Neonatal Sepsis and Inflammatory Mediators

Autor(es)

Machado, Juliana Reis ^{[1, 2]} ; Soave, Danilo Figueiredo ^[3] ; da Silva, Marcos Vinicius ^[4] ; de Menezes, Liliana Borges ^[1] ; Etchebehere, Renata Margarida ^[5] ; Goncalves dos Reis Monteiro, Maria Luiza ^[2] ; dos Reis, Marlene Antonia ^[2] ; Miranda Correa, Rosana Rosa ^[2] ; Nunes Celes, Mara Rubia ^{[3, 1]}

Afiliação do(s) autor(es)

^[1] Univ Fed Goias, Inst Trop Pathol & Publ Hlth, Dept Pathol, BR-74605050 Goiania, Go - Brazil

^[2] Univ Fed Goias, Inst Biol & Nat Sci, Dept Gen Pathol, BR-74605050 Uberaba, MG - Brazil

^[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pathol, BR-14049900 Ribeirao Preto, SP - Brazil

^[4] Univ Fed Triangulo Mineiro, Inst Biol & Nat Sci, Immunol Lab, BR-38025180 Uberaba, MG - Brazil

^[5] Univ Fed Triangulo Mineiro, Clin Hosp, Surg Pathol Serv, BR-38025180 Uberaba, MG - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Mediators of Inflammation; 2014.
• Citações Web of Science: 37

Resumo

Neonatal sepsis is a major cause of morbidity and mortality and its signs and symptoms are nonspecific, which makes the diagnosis difficult. The routinely used laboratory tests are not effective methods of analysis, as they are extremely nonspecific and often cause inappropriate use of antibiotics. Sepsis is the result of an infection associated with a systemic inflammatory response with production and release of a wide range of inflammatory mediators. Cytokines are potent inflammatory mediators and their serum levels are increased during infections, so changes from other inflammatory effector molecules may occur. Although proinflammatory and anti-inflammatory cytokines have been identified as probable markers of neonatal infection, in order to characterize the inflammatory response during sepsis, it is necessary to analyze a panel of cytokines and not only the measurement of individual cytokines. Measurements of inflammatory mediators bring new options for diagnosing and following up neonatal sepsis, thus enabling early treatment and, as a result, increased neonatal survival. By taking into account the magnitude of neonatal sepsis, the aim of this review is to address the role of cytokines in the pathogenesis of neonatal sepsis and its value as a diagnostic criterion. (AU)

• Processo FAPESP: 04/01777-0 - Sepsis e choque septico: alteracoes funcionais e morfologicas do coracao. estudo experimental em camundongos.
• Beneficiário: Mara Rúbia Nunes Celes
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 04/14578-5 - Sepsis e choque septico: alteracoes funcionais e morfologicas do coracao. estudo experimental em camundongos.
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• Modalidade de apoio: Auxílio à Pesquisa - Regular
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• Beneficiário: Maria José Figueiredo
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
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• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
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• Beneficiário: Danilo Figueiredo Soave
• Modalidade de apoio: Bolsas no Brasil - Doutorado