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Ano de início
Entree

Phenotypic analysis of seizure-induced cell proliferation

Processo: 01/00142-2
Linha de fomento:Bolsas no Exterior - Pesquisa
Vigência (Início): 10 de agosto de 2001
Vigência (Término): 09 de agosto de 2002
Área do conhecimento:Ciências Biológicas - Fisiologia - Fisiologia de Órgãos e Sistemas
Pesquisador responsável:Fulvio Alexandre Scorza
Beneficiário:Fulvio Alexandre Scorza
Anfitrião: Daniel Henry Lowenstein
Instituição-sede: Centro de Ciências Biomédicas. Universidade de Mogi das Cruzes (UMC). Mogi das Cruzes , SP, Brasil
Local de pesquisa : Harvard University, Boston, Estados Unidos  

Resumo

This research is designed to explore the biological basis of seizure-induced neurogenesis in the mature central nervous system (CNS) and the role of neurogenesis in the pathophysiology of epilepsy. Previous work has demonstrated that various forms of experimental seizures paradigms, lead to a marked increase in the mitotic activity of precursor cell located at the subgranular zone of the adult dentate gyrus which differentiates into mature dentate granule cells. The aim of this study is to verify the factors determining cell fate during the normal, early development of the CNS involved in controlling the lineage of newly-born cells after seizures. These experiments will lead to our understanding the seizure- induced plasticity and the factors that control precursor cell fate in the adult animal following seizures. (AU)