Cobalt(III) complexes with thiosemicarbazones as potential anti-Mycobacterium tuberculosis agents

Autor(es)

Oliveira, Carolina G. ^[1] ; Maia, Pedro Ivo da S. ^[2] ; Miyata, Marcelo ^[3] ; Pavan, Fernando R. ^[3] ; Leite, Clarice Q. F. ^[3] ; de Almeida, Eduardo Tonon ^[4] ; Deflon, Victor M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13566590 Sao Carlos, SP - Brazil

^[2] Univ Fed Triangulo Mineiro, Dept Quim, BR-38025440 Uberaba, MG - Brazil

^[3] Univ Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP - Brazil

^[4] Univ Fed Alfenas, Inst Quim, BR-37130000 Alfenas, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of the Brazilian Chemical Society; v. 25, n. 10, p. 1848+, OCT 2014.
• Citações Web of Science: 13

Resumo

CoIII complexes derived from 2-acetylpyridine N(4)-R thiosemicarbazone (Hatc-R, R = alkyl, aryl) have been characterized by elemental analysis, FTIR, UV-Visible and ¹H NMR spectroscopies, cyclic voltammetry (CV), conductimetry measurements and single crystal X-ray diffractometry. The results obtained are consistent with the oxidation of the CoII center to CoIII upon coordination of the monoanionic N,N,S-tridentate thiosemicarbazone ligands, resulting in octahedral ionic complexes of the type [Co(atc-R)2]Cl. Electrochemistry studies show two reversible processes referring to the redox couples CoIII/CoII and CoII/CoI which can be modified by the inductive effects of the substituents groups at the N4 position of the ligands. Two CoIII complexes showed satisfactory activity with minimal inhibitory concentration value under 10 µmol L- 1 and one presented quite low cytotoxicity against VERO and J774A.1 cells (IC50), resulting in high selectivity index (SI > 10). (AU)

• Processo FAPESP: 11/16380-1 - Complexos de Au, Re e Tc com tiossemicarbazonas de interesse no desenvolvimento de fármacos ou radiofármacos para diagnóstico ou terapia
• Beneficiário: Pedro Ivo da Silva Maia
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 09/54011-8 - EMU: aquisição de difratômetro de raios X de monocristal para análise estrutural de moléculas pequenas e proteínas
• Beneficiário: Victor Marcelo Deflon
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários
• Processo FAPESP: 13/14957-5 - Investigação do potencial contra tuberculose de uma nova classe de compostos furoxânicos e compostos nanoestruturados de rutênio(II) e cobre(II)
• Beneficiário: Fernando Rogério Pavan
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores