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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Ruthenium(II) complexes with hydroxypyridinecarboxylates: Screening potential metallodrugs against Mycobacterium tuberculosis

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Autor(es):
Barbosa, Marilia I. F. [1] ; Correa, Rodrigo S. [1] ; Pozzi, Lucas V. [1] ; Lopes, Erica de O. [2] ; Pavan, Fernando R. [2] ; Leite, Clarice Q. F. [2] ; Ellena, Javier [3] ; Machado, Sergio de P. [4] ; Von Poelhsitz, Gustavo [5] ; Batista, Alzir A. [1]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Estadual Paulista, Dept Ciencias Biol, Fac Ciencias Farmaceut, BR-14800900 Araraquara, SP - Brazil
[3] Univ Sao Paulo, Inst Fis Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil
[4] Univ Fed Rio de Janeiro, Inst Quim, BR-21941590 Rio De Janeiro, RJ - Brazil
[5] Univ Fed Uberlandia, Inst Quim, BR-38400902 Uberlandia, MG - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: Polyhedron; v. 85, p. 376-382, JAN 8 2015.
Citações Web of Science: 17
Resumo

Three promising antimycobacterium tuberculosis ruthenium(II) complexes with the deprotonated ligands 2-hydroxynicotinic acid (2-OHnicH), 6-hydroxynicotinic acid (6-OHnicH) and 3-hydroxypicolinic acid (3-OHpicH) were synthesized and characterized. Structural analysis revealed three different coordination modes depending of the hydroxypyridinecarboxylate ligand. In the complex {[}Ru(2-OHnic)(dppb)(bipy)PF6 (1), the 2-OHnic anion is coordinated by the O,O-chelating mode (via carboxylate group and phenolate oxygen), in the Ru(6-OHnic)(dppb)(bipy)]PF6 (2) a O-O chelation by the carboxylate group is observed for the 6-OHnic ligand and for the complex {[}Ru(3-OHpic)(dppb)(bipy))PF6 (3) a N,O-chelating mode (via carboxylate) occurs to the 3-OHpic anion. The compounds were evaluated for activity against Mycobacterium tuberculosis H(37)Rv ATCC 27294 using Resazurin Microtitre Assay (REMA) plate method and cytotoxicity in VERO CCL-81 cell line. All the synthesized compounds exhibited good antimycobacterial activity and a completely lack of cytotoxicity activity, indicating a good selectivity index. (C) 2014 Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 13/26559-4 - Modificações estruturais em complexos de Ru(II) biologicamente ativos para o desenho de novos candidatos a metalofármacos
Beneficiário:Rodrigo de Souza Corrêa
Linha de fomento: Bolsas no Brasil - Pós-Doutorado