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Ano de início
Entree

Tyrosyl phosphorylation and vascular permeability during cardiac surgery

Processo: 99/07234-8
Linha de fomento:Bolsas no Exterior - Pesquisa
Vigência (Início): 01 de abril de 2000
Vigência (Término): 30 de junho de 2001
Área do conhecimento:Ciências Biológicas - Farmacologia - Farmacologia Geral
Pesquisador responsável:Renato Do Rego de Araujo Faro
Beneficiário:Renato Do Rego de Araujo Faro
Anfitrião: Frank William Sellke
Instituição-sede: Pessoa Física
Local de pesquisa : Harvard University, Boston, Estados Unidos  

Resumo

The objective of the research is to determine the roles of tyrosyl kinase/phosphatase activities and protein tyrosyl phosphorylation in mediating acute changes in coronary and systemic microvascular permeability, during ischemic cardioplegia and cardiopulmonary bypass (CPB). This work will be accomplished through a reductive approach using molecular and cellular biology techniques to examine the protein tyrosyl phosphorylation and gene expressions involved in maintaining vascular adhesion and integrity in a porcine model of cardioplegia and CPB and in isolated rat microvessels. We will correlate these molecular and cellular changes with in vivo and in vitro indices of vascular permeability. (AU)