciências da Saúde - Farmácia
• Acordo de Cooperação: CNPq - INCTs
• Pesquisador responsável: Maria Vitória Lopes Badra Bentley
• Beneficiário: Maria Vitória Lopes Badra Bentley
• Instituição Sede: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brasil
• Auxílio(s) vinculado(s): 17/17075-4 - INCT 2014 - nanotecnologia farmacêutica: uma abordagem transdisciplinar - Proc. n. 2014/50928-2, NanoSight NS300, AP.EMU; 17/17076-0 - INCT 2014 - nanotecnologia farmacêutica: uma abordagem transdisciplinar - Proc. n. 2014/50928-2, vitrocell system, AP.EMU; 17/17078-3 - INCT 2014 - nanotecnologia farmacêutica: uma abordagem transdisciplinar - Proc. n. 2014/50928-2, microscópio de força atômica, AP.EMU; + mais auxílios vinculados 17/17079-0 - INCT 2014 - nanotecnologia farmacêutica: uma abordagem transdisciplinar - Proc. n. 2014/50928-2, sistema automático testes em células de difusão, AP.EMU; 17/17455-1 - INCT 2014 - nanotecnologia farmacêutica: uma abordagem transdisciplinar - Proc. n. 2014/50928-2, microscópio de fluorescência, AP.EMU; 17/17456-8 - INCT 2014 - Nanotecnologia farmacêutica: uma abordagem transdisciplinar - Proc. n. 2014/50928-2, cromatógrafo líquido de ultra eficiência - UPLC, AP.EMU - menos auxílios vinculados
• Bolsa(s) vinculada(s): 24/05678-0 - Carreador lipídico nanoestruturado para co-entrega de siRNA e berberina na terapia tópica de feridas cutâneas crônicas: desenvolvimento, caracterização físico-química e eficácia in vitro, BP.MS; 24/18425-2 - Sistemas nanoestruturados para liberação de fármacos e genes: obtenção por microfluídica e avaliação por microscopia de força atômica e plataforma organ-on-a-chip, BP.TT; 23/14018-0 - Lipossomas funcionalizados para a otimização de liberação de enzimas na terapia de doenças lisossomais: caracterização por microscopia de força atômica com microfluídica e avaliação em plataforma Organ-on-a-chip, BP.TT; + mais bolsas vinculadas 22/10086-9 - Nanodispersões de fase líquido-cristalina como sistema carreador de mRNA para administração intranasal de vacina gênica, BP.DR; 22/01969-4 - Nanopartículas líquido-cristalinas multifuncionais para co-liberação de siRNAs e piperina no tratamento tópico do vitiligo: desenvolvimento, caracterização e estudos in vitro, BP.DR; 18/23357-5 - Cocristais multicomponentes de Anti-Inflamatórios Não Esteróides (AINEs) e Inibidores de Bomba de Prótons (IBPs): desenvolvimento, caracterização e avaliação biológica in vitro e in vivo, BP.PD; 19/10761-5 - Sistemas multifuncionais destinados à liberação cólon específica do bevacizumabe para o tratamento do Câncer Colorretal, BP.DR; 19/19372-1 - Nanodispersões de fase líquida-cristalina como carreador de piperina para o tratamento tópico do vitiligo: desenvolvimento e avaliação, BP.IC; 18/25377-3 - Avaliação do potencial de nanopartículas de sílica mesoporosas funcionalizadas com cetuximabe para veiculação de docetaxel no tratamento do câncer de próstata., BP.PD; 18/23430-4 - Avaliação do potencial de lipossomas funcionalizados com bevacizumabe ou ácido hialurônico para incorporação de abiraterona no tratamento do câncer de próstata, BP.PD; 18/23442-2 - Avaliação do potencial de lipossomas para co-encapsulação de anfotericina B e micafungina no tratamento de infecção sistêmica causada por Candida auris, BP.PD; 18/08253-9 - Desenvolvimento e caracterização de nanodispersão de fase líquido-cristalina como sistema carreador multifuncional de siRNA TNF-alfa e Triptolida no tratamento tópico da psoríase, BP.MS - menos bolsas vinculadas
• Assunto(s): Biologia Nanotecnologia Fármacos Cosméticos Toxicologia Doenças parasitárias Indústrias Institutos de pesquisa
• Palavra(s)-Chave do Pesquisador: Biologia

Resumo

O INCT NANOFARMA representa uma importante estratégia de associação de competências já consolidadas na área de Nanotecnologia aplicada à medicamentos e cosméticos de grupos de pesquisa de várias universidades do Brasil, os quais atuam no desenvolvimento de projetos ligados à obtenção de nanocarreadores para diversas moléculas com atividade biológica, visando sua aplicação em terapias onde a Nanotecnologia pode agregar valores terapêuticos, avançar no desenvolvimento de técnicas e processos de obtenção, caracterização e avaliação destes produtos, bem como no entendimento dos aspectos químicos e biológicos (estudos mecanísticos de interação destes sistemas com tecidos/células e aspectos toxicológicos) envolvidos na obtenção e uso destes medicamentos. O INCT NANOFARMA, com a proposta de um INCT voltado à Nanotecnologia Farmacêutica no aspecto transdisciplinar da matéria, irá ainda agregar conhecimento técnico e ampliar as possibilidades de inovação das empresas associadas aos Parques Tecnológicos agregados às universidades envolvidas. Ele estará engajado nas propostas da Estratégia Nacional de Ciência, Tecnologia e Inovação, e desenvolverá, de forma articulada e integrada, pesquisa na fronteira do conhecimento, tecnologias para o setor público, atuará junto à sociedade na disseminação do conhecimento e formação de recursos humanos especializados, avançará nos aspectos regulatórios e deficientes da toxicologia e segurança de produtos de base nanotecnológica, viabilizará a geração de produtos inovadores baseados na Nanotecnologia, propiciado maior competitividade em acordos de cooperação nacional e internacional em áreas estratégicas da saúde, e maiores possibilidades de capacitação e fixação de recursos humanos, e finalmente, permitirá A gestão do INCT NANOFARMA será feita através do comitê gestor, o qual é composto por pesquisadores do INCT NANOFARMA abrangendo diferentes universidades e regiões do país, garantido, assim, abrangência institucional e nacional nas principais decisões deste INCT. As pesquisas e projetos vinculados ao INCT NANOFARMA serão desenvolvidos associados às plataformas de pesquisa para compreensão e entendimento dos diferentes aspectos envolvidos na ciência de medicamentos de base nanotecnológica. Os pesquisadores do INCT NANOFARMA através de seus projetos, equipe e laboratórios atuam de forma mais especificas em uma determinada plataforma, mas permeiam outras, mostrando a articulação do grupo nos principais temas de pesquisa da presente proposta. A equipe do INCT NANOFARMA destaca-se na produção científica qualificada nas áreas de abrangência da Nanotecnologia, caracterizando-se por ser uma equipe geradora de conhecimento transdisciplinar nesta área. Conta com profissionais de diferentes formações, a saber farmacêuticos (na sua maioria), químicos, engenheiros químicos e de produção, biólogos, físicos, biomédicos, etc. Sua produção científica resulta na publicação de cerca de 1213 trabalhos científicos em periódicos indexados nos últimos 05 anos. Os pesquisadores envolvidos apresentam Fator H relevantes considerando a área de atuação de pesquisa aplicada: cerca de 60% apresentam FH (ISI) entre 13 e 25 e 13% FH maiores ou igual a 20. Não se considera nesta abordagem os FH dos pesquisadores estrangeiros os quais chegam ao número de 166, evidenciando a excelência dos colaboradores estrangeiros que estão apoiando e está proposta. A formação de recursos humanos também é um destaque, com orientações concluídas de 787 alunos de iniciação científica, 586 de mestrado, 299 de doutorado e 88 pós-doutorados. Em andamento, os membros do INCT NANOFARMA estão contribuindo para a formação de 72 alunos de iniciação científica, 97 de mestrado, 151 de doutorado e 37 pesquisadores em pós-doutoramento. A qualidade dos trabalhos orientados é refletida por um fato de extrema relevância. A equipe do INCT NANOFARMA orientou 06 teses de doutorado que foram premiadas no Prêmio CAPES de Tese da área da Farmácia (05) e da área de Biotecnologia (01), destacando-se que de oito edições da área da Farmácia 05 premiações são de pesquisadores do INCT NANOFARMA. Com relação à contribuição tecnológica os membros do INCT NANOFARMA são inventores em 171 patentes junto ao INPI, sendo várias delas também depositada no exterior e já comercializadas pelo setor privado (Figura 3). As perspectivas de impacto para o projeto abrangem não apenas os aspectos técnicos/tecnológicos e científicos, mas também cultural, econômico, ambiental, com foco na formação de pessoas qualificadas em todos os níveis para compreender, analisar, interpretar, utilizar, desenvolver, pesquisar, produzir e controlar produtos farmacêuticos que utilizem nanotecnologias. O desenvolvimento do projeto refletirá em impacto científico e tecnológico para as instituições de pesquisa e pesquisadores envolvidos, ampliando laços de multidisciplinaridade e produtividade, levando ao fortalecimento de colaborações e ao intercâmbio de ideias. Este impacto será evidenciado em publicações voltadas à disseminação do conhecimento. Impactos econômicos são evidentes para o setor industrial a partir da aplicação da nanotecnologia. Além da pesquisa na fronteira do conhecimento e do potencial do de desenvolver produtos altamente inovadores e de alto valor agregado para o setor industrial, este Instituto poderá contribuir para o desenvolvimento de capacitação e inovação de interesse para o país para resolver problemas antigos de saúde pública, como as doenças parasitárias de grande impacto populacional sem resolução, utilizando-se a sua capacidade científica e tecnológica instalada nas universidades. O Instituto tem patentes depositadas (fase de PCT) envolvendo formulações nanoestruturadas que poderão ter a tecnologia repassada para indústrias do setor público ou privado. (AU)

