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Ano de início
Entree

Participation of opioids in respiratory rhythmogenesis

Processo: 03/09723-3
Linha de fomento:Bolsas no Exterior - Pesquisa
Vigência (Início): 03 de janeiro de 2005
Vigência (Término): 28 de fevereiro de 2005
Área do conhecimento:Ciências Biológicas - Fisiologia - Fisiologia Comparada
Pesquisador responsável:Luciane Helena Gargaglioni Batalhão
Beneficiário:Luciane Helena Gargaglioni Batalhão
Anfitrião: Richard J. A. Wilson
Instituição-sede: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brasil
Local de pesquisa : University of Calgary, Canadá  
Assunto(s):Respiração animal   Anfíbios   Bulbo (sistema nervoso)   Analgésicos opioides

Resumo

The medulla is recognized as playing a key role in generating the respiratory rhythm. In anurans amphibians, two coupled but spatially distinct areas within the medulla are necessary for generating buccal and lung ventilation. Recent studies in mammals using opioids suggest that the mammalian respiratory rhythm generator may also be composed of two populations of rhythmogenic neurons: opioid-sensitive neurons (I neurons) located within the PreBotzinger Complex (preBötzC), and opioid-insensitive neurons (pre-l neurons) located within and rostral to the preBötzC. In this proposal, I will determine whether the lung and buccal oscillators are functionally similar to the I and Prel oscillators of mammals. I will test the hypothesis that the amphibian oscillators, like the mammalian oscillators, differ in their sensitivity to opioids. (AU)