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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Development of a buccal mucoadhesive film for fast dissolution: mathematical rationale, production and physicochemical characterization

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Autor(es):
Vila, Marta M. D. C. [1] ; Tardelli, Edgard R. [1] ; Chaud, Marco V. [1] ; Tubino, Matthieu [2] ; Balcao, Victor M. [1, 3, 4]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sorocaba, Lab Dev & Evaluat Bioact Subst, BR-18023000 Sao Paulo - Brazil
[2] Univ Estadual Campinas, Inst Chem, Sao Paulo - Brazil
[3] Univ Minho, Ctr Biol Engn, IBB, Braga - Portugal
[4] Univ Fernando Pessoa, Fac Hlth Sci, Oporto - Portugal
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: DRUG DELIVERY; v. 21, n. 7, p. 530-539, NOV 2014.
Citações Web of Science: 8
Resumo

The validity of a mathematical rationale for preparation of a fast-dissolving buccal mucoadhesive was tested. A buccal mucoadhesive biopolymeric formulation has been developed having pullulan as the main component. The formulation was duly evaluated physicochemically, via assays for intrinsic viscosity (resulting in 71.61 cm(3) g(-1)), differential scanning calorimetry analysis (resulting in a Tg = 63 degrees C), thermogravimetric analysis (244-341 degrees C), moisture content determinations (14%, w/w), dissolution timeframe (41.6 s), mucoadhesion force (40 kg/cm(2)), scanning electron microscopy analyses (critical ray under 1.0 mu m), mechanic strength (tensile strength = 58 N/mm(2), deformation = 4.4%). The mucoadhesive formulation exhibited important characteristics for a drug carrier, that is, a 6 cm(2) area, a fast dissolution timeframe, an adequate mucoadhesivity, resistance to both oxygen and water vapor penetration, increased viscosity in solution (ranging from 33.2 cm(3)/g to 71.61 cm(3)/g), easy molding, suitable water solubility and transparency. (AU)

Processo FAPESP: 11/51077-8 - Vitor Manuel Cardoso Figueiredo Balcão | Universidade Fernando Pessoa - Portugal
Beneficiário:Marta Maria Duarte Carvalho Vila
Linha de fomento: Auxílio à Pesquisa - Pesquisador Visitante - Internacional