Modulation of defensive behavior by Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channels

Autor(es)

Aguiar, D. C. ^[1] ; Moreira, F. A. ^[1] ; Terzian, A. L. ^{[2, 3]} ; Fogaca, M. V. ^{[4, 5]} ; Lisboa, S. F. ^{[4, 5]} ; Wotjak, C. T. ^[2] ; Guimaraes, F. S. ^{[5, 4]}

Afiliação do(s) autor(es)

^[1] Univ Fed Minas Gerais, Inst Biol Sci, Dept Pharmacol, BR-31270901 Belo Horizonte, MG - Brazil

^[2] Max Planck Inst Psychiat, D-80804 Munich - Germany

^[3] Univ Munich, Grad Sch Syst Neurosci, D-82152 Martinsried - Germany

^[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pharmacol, BR-14049900 Ribeirao Preto, SP - Brazil

^[5] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, BR-14049900 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS; v. 46, n. 3, SI, p. 418-428, OCT 2014.
• Citações Web of Science: 28

Resumo

The Transient Receptor Potential Vanilloid Type-1 (TRPV1) was first characterized in primary afferent fibers as a receptor for capsaicin (the pungent ingredient of chili peppers). Later on, this cation-permeable ion channel was also described in the central nervous system, where its main putative endogenous ligand is N-arachidonoyl ethanolamide (an endocannabinoid, also known as anandamide). Recent results employing genetic, pharmacological and histochemical techniques indicate that TRPV1 tonically modulate anxiety, fear and panic responses in brain regions related to defensive responses, such as the dorsal periaqueductal gray, the hippocampus and the medial prefrontal cortex. Genetic deletion or antagonism of this ion channel induces anxiolytic-like effects in several animal models. The main mechanism responsible for TRPV1-mediated effects on anxiety seems to involve facilitation of glutamatergic neurotransmission. In addition, there is evidence for interactions with other neurotransmitter systems, such as nitric oxide and endocannabinoids. (C) 2014 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 12/17626-7 - Mecanismos celulares e moleculares envolvidos no papel de neurotransmissores atípicos em transtornos neuropsiquiátricos
• Beneficiário: Francisco Silveira Guimaraes
• Linha de fomento: Auxílio à Pesquisa - Temático