Study of in vitro degradation of brushite cements scaffolds

Autor(es)

Reno, Caroline de Oliveira ^[1] ; Pereta, Nicholas C. ^[1] ; Bertran, Celso A. ^[2] ; Motisuke, Mariana ^[1] ; de Sousa, Eliandra ^[1]

Afiliação do(s) autor(es)

^[1] Fed Univ Sao Paulo UNIFESP, Inst Sci & Technol, Bioceram Lab, BR-12231280 Sao Paulo - Brazil

^[2] Univ Campinas UNICAMP, Inst Chem, Dept Phys Chem, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE; v. 25, n. 10, p. 2297-2303, OCT 2014.
• Citações Web of Science: 8

Resumo

An interest path to fabricate supports for tissue engineering is to foam calcium phosphate cement's pastes leading to an increase on material's total porosity and interconnectivity which facilitates cells' adhesion, proliferation and differentiation. The aim of this work is to develop scaffolds of brushite cement and to evaluate its in vitro degradation rate. Macroporosity was obtained by foaming the liquid phase with different non-ionic surfactants (Tween 80 and Lutensol ON-110). The foam stability was achieved by adding chitosan. The scaffolds were immersed in Ringers(A (R)) solution during 7, 14, 21 and 28 days and samples' microstructure, weight loss, mechanical resistance and apparent porosity were evaluated. Both scaffolds presented interconnected macropores with sizes ranging from 100 to 360 A mu m and total porosities higher than 60 %. These properties could facilitate cell infiltration, bone growth and vascularization. The scaffolds obtained in this work should be considered as promising materials for application in bone tissue engineering. (AU)

• Processo FAPESP: 10/00863-0 - Processamento e caracterização de suportes porosos nanoestruturados do tipo B-TCP/Al2O3 para aplicações biomédicas
• Beneficiário: Eliandra de Sousa Trichês
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/09240-9 - Otimização de cimentos de fosfato de cálcio para aplicação na ortopedia e na engenharia tecidual
• Beneficiário: Mariana Motisuke
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/21198-0 - Fabricação de microesferas bioativas e reabsorvíveis de fosfato de cálcio para a liberação controlada de drogas
• Beneficiário: Caroline de Oliveira Renó
• Modalidade de apoio: Bolsas no Brasil - Mestrado