Comparison of preoperative tramadol and pethidine on postoperative pain in cats undergoing ovariohysterectomy

Autor(es)

Evangelista, Marina C. ^[1] ; Silva, Rodrigo A. ^[1] ; Cardozo, Larissa B. ^[1] ; Kahvegian, Marcia A. P. ^[1] ; Rossetto, Thais C. ^[1] ; Matera, Julia M. ^[1] ; Fantoni, Denise T. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Surg, Fac Med Vet & Zootecnia, BR-05508 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BMC Veterinary Research; v. 10, OCT 15 2014.
• Citações Web of Science: 7

Resumo

Background: A variety of analgesic agents are available, and which one can be used in dogs and cats is a highly controversial issue, existing however a fear in the use of opiates due to possible adverse effects that these drugs can cause. The aim of this study was to compare the analgesic effect provided by the administration of tramadol or pethidine on early postoperative pain of cats undergoing ovariohysterectomy in a double-blind prospective study. Fourty-two animals were randomly assigned into three groups. Pet received pethidine (6 mg/kg), Tra 2 received tramadol (2 mg/kg) and Tra 4 received tramadol (4 mg/kg); all intramuscularly and associated with acepromazine (0.1 mg/kg). The efficacy of each analgesic regimen was evaluated prior to surgery (baseline - T-BL), during surgery and 1, 3 and 6 hours after extubation with subjective pain scale, physiologic parameters, serum concentrations of glucose, cortisol and IL-6. Results: Changes in cardiovascular system were not clinically relevant. There were no significant differences in pain scores (P > 0.05) during the study, although the number of rescue analgesia was significantly higher (P < 0.05) at Pet group (5/14) than Tra 4 group (0/14), whereas in Tra 2, two animals (2/14) required additional analgesia. The serum cortisol values of Pet group were significantly higher at T-1h T-3h (P < 0.05) and T-6h (P < 0.01) when compared to baseline (induction), also it was noticed a significant difference among the groups at T-6h (Pet values were higher than Tra 2 and Tra 4; P < 0.05). Conclusions: Tramadol provided adequate analgesia and it was more effective than pethidine to at least six hours for the studied animals. At the higher dose (4 mg/kg) tramadol is probably more effective, since rescue analgesia was not necessary. No significant changes were observed physiological parameter that could contraindicate the use of these opioid in described doses, for the feline species. (AU)

• Processo FAPESP: 10/18900-0 - Avaliação da dor através de parâmetros objetivos e subjetivos em gatas submetidas à ovariossalpingohisterectomia com o uso de meperidina ou tramadol
• Beneficiário: Marina Cayetano Evangelista
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica