| Texto completo | |
| Autor(es): |
Número total de Autores: 3
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| Afiliação do(s) autor(es): | [1] Maua Inst Technol IMT, BR-09580900 Sao Caetano do Sul, SP - Brazil
[2] Univ Campinas UNICAMP, Sch Chem Engn, Campinas, SP - Brazil
Número total de Afiliações: 2
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| Tipo de documento: | Artigo Científico |
| Fonte: | Powder Technology; v. 269, p. 185-192, JAN 2015. |
| Citações Web of Science: | 7 |
| Resumo | |
In this work, didofenac sodium pellets were produced through an extrusion/spheronization process and subsequently coated in a fluidized bed coater column with a Wurster insert. The aim of this work was to study the coating of pellets with two commercial aqueous enteric polymer suspensions, Advantia (R) Performance and Acryl-Eze (R) MP. The coating process was studied with a 2(3) experimental design. The variables were as follows: inlet air temperature, suspension flow rate and coating polymer. The response variables were as follows: the process efficiency, which generated results above 782%, and the agglomeration fraction, which generated results below 8%. The polymer coating type was the variable that influenced the response variables the most. The minimum masses gain needed to achieve enteric release were also determined: Actyl-Eze (R) MP: 9.7% and Advantia (R) Performance: 8.6%. The coated pellets were tested for drug content, dissolution and stability. Neither the drug content nor the release profiles were significantly affected by storage at 40 degrees C and 75%. The suspensions were tested for rheology, contact angle and static wettability to investigate the characteristics of the polymer. (C) 2014 Elsevier B.V. All rights reserved. (AU) | |
| Processo FAPESP: | 09/11834-4 - Comparação de diferentes polímeros comeriais empregados no recobrimento de microgrânulos de liberação modificada. |
| Beneficiário: | Roberta Albