Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Acute cardiopulmonary effects induced by the inhalation of concentrated ambient particles during seasonal variation in the city of Sao Paulo

Texto completo
Autor(es):
de Brito, Jose Mara [1] ; Macchione, Mariangela [1] ; Yoshizaki, Kelly [1] ; Toledo-Arruda, Alessandra Choqueta [2] ; Saraiva-Romanholo, Beatriz Mangueira [2] ; Andrade, Maria de Fatima [3] ; Mauad, Thais [1] ; Rodriguez Ferreira Rivero, Dolores Helena [1] ; Nascimento Saldiva, Paulo Hilario [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Med, Dept Pathol, Lab Expt Air Pollut, BR-01246903 Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, Dept Med, Lab Expt Therapeut, BR-01246903 Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Astron Geophys & Atmospher Sci, BR-01246903 Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Journal of Applied Physiology; v. 117, n. 5, p. 492-499, SEP 1 2014.
Citações Web of Science: 8
Resumo

Ambient particles may undergo modifications to their chemical composition as a consequence of climatic variability. The determination of whether these changes modify the toxicity of the particles is important for the understanding of the health effects associated with particle exposure. The objectives were to determine whether low levels of particles promote cardiopulmonary effects, and to assess if the observed alterations are influenced by season. Mice were exposed to 200 mu g/m(3) concentrated ambient particles (CAPs) and filtered air (FA) in cold/dry and warm/humid periods. Lung hyperresponsiveness, heart rate, heart rate variability, and blood pressure were evaluated 30 min after each exposure. After 24 h, blood and tissue samples were collected. During both periods (warm/humid and cold/dry), CAPs induced alterations in red blood cells and lung inflammation. During the cold/dry period, CAPs reduced the mean corpuscular volume levels and increased erythrocytes, hemoglobin, mean corpuscular hemoglobin concentration, and red cell distribution width coefficient variation levels compared with the FA group. Similarly, CAPs during the warm/humid period decreased mean corpuscular volume levels and increased erythrocytes, hemoglobin, hematocrit, and red cell distribution width coefficient variation levels compared with the FA group. CAPs during the cold/dry period increased the influx of neutrophils in the alveolar parenchyma. Short-term exposure to low concentrations of CAPs elicited modest but significant pulmonary inflammation and, to a lesser extent, changes in blood parameters. In addition, our data support the concept that changes in climate conditions slightly modify particle toxicity because equivalent doses of CAPs in the cold/dry period produced a more exacerbated response. (AU)

Processo FAPESP: 10/50841-3 - Avaliação da exposição aguda as partículas urbanas concentradas e da exaustão de motores diesel e biodiesel sobre o perfil inflamatório pulmonar e sistêmico de camundongos
Beneficiário:Jôse Mára de Brito
Linha de fomento: Bolsas no Brasil - Doutorado