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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The emerging role of extracellular vesicles as biomarkers for urogenital cancers

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Autor(es):
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Nawaz, Muhammad [1] ; Camussi, Giovanni [2] ; Valadi, Hadi [3] ; Nazarenko, Irina [4] ; Ekstrom, Karin [3] ; Wang, Xiaoqin [3] ; Principe, Simona [5] ; Shah, Neelam [6] ; Ashraf, Naeem M. [7] ; Fatima, Farah [1] ; Neder, Luciano [1] ; Kislinger, Thomas [5]
Número total de Autores: 12
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, BR-05508 Sao Paulo - Brazil
[2] Univ Turin, I-10124 Turin - Italy
[3] Univ Gothenburg, BIOMATCELL VINN Excellence Ctr Biomat & Cell Ther, Gothenburg - Sweden
[4] Univ Med Ctr Freiburg, Freiburg - Germany
[5] Princess Margaret Canc Ctr, Toronto, ON M5G 1L7 - Canada
[6] Monash Univ, Clayton, Vic 3800 - Australia
[7] Univ Gujrat, Gujrat - Pakistan
Número total de Afiliações: 7
Tipo de documento: Artigo de Revisão
Fonte: NATURE REVIEWS UROLOGY; v. 11, n. 12, p. 688-701, DEC 2014.
Citações Web of Science: 121
Resumo

The knowledge gained from comprehensive profiling projects that aim to define the complex genomic alterations present within cancers will undoubtedly improve our ability to detect and treat those diseases, but the influence of these resources on our understanding of basic cancer biology is still to be demonstrated. Extracellular vesicles have gained considerable attention in past years, both as mediators of intercellular signalling and as potential sources for the discovery of novel cancer biomarkers. In general, research on extracellular vesicles investigates either the basic mechanism of vesicle formation and cargo incorporation, or the isolation of vesicles from available body fluids for biomarker discovery. A deeper understanding of the cargo molecules present in extracellular vesicles obtained from patients with urogenital cancers, through high-throughput proteomics or genomics approaches, will aid in the identification of novel diagnostic and prognostic biomarkers, and can potentially lead to the discovery of new therapeutic targets. (AU)

Processo FAPESP: 12/24574-3 - Perfil de citocinas na infecção pelo vírus da dengue: identificação de potenciais biomarcadores para diagnóstico e prognóstico
Beneficiário:Muhammad Nawaz
Linha de fomento: Bolsas no Brasil - Doutorado Direto