Publicações científicas

(190)

(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)

VIEGAS, JULIANA SANTOS ROSA; PRACA, FABIOLA GARCIA; KRAVICZ, MARCELO; BENTLEY, MARIA VITORIA LOPES BADRA. Therapeutic applications and delivery systems for triptolide. DRUG DELIVERY AND TRANSLATIONAL RESEARCH, v. 10, n. 6, SI, AUG 2020. (14/50928-2, 19/04448-2)

VON ZUBEN, ELIETE DE SOUZA; ELOY, JOSIMAR OLIVEIRA; SOUSA ARAUJO, VICTOR HUGO; DAFLON GREMIAO, MARIA PALMIRA; CHORILLI, MARLUS. nsulin-loaded liposomes functionalized with cell-penetrating peptides: influence on drug release and permeation through porcine nasal mucos. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 622, AUG 5 2021. (14/50928-2)

MARENA, GABRIEL DAVI; RAMOS, MATHEUS APARECIDO DOS SANTOS; BAUAB, TAIS MARIA; CHORILLI, MARLUS. A Critical Review of Analytical Methods for Quantification of Amphotericin B in Biological Samples and Pharmaceutical Formulations. CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY, SEP 2020. (14/50928-2, 18/23442-2)

NEVES BORGHETI-CARDOSO, LIVIA; ROSA VIEGAS, JULIANA SANTOS; PUPO SILVESTRINI, ANA VITORIA; CARON, ANGELO LUIS; PRACA, FABIOLA GARCIA; KRAVICZ, MARCELO; LOPES BADRA BENTLEY, MARIA VITORIA. Nanotechnology approaches in the current therapy of skin cancer. Advanced Drug Delivery Reviews, v. 153, n. SI, p. 109-136, JAN 1 2020. (14/50928-2, 19/04448-2)

PORTAPILLA, GISELE BULHOES; PEREIRA, LUIZ MIGUEL; BRONZON DA COSTA, CASSIA MARIANA; PROVIDELLO, MAIARA VOLTARELLI; SAMPAIO OLIVEIRA, PEDRO ALEXANDRE; GOULART, AMANDA; ANCHIETA, NAIRA FERREIRA; WAINWRIGHT, MARK; LEITE BRAGA, GILBERTO UBIDA; DE ALBUQUERQUE, SERGIO. Phenothiazinium Dyes Are Active against Trypanosoma cruzi In Vitro. BIOMED RESEARCH INTERNATIONAL, 2019. (14/50928-2)

GAZZI, R. P.; FRANK, L. A.; ONZI, G.; POHLMANN, A. R.; GUTERRES, SILVIA S.. New pectin-based hydrogel containing imiquimod-loaded polymeric nanocapsules for melanoma treatment. DRUG DELIVERY AND TRANSLATIONAL RESEARCH, v. 10, n. 6, SI, JUN 2020. (14/50928-2)

FERREIRA, NATALIA N.; GRANJA, SARA; BONI, I, FERNANDA; PREZOTTI, FABIOLA G.; FERREIRA, LEONARDO M. B.; CURY, BEATRIZ S. F.; REIS, RUI M.; BALTAZAR, FATIMA; GREMIAO, MARIA PALMIRA D.. Modulating chitosan-PLGA nanoparticle properties to design a co-delivery platform for glioblastoma therapy intended for nose-to-brain route. DRUG DELIVERY AND TRANSLATIONAL RESEARCH, v. 10, n. 6, SI, JUL 2020. (14/50928-2)

FLAVIA RODRIGUES DA SILVA; MAYARA RODRIGUES BRANDÃO DE PAIVA; LAYS FERNANDA NUNES DOURADO; RUMMENIGGE OLIVEIRA SILVA; CAROLINA NUNES DA SILVA; BRUNA LOPES DA COSTA; CIBELE RODRIGUES TOLEDO; MARIA ELENA DE LIMA; ARMANDO DA SILVA-CUNHA. Intravitreal injection of the synthetic peptide LyeTx I b, derived from a spider toxin, into the rabbit eye is safe and prevents neovascularization in a chorioallantoic membrane model. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, 2018-12-17. (14/50928-2)

ALEXSANDRA CONCEIÇÃO APOLINÁRIO; GIOVANNA CASSONE SALATA; ARTHUR F. R. BIANCO; CLAUDIO FUKUMORI; LUCIANA BIAGINI LOPES. ABRINDO A CAIXA DE PANDORA DOS NANOMEDICAMENTOS: HÁ REALMENTE MUITO MAIS ‘ESPAÇO LÁ EMBAIXO’. Química Nova, v. 43, n. 2, p. 212-225, 2020-05-18. (17/23213-0, 14/50928-2, 18/14375-0, 18/13877-1)

PREZOTTI, FABIOLA GARAVELLO; SIEDLE, IZABEL; BONI, FERNANDA ISADORA; CHORILLI, MARLUS; MUELLER, INGRID; FERREIRA CURY, BEATRIZ STRINGHETTI. Mucoadhesive films based on gellan gum/pectin blends as potential platform for buccal drug delivery. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, v. 25, n. 2, p. 159-167, FEB 7 2020. (11/16847-7, 14/50928-2)

AIRES-FERNANDES, MARIZA; ELOY, JOSIMAR O.; VICTORELLI, FRANCESCA DAMIANI; FERREIRA, PAULA SCANAVEZ; PIRONI, ANDRESSA MARIA; CHORILLI, MARLUS. Reversed-phase high-performance liquid chromatography: A fast and efficient analytical method to quantify docetaxel-loaded pegylated liposomes in release study. JOURNAL OF SEPARATION SCIENCE, v. 44, n. 21, SEP 2021. (18/26422-2, 17/25190-8, 14/50928-2)

DE OLIVEIRA CARDOSO, VALERIA MARIA; PEREIRA DE BRITO, NATALIA ARAUJO; FERREIRA, NATALIA NORONHA; BONI, FERNANDA ISADORA; BARBOZA FERREIRA, LEONARDO MIZIARA; CARVALHO, SUZANA GONCALVES; DAFLON GREMIAO, MARIA PALMIRA. Design of mucoadhesive gellan gum and chitosan nanoparticles intended for colon-specific delivery of peptide drugs. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 628, NOV 5 2021. (14/50928-2, 16/09671-3, 15/21412-0, 18/04546-1)

CE, RODRIGO; COUTO, GABRIELA KLEIN; PACHECO, BARBARA ZOCHE; DALLEMOLE, DANIELI ROSANE; PASCHOAL, JULIA DAME; PACHECO, BRUNA SILVEIRA; GUTERRES, SILVIA STANISCUASKI; SEIXAS, FABIANA; COLLARES, TIAGO; POHLMANN, ADRIANA RAFFIN. Folic acid-doxorubicin polymeric nanocapsules: A promising formulation for the treatment of triple-negative breast cancer. European Journal of Pharmaceutical Sciences, v. 165, OCT 1 2021. (14/50928-2)

ROSA, JULIANA; SUZUKI, ISABELLA; KRAVICZ, MARCELO; CARON, ANGELO; PUPO, ANA VITORIA; GARCIA PRACA, FABIOLA; LOPES BADRA BENTLEY, MARIA VITORIA. Current Non-viral siRNA Delivery Systems as a Promising Treatment of Skin Diseases. CURRENT PHARMACEUTICAL DESIGN, v. 24, n. 23, p. 2644-2663, 2018. (14/50928-2)

SALATA, GIOVANNA CASSONE; MALAGO, ISABELLA D.; CARVALHO DARTORA, VANESSA F. M.; MARCAL PESSOA, ANA FLAVIA; DE ABREU FANTINI, MARCIA CARVALHO; COSTA, SORAIA K. P.; MACHADO-NETO, JOAO AGOSTINHO; LOPES, LUCIANA B.. Microemulsion for Prolonged Release of Fenretinide in the Mammary Tissue and Prevention of Breast Cancer Development. MOLECULAR PHARMACEUTICS, v. 18, n. 9, p. 3401-3417, SEP 6 2021. (14/50928-2, 19/23864-7, 16/06146-5, 08/52084-5, 17/23213-0, 18/13877-1)

MENEGUIN, ANDREIA BAGLIOTTI; SABIO, RAFAEL MIGUEL; DE SOUZA, MAURICIO PALMEIRA CHAVES; FERNANDES, RICHARD PEROSA; DE OLIVEIRA, ANSELMO GOMES; CHORILLI, MARLUS. Cellulose Nanofibers Improve the Performance of Retrograded Starch/Pectin Microparticles for Colon-Specific Delivery of 5-ASA. PHARMACEUTICS, v. 13, n. 9, SEP 2021. (19/19817-3, 14/50928-2)

MIRANDA, M. A.; SILVA, L. B.; CARVALHO, I. P. S.; AMARAL, R.; DE PAULA, M. H.; SWIECH, K.; BASTOS, J. K.; PASCHOAL, J. A. R.; EMERY, F. S.; DOS REIS, R. B.; et al. Targeted uptake of folic acid-functionalized polymeric nanoparticles loading glycoalkaloidic extract in vitro and in vivo assays. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 192, AUG 2020. (14/50928-2, 12/50762-1)

DOS SANTOS, ALINE MARTINS; CARVALHO, SUZANA GONCALVES; BARBOZA FERREIRA, LEONARDO MIZIARA; CHORILLI, MARLUS; DAFLON GREMIAO, MARIA PALMIRA. Understanding the role of electrostatic interactions on the association of 5-fluorouracil to chitosan-TPP nanoparticles. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 640, p. 8-pg., 2022-05-05. (14/50928-2, 16/01464-9)

DOS SANTOS, ALINE MARTINS; MENEGUIN, ANDREIA BAGLIOTTI; AKHTER, DEWAN TASLIMA; FLETCHER, NICHOLAS; HOUSTON, ZACHARY H.; BELL, CRAIG; THURECHT, KRISTOFER J.; GREMIA, MARIA PALMIRA DAFLON. Understanding the role of colon-specific microparticles based on retrograded starch/pectin in the delivery of chitosan nanoparticles along the gastrointestinal tract. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, v. 158, p. 371-378, JAN 2021. (14/50928-2, 17/25846-0, 16/01464-9)

LORENZONI, RICARDO; CONTRI, RENATA VIDOR; FREITAS DE LIMA, CLEVERTON KLEITON; BARRETO, FABIANO; DE ARAUJO, BIBIANA VERLINDO; POHLMANN, ADRIANA RAFFIN; PALHARES DE MIRANDA, ANA LUISA; DALLA COSTA, TERESA; GUTERRES, SILVIA STANISCUASKI. Dermatopharmacokinetic and pharmacodynamic evaluation of a novel nanostructured formulation containing capsaicinoids for treating neuropathic pain. International Journal of Pharmaceutics, v. 596, MAR 1 2021. (14/50928-2)

SALATA, GIOVANNA CASSONE; LOPES, LUCIANA B.. Phosphatidylcholine-Based Nanoemulsions for Paclitaxel and a P-Glycoprotein Inhibitor Delivery and Breast Cancer Intraductal Treatment. PHARMACEUTICALS, v. 15, n. 9, p. 23-pg., 2022-09-01. (18/13877-1, 14/50928-2)

MARENA, GABRIEL DAVI; CARVALHO, GABRIELA CORREA; RAMOS, MATHEUS APARECIDO DOS SANTOS; CHORILLI, MARLUS; BAUAB, TAIS MARIA. Anti-Candida auris activity in vitro and in vivo of micafungin loaded nanoemulsions. Medical Mycology, v. 61, n. 2, p. 11-pg., 2023-02-03. (19/26821-7, 19/09831-9, 14/50928-2, 18/23442-2)

DOS SANTOS, ALINE MARTINS; TAVARES JUNIOR, ALBERTO GOMES; CARVALHO, SUZANA GONCALVES; CHORILLI, MARLUS. An Updated Review on Properties, Nanodelivery Systems, and Analytical Methods for the Determination of 5-Fluorouracil in Pharmaceutical and Biological Samples. CURRENT PHARMACEUTICAL DESIGN, v. 28, n. 18, p. 12-pg., 2022-01-01. (20/06093-4, 14/50928-2)

SCHULTZE, EDUARDA; BUSS, JULIETI; CORADINI, KARINE; BEGNINI, KARINE RECH; GUTERRES, SILVIA S.; COLLARES, TIAGO; RUVER BECK, RUY CARLOS; POHLMANN, ADRIANA R.; SEIXAS, FABIANA KOMMLING. Tretinoin-loaded lipid-core nanocapsules overcome the triple-negative breast cancer cell resistance to tretinoin and show synergistic effect on cytotoxicity induced by doxorubicin and 5-fluororacil. BIOMEDICINE & PHARMACOTHERAPY, v. 96, p. 404-409, DEC 2017. (14/50928-2)

DALLEMOLE, DANIELI ROSANE; TERROSO, THATIANA; ALVES, ALINE DE CRISTO SOARES; SCHOLL, JULIETE NATHALI; ONZI, GIOVANA RAVIZZONI; CE, RODRIGO; PAESE, KARINA; BATTASTINI, ANA MARIA OLIVEIRA; GUTERRES, SILVIA STANISCUASKI; FIGUEIRO, FABRICIO; et al. Nanoformulation Shows Cytotoxicity against Glioblastoma Cell Lines and Antiangiogenic Activity in Chicken Chorioallantoic Membrane. PHARMACEUTICS, v. 13, n. 6, JUN 2021. (14/50928-2)

CARVALHO, GABRIELA CORREA; SABIO, RAFAEL MIGUEL; DE CASSIA RIBEIRO, TAIS; MONTEIRO, ANDREIA SOFIA; PEREIRA, DANIELA VASSALO; RIBEIRO, SIDNEY JOSE LIMA; CHORILLI, MARLUS. Highlights in Mesoporous Silica Nanoparticles as a Multifunctional Controlled Drug Delivery Nanoplatform for Infectious Diseases Treatment. PHARMACEUTICAL RESEARCH, v. 37, n. 10, SEP 7 2020. (14/50928-2)

ZUGLIANELLO, CARINE; CHAMORRO, ANDRES F.; DE OLIVEIRA, VANESSA A.; XAVIER JUNIOR, FRANCISCO H.; LEMOS-SENNA, ELENARA. Dextran Sulfate/Pramlintide Polyelectrolyte Nanoparticles as a Promising Delivery System: Optimization, Evaluation of Supramolecular Interactions and Effect on Conformational Stability of the Peptide Drug. Journal of the Brazilian Chemical Society, v. 32, n. 8, p. 1642-1653, AUG 2021. (14/50928-2)

ALVES, ALINE DE CRISTO SOARES; BRUINSMANN, FRANCIELE ALINE; GUTERRES, SILVIA STANISCUASKI; POHLMANN, ADRIANA RAFFIN. Organic Nanocarriers for Bevacizumab Delivery: An Overview of Development, Characterization and Applications. Molecules, v. 26, n. 14, JUL 2021. (14/50928-2)

TAVARES, R. S. N.; TAO, THI PHUONG; MASCHMEYER, I; MARIA-ENGLER, S. S.; SCHAEFER-KORTING, M.; WINTER, A.; ZOSCHKE, C.; LAUSTER, R.; MARX, U.; GASPAR, L. R.. Toxicity of topically applied drugs beyond skin irritation: Static skin model vs. Two organs-on-a-chip. International Journal of Pharmaceutics, v. 589, NOV 15 2020. (14/50928-2)

FELIPPIM, ELISA C.; MARCATO, PRISCYLA D.; MAIA CAMPOS, PATRICIA MARIA BERARDO GONCALVES. Development of Photoprotective Formulations Containing Nanostructured Lipid Carriers: Sun Protection Factor, Physical-Mechanical and Sensorial Properties. AAPS PHARMSCITECH, v. 21, n. 8, NOV 8 2020. (14/50928-2)

KRAVICZ, MARCELO H.; BALOGH, DEBORA T.; KAR, MRITYUNJOY; WEDEPOHL, STEFANIE; BENTLEY, MARIA VITORIA L. B.; CALDERON, MARCELO. Influence of Alkyl Chains of Modified Polysuccinimide-Based Polycationic Polymers on Polyplex Formation and Transfection. Macromolecular Bioscience, v. 19, n. 10, AUG 2019. (14/50928-2)

MIRANDA, MARIZA A.; MARCATO, PRISCYLA D.; CARVALHO, IVANA P. S.; SILVA, LETICIA B.; RIBEIRO, DIEGO L.; AMARAL, ROBSON; SWIECH, KAMILLA; BASTOS, JAIRO K.; PASCHOAL, JONAS A. R.; DOS REIS, RODOLFO B.; et al. Assessing the cytotoxic potential of glycoalkaloidic extract in nanoparticles against bladder cancer cells. Journal of Pharmacy and Pharmacology, v. 71, n. 10, AUG 2019. (14/50928-2, 15/14665-0)

VERAGTEN, ANNELIEKE; CONTRI, RENATA VIDOR; BETTI, ANDRESA HEEMANN; HERZFELDT, VIVIAN; FRANK, LUIZA ABRAHAO; POHLMANN, ADRIANA RAFFIN; KUZE RATES, STELA MARIS; GUTERRES, SILVIA STANISCUASKI. Chitosan-coated nanocapsules ameliorates the effect of olanzapine in prepulse inhibition of startle response (PPI) in rats following oral administration. REACTIVE & FUNCTIONAL POLYMERS, v. 148, MAR 2020. (14/50928-2)

DA SILVA, CAROLINA NUNES; DA SILVA, FLAVIA RODRIGUES; NUNES DOURADO, LAYS FERNANDA; MENDES DOS REIS, PABLO VICTOR; SILVA, RUMMENIGGE OLIVEIRA; DA COSTA, BRUNA LOPES; NUNES, PAULA SANTOS; AMARAL, FLAVIO ALMEIDA; DOS SANTOS, VERA LUCIA; DE LIMA, MARIA ELENA; et al. A New Topical Eye Drop Containing LyeTxI-b, A Synthetic Peptide Designed from A Lycosa erithrognata Venom Toxin, Was Effective to Treat Resistant Bacterial Keratitis. TOXINS, v. 11, n. 4, APR 2019. (14/50928-2)

PASSOS, JULIA SAPIENZA; DE MARTINO, LUIZA CAPELLO; CARVALHO DARTORA, VANESSA FRANCO; DE ARAUJO, GABRIEL L. B.; ISHIDA, KELLY; LOPES, LUCIANA B.. Development, skin targeting and antifungal efficacy of topical lipid itraconazole. European Journal of Pharmaceutical Sciences, v. 149, JUN 15 2020. (17/04174-4, 14/50928-2, 17/19374-9, 15/07993-0, 18/13877-1, 13/16617-7)

MENEGUIN, ANDREIA BAGLIOTTI; SILVESTRE, AMANDA LETICIA POLLI; SPOSITO, LARISSA; DE SOUZA, MAURICIO PALMEIRA CHAVES; SABIO, RAFAEL MIGUEL; ARAUJO, VICTOR HUGO SOUSA; CURY, BEATRIZ STRINGHETTI FERREIRA; CHORILLI, MARLUS. The role of polysaccharides from natural resources to design oral insulin micro- and nanoparticles intended for the treatment of Diabetes mellitus: A review. Carbohydrate Polymers, v. 256, MAR 15 2021. (19/09597-6, 14/50928-2, 19/19817-3)

DA SILVA, FLAVIA RODRIGUES; SILVA, RUMMENIGGE OLIVEIRA; DE CASTRO OLIVEIRA, HORTENCIA MACIEL; NUNES DOURADO, LAYS FERNANDA; DA COSTA, BRUNA LOPES; LIMA, BRUNO SANTOS; LIMA SANTOS, NAYARA GOMES; PALANCH REPEKE, CARLOS EDUARDO; MENEZES, GUSTAVO BATISTA; DE SOUZA ARAUJO, ADRIANO ANTUNES; et al. Gelatin-based membrane containing usnic acid-loaded liposomes: A new treatment strategy for corneal healing. BIOMEDICINE & PHARMACOTHERAPY, v. 130, OCT 2020. (14/50928-2)

SILVESTRINI, ANA VITORIA PUPO; CARON, ANGELO LUIS; VIEGAS, JULIANA; PRACA, FABIOLA GARCIA; BENTLEY, MARIA VITORIA LOPES BADRA. Advances in lyotropic liquid crystal systems for skin drug delivery. Expert Opinion on Drug Delivery, v. 17, n. 12, p. 1781-1805, DEC 1 2020. (14/50928-2)

SPAGOLLA NAPOLEAO TAVARES, RENATA; STUCHI MARIA-ENGLER, SILVYA; COLEPICOLO, PIO; DEBONSI, HOSANA MARIA; SCHAEFER-KORTING, MONIKA; MARX, UWE; RIGO GASPAR, LORENA; ZOSCHKE, CHRISTIAN. Skin Irritation Testing beyond Tissue Viability: Fucoxanthin Effects on Inflammation, Homeostasis, and Metabolism. PHARMACEUTICS, v. 12, n. 2, FEB 2020. (14/50928-2, 16/06931-4)

DE OLIVEIRA CARDOSO, VALERIA MARIA; DAFLON GREMIAO, MARIA PALMIRA; FERREIRA CURY, BEATRIZ STRINGHETTI. Mucin-polysaccharide interactions: A rheological approach to evaluate the effect of pH on the mucoadhesive properties. International Journal of Biological Macromolecules, v. 149, p. 234-245, APR 15 2020. (17/16324-0, 14/50928-2, 15/21412-0)

LAMAS DE SOUZA, SARAH OLIVEIRA; ANDRADE GUERRA, MARIA CAROLINA; DIAS HENEINE, LUIZ GUILHERME; DE OLIVEIRA, CAROLINA REIS; CUNHA JUNIOR, ARMANDO DA SILVA; FIALHO, SILVIA LIGORIO; OREFICE, RODRIGO LAMBERT. Biodegradable core-shell electrospun nanofibers containing bevacizumab to treat age-related macular degeneration. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, v. 29, n. 11, NOV 2018. (14/50928-2)

DA SILVA, FLAVIA RODRIGUES; BRANDAO DE PAIVA, MAYARA RODRIGUES; NUNES DOURADO, LAYS FERNANDA; SILVA, RUMMENIGGE OLIVEIRA; DA SILVA, CAROLINA NUNES; DA COSTA, BRUNA LOPES; TOLEDO, CIBELE RODRIGUES; DE LIMA, MARIA ELENA; DA SILVA-CUNHA, ARMANDO. Intravitreal injection of the synthetic peptide LyeTx I b, derived from a spider toxin, into the rabbit eye is safe and prevents neovascularization in a chorio-allantoic membrane model. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, NOV 21 2018. (14/50928-2)

CE, RODRIGO; SILVA, RODRIGO CAMPOS; TRENTIN, DANIELLE SILVA; BARRETO DE MARCHI, JOAO GUILHERME; PAESE, KARINA; GUTERRES, SILVIA STANISCUASKI; MACEDO, ALEXANDRE JOSE; POHLMANN, ADRIANA RAFFIN. Galleria mellonella Larvae as an In Vivo Model to Evaluate the Toxicity of Polymeric Nanocapsules. Journal of Nanoscience and Nanotechnology, v. 20, n. 3, p. 1486-1494, MAR 2020. (14/50928-2)

MAGALHAES, MILENA C. R. S.; CASTRO, BRENDA F. M.; DE CASTRO, WHOCELY V.; BARROS, ANDRE L. B.; FERNANDES, RENATA S.; SILVA-CUNHA, ARMANDO; FIALHO, SILVIA L.. Permeability and in vivo distribution of poly(epsilon-caprolactone) nanoparticles loaded with zidovudine. JOURNAL OF NANOPARTICLE RESEARCH, v. 20, n. 7, JUN 27 2018. (14/50928-2)

PIVETTA, THAIS P.; SILVA, LETICIA B.; KAWAKAMI, CAMILA M.; ARAUJO, MARGARETE M.; DEL LAMA, MARIA PERPETUA F. M.; NAAL, ROSE MARY Z. G.; MARIA-ENGLER, SILVYA S.; GASPAR, LORENA R.; MARCATO, PRISCYLA D.. Topical formulation of quercetin encapsulated in natural lipid nanocarriers: Evaluation of biological properties and phototoxic effect. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 53, OCT 2019. (12/50762-1, 16/07596-4, 14/50928-2, 13/24413-2, 08/57805-2)

CE, RODRIGO; LAVAYEN, VLADIMIR; COUTO, GABRIELA KLEIN; DE MARCHI, JOAO GUILHERME BARRETO; PACHECO, BARBARA ZOCHE; NATIVIDADE, LETICIA ANTUNES; FRACARI, TIAGO OST; CIOCHETA, TAIANE MEDEIRO; DE CRISTO SOARES ALVES, ALINE; JORNADA, DENISE SOLEDADE; et al. Folic Acid-Doxorubicin-Double-Functionalized-Lipid-Core Nanocapsules: Synthesis, Chemical Structure Elucidation, and Cytotoxicity Evaluation on Ovarian (OVCAR-3) and Bladder (T24) Cancer Cell Lines. PHARMACEUTICAL RESEARCH, v. 38, n. 2, p. 301-317, FEB 2021. (14/50928-2)

SAITO, MAX S.; ZATTA, KELLY C.; SATHLER, PLINIO C.; FURTADO, PRISCILA S.; MIGUEL, NADIA C. O.; FRATTANI, FLAVIA S.; BERGER, MARKUS; LAVAYEN, VLADIMIR; POHLMANN, ADRIANA R.; GUTERRES, SILVIA S.. Therapeutic implementation in arterial thrombosis with pulmonary administration of fucoidan microparticles containing acetylsalicylic acid. International Journal of Pharmaceutics, v. 622, p. 11-pg., 2022-06-25. (14/50928-2)

MOREIRA CASTRO, BRENDA FERNANDA; FULGENCIO, GUSTAVO DE OLIVEIRA; DOMINGOS, LUISA CANGUSSU; LACERDA COTTA, OLIVER ARAUJO; SILVA-CUNHA, ARMANDO; FIALHO, SILVIA LIGORIO. Positively charged polymeric nanoparticles improve ocular penetration of tacrolimus after topical administration. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 60, DEC 2020. (14/50928-2)

CASARINI, TALITA PIZZA ANUNCIATO; FRANK, LUIZA ABRAHAO; POHLMANN, ADRIANA RAFFIN; GUTERRES, SILVIA STANISCUASKI. Dermatological applications of the flavonoid phloretin. European Journal of Pharmacology, v. 889, DEC 15 2020. (14/50928-2)

REMIAO, MARIANA H.; SEGATTO, NATALIA V.; POHLMANN, ADRIANA; GUTERRES, SILVIA S.; SEIXAS, FABIANA K.; COLLARES, TIAGO. The Potential of Nanotechnology in Medically Assisted Reproduction. FRONTIERS IN PHARMACOLOGY, v. 8, JAN 11 2018. (14/50928-2)

CALGAROTO, SELMA; FAURI, LUCAS E.; FRANK, LUIZA A.; PAESE, KARINA; GUTERRES, SILVIA S.; POHLMANN, ADRIANA R.. Chemical stability, mass loss and hydrolysis mechanism of sterile and non-sterile lipid-core nanocapsules: The influence of the molar mass of the polymer wall. REACTIVE & FUNCTIONAL POLYMERS, v. 133, p. 161-172, DEC 2018. (14/50928-2)

CARVALHO, I. P. S.; MIRANDA, M. A.; SILVA, L. B.; CHRYSOSTOMO-MASSARO, T. N.; PASCHOAL, J. A. R.; BASTOS, J. K.; MARCATO, P. D.. IN VITRO Anticancer Activity and Physicochemical Properties of SOLANUM LYCOCARPUM Alkaloidic Extract Loaded in Natural Lipid-Based Nanoparticles. COLLOID AND INTERFACE SCIENCE COMMUNICATIONS, v. 28, p. 5-14, JAN 2019. (14/50928-2, 12/50762-1, 14/16727-0)

DIAS, MARINA FRANCA; PINHEIRO DE FIGUEIREDO, BRUNA CAROLINE; TEIXEIRA-NETO, JULIA; ANDRADE GUERRA, MARIA CAROLINA; FIALHO, SILVIA LIGORIO; CUNHA, ARMANDO SILVA. In vivo evaluation of antitumoral and antiangiogenic effect of imiquimod-oaded polymeric nanoparticles. BIOMEDICINE & PHARMACOTHERAPY, v. 103, p. 1107-1114, JUL 2018. (14/50928-2)

VICTORELLI, FRANCESCA DAMIANI; FIORAMONTI CALIXTO, GIOVANA MARIA; DOS SANTOS RAMOS, MATHEUS APARECIDO; BAUAB, TAIS MARIA; CHORILLI, MARLUS. Metronidazole-Loaded Polyethyleneimine and Chitosan-Based Liquid Crystalline System for Treatment of Staphylococcal Skin Infections. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, v. 14, n. 1, p. 227-237, JAN 2018. (14/50928-2, 13/01565-1, 17/10016-2)

SALATA, GIOVANNA C.; MALAGO, ISABELLA D.; LOPES, LUCIANA B.. A Lipid-Based In Situ-Forming Hexagonal Phase for Prolonged Retention and Drug Release in the Breast Tissue. AAPS PHARMSCITECH, v. 23, n. 7, p. 14-pg., 2022-09-19. (14/50928-2, 18/13877-1, 19/23864-7)

OGUNJIMI, ABAYOMI TOLULOPE; CHAHUD, FERNANDO; LOPEZ, RENATA F. V.. Isotretinoin-Delonix polymeric nanoparticles: Potentials for skin follicular targeting in acne treatment. International Journal of Pharmaceutics, v. 610, DEC 15 2021. (14/22451-7, 14/50928-2)

MARENA, GABRIEL DAVI; RAMOS, MATHEUS APARECIDO DOS SANTOS; BAUAB, TAIS MARIA; CHORILLI, MARLUS. A Critical Review of Analytical Methods for Quantification of Amphotericin B in Biological Samples and Pharmaceutical Formulations. CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY, v. 52, n. 3, p. 22-pg., 2020-09-01. (14/50928-2, 18/23442-2)

VIEGAS, JULIANA SANTOS ROSA; BENTLEY, MARIA VITORIA LOPES BADRA; VICENTINI, FABIANA TESTA MOURA DE CARVALHO. Challenges to perform an efficiently gene therapy adopting non-viral vectors: Melanoma landscape. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 78, p. 18-pg., 2022-11-14. (14/50928-2, 19/04448-2, 19/08891-8)

ZUGLIANELLO, CARINE; FRANCA, ANGELA P.; DE SOUZA, BRUNA S.; AGNES, JONATHAN P.; PREDIGER, RUI D.; LEMOS-SENNA, ELENARA. Intranasal administration of dextran-pramlintide polyelectrolyte complex-coated nanoemulsions improves cognitive impairments in a mouse model of Alzheimer's disease. International Journal of Biological Macromolecules, v. 281, p. 9-pg., 2024-10-11. (14/50928-2)

MORENO, ANA PAULA DIAS; MARCATO, PRISCYLA DANIELY; SILVA, LETICIA BUENO; DE SOUZA SALVADOR, SERGIO LUIZ; DEL ARCO, MARINA CONSTANTE GABRIEL; DE MORAES, JULIANA CRISTINA BIAZZOTO; DA SILVA, ROBERTO SANTANA; DE ROSSI, ANDIARA. Antibacterial Activity of Epigallocatechin-3-gallate (EGCG) Loaded Lipid-chitosan Hybrid Nanoparticle against Planktonic Microorganisms. JOURNAL OF OLEO SCIENCE, v. 73, n. 5, p. 8-pg., 2024-05-01. (14/50928-2, 18/13465-5)

MOJEIKO, GABRIELA; APOLINARIO, ALEXSANDRA CONCEICA; SALATA, GIOVANNA CASSONE; CHORILLI, MARLUS; LOPES, LUCIANA B.. Optimization of nanoemulsified systems containing lamellar phases for co-delivery of celecoxib and endoxifen to the skin aiming for breast cancer chemoprevention and treatment. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 646, p. 14-pg., 2022-08-05. (19/26048-6, 18/14375-0, 19/00196-9, 18/13877-1, 14/50928-2)

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FERREIRA, NATALIA N.; BONI, FERNANDA, I; BALTAZAR, FATIMA; GREMIAO, MARIA P. D.. Validation of an innovative analytical method for simultaneous quantification of alpha-cyano-4-hydroxycinnamic acid and the monoclonal antibody cetuximab using HPLC from PLGA-based nanoparticles. Journal of Pharmaceutical and Biomedical Analysis, v. 190, p. 10-pg., 2020-10-25. (14/50928-2, 16/09671-3)

DARTORA, VANESSA F. C.; SALATA, GIOVANNA C.; PASSOS, JULIA S.; BRANCO, PAOLA C.; SILVEIRA, EDILBERTO; STEINER, ALEXANDRE A.; V. COSTA-LOTUFO, LETICIA; LOPES, LUCIANA B.. Hyaluronic acid nanoemulsions improve piplartine cytotoxicity in 2D and 3D breast cancer models and reduce tumor development after intraductal administration. International Journal of Biological Macromolecules, v. 219, p. 12-pg., 2022-08-05. (14/50928-2, 18/17679-0, 18/03418-0, 20/01208-8, 17/04174-4, 15/17177-6)

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DE SOUZA, IZADORA; GRIMMELPREZ, GABRIELLA C. P.; YAMAGUCHI, KLENICY K. L.; SCHLEUSENER, JOHANNES; LOHAN, SILKE B.; MEINKE, MARTINA C.; GASPAR, LORENA R.. Evaluation of Residues of Amazonian Fruit Piquia (Caryocar villosum) as Sustainable Ingredient for Sunscreen and Cosmetic Formulations. ANTIOXIDANTS, v. 14, n. 2, p. 22-pg., 2025-02-01. (14/50928-2)

OLIVEIRA, ANA MARIA SANTOS; SANTOS, ANAMARIA MENDONCA; NASCIMENTO JR, JOSE ADAO CARVALHO; SANTANA JR, CLAUDIO CARVALHO; BRITO, JOAO RAFAEL LISBOA REGO; DOS SANTOS, JUSSARA SECUNDO; SHANMUGAM, SARAVANAN; MENEZES, PAULA DOS PASSOS; FRANK, LUIZA ABRAHAO; SERAFINI, MAIRIM RUSSO. Pharmaceutical technological trends containing flavonoids: a patent review. Future Medicinal Chemistry, v. 17, n. 3, p. 17-pg., 2025-01-23. (14/50928-2)

MORAES, VITOR TASSARA; CAIRES, FRANCO JAZON; DA SILVA-NETO, PEDRO V.; MENDONCA, JACQUELINE NAKAU; FRAGA-SILVA, THAIS F. C.; FONTANEZI, BIANCA BUENO; MARCATO, PRISCYLA DANIELY; DEPERON BONATO, VANIA LUIZA; SORGI, CARLOS ARTERIO; BERALDO MORAES, LUIZ ALBERTO; et al. Naphthoquinone derivatives as potential immunomodulators: prospective for COVID-19 treatment. RSC ADVANCES, v. 14, n. 10, p. 10-pg., 2024-02-21. (22/05327-7, 22/16916-3, 14/50928-2, 21/13532-7)

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CARVALHO, SUZANA; SILVEIRA, MARIA JOSE; DOMINGUES, MARIANA; FERREIRA, BARBARA; PEREIRA, CATARINA LEITE; GREMIAO, MARIA PALMIRA; SARMENTO, BRUNO. Multicellular Quadruple Colorectal Cancer Spheroids as an In Vitro Tool for Antiangiogenic Potential Evaluation of Nanoparticles. ADVANCED THERAPEUTICS, v. N/A, p. 11-pg., 2023-01-22. (14/50928-2, 19/10761-5, 21/08699-0)

GUERRA, MARIA CAROLINA ANDRADE; TEIXEIRA NETO, JULIA; GOMES, MICHELE GOUVEA; DOURADO, LAYS FERNANDA NUNES; OREFICE, RODRIGO LAMBERT; HENEINE, LUIZ GUILHERME DIAS; SILVA-CUNHA, ARMANDO; FIALHO, SILVIA LIGORIO. Nanofiber-coated implants: Development and safety after intravitreal application in rabbits. International Journal of Pharmaceutics, v. 636, p. 12-pg., 2023-03-13. (14/50928-2)

PEREIRA OLIVEIRA, CYNTHIA NARA; NANI LEITE, MARCEL; DE PAULA, NATALIA APARECIDA; ARAUJO MARTINS, YUGO; FIGUEIREDO, SONIA APARECIDA; CIPRIANI FRADE, MARCO ANDREY; LOPEZ, RENATA FONSECA VIANNA. Nanoemulsions Based on Sunflower and Rosehip Oils: The Impact of Natural and Synthetic Stabilizers on Skin Penetration and an Ex Vivo Wound Healing Model. PHARMACEUTICS, v. 15, n. 3, p. 24-pg., 2023-03-01. (14/22451-7, 16/16437-7, 14/50928-2)

POLITI, FLAVIO AUGUSTO SANCHES; CARVALHO, SUZANA GONCALVES; RODERO, CAMILA FERNANDA; DOS SANTOS, KAIO PINI; MENEGUIN, ANDREIA BAGLIOTTI; SORRECHIA, RODRIGO; CHIAVACCI, LEILA APARECIDA; CHORILLI, MARLUS. Piperine-loaded nanoparticles incorporated into hyaluronic acid/sodium alginate-based membranes for the treatment of inflammatory skin diseases. International Journal of Biological Macromolecules, v. 227, p. 13-pg., 2023-02-01. (19/10761-5, 14/50928-2)

