Calcium phosphate nanoparticles functionalized with a dimethacrylate monomer

Autor(es)

Rodrigues, Marcela Charantola ^[1] ; Reis Hewer, Thiago Lewis ^[2] ; de Souza Brito, Giancarlo Esposito ^[3] ; Arana-Chavez, Victor Elias ^[1] ; Braga, Roberto Ruggiero ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Dent, Dept Biomat & Oral Biol, BR-05508000 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Dept Chem Engn, BR-05508000 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Inst Phys, Dept Appl Phys, BR-05508090 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Materials Science & Engineering C-Materials for Biological Applications; v. 45, p. 122-126, DEC 1 2014.
• Citações Web of Science: 15

Resumo

The synthesis of calcium phosphate nanoparticles may include modifying agents to tailor particle size, reduce agglomeration and add specific functionalities. This study describes the synthesis of dicalcium phosphate dihydrate (DCPD) nanoparticles functionalized with triethylene glycol dimethacrylate (TEGDMA), added to one of the reacting solutions, with the purpose of reducing agglomeration and improving the compatibility with vinyl-based resin matrices. The nanoparticles were characterized by X-ray diffraction (XRD), Fourier-transformed infrared spectroscopy (FTIR), elemental analysis, thermogravimetric analysis (TGA), transmission electronic microscopy (TEM), dynamic light scattering (DLS), and surface area (BET). As controls, proprietary DCPD nanoparticles and nanoparticles synthesized without the addition of TEGDMA ({''}bare{''}) were subjected to the same analytical methods. XRD revealed a similar crystalline structure of the synthesized materials in comparison to the proprietary nanoparticles. The presence of a TEGDMA layer was confirmed by elemental analysis and TGA, corresponding to a mass fraction of 8.5%. FTIR analysis of the functionalized nanoparticles revealed the suppression of some absorbance bands found in the neat TEGDMA. A chemisorption mechanism between TEGDMA and the surface of primary particles by ion-dipole interaction involving TEGDMA oxyethylene, and also an interaction mechanism between the particle surface and terminal-CH3 groups are proposed. Functionalized nanoparticles showed 3 to 11 times higher surface area than the controls, in agreement with DLS data, indicating lower agglomeration. (C) 2014 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 12/04532-4 - Compósitos bioativos: efeito de diferentes compostos de fosfato de cálcio e da formulação da matriz orgânica sobre o potencial remineralizador e propriedades físico-químicas de materiais experimentais
• Beneficiário: Roberto Ruggiero Braga
• Modalidade de apoio: Auxílio à Pesquisa - Regular