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Luis Felipe Santos Mendes

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Universidade de São Paulo (USP). Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP)  (Instituição-sede da última proposta de pesquisa)
País de origem: Brasil

Luis Felipe Santos Mendes studied Biomolecular Physics in the Physics Department of the University of São Paulo and graduated in 2011. For his work with distance measurements using continuous-wave and pulsed electron magnetic resonance applied to proteins involved in calcium-response homeostasis, he was awarded and granted to spent three months in the Gunnar Jeschke lab at the ETH-Zurich. As a PhD student in the Faculty of Philosophy, Science and Letters of the University of São Paulo, he was inserted in a structural biology project involving a multitask, membrane-associated protein, called GRASP, which works as key factors in the Golgi biogenesis and Unconventional Secretory Pathways. During the PhD, he spent one year as a guest student in the "Biomembrane Structure Unit" of the University of Oxford-UK (supervision of Prof. Dr Anthony Watts) and one month in the Chemistry Department of NCSU (guidance of Prof. Dr Alex I. Smirnov). His thesis was selected by the Brazilian Physical Society as the best one in the Biological Physics field defended during the biennial 2017/2018. He currently works as a postdoctoral fellow at the Physics Department of the University of São Paulo. Understanding how is the intricated relationship between peripherical/integral membrane proteins with the biological membranes, and how they both work in a biophysical perspective, is still a major challenge, and one we address using a range of biophysical methods that include magnetic resonances, optical spectroscopies and biochemical/biophysical assays. Of particular interest are proteins involved in the early secretory pathway, some of which are soluble intrinsically disordered proteins and also integral membrane proteins (p24/TMED family) - linked to the Center for Research in Inflammatory Diseases. Inside this main project, we also started to seek an explanation for the presence of one Metazoa-specific protein paralogy (the peripheral Golgi membrane proteins GRASP55/GRASP65) by going back to the past using Protein Ancestor Sequence Reconstruction. He has experience in classical molecular biology techniques (cloning, subcloning, mutant construction, expression and purification of heterologous soluble/membrane proteins) and a variety of spectroscopic and calorimetric techniques, with special emphasis on Circular Dichroism (conventional and synchrotron-radiation), fluorescence (steady-state and lifetime techniques), Magnetic Resonances (electronic and nuclear) and Differential Scanning Fluorimetry and Calorimetry (DSF and DSC). (Fonte: Currículo Lattes)

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Publicações resultantes de Auxílios e Bolsas sob responsabilidade do(a) pesquisador(a) (11)

(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)

Publicações10
Citações31
Cit./Artigo3,1
Dados do Web of Science

MENDES, LUIS F. S.; FONTANA, NATALIA A.; OLIVEIRA, CAROLINA G.; FREIRE, MARJORIE C. L. C.; LOPES, JOSE L. S.; MELO, FERNANDO A.; COSTA-FILHO, ANTONIO J.. The GRASP domain in golgi reassembly and stacking proteins: differences and similarities between lower and higher Eukaryotes. FEBS Journal, v. 286, n. 17, p. 3340-3358, . Citações Web of Science: 2. (16/23863-2, 12/20367-3, 15/50366-7, 09/53989-4, 17/24669-8)

MENDES, LUIS FELIPE S.; BATISTA, MARIANA R. B.; JUDGE, PETER J.; WATTS, ANTHONY; REDFIELD, CHRISTINA; COSTA-FILHO, ANTONIO J.. Conformational flexibility of GRASPs and their constituent PDZ subdomains reveals structural basis of their promiscuous interactome. FEBS Journal, v. 287, n. 15, . Citações Web of Science: 0. (12/20367-3, 15/50366-7, 16/09676-5, 17/24669-8)

MENDES, LUIS F. S.; GARCIA, ASSUERO F.; KUMAGAI, PATRICIA S.; DE MORAIS, FABIO R.; MELO, FERNANDO A.; KMETZSCH, LIVIA; VAINSTEIN, MARILENE H.; RODRIGUES, MARCIO L.; COSTA-FILHO, ANTONIO J.. New structural insights into Golgi Reassembly and Stacking Protein (GRASP) in solution. SCIENTIFIC REPORTS, v. 6, . Citações Web of Science: 6. (12/20367-3, 12/13309-7)

MENDES, LUIS F. S.; BASSO, LUIS G. M.; KUMAGAI, PATRICIA S.; FONSECA-MALDONADO, RAQUEL; COSTA-FILHO, ANTONIO J.. Disorder-to-order transitions in the molten globule-like Golgi Reassembly and Stacking Protein. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1862, n. 4, p. 855-865, . Citações Web of Science: 4. (15/18390-5, 12/20367-3, 15/50366-7, 11/21767-2, 12/13309-7, 14/00206-0)

ALVAREZ, NATALIA; MENDES, LUIS F. S.; GABRIELA KRAMER, M.; TORRE, MARIA H.; COSTA-FILHO, ANTONIO J.; ELLENA, JAVIER; FACCHIN, GIANELLA. Development of copper(II)-diimine-iminodiacetate mixed ligand complexes as potential antitumor agents. Inorganica Chimica Acta, v. 483, p. 61-70, . Citações Web of Science: 11. (17/24669-8, 12/13309-7)

MENDES, LUIS F. S.; FONTANA, NATALIA A.; REDDY, S. THIRUPATHI; UVERSKY, VLADIMIR N.; COSTA-FILHO, ANTONIO J.. The exquisite structural biophysics of the Golgi Reassembly and Stacking Proteins. International Journal of Biological Macromolecules, v. 164, p. 3632-3644, . Citações Web of Science: 0. (12/20367-3, 15/50366-7, 16/23863-2, 17/24669-8, 17/12146-0)

ALVAREZ, NATALIA; VINA, DIANA; LEITE, CELISNOLIA M.; MENDES, LUIS F. S.; BATISTA, ALZIR A.; ELLENA, JAVIER; COSTA-FILHO, ANTONIO J.; FACCHIN, GIANELLA. Synthesis and structural characterization of a series of ternary copper(II)-L-dipeptide-neocuproine complexes. Study of their cytotoxicity against cancer cells including MDA-MB-231, triple negative breast cancer cells. Journal of Inorganic Biochemistry, v. 203, . Citações Web of Science: 3. (17/24669-8, 15/50366-7)

THIRUPATHI REDDY, S.; SANTOS MENDES, LUIS FELIPE; FONTANA, NATALIA APARECIDA; COSTA-FILHO, ANTONIO JOSE. Exploring structural aspects of the human Golgi matrix protein GRASP55 in solution. International Journal of Biological Macromolecules, v. 135, p. 481-489, . Citações Web of Science: 0. (16/23863-2, 17/12146-0, 17/24669-8, 15/16812-0, 15/50366-7, 12/20367-3)

MICHELETTO, MARIANA C.; MENDES, LUIS F. S.; BASSO, LUIS G. M.; FONSECA-MALDONADO, RAQUEL G.; COSTA-FILHO, ANTONIO J.. Lipid membranes and acyl-CoA esters promote opposing effects on acyl-CoA binding protein structure and stability. International Journal of Biological Macromolecules, v. 102, p. 284-293, . Citações Web of Science: 2. (15/18390-5, 12/13309-7, 14/00206-0, 15/50366-7)

FONTANA, N. A.; FONSECA-MALDONADO, R.; MENDES, L. F. S.; MELEIRO, L. P.; COSTA-FILHO, A. J.. The yeast GRASP Grh1 displays a high polypeptide backbone mobility along with an amyloidogenic behavior. SCIENTIFIC REPORTS, v. 8, . Citações Web of Science: 3. (15/18390-5, 16/09676-5, 16/23863-2, 12/20367-3, 15/50366-7, 12/13309-7)

Publicações acadêmicas

(Referências obtidas automaticamente das Instituições de Ensino e Pesquisa do Estado de São Paulo)

MENDES, Luis Felipe Santos. Caracterização estrutural e dinâmica da proteína de estruturação e compactação do complexo de Golgi (GRASP) em solução. Tese (Doutorado) -  Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto.  Universidade de São Paulo (USP).  Ribeirão Preto.  (12/13309-7

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