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DE PAULA, MARIANA CARLOMAGNO; CARVALHO, SUZANA GONCALVES; SILVESTRE, AMANDA LETICIA POLLI; DOS SANTOS, ALINE MARTINS; MENEGUIN, ANDREIA BAGLIOTTI; CHORILLI, MARLUS. The role of hyaluronic acid in the design and functionalization of nanoparticles for the treatment of colorectal cancer. Carbohydrate Polymers, v. 320, p. 19-pg., 2023-11-15. (20/06093-4, 14/50928-2)

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MARENA, GABRIEL DAVI; RAMOS, MATHEUS APARECIDO DOS SANTOS; CARVALHO, GABRIELA CORREA; PARIS JUNIOR, JOSE ALBERTO; RESENDE, FLAVIA APARECIDA; CORREA, IONE; ONO, GABRIELA YUKI BRESSANIM; SOUSA ARAUJO, VICTOR HUGO; DE CAMARGO, BRUNA ALMEIDA FURQUIM; BAUAB, TAIS MARIA; et al. Natural product-based nanomedicine applied to fungal infection treatment: A review of the last 4 years. Phytotherapy Research, v. 36, n. 7, p. 36-pg., 2022-05-29. (18/23442-2, 14/50928-2, 19/09831-9)

AMARAL, VENANCIO A.; DE SOUZA, JULIANA FERREIRA; ALVES, THAIS F. R.; DE OLIVEIRA JUNIOR, JOSE M.; SEVERINO, PATRICIA; ARANHA, NORBERTO; SOUTO, ELIANA B.; CHAUD, MARCO V.. Psidium guajava L. phenolic compound-reinforced lamellar scaffold for tracheal tissue engineering. DRUG DELIVERY AND TRANSLATIONAL RESEARCH, v. N/A, p. 18-pg., 2023-08-11. (14/50928-2)

SATO, MARIANA RILLO; OSHIRO-JUNIOR, JOAO AUGUSTO; RODERO, CAMILA FERNANDA; BONI, FERNANDA ISADORA; ARAUJO, VICTOR HUGO SOUSA; BAUAB, TAIS MARIA; NICHOLAS, DEAN; CALLAN, JOHN FRANCIS; CHORILLI, MARLUS. Enhancing Antifungal Treatment of Candida albicans with Hypericin-Loaded Nanostructured Lipid Carriers in Hydrogels: Characterization, In Vitro, and In Vivo Photodynamic Evaluation. PHARMACEUTICALS, v. 16, n. 8, p. 12-pg., 2023-08-01. (18/17573-7, 16/11198-4, 14/50928-2, 19/10261-2, 19/17913-5)

JUSTINO, ISABELA ARAUJO; FURLAN, JOAO PEDRO RUEDA; FERREIRA, IASMIN ROSANE SILVA; MARINCEK, ANDREIA; ALDANA-MEJIA, JENNYFER A.; TUCCI, LUIZ FERNANDO FORTUNATO; BASTOS, JAIRO KENUPP; STEHLING, ELIANA GUEDES; MARZOCCHI-MACHADO, CLENI M.; MARCATO, PRISCYLA DANIELY. Antimicrobial, Antioxidant, and Anticancer Effects of Nanoencapsulated Brazilian Red Propolis Extract: Applications in Cancer Therapy. PROCESSES, v. 12, n. 12, p. 26-pg., 2024-12-01. (17/04138-8, 18/13465-5, 14/50928-2, 21/01655-7)

GOMES, G. S.; BENIN, T.; FERREIRA, E. C. J.; PALMA, V. M.; ALVES, A. C. S.; VISIOLI, F.; LONGHI, M. S.; POHLMANN, A. R.; GUTERRES, S. S.; FRANK, L. A.. Pectin-based hydrogel loaded with polymeric nanocapsules for the cutaneous delivery of tacrolimus: A targeted approach for the treatment of psoriasis. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 99, p. 13-pg., 2024-07-24. (14/50928-2)

ORTIZ, MANOEL; COUTINHO, DIEGO DE SA; CIAMBARELLA, BIANCA TORRES; DE SOUZA, EVERTON TENORIO; LEITE D'ALMEIDA, ANA PAULA; DURLI, TAIS LUSA; RODRIGUES E SILVA, PATRICIA MACHADO; BERNARDI, ANDRESSA; SONVICO, FABIO; POHLMANN, ADRIANA RAFFIN; et al. Intranasal administration of budesonide-loaded nanocapsule microagglomerates as an innovative strategy for asthma treatment. DRUG DELIVERY AND TRANSLATIONAL RESEARCH, v. 10, n. 6, p. 16-pg., 2020-08-12. (14/50928-2)

MILANESI, LAURA HAUTRIVE; ROSSATO, DOMENIKA RUBERT; OLIVEIRA ROSA, JESSICA LEANDRA; D'AVILA, LIVIA FERRAZ; METZ, VINICIA GARZELLA; RAMPELOTTO, CAMILA RECK; PEREIRA, VIVIANE GONCALVES; SCHAFFAZICK, SCHEILA REZENDE; DE BONA DA SILVA, CRISTIANE; BURGER, MARILISE E.. Ferulic acid-loaded nanostructure prevents morphine reinstatement: the involvement of dopamine system, NRF2, and Delta FosB in the striatum brain area of rats. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, v. 396, n. 7, p. 11-pg., 2023-02-15. (14/50928-2)

DOS SANTOS, NATALIA CRISTINE DIAS; BRUZADELLE-VIEIRA, PAULA; NORONHA, NADIA DE CASSIA; MIZUKAMI-MARTINS, AMANDA; ORELLANA, MARISTELA DELGADO; BENTLEY, MARIA VITORIA L. B.; COVAS, DIMAS TADEU; SWIECH, KAMILLA; MALMEGRIM, KELEN CRISTINA RIBEIRO. Transitioning from static to suspension culture system for large-scale production of xeno-free extracellular vesicles derived from mesenchymal stromal cells. BIOTECHNOLOGY PROGRESS, v. 40, n. 3, p. 13-pg., 2024-01-21. (13/08135-2, 14/50928-2, 18/06994-1)

NHANI, GABRIELA BRAGA BARROS; DI FILIPPO, LEONARDO DELELLO; DE PAULA, GEANNE APARECIDA; MANTOVANELLI, VITORIA RIBEIRO; DA FONSECA, PATRICIA PEREIRA; TASHIRO, FELIPE MOTA; MONTEIRO, DIANA COELHO; FONSECA-SANTOS, BRUNO; DUARTE, JONATAS L.; CHORILLI, MARLUS. High-Tech Sustainable Beauty: Exploring Nanotechnology for the Development of Cosmetics Using Plant and Animal By-Products. COSMETICS, v. 11, n. 4, p. 29-pg., 2024-08-01. (14/50928-2, 12/19568-4, 14/24180-0)

MEDEIROS, LEONARDO; DOS SANTOS, ROGERIO F.; NERVIS, BRENDA DA ROLT; JACOBI, MARLY; HASHIZUME, LINA NAOMI; GAZZI, RAFAELA P.; VISIOLI, FERNANDA; NUNES, JULIA SILVEIRA; LAVAYEN, VLADIMIR; DE FRANCO, VINICIUS C.; et al. Synthesis of films based on chitosan and protic ionic liquids to be used as wound dressing on the oral mucosa. International Journal of Biological Macromolecules, v. 253, p. 12-pg., 2023-10-14. (14/50928-2)

GUNDEL, SAMANTA DA SILVA; DALLEMOLE, DANIELI ROSANE; ALVES, ALINE DE CRISTO SOARES; DA ROSA, SOLON ANDRADES; OLIVEIRA, FERNANDA DITTRICH PINTO; OURIQUE, ALINE FERREIRA; LENZ, GUIDO; GUTERRES, SILVIA STANISCUASKI; POHLMANN, ADRIANA RAFFIN. Nanoencapsulation of etoposide promotes increased long-term DNA damage, greater induction of senescence and reduces population regrowth of lung cancer cells. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 100, p. 12-pg., 2024-08-24. (14/50928-2)

BALIAN, GIOVANA MARIA FIORAMONTI CALIXTO; LUIZ, MARCELA TAVARES; DI FILIPPO, LEONARDO DELELLO; CHORILLI, MARLUS. Mucoadhesive liquid crystal precursor system for photodynamic therapy of oral cancer mediated by methylene blue. Photodiagnosis and Photodynamic Therapy, v. 44, p. 8-pg., 2023-10-03. (13/01565-1, 14/50928-2, 16/06337-5, 21/04007-6, 19/07245-5)

LUCAS, CAROLINE G.; REMIAO, MARIANA H.; BRUINSMANN, FRANCIELE A.; LOPES, ISADORA A. R.; BORGES, MORGANA A.; FEIJO, ANA LAURA S.; BASSO, ANDREA CRISTINA; POHLMANN, ADRIANA R.; GUTERRES, SILVIA S.; CAMPOS, VINICIUS F.; et al. High doses of lipid-core nanocapsules do not affect bovine embryonic development &ITin vitro&IT. TOXICOLOGY IN VITRO, v. 45, n. 1, p. 194-201, DEC 2017. (14/50928-2)

CAMPOS, PATRICIA MAZUREKI; PRACA, FABIOLA GARCIA; MUSSI, SAMUEL VIDAL; FIGUEIREDO, SONIA APARECIDA; FANTINI, MARCIA CARVALHO DE ABREU; FONSECA, MARIA JOSE VIEIRA; TORCHILIN, VLADIMIR P.; BENTLEY, MARIA VITORIA LOPES BADRA. Liquid crystalline nanodispersion functionalized with cell-penetrating peptides improves skin penetration and anti-inflammatory effect of lipoic acid after in vivo skin exposure to UVB radiation. DRUG DELIVERY AND TRANSLATIONAL RESEARCH, v. 10, n. 6, SI, AUG 2020. (14/50928-2)

