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Geraldo Aleixo da Silva Passos Júnior

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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP)  (Instituição-sede da última proposta de pesquisa)
País de origem: Brasil

Graduated in Biology from UNESP State University São Paulo, Brazil (1980-83), Master MSc (1984-86) and PhD (1986-88) in Biochemistry from Ribeirão Preto Medical School, University of São Paulo, USP, Brazil. His postdoctoral studies were conducted at the Molecular Genetics Institute of Montpellier (CNRS, Montpellier, France), (1992-94). Then he worked during several years (1997-2017) in close collaboration at INSERM U1090 in Marseille (France) studying the large scale gene expression (transcriptome) of the mouse thymus gland. Currently he is Associate Professor (Genetics and Molecular Biology) at School of Dentistry and Ribeirão Preto Medical School University of São Paulo, Campus of Ribeirão Preto, Brazil. He is the coordinator of the Molecular Immunogenetics Group (http://sites.usp.br/imunogenetica/), whose research lab is located at Department of Genetics, Ribeirão Preto Medical School, USP. He is the coordinator of the FAPESP Thematic Project "Using Crispr-Cas9 System to Edit the Aire Gene in mTEC Cells". Member of the Board of Academic Editors of Frontiers in Immunology. Is the editor of the book "Thymus Transcriptome and Cell Biology" (https://www.springer.com/us/book/9783030120399) published in 2019 by Springer Nature Switzerland AG. He has experience on molecular genetics, focusing mainly on the following topics: functional genomics (transcriptome analysis of mRNAs, miRNAs and lncRNAs) of the immune system (Aire gene, transcriptome profiling, induction of indel mutations in the Aire gene by using CRISPR-Cas9, microRNAs and autoimmunity). He also works on projects on gene expression regulation during osteoblastic differentiation of mesenchymal stem cells isolated from human dental pulp. He was the adviser of two PhD theses awarded by CAPES Ministry of Education (2008 CAPES Thesis Award and 2010 CAPES Thesis Honor in Genetics). (Fonte: Currículo Lattes)

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Publicações resultantes de Auxílios e Bolsas sob responsabilidade do(a) pesquisador(a) (38)

(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)

Publicações21
Citações251
Cit./Artigo12,0
Dados do Web of Science

MELLO, STEPHANO S.; FACHIN, ANA L.; JUNTA, CRISTINA M.; SANDRIN-GARCIA, PAULA; DONADI, EDUARDO A.; PASSOS, GERALDO A. S.; SAKAMOTO-HOJO, ELZA T.. Delayed Effects of Exposure to a Moderate Radiation Dose on Transcription Profiles in Human Primary Fibroblasts. Environmental and Molecular Mutagenesis, v. 52, n. 2, p. 117-129, . Citações Web of Science: 8. (99/12135-9, 02/07314-6)

TREVISAN, G. L.; TAMIA-FERREIRA, M. C.; PASSOS, G. A. S.; JUNTA, C. M.. Immunoglobulin V-lambda transcription profiling of systemic lupus erythematosus patients reveals biased usage of genes located near the J lambda-C lambda segments. Scandinavian Journal of Immunology, v. 59, n. 4, p. 395-399, . (98/05584-9, 98/09789-4, 00/12495-4, 99/12135-9)

TREVISAN‚ G.L.; RASSI‚ D.M.; BAIÃO‚ A.M.T.; SANDRIN-GARCIA‚ P.; MELLO‚ S.S.; TAMIA-FERREIRA‚ M.C.; JUNTA‚ C.M.; FACHIN‚ A.L.; MARQUES‚ M.; SAKAMOTO-HOJO‚ E.T.; et al. Using cDNA microarrays to identify human CD19+ B cell gene products (ESTs) originated from systemic lupus erythematosus susceptibility loci. AUTOIMMUNITY REVIEWS, v. 5, n. 5, p. 319-323, . (99/12135-9, 00/11793-1)

