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Robert Ryan Geyer

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Universidade de São Paulo (USP). Instituto de Química (IQ)  (Instituição-sede da última proposta de pesquisa)
País de origem: Estados Unidos

Ryan obtained his undergraduate degree in biology and chemistry at Earlham College, Richmond, Indiana, USA, in 1998. He studied molecular biology and biochemistry at Wright State University School of Medicine in Dayton, Ohio, USA, where he received his Ph.D. degree in 2007 under the mentorship of Professor Lawrence J. Prochaska. Ryan was a postdoctoral fellow at the Department of Physiology and Biophysicis, at Case Western Reserve University School of Medicine, Cleveland, Ohio. Ryan has experience in two dimensional NMR (2D-NMR) to investigate protein-protein interactions of membrane proteins, protein expression and purification, surface labeling, and proteomics. Using biochemical techniques, Ryan worked to identify the DIDS binding site in the water channel Aquaporin 1 towards the goal of elucidating the molecular mechanism of CO2 transport through the protein. Also Ryan has been working with the identification of O2 channels in red blood cells (RBCs). In this project, a stopped-flow absorbance spectroscopy approach was developed to monitor the rate of oxygenation and deoxygenation of RBCs in the presence and absence of inhibitors, as well as in knockout mice (which resulted in a patent for an assay measuring red blood hemolysis, by measuring carbonic anhydrase activity (US Patent App. 15/174,445). These projects were funded by the Office of Naval Research. Ryan was also postdoctoral fellow at the Department of Biochemistry, at University of Sao Paulo, Sao Paulo, Brazil, where in collaboration with investigators from the CEPID REDOXOMA gained a better understanding of the physiological consequences of oxidative protein posttranslational modifications, and molecular mechanisms of enzymes involved in antioxidant defense. (Fonte: Currículo Lattes)

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Publicações resultantes de Auxílios e Bolsas sob responsabilidade do(a) pesquisador(a) (3)

(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)

Publicações3
Citações14
Cit./Artigo4,7
Dados do Web of Science

KABUTOMORI, JESSICA; BELOTO-SILVA, OLIVIA; GEYER, R. RYAN; MUSA-AZIZ, RAIF. Lithobates catesbeianus (American Bullfrog) oocytes: a novel heterologous expression system for aquaporins. BIOLOGY OPEN, v. 7, n. 4, . Citações Web of Science: 0. (13/11364-3, 13/23087-4, 13/10780-3)

PEIXOTO, ALBERT SOUZA; RYAN GEYER, R.; IQBAL, ASIF; TRUZZI, DANIELA R.; SOARES MORETTI, ANA I.; LAURINDO, FRANCISCO R. M.; AUGUSTO, OHARA. Peroxynitrite preferentially oxidizes the dithiol redox motifs of protein-disulfide isomerase. Journal of Biological Chemistry, v. 293, n. 4, p. 1450-1465, . Citações Web of Science: 3. (13/07937-8, 08/57721-3)

TAIRUM, CARLOS A.; SANTOS, MELINA CARDOSO; BREYER, CARLOS A.; RYAN GEYER, R.; NIEVES, CECILIA J.; PORTILLO-LEDESMA, STEPHANIE; FERRER-SUETA, GERARDO; TOLEDO, JR., JOSE CARLOS; TOYAMA, MARCOS H.; AUGUSTO, OHARA; et al. Catalytic Thr or Ser Residue Modulates Structural Switches in 2-Cys Peroxiredoxin by Distinct Mechanisms. SCIENTIFIC REPORTS, v. 6, . Citações Web of Science: 11. (07/50930-3, 13/07937-8)

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