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ISOLATION AND PURIFICATION PROCEDURE OF VASOPEPTIDASE PEPTIDE INHIBITORS

Tipo de documento:Patente
Inventor(es): Antônio Carlos Martins de Camargo; Fernanda Calheta Vieira Portaro; Alessandra Ferragini Murback; Danielle Alves Ianzer; Sandra Helena Poliselli Farsky; Mario Sergio Palma; Mirian Akemi Furuie Hayashi
Depositante: Antonio Carlos Martins de Camargo ; Biolab Sanus Farmacêutica Ltda ; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Data do depósito: 18 de março de 2002
Registro INPI:
PCT/BR2002/000041 - Consulta INPI
IPC: C12Q 1/68 G01N 27/447 C07K 7/06 C07K 7/08 G01N 33/53 B01J 20/281 G01N 30/72 G01N 30/88 A61P 9/12 A61K 38/00 A61P 43/00 C12N 9/64 C12N 15/09 G01N 33/566 A61P 9/08 G01N 33/60 G01N 30/34 C07K 1/10 G01N 30/46 G01N 27/62 C12N 9/99
Patente licenciada para a empresa: Coinfar
Resumo

The present invention patent refers to the isolation and purification of peptides secreted by serpent venom glands, specifically Bothrops jararaca; to the peptide thus obtained, as well as to the production procedures by genetic engineering techniques in procaryotic and eukaryotic systems; to the engineered peptide thus obtained; to the production of said peptide by chemical synthesis, as well as to the peptide resulting from this chemical processing. It also refers to the utilization of said peptides, obtained by different procedures, in distinct pharmaceutical compositions, and introduced into the organism by a variety of means, in order for them to act as inhibitors of vasopeptidases, and consequently reduce systemic arterial blood pressure, and show local vasodilating action.


Processo FAPESP: 00/10025-0 - Inibidores secretados e endógenos das vasopeptidases derivados do precursor dos BPP-CNP da Bothrops jararaca
Beneficiário:Mirian Akemi Furuie Hayashi
Pesquisador responsável:Antonio Carlos Martins de Camargo
Instituição: Secretaria da Saúde (São Paulo - Estado). Instituto Butantan
Linha de fomento: Bolsas no Brasil - Pós-Doutorado