RASSI‚ D.M.; JUNTA‚ C.M.; FACHIN‚ A.N.A.L.; SANDRIN-GARCIA‚ P.; MELLO‚ S.S.; FERNANDES‚ A.N.A.P.M.; DEGHAIDE‚ N.N.H.S.; FOSS-FREITAS‚ M.C.; FOSS‚ M.C.; SAKAMOTO-HOJO‚ E.T.; et al. Is HLA Class II Profile Relevant for the Study of Large-Scale Differentially Expressed Genes in Type 1 Diabetes Mellitus Patients?. Annals of the New York Academy of Sciences, v. 1079, n. 1, p. 305-309, . (99/12135-9, 01/04101-9)

RASSI‚ D.M.; JUNTA‚ C.M.; FACHIN‚ A.N.A.L.; SANDRIN-GARCIA‚ P.; MELLO‚ S.; MARQUES‚ M.; FERNANDES‚ A.N.A.P.M.; FOSS-FREITAS‚ M.C.; FOSS‚ M.C.; SAKAMOTO-HOJO‚ E.T.; et al. Metabolism genes are among the differentially expressed ones observed in lymphomononuclear cells of recently diagnosed type 1 diabetes mellitus patients. Annals of the New York Academy of Sciences, v. 1079, n. 1, p. 171-176, . (99/12135-9, 01/04101-9)

SILVA‚ G.L.; JUNTA‚ C.M.; MELLO‚ S.S.; GARCIA‚ P.S.; RASSI‚ D.M.; SAKAMOTO-HOJO‚ E.T.; DONADI‚ E.A.; PASSOS‚ G.A.S.. Profiling Meta-Analysis Reveals Primarily Gene Coexpression Concordance between Systemic Lupus Erythematosus and Rheumatoid Arthritis. Annals of the New York Academy of Sciences, v. 1110, n. 1, p. 33-46, . (99/12135-9)

CARDOSO‚ R.S.; JUNTA‚ C.M.; MACEDO‚ C.; MAGALHÃES‚ D.A.R.; SILVEIRA‚ E.L.V.; PAULA‚ M.O.; MARQUES‚ M.; MELLO‚ S.S.; ZÁRATE-BLADÉS‚ C.R.; NGUYEN‚ C.; et al. Hybridization signatures of gamma-irradiated murine fetal thymus organ culture (FTOC) reveal modulation of genes associated with T-cell receptor V (D) J recombination and DNA repair. Molecular Immunology, v. 43, n. 5, p. 464-472, . (99/12135-9, 00/09994-9)

FACHIN‚ A.L.; MELLO‚ S.S.; SANDRIN-GARCIA‚ P.; JUNTA‚ C.M.; DONADI‚ E.A.; PASSOS‚ G.A.S.; SAKAMOTO-HOJO‚ E.T.. Gene expression profiles in human lymphocytes irradiated in vitro with low doses of gamma rays. RADIATION RESEARCH, v. 168, n. 6, p. 650-665, . (99/12135-9, 02/07314-6, 01/10995-2)

DONATE, PAULA B.; FORNARI, THAIS A.; MACEDO, CLAUDIA; CUNHA, THIAGO M.; NASCIMENTO, DANIELE C. B.; SAKAMOTO-HOJO, ELZA T.; DONADI, EDUARDO A.; CUNHA, FERNANDO Q.; PASSOS, GERALDO A.. T Cell Post-Transcriptional miRNA-mRNA Interaction Networks Identify Targets Associated with Susceptibility/Resistance to Collagen-induced Arthritis. PLoS One, v. 8, n. 1, . Citações Web of Science: 14. (08/56594-8)

FACHIN, ANA LUCIA; MELLO, STEPHANO SPANO; SANDRIN-GARCIA, PAULA; JUNTA, CRISTINA MORAES; GHILARDI-NETTO, THOMAZ; DONADI, EDUARDO ANTONIO; DA SILVA PASSOS, GERALDO ALEIXO; SAKAMOTO-HOJO, ELZA TIEMI. Gene Expression Profiles in Radiation Workers Occupationally Exposed to Ionizing Radiation. JOURNAL OF RADIATION RESEARCH, v. 50, n. 1, p. 61-71, . Citações Web of Science: 43. (99/12135-9, 02/07314-6, 01/10995-2)

