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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Vaccination of grazing calves with antigens from the intestinal membranes of Haemonchus contortus: effects against natural challenge with Haemonchus placei and Haemonchus similis

Texto completo
Autor(es):
Bassetto, C. C. [1] ; Silva, M. R. L. [1] ; Newlands, G. F. J. [2] ; Smith, W. D. [2] ; Ratti Junior, J. [3] ; Martins, C. L. [3] ; Amarante, A. F. T. [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] UNESP Univ Estadual Paulista, Inst Biociencias, Dept Parasitol, BR-18618000 Botucatu, SP - Brazil
[2] Moredun Res Inst, Edinburgh EH26 0PZ, Midlothian - Scotland
[3] UNESP, Dept Anim Prod, Fac Med Vet & Zootecnia, BR-18618000 Botucatu, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: International Journal for Parasitology; v. 44, n. 10, p. 697-702, SEP 2014.
Citações Web of Science: 7
Resumo

A vaccine containing integral membrane glycoproteins from the intestine of Haemonchus contortus was evaluated in three groups of eight 5 months old grazing calves, naturally infected by Haemonchus similis, Haemonchus placei and other gastrointestinal nematodes. Vaccinated calves received 5 or 50 mu g of the antigen and 1 mg of saponin adjuvant, while the controls received adjuvant alone, initially three times, 3 weeks apart and then four more times at 6 weeks intervals. Three weeks after the last immunisation all of the calves were euthanised for worm counts. Immunisation stimulated high titre antibodies against the vaccine antigens, reduced the egg output of Haemonchus spp. by 85% and the numbers of H. placei and H. shnilis by 63% and 32%, respectively, compared with control calves. It was concluded that vaccination with intestinal membrane glycoproteins from H. contortus could substantially reduce the transmission of H. placei and H. similis, thus providing protective benefit downstream. This appears to be the first known successful demonstration of a vaccine protective for cattle naturally exposed to infection with any gastrointestinal nematode parasite. (C) 2014 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 10/18678-5 - Proteção de ovinos e bovinos contra haemoncose após imunização com antígenos oriundos da membrana intestinal de Haemonchus contortus
Beneficiário:César Cristiano Bassetto
Linha de fomento: Bolsas no Brasil - Doutorado