ORTIZ, MANOEL; COUTINHO, DIEGO DE SA; CIAMBARELLA, BIANCA TORRES; DE SOUZA, EVERTON TENORIO; LEITE D'ALMEIDA, ANA PAULA; DURLI, TAIS LUSA; RODRIGUES E SILVA, PATRICIA MACHADO; BERNARDI, ANDRESSA; SONVICO, FABIO; POHLMANN, ADRIANA RAFFIN; et al. Intranasal administration of budesonide-loaded nanocapsule microagglomerates as an innovative strategy for asthma treatment. DRUG DELIVERY AND TRANSLATIONAL RESEARCH, v. 10, n. 6, SI, AUG 2020. (14/50928-2)

VICTORELLI, FRANCESCA DAMIANI; DE OLIVEIRA CARDOSO, VALERIA MARIA; FERREIRA, NATALIA NORONHA; FIORAMONTI CALIXTO, GIOVANA MARIA; FONTANA, CARLA RAQUEL; BALTAZAR, FATIMA; DAFLON GREMIAO, MARIA PALMIRA; CHORILLI, MARLUS. Chick embryo chorioallantoic membrane as a suitable in vivo model to evaluate drug delivery systems for cancer treatment: A review. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, v. 153, p. 273-284, AUG 2020. (14/50928-2, 19/07245-5, 18/04546-1, 13/01565-1, 16/09671-3, 15/21412-0, 16/06337-5, 17/10016-2, 17/23357-2)

VIEGAS, JULIANA SANTOS ROSA; PRACA, FABIOLA GARCIA; CARON, ANGELO LUIS; SUZUKI, ISABELLA; SILVESTRINI, ANA VITORIA PUPO; MEDINA, WANESSA SILVA GARCIA; DEL CIAMPO, JOSE ORESTES; KRAVICZ, MARCELO; BENTLEY, MARIA VITORIA LOPES BADRA. Nanostructured lipid carrier co-delivering tacrolimus and TNF-alpha siRNA as an innovate approach to psoriasis. DRUG DELIVERY AND TRANSLATIONAL RESEARCH, v. 10, n. 3, SI, FEB 2020. (14/50928-2)

ANTONOW, MICHELLI B.; FRANCO, CAMILA; PRADO, WILLIAN; BECKENKAMP, ALINE; SILVEIRA, GUSTAVO P.; BUFFON, ANDREIA; GUTERRES, SILVIA S.; POHLMANN, ADRIANA R.. Arginylglycylaspartic Acid-Surface-Functionalized Doxorubicin-Loaded Lipid-Core Nanocapsules as a Strategy to Target Alpha(V) Beta(3) Integrin Expressed on Tumor Cells. NANOMATERIALS, v. 8, n. 1, JAN 2018. (14/50928-2)

POUND-LANA, GWENAELLE E. N.; GARCIA, GIANI M.; TRINDADE, IZABEL C.; CAPELARI-OLIVEIRA, PATRICIA; PONTIFICE, THAIS GODINHO; VILELA, JOSE MARIO C.; ANDRADE, MARGARETH S.; NOTTELET, BENJAMIN; POSTACCHINI, BRUNA B.; MOSQUEIRA, VANESSA C. F.. Phthalocyanine photosensitizer in polyethylene glycol-block-poly(lactide-co-benzyl glycidyl ether) nanocarriers: Probing the contribution of aromatic donor-acceptor interactions in polymeric nanospheres. Materials Science & Engineering C-Materials for Biological Applications, v. 94, p. 220-233, JAN 1 2019. (14/50928-2)

SILVA, RUMMENIGGE OLIVEIRA; DA COSTA, BRUNA LOPES; DA SILVA, FLAVIA RODRIGUES; DA SILVA, CAROLINA NUNES; DE PAIVA, MAYARA BRANDAO; NUNES DOURADO, LAYS FERNANDA; MALACHIAS, ANGELO; DE SOUZA ARAUJO, ADRIANO ANTUNES; NUNES, PAULA SANTOS; SILVA-CUNHA, ARMANDO. Treatment for chemical burning using liquid crystalline nanoparticles as an ophthalmic delivery system for pirfenidone. International Journal of Pharmaceutics, v. 568, SEP 10 2019. (14/50928-2)

FRANK, LUIZA ABRAHAO; GAZZI, R. P.; MELLO, P. A.; CHAVES, P.; PENA, F.; BECK, R. C. R.; BUFFON, A.; POHLMANN, A. R.; GUTERRES, SILVIA S.. Anti-HPV Nanoemulsified-Imiquimod: A New and Potent Formulation to Treat Cervical Cancer. AAPS PHARMSCITECH, v. 21, n. 2, JAN 6 2020. (14/50928-2)

MICHALOWSKI, CECILIA B.; ARBO, MARCELO D.; ALTKNECHT, LOUISE; ANCIUTI, ANDREIA N.; ABREU, ANGELICA S. G.; ALENCAR, LUCIANA M. R.; POHLMANN, ADRIANA R.; GARCIA, SOLANGE C.; GUTERRES, SILVIA S.. Oral Treatment of Spontaneously Hypertensive Rats with Captopril-Surface Functionalized Furosemide-Loaded Multi-Wall Lipid-Core Nanocapsules. PHARMACEUTICS, v. 12, n. 1, JAN 2020. (14/50928-2)

CE, RODRIGO; PACHECO, BARBARA Z.; CIOCHETA, TAIANE M.; BARBOSA, FABIO S.; ALVES, ALINE DE C. S.; DALLEMOLE, DANIELI R.; LAVAYEN, VLADIMIR; GUTERRES, SILVIA S.; STEPPE, MARTIN; POHLMANN, ADRIANA R.. A set of synthetic data, antibacterial evaluation and bacterial interaction with lipid-core nanocapsules containing fusidic acid. DATA IN BRIEF, v. 36, JUN 2021. (14/50928-2)

APOLINARIO, ALEXSANDRA CONCEICAO; HAUSCHKE, LEON; NUNES, JESSICA RIBEIRO; LOPES, LUCIANA BIAGINI. Lipid nanovesicles for biomedical applications: `What is in a name'?. PROGRESS IN LIPID RESEARCH, v. 82, APR 2021. (18/14375-0, 14/50928-2, 18/13877-1)

MOJEIKO, GABRIELA; PASSOS, JULIA SAPIENZA; APOLINARIO, ALEXSANDRA CONCEICAO; LOPES, LUCIANA BIAGINI. opical transdermal chemoprevention of breast cancer: where will nanomedical approaches deliver us. Nanomedicine, v. 16, n. 19, JUL 2021. (18/13877-1, 18/14375-0, 19/00196-9, 20/01208-8, 14/50928-2)

MILANESI, LAURA HAUTRIVE; ROSSATO, DOMENIKA RUBERT; OLIVEIRA DA ROSA, JESSICA LEANDRA; D'AVILA, LIVIA FERRAZ; METZ, VINICIA GARZELLA; WOLF, JESSICA FERNANDA; REIS, VANESSA B.; DE ANDRADE, DIEGO F.; JANK, LOUISE; BECK, RUY C. R.; et al. Topiramate-chitosan nanoparticles prevent morphine reinstatement with no memory impairment: Dopaminergic and glutamatergic molecular aspects in rats. NEUROCHEMISTRY INTERNATIONAL, v. 150, NOV 2021. (14/50928-2)

LEITE, MARCEL NANI; ROSA VIEGAS, JULIANA SANTOS; GARCIA PRACA, FABIOLA SILVA; DE PAULA, NATALIA APARECIDA; ZAMBELLI RAMALHO, LEANDRA NAIRA; LOPES BADRA BENTLEY, MARIA VITORIA; CIPRIANI FRADE, MARCO ANDREY. Ex vivo model of human skin (hOSEC) for assessing the dermatokinetics of the anti-melanoma drug Dacarbazine. European Journal of Pharmaceutical Sciences, v. 160, MAY 1 2021. (16/16437-7, 14/50928-2, 19/04448-2)

CALIXTO, GIOVANA MARIA FIORAMONTI; VICTORELLI, FRANCESCA DAMIANI; FRANZ-MONTAN, MICHELLE; BALTAZAR, FATIMA; CHORILLI, MARLUS. Innovative Mucoadhesive Precursor of Liquid Crystalline System Loading Anti-Gellatinolytic Peptide for Topical Treatment of Oral Cancer. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, v. 17, n. 2, p. 253-262, FEB 2021. (14/50928-2, 19/07245-5, 16/06337-5)

ZUGLIANELLO, CARINE; LEMOS-SENNA, ELENARA. The nanotechnological approach for nasal delivery of peptide drugs: a comprehensive review. Journal of Microencapsulation, v. 39, n. 2, p. 20-pg., 2022-03-29. (14/50928-2)

MARENA, GABRIEL DAVI; DOS SANTOS RAMOS, MATHEUS APARECIDO; CARVALHO, GABRIELA CORREA; DE LIMA, LAURA CAMINITTI; CARNEIRO SOARES DO NASCIMENTO, ANDRE LUIZ; SABIO, RAFAEL MIGUEL; RODERO, CAMILA FERNANDA; SPOSITO, LARISSA; BAUAB, TAIS MARIA; CHORILLI, MARLUS. Development and characterization of an amphotericin B - loaded nanoemulsion applied to Candida auris biofilms control. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 74, p. 14-pg., 2022-07-20. (19/26821-7, 18/25377-3, 19/09597-6, 19/09831-9, 18/23442-2, 14/50928-2, 17/22758-3, 18/23357-5)

VON ZUBEN, ELIETE DE SOUZA; ELOY, JOSIMAR OLIVEIRA; INACIO, MAIARA DESTRO; ARAUJO, VICTOR HUGO SOUSA; BAVIERA, AMANDA MARTINS; GREMIAO, MARIA PALMIRA DAFLON; CHORILLI, MARLUS. Hydroxyethylcellulose-Based Hydrogels Containing Liposomes Functionalized with Cell-Penetrating Peptides for Nasal Delivery of Insulin in the Treatment of Diabetes. PHARMACEUTICS, v. 14, n. 11, p. 20-pg., 2022-11-01. (14/50928-2)

PUPO SILVESTRINI, ANA VITORIA; DEBIASI, BRYAN WENDER; PRACA, FABIOLA GARCIA; LOPES BADRA BENTLEY, MARIA VITORIA. Progress and challenges of lyotropic liquid crystalline nanoparticles for innovative therapies. International Journal of Pharmaceutics, v. 628, p. 23-pg., 2022-10-23. (14/50928-2)

MARENA, GABRIEL DAVI; DOS SANTOS RAMOS, MATHEUS APARECIDO; LIMA, LAURA CAMINITTI; CHORILLI, MARLUS; BAUAB, TAIS MARIA. alleria mellonella for systemic assessment of anti-Candida auris using amphotericin B loaded in nanoemulsio. Science of The Total Environment, v. 807, n. 3, FEB 10 2022. (18/23442-2, 14/50928-2, 19/09831-9)

OLIVEIRA, NATALIA KRONBAUER; FRANK, LUIZA ABRAHAO; SQUIZANI, EAMIM DAIDRE; REUWSAAT, JULIA CATARINA VIEIRA; MARQUES, BARBARA MACHADO; MOTTA, HERYK; GARCIA, ANE WICHINE ACOSTA; KINSKOVSKI, URIEL PERIN; BARCELLOS, VANESSA ABREU; SCHRANK, AUGUSTO; et al. New nanotechnological formulation based on amiodarone-loaded lipid core nanocapsules displays anticryptococcal effect. European Journal of Pharmaceutical Sciences, v. 162, JUL 1 2021. (14/50928-2)

VICTORELLI, FRANCESCA DAMIANI; DE OLIVEIRA CARDOSO, VALERIA MARIA; FERREIRA, NATALIA NORONHA; FIORAMONTI CALIXTO, GIOVANA MARIA; FONTANA, CARLA RAQUEL; BALTAZAR, FATIMA; DAFLON GREMIAO, MARIA PALMIRA; CHORILLI, MARLUS. Chick embryo chorioallantoic membrane as a suitable in vivo model to evaluate drug delivery systems for cancer treatment: A review. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, v. 153, p. 12-pg., 2020-08-01. (17/10016-2, 17/23357-2, 19/07245-5, 13/01565-1, 18/04546-1, 16/06337-5, 15/21412-0, 14/50928-2, 16/09671-3)

NEVES BORGHETI-CARDOSO, LIVIA; ROSA VIEGAS, JULIANA SANTOS; PUPO SILVESTRINI, ANA VITORIA; CARON, ANGELO LUIS; PRACA, FABIOLA GARCIA; KRAVICZ, MARCELO; LOPES BADRA BENTLEY, MARIA VITORIA. Nanotechnology approaches in the current therapy of skin cancer. Advanced Drug Delivery Reviews, v. 153, p. 28-pg., 2020-01-01. (19/04448-2, 14/50928-2)

BRUINSMANN, FRANCIELE ALINE; VAZ, GUSTAVO RICHTER; SOARES ALVES, ALINE DE CRISTO; AGUIRRE, TANIRA; POHLMANN, ADRIANA RAFFIN; GUTERRES, SILVIA STANISCUASKI; SONVICO, FABIO. Nasal Drug Delivery of Anticancer Drugs for the Treatment of Glioblastoma: Preclinical and Clinical Trials. Molecules, v. 24, n. 23, DEC 2019. (14/50928-2)

DOURADO, LAYS FERNANDA NUNES; SILVA, CAROLINA NUNES; ANJOS, LILIAN CARNEIRO DOS; MORTARI, MARCIA RENATA; SILVA-CUNHA, ARMANDO; FIALHO, SILVIA LIGORIO. Ischemia-induced retinal injury is attenuated by Neurovespina, a peptide from the venom of the social wasp Polybia occidentalis. Neuropeptides, v. 85, FEB 2021. (14/50928-2)

SHIKIDA, DANIELLE NISHIDA RAMOS; DALMOLIN, LUCIANA FACCO; FUMAGALLI, FERNANDO; EMERY, FLAVIO DA SILVA; LOPEZ, V, RENATA F.. Arginine-conjugated chitosan nanoparticles for topical arginine release in wounds. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 61, FEB 2021. (14/50928-2, 14/22451-7)

ANUNCIATO CASARINI, TALITA PIZZA; FRANK, LUIZA ABRAHAO; BENIN, TAINARA; ONZI, GIOVANA; POHLMANN, ADRIANA RAFFIN; GUTERRES, SILVIA STANISCUASKI. Innovative hydrogel containing polymeric nanocapsules loaded with phloretin: Enhanced skin penetration and adhesion. Materials Science & Engineering C-Materials for Biological Applications, v. 120, JAN 2021. (14/50928-2)

ALVES, MAYARA R.; PAIVA, MATEUS F.; CAMPOS, PABLO T. A.; DE FREITAS, ELON F.; CLEMENTE, MARIA CLARA H.; MARTINS, V, GESLEY ALEX; SILVEIRA JR, ALCEU T.; CIDES DA SILVA, LUIS C.; FANTINI, MARCIA C. A.; DIAS, SILVIA C. L.; et al. Accessibility and strength of H-acceptor hydroxyls of ordered mesoporous silicas probed by pyridine donor. JOURNAL OF POROUS MATERIALS, v. 28, n. 2, p. 323-335, APR 2021. (14/50928-2, 17/17075-4)

FERNANDES, MARIZA AIRES; ELOY, JOSIMAR O.; LUIZ, MARCELA TAVARES; RAMOS JUNIOR, SERGIO LUIZ; BORGES, JULIO CESAR; DE LA FUENTE, LAURA RODRIGUEZ; LUIS, CLARA ORTEGA-DE SAN; MARCHETTI, JULIANA MALDONADO; SANTOS-MARTINEZ, MARIA J.; CHORILLI, MARLUS. Transferrin-functionalized liposomes for docetaxel delivery to prostate cancer cells. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 611, FEB 20 2021. (17/25190-8, 14/50928-2, 18/26422-2)

BOTTEON, C. E. A.; SILVA, L. B.; CCANA-CCAPATINTA, G. V.; SILVA, T. S.; AMBROSIO, S. R.; VENEZIANI, R. C. S.; BASTOS, J. K.; MARCATO, P. D.. Biosynthesis and characterization of gold nanoparticles using Brazilian red propolis and evaluation of its antimicrobial and anticancer activities. SCIENTIFIC REPORTS, v. 11, n. 1, JAN 21 2021. (17/04138-8, 14/50928-2, 18/13465-5)

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FUKUMORI, CLAUDIO; BRANCO, PAOLA CRISTINA; BARRETO, THAYNA; ISHIDA, KELLY; LOPES, LUCIANA B.. Development and cytotoxicity evaluation of multiple nanoemulsions for oral co-delivery of 5-fluorouracil and short chain triglycerides for colorectal cancer. European Journal of Pharmaceutical Sciences, v. 187, p. 15-pg., 2023-05-20. (18/13877-1, 14/50928-2, 19/03241-5)

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SABIO, RAFAEL MIGUEL; MENEGUIN, ANDREIA BAGLIOTTI; DOS SANTOS, ALINE MARTINS; MONTEIRO, ANDREIA SOFIA; CHORILLI, MARLUS. Exploiting mesoporous silica nanoparticles as versatile drug carriers for several routes of administration. Microporous and Mesoporous Materials, v. 312, JAN 2021. (18/25377-3, 14/50928-2)

MOREIRA CASTRO, BRENDA FERNANDA; VIEIRA, LORENA CARLA; VASCONCELOS-SANTOS, DANIEL VITOR; DE FREITAS CENACHI, SARAH PEREIRA; LACERDA COTTA, OLIVER ARAUJO; ANDRADE GUERRA, MARIA CAROLINA; BRANDAO PAIVA, MAYARA RODRIGUES; SILVA, LUCIANA MARIA; SILVA-CUNHA, ARMANDO; FIALHO, SILVIA LIGORIO. Intravitreal thalidomide ameliorates inflammation in a model of experimental uveitis induced by BCG. International Immunopharmacology, v. 81, APR 2020. (14/50928-2)

CAMPOS, PATRICIA MAZUREKI; PETRILLI, RAQUEL; LOPEZ, V, RENATA F.. The prominence of the dosage form design to treat ocular diseases. International Journal of Pharmaceutics, v. 586, AUG 30 2020. (17/05930-7, 14/50928-2, 14/22451-7)

CANALES, CHRISTIAN S. CARNERO; CAZORLA, JESSICA INGRID MARQUEZ; CAZORLA, RENZO MARIANITO MARQUEZ; ROQUE-BORDA, CESAR AUGUSTO; POLINARIO, GIULIA; BANDA, RUFO A. FIGUEROA; SABIO, RAFAEL MIGUEL; CHORILLI, MARLUS; SANTOS, HELDER A.; PAVAN, FERNANDO ROGERIO. Breaking barriers: The potential of nanosystems in antituberculosis therapy. BIOACTIVE MATERIALS, v. 39, p. 29-pg., 2024-09-01. (20/16573-3, 22/02661-3, 14/50928-2)

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