EVANGELISTA, ADRIANE F.; COLLARES, CRISTHIANNA V. A.; XAVIER, DANILO J.; MACEDO, CLAUDIA; MANOEL-CAETANO, FERNANDA S.; RASSI, DIANE M.; FOSS-FREITAS, MARIA C.; FOSS, MILTON C.; SAKAMOTO-HOJO, ELZA T.; NGUYEN, CATHERINE; et al. Integrative analysis of the transcriptome profiles observed in type 1, type 2 and gestational diabetes mellitus reveals the role of inflammation. BMC MEDICAL GENOMICS, v. 7, . Citações Web of Science: 16. (10/12069-7, 10/00932-2, 10/05622-1, 08/56594-8)

SANDRIN-GARCIA‚ P.; MACEDO‚ C.; MARTELLI‚ LR; RAMOS‚ ES; GUION-ALMEIDA‚ ML; RICHIERI-COSTA‚ A.; PASSOS‚ GAS. Recurrent 22q11. 2 deletion in a sibship suggestive of parental germline mosaicism in velocardiofacial syndrome. Clinical Genetics, v. 61, n. 5, p. 380-383, . (98/05584-9, 98/09789-4, 99/09051-8, 97/13599-3)

MACEDO‚ C.; MORAES JUNTA‚ C.; PASSOS‚ G.A.S.. Onset of T-cell receptor V [beta] 8.1 and D [beta] 2.1 V (D) J recombination during thymus development of inbred mouse strains. Immunology Letters, v. 69, n. 3, p. 371-373, . (98/05584-9, 98/09789-4)

SAKAMOTO-HOJO, E. T.; PEREIRA, E.; FACHIN, A. L.; CARDOSO, R. S.; DONADI, E. A.; PASSOS, G. A. S.; MELLO, S. S.; JUNTA, C. M.. Gene expression profiles in human cells submitted to genotoxic stress. MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH, v. 544, n. 2-3, p. 403-413, . (00/01005-6, 00/09063-5, 02/01441-6, 01/10995-2, 01/09519-1, 99/12135-9)

MAGALHÃES, DANIELLE A. R.; MACEDO, CLAUDIA; JUNTA, CRISTINA M.; MELLO, STEPHANO S.; MARQUES, MÁRCIA M. C.; CARDOSO, RENATO S.; SAKAMOTO-HOJO, ELZA T.; DONADI, EDUARDO A.; PASSOS, GERALDO A. S.. Hybridization signatures during thymus ontogeny reveals modulation of genes coding for T-cell signaling proteins. Molecular Immunology, v. 42, n. 9, p. 1043-1048, . (99/12135-9, 01/08278-0)

PEREIRA‚ E.; TAMIA-FERREIRA‚ M.C.; CARDOSO‚ R.S.; MELLO‚ S.S.; SAKAMOTO-HOJO‚ E.T.; PASSOS‚ G.A.S.; DONADI‚ E.A.. Immunosuppressive therapy modulates T lymphocyte gene expression in patients with systemic lupus erythematosus. Immunology, v. 113, n. 1, p. 99-105, . (99/12135-9)

SOUSA CARDOSO‚ R.; MAGALHÃES‚ D.A.R.; BAIÃO‚ A.M.T.; JUNTA‚ C.M.; MACEDO‚ C.; MARQUES‚ M.; SAKAMOTO-HOJO‚ E.T.; DONADI‚ E.A.; PASSOS‚ G.A.S.. Onset of promiscuous gene expression in murine fetal thymus organ culture. Immunology, v. 119, n. 3, p. 369-375, . (99/12135-9)

R.G.P. QUEIROZ; M.C. TAMIA-FERREIRA; I.F. CARVALHO; F.C. PETEAN; G.A.S. PASSOS. Association between EcoRI fragment-length polymorphism of the immunoglobulin lambda variable 8 (IGLV8) gene family with rheumatoid arthritis and systemic lupus erythematosus. Brazilian Journal of Medical and Biological Research, v. 34, n. 4, p. 525-528, . (98/09789-4, 98/05584-9)

