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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

What are the similarities and differences between schizophrenia and schizophrenia-like psychosis of epilepsy? A neuropathological approach to the understanding of schizophrenia spectrum and epilepsy

Texto completo
Autor(es):
Kandratavicius, Ludmyla [1, 2] ; Hallak, Jaime Eduardo [1, 2, 3] ; Leite, Joao Pereira [1, 2]
Número total de Autores: 3
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, Sao Paulo - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Neurosci & Behav, BR-14049900 Ribeirao Preto, SP - Brazil
[3] Natl Inst Sci & Technol Translat Med INCT TM CNPq, Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo de Revisão
Fonte: Epilepsy & Behavior; v. 38, n. SI, p. 143-147, SEP 2014.
Citações Web of Science: 5
Resumo

Temporal lobe epilepsy (TLE) and psychosis coexist more frequently than chance would predict. In this short review, clinical and neuropathological findings of schizophrenia, TLE, and psychosis of epilepsy are described to enhance our understanding of the noncoincidental association between these conditions. In addition, psychosis of epilepsy was included for the first time in the Diagnostic and Statistical Manual of Mental Disorders (DSM), in the recently launched 5th edition, and improvement in diagnostic criteria was highlighted. Since the hippocampus has long been considered an anatomical area involved in the pathophysiology of TLE and schizophrenia, neuropathological studies of psychoses of epilepsy may contribute to our understanding of the pathophysiology of psychosis in general. The discovery of shared mechanisms and/or affected neurochemicals in TLE and schizophrenia might disclose important clues on the vulnerability of patients with TLE to psychotic symptoms and be an opportunity for new treatment development. (C) 2014 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 07/56721-7 - Neurotrofinas na epilepsia do lobo temporal associada ou não a comorbidades psiquiátricas e no modelo animal de lítio-pilocarpina
Beneficiário:Ludmyla Kandratavicius
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 05/56447-7 - Pesquisa através de imagens por ressonância magnética de alto campo destinadas a estudos em humanos
Beneficiário:João Pereira Leite
Linha de fomento: Auxílio à Pesquisa - Programa CINAPCE - Temático