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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Directional selection can drive the evolution of modularity in complex traits

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Autor(es):
Melo, Diogo [1] ; Marroig, Gabriel [1]
Número total de Autores: 2
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Biociencias, Dept Genet & Biol Evolut, BR-05508090 Sao Paulo - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Proceedings of the National Academy of Sciences of the United States of America; v. 112, n. 2, p. 470-475, JAN 13 2015.
Citações Web of Science: 32
Resumo

Modularity is a central concept in modern biology, providing a powerful framework for the study of living organisms on many organizational levels. Two central and related questions can be posed in regard to modularity: How does modularity appear in the first place, and what forces are responsible for keeping and/or changing modular patterns? We approached these questions using a quantitative genetics simulation framework, building on previous results obtained with bivariate systems and extending them to multivariate systems. We developed an individual-based model capable of simulating many traits controlled by many loci with variable pleiotropic relations between them, expressed in populations subject to mutation, recombination, drift, and selection. We used this model to study the problem of the emergence of modularity, and hereby show that drift and stabilizing selection are inefficient at creating modular variational structures. We also demonstrate that directional selection can have marked effects on the modular structure between traits, actively promoting a restructuring of genetic variation in the selected population and potentially facilitating the response to selection. Furthermore, we give examples of complex covariation created by simple regimes of combined directional and stabilizing selection and show that stabilizing selection is important in the maintenance of established covariation patterns. Our results are in full agreement with previous results for two-trait systems and further extend them to include scenarios of greater complexity. Finally, we discuss the evolutionary consequences of modular patterns being molded by directional selection. (AU)

Processo FAPESP: 10/04497-9 - Evolução morfológica e modularidade
Beneficiário:Diogo Amaral Reboucas Melo
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 11/14295-7 - Modularidade e suas consequências evolutivas
Beneficiário:Gabriel Henrique Marroig Zambonato
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 12/20180-0 - Técnicas computacionais em genética quantitativa
Beneficiário:Diogo Amaral Reboucas Melo
Linha de fomento: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico