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Entree

IMMUNOGENICAL COMPLEX FORMED BY VACCINAL ANTIGENS ENCAPSULATED BY NANOSTRUCTURED MESOPOROUS SILICA

Tipo de documento:Patente
Inventor(es): Ogari de Castro Pacheco; Osvaldo Augusto Brazil Esteves Sant'Anna; Lucildes Pita Mercuri; Jivaldo do Rosário Matos; Marcia Carvalho de Abreu Fantini
Depositante: Cristália Produtos Químicos Farmacêuticos Ltda ; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Data do depósito: 12 de setembro de 2006
Registro INPI:
US12/066,489 - Consulta INPI
IPC: A61K 39/00 C12Q 1/70 A61K 39/295 A61K 39/116
Resumo

The present invention relates to a product named "immunogenical complex", which comprises an adjuvant characterized by solid particles of highly ordinated nanostructured mesoporous silica, preferably, SBA-15 Silica, and vaccinal antigens of several natures, encapsulated in the referred to adjuvants. The immunogenical complex of the present invention allows the presentation of the antigens that compose it to lymphocytes, in a safe, gradual and extended way, which leads to a more efficient immunological memory, increases the immunogenicity of the antigen and improves the production of antibodies. This ensures an efficient immunological protection with fewer amounts of antigens and/or less repetitions of vaccinal doses. In addition, the characteristics of the immunogenical complex of the present invention promotes effective immunity induction, homogeneous in "god and bad respondent" individuals.


Processo FAPESP: 04/11597-9 - Estudo experimental do efeito adjuvante da sílica nanoestruturada SBA-15
Beneficiário:Luciana Vieira Carvalho
Pesquisador responsável:Osvaldo Augusto Brazil Esteves Sant'Anna
Instituição: Secretaria da Saúde (São Paulo - Estado). Instituto Butantan
Linha de fomento: Bolsas no Brasil - Mestrado