MELLO, STEPHANO S.; FACHIN, ANA L.; JUNTA, CRISTINA M.; SANDRIN-GARCIA, PAULA; DONADI, EDUARDO A.; PASSOS, GERALDO A. S.; SAKAMOTO-HOJO, ELZA T.. Delayed Effects of Exposure to a Moderate Radiation Dose on Transcription Profiles in Human Primary Fibroblasts. Environmental and Molecular Mutagenesis, v. 52, n. 2, p. 117-129, . Citações Web of Science: 8. (99/12135-9, 02/07314-6)

TREVISAN, G. L.; TAMIA-FERREIRA, M. C.; PASSOS, G. A. S.; JUNTA, C. M.. Immunoglobulin V-lambda transcription profiling of systemic lupus erythematosus patients reveals biased usage of genes located near the J lambda-C lambda segments. Scandinavian Journal of Immunology, v. 59, n. 4, p. 395-399, . (98/05584-9, 98/09789-4, 00/12495-4, 99/12135-9)

FACHIN, ANA LUCIA; MELLO, STEPHANO SPANO; SANDRIN-GARCIA, PAULA; JUNTA, CRISTINA MORAES; GHILARDI-NETTO, THOMAZ; DONADI, EDUARDO ANTONIO; DA SILVA PASSOS, GERALDO ALEIXO; SAKAMOTO-HOJO, ELZA TIEMI. Gene Expression Profiles in Radiation Workers Occupationally Exposed to Ionizing Radiation. JOURNAL OF RADIATION RESEARCH, v. 50, n. 1, p. 61-71, . Citações Web of Science: 43. (99/12135-9, 02/07314-6, 01/10995-2)

TREVISAN, G. L.; TAMIA-FERREIRA, M. C.; PASSOS, G. A. S.; JUNTA, C. M.. Immunoglobulin V-lambda transcription profiling of systemic lupus erythematosus patients reveals biased usage of genes located near the J lambda-C lambda segments. Scandinavian Journal of Immunology, v. 59, n. 4, p. 395-399, . (98/05584-9, 98/09789-4, 00/12495-4, 99/12135-9)

TREVISAN‚ G.L.; RASSI‚ D.M.; BAIÃO‚ A.M.T.; SANDRIN-GARCIA‚ P.; MELLO‚ S.S.; TAMIA-FERREIRA‚ M.C.; JUNTA‚ C.M.; FACHIN‚ A.L.; MARQUES‚ M.; SAKAMOTO-HOJO‚ E.T.; et al. Using cDNA microarrays to identify human CD19+ B cell gene products (ESTs) originated from systemic lupus erythematosus susceptibility loci. AUTOIMMUNITY REVIEWS, v. 5, n. 5, p. 319-323, . (99/12135-9, 00/11793-1)

RASSI‚ D.M.; JUNTA‚ C.M.; FACHIN‚ A.N.A.L.; SANDRIN-GARCIA‚ P.; MELLO‚ S.S.; FERNANDES‚ A.N.A.P.M.; DEGHAIDE‚ N.N.H.S.; FOSS-FREITAS‚ M.C.; FOSS‚ M.C.; SAKAMOTO-HOJO‚ E.T.; et al. Is HLA Class II Profile Relevant for the Study of Large-Scale Differentially Expressed Genes in Type 1 Diabetes Mellitus Patients?. Annals of the New York Academy of Sciences, v. 1079, n. 1, p. 305-309, . (99/12135-9, 01/04101-9)

RASSI‚ D.M.; JUNTA‚ C.M.; FACHIN‚ A.N.A.L.; SANDRIN-GARCIA‚ P.; MELLO‚ S.; MARQUES‚ M.; FERNANDES‚ A.N.A.P.M.; FOSS-FREITAS‚ M.C.; FOSS‚ M.C.; SAKAMOTO-HOJO‚ E.T.; et al. Metabolism genes are among the differentially expressed ones observed in lymphomononuclear cells of recently diagnosed type 1 diabetes mellitus patients. Annals of the New York Academy of Sciences, v. 1079, n. 1, p. 171-176, . (99/12135-9, 01/04101-9)

SILVA‚ G.L.; JUNTA‚ C.M.; MELLO‚ S.S.; GARCIA‚ P.S.; RASSI‚ D.M.; SAKAMOTO-HOJO‚ E.T.; DONADI‚ E.A.; PASSOS‚ G.A.S.. Profiling Meta-Analysis Reveals Primarily Gene Coexpression Concordance between Systemic Lupus Erythematosus and Rheumatoid Arthritis. Annals of the New York Academy of Sciences, v. 1110, n. 1, p. 33-46, . (99/12135-9)

CARDOSO‚ R.S.; JUNTA‚ C.M.; MACEDO‚ C.; MAGALHÃES‚ D.A.R.; SILVEIRA‚ E.L.V.; PAULA‚ M.O.; MARQUES‚ M.; MELLO‚ S.S.; ZÁRATE-BLADÉS‚ C.R.; NGUYEN‚ C.; et al. Hybridization signatures of gamma-irradiated murine fetal thymus organ culture (FTOC) reveal modulation of genes associated with T-cell receptor V (D) J recombination and DNA repair. Molecular Immunology, v. 43, n. 5, p. 464-472, . (99/12135-9, 00/09994-9)

FACHIN‚ A.L.; MELLO‚ S.S.; SANDRIN-GARCIA‚ P.; JUNTA‚ C.M.; DONADI‚ E.A.; PASSOS‚ G.A.S.; SAKAMOTO-HOJO‚ E.T.. Gene expression profiles in human lymphocytes irradiated in vitro with low doses of gamma rays. RADIATION RESEARCH, v. 168, n. 6, p. 650-665, . (99/12135-9, 02/07314-6, 01/10995-2)

DA SILVA‚ M.I.; PASSOS‚ G.A.S.. The human immunoglobulin variable lambda locus IGLV9 gene is a monomorphic marker in the urban Brazilian population. Immunology Letters, v. 69, n. 3, p. 369-370, . (98/05584-9, 98/09789-4)

MORAES JUNTA‚ C.; PASSOS‚ G.A.S.. Genomic EcoRI polymorphism and cosmid sequencing reveal an insertion/deletion and a new IGLV5 allele in the human immunoglobulin lambda variable locus (22q11. 2/IGLV). IMMUNOGENETICS, v. 55, n. 1, p. 10-15, . (98/05584-9, 98/09789-4, 96/07847-1)

MORAES JUNTA‚ C.; PASSOS‚ G.A.S.. Genomic EcoRI polymorphism and cosmid sequencing reveal an insertion/deletion and a new IGLV5 allele in the human immunoglobulin lambda variable locus (22q11. 2/IGLV). IMMUNOGENETICS, v. 55, n. 1, p. 10-15, . (98/05584-9, 98/09789-4, 96/07847-1)

FORNARI, THAIS A.; DONATE, PAULA B.; ASSIS, AMANDA F.; MACEDO, CLAUDIA; SAKAMOTO-HOJO, ELZA T.; DONADI, EDUARDO A.; PASSOS, GERALDO A.. Comprehensive Survey of miRNA-mRNA Interactions Reveals That Ccr7 and Cd247 (CD3 zeta) are Posttranscriptionally Controlled in Pancreas Infiltrating T Lymphocytes of Non-Obese Diabetic (NOD) Mice. PLoS One, v. 10, n. 11, . Citações Web of Science: 11. (13/08216-2, 08/56594-8)

TAKAHASHI, PAULA; XAVIER, DANILO J.; EVANGELISTA, ADRIANE F.; MANOEL-CAETANO, FERNANDA S.; MACEDO, CLAUDIA; COLLARES, CRISTHIANNA V. A.; FOSS-FREITAS, MARIA C.; FOSS, MILTON C.; RASSI, DIANE M.; DONADI, EDUARDO A.; et al. MicroRNA expression profiling and functional annotation analysis of their targets in patients with type 1 diabetes mellitus. Gene, v. 539, n. 2, p. 213-223, . Citações Web of Science: 30. (10/12069-7, 10/00932-2, 10/05622-1, 08/56594-8)

COTRIM-SOUSA, LARISSA; FREIRE-ASSIS, AMANDA; PEZZI, NICOLE; TANAKA, PEDRO PARANHOS; OLIVEIRA, ERNNA HERIDA; PASSOS, GERALDO ALEIXO. Adhesion between medullary thymic epithelial cells and thymocytes is regulated by miR-181b-5p and miR-30b. Molecular Immunology, v. 114, p. 600-611, . Citações Web of Science: 1. (13/17481-1, 17/10780-4)

PASSOS, GERALDO A.; SPECK-HERNANDEZ, CESAR A.; ASSIS, AMANDA F.; MENDES-DA-CRUZ, DANIELLA A.. Update on Aire and thymic negative selection. IMMUNOLOGY, v. 153, n. 1, p. 10-20, . Citações Web of Science: 14. (13/17481-1)

SPECK-HERNANDEZ, CESAR A.; ASSIS, AMANDA F.; FELICIO, RAFAELA F.; COTRIM-SOUSA, LARISSA; PEZZI, NICOLE; LOPES, GABRIEL S.; BOMBONATO-PRADO, KARINA F.; GIULIATTI, SILVANA; PASSOS, GERALDO A.. Aire Disruption Influences the Medullary Thymic Epithelial Cell Transcriptome and Interaction With Thymocytes. FRONTIERS IN IMMUNOLOGY, v. 9, . Citações Web of Science: 3. (13/17481-1)

XAVIER, DANILO J.; TAKAHASHI, PAULA; EVANGELISTA, ADRIANE F.; FOSS-FREITAS, MARIA C.; FOSS, MILTON C.; DONADI, EDUARDO A.; PASSOS, GERALDO A.; SAKAMOTO-HOJO, ELZA T.. Assessment of DNA damage and mRNA/miRNA transcriptional expression profiles in hyperglycemic versus non-hyperglycemic patients with type 2 diabetes mellitus. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, v. 776, n. SI, p. 98-110, . Citações Web of Science: 11. (10/12069-7, 08/56594-8)

OLIVEIRA, ERNNA H.; ASSIS, AMANDA F.; SPECK-HERNANDEZ, CESAR A.; DUARTE, MAX JORDAN; PASSOS, GERALDO A.. Aire Gene Influences the Length of the 3 ` UTR of mRNAs in Medullary Thymic Epithelial Cells. FRONTIERS IN IMMUNOLOGY, v. 11, . Citações Web of Science: 0. (13/17481-1, 17/10780-4)

Publicações acadêmicas

(Referências obtidas automaticamente das Instituições de Ensino e Pesquisa do Estado de São Paulo)

TAVARES, Thais Arouca Fornari. Análise da expressão gênica promíscua no timo de camundongos NOD (non obese diabetic) durante a emergência do Diabetes melitus tipo 1. Dissertação (Mestrado) -  Faculdade de Medicina de Ribeirão Preto.  Universidade de São Paulo (USP).  Ribeirão Preto.  (05/57231-8

OLIVEIRA, Ernna Hérida Domingues de. Vias de regulação da expressão gênica promíscua no timo envolve Aire e microRNAs. Tese (Doutorado) -  Faculdade de Medicina de Ribeirão Preto.  Universidade de São Paulo (USP).  Ribeirão Preto.  (09/54694-8

MAGALHÃES, Danielle Aparecida Rosa de. Análise do transcriptoma durante a ontogenia do timo.. Tese (Doutorado) -  Faculdade de Medicina de Ribeirão Preto.  Universidade de São Paulo (USP).  Ribeirão Preto.  (03/00982-6

CARDOSO, Renato Sousa. Avaliação dos efeitos da radiação gama na expressão de genes reguladores da recombinação V(D)J de receptores de células T.  172 f. Tese (Doutorado) -  Faculdade de Medicina de Ribeirão Preto.  Universidade de São Paulo (USP).  Ribeirão Preto.  (00/09994-9

ESPANHOL, Aline Renata. Cinética da expressão gênica diferencial durante a ontogenia do timo.  73 f. Dissertação (Mestrado) -  Centro de Ciências Biológicas e da Saúde.  Universidade Federal de São Carlos (UFSCAR).  São Carlos.  (00/01705-8

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