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Lopes, Mariana Pezzute
[1]
;
Nunes Santos, Magnun Nueldo
[1]
;
Faber, Eliel Wagner
[1]
;
Cavalcanti Bezerra, Marcos Andre
[2]
;
Domingues Hatzlhofer, Betania Lucena
[2]
;
Albuquerque, Dulcineia Martins
[3]
;
Zaccariotto, Tania Regina
[1]
;
Ribeiro, Daniela Maria
[1]
;
Araujo, Aderson da Silva
[2]
;
Costa, Fernando Ferreira
[3]
;
Sonati, Maria de Fatima
[1]
Número total de Autores: 11
|
| Afiliação do(s) autor(es): | [1] State Univ Campinas UNICAMP, Sch Med Sci, Dept Clin Pathol, BR-13083970 Campinas, SP - Brazil
[2] HEMOPE Fdn, Pernambuco Hematol & Hemotherapy Ctr, BR-52011900 Recife, PE - Brazil
[3] Univ Estadual Campinas, Hematol & Hemotherapy Ctr, BR-13083878 Campinas, SP - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | DISEASE MARKERS; 2014. |
| Citações Web of Science: | 3 |
| Resumo | |
Background. Previous studies on the role of inflammation in the pathophysiology of sickle cell disease (SCD) suggested that the CCR5 Delta 32 allele, which is responsible for the production of truncated C-C chemokine receptor type 5 (CCR5), could confer a selective advantage on patients with SCD because it leads to a less efficient Th1 response. We determined the frequency of the CCR5 Delta 32 polymorphism in 795 Afro-Brazilian SCD patients followed up at the Pernambuco Hematology and Hemotherapy Center, in Northeastern Brazil, divided into a pediatric group (3 months-17 years, n = 483) and an adult group (18-70 years, n = 312). The adult patients were also compared to a healthy control group (blood donors, 18-61 years, n = 247). Methods. The CCR5/CCR5 Delta 32 polymorphism was determined by allele-specific PCR. Results. No homozygous patient for the CCR5 Delta 32 allele was detected. The frequency of heterozygotes in the study population (patients and controls) was 5.8%, in the total SCD patients 5.1%, in the children 5.4%, in the adults with SCD 4.8%, and in the adult controls 8.1%. These differences did not reach statistical significance. Conclusions. Our findings failed to demonstrate an important role of the CCR5 Delta 32 allele in the population sample studied here. (AU) | |
| Processo FAPESP: | 08/57441-0 - Alterações clínicas, celulares e moleculares nas hemoglobinopatias e em outras anemias hemolíticas hereditárias |
| Beneficiário: | Fernando Ferreira Costa |
| Linha de fomento: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 11/02622-3 - Aspectos inflamatórios versus genótipos da haptoglobina e da hemopexina e presença do polimorfismo ccr5d32 na anemia falciforme |
| Beneficiário: | Maria de Fatima Sonati |
| Linha de fomento: | Auxílio à Pesquisa - Regular |