Busca avançada
Ano de início
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The benzodiazepine midazolam acts on the expression of the defensive behavior, but not on the processing of aversive information, produced by exposure to the elevated plus maze and electrical stimulations applied to the inferior colliculus of rats

Texto completo
Saito, Viviane M. [1, 2] ; Brandao, Marcus L. [1, 2]
Número total de Autores: 2
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, FFCLRP, Lab Neuropsychopharmacol, BR-14040901 Ribeirao Preto, SP - Brazil
[2] Inst Neurociencias & Comportamento, BR-14050000 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Neuropharmacology; v. 88, n. SI, p. 180-186, JAN 2015.
Citações Web of Science: 3

Electrical stimulation of midbrain tectum structures, particularly the dorsal periaqueductal gray (dPAG) and inferior colliculus (IC), produces defensive responses such as freezing and escape behavior. Freezing also results after termination of this stimulation (post-stimulation freezing; PSF). Whereas these responses are critically mediated by GABA in the dPAG, it is unclear how GABA-benzodiazepine mechanisms mediate the expression of fear (freezing and escape behaviors) and the processing of aversive information (PSF) produced by electrical stimulation of the IC. Since dorsal (ICd) and ventral regions (ICv) of the IC react differentially to aversive stimulation, we hypothesized that these regions might be sensitive to the action of benzodiazepine drugs when rats are submitted to animal models of anxiety: the elevated plus maze (EPM) and the IC electrical stimulation procedure. Midazolam (5, 10 or 20 nmol) was injected into the ICd or ICv of rats subjected to one of these tests. Intra-ICv, but not intra-lCd injections, of midazolam reduced the aversiveness of the IC electrical stimulation and decreased fear in the EPM, as assessed by its traditional and complementary measures. In contrast, the IC post-stimulation freezing remained unaltered with midazolam treatments. Thus, there is a clear pharmacological dissociation in the reactivity of dorsal and ventral regions of the IC to fear-provoking stimuli of the two animal models of anxiety used in this study. The present results support the proposal that benzodiazepine-mediated mechanisms are only involved in the output mechanisms of defensive behavior and not involved in the processing of ascending aversive information from the IC. This article is part of the Special Issue entitled `GABAergic Signaling in Health and Disease'. (C) 2014 Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 12/03707-5 - Papel dos mecanismos GABAérgicos do colículo inferior e da substância cinzenta periaquedutal na interface sensoriomotora do medo e ansiedade
Beneficiário:Viviane Mitsuko Neves Saito
Modalidade de apoio: Bolsas no Brasil - Doutorado
Processo FAPESP: 11/00041-3 - Neurobiologia do estresse: a interface sensório-motora
Beneficiário:Marcus Lira Brandão
Modalidade de apoio: Auxílio à Pesquisa - Temático