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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Does elective neck dissection in T1/T2 carcinoma of the oral tongue and floor of the mouth influence recurrence and survival rates?

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Autor(es):
Kelner, Natalie [1] ; Vartanian, Jose Guilherme [1] ; Lopes Pinto, Clovis Antonio [2] ; Coutinho-Camillo, Claudia Malheiros [2] ; Kowalski, Luiz Paulo [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] ACCamargo Canc Ctr, Dept Otorhinolaryngol Head & Neck Surg, BR-01509900 Sao Paulo - Brazil
[2] ACCamargo Canc Ctr, Dept Pathol, BR-01509900 Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY; v. 52, n. 7, p. 590-597, SEP 2014.
Citações Web of Science: 12
Resumo

The aim of this study was to evaluate the results of elective neck dissection compared with observation (control group) in selected cases of early carcinoma of the oral tongue and floor of the mouth. It was a retrospective analysis of 222 patients who had the tumour resected (161 also had elective neck dissection). Occult lymph node metastases were detected in 33/161 (21%), and neck recurrences were diagnosed in 10 of the 61 patients in the control group (16%). Occult lymph node metastases reduced the 5-year disease-specific survival from 90% to 65% (p = 0.001) and it was 96% among the controls. The 5-year disease-specific survival was 85% in the group treated by neck dissection and 96% in the observation group (p = 0.09). Rigorous follow-up of selected low risk patients is associated with high rates of salvage, and overall survival was similar to the observed survival in patients treated by elective neck dissection. Observation is a reasonable option in the treatment of selected patients. (C) 2014 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 11/03507-3 - Fatores clínico-patológicos e expressão imunoistoquímica de potenciais marcadores preditivos para metástase cervical em carcinoma epidermóide inicial (T1-T2) de língua e assoalho bucal
Beneficiário:Natalie Kelner de Queiroz
Linha de fomento: Bolsas no Brasil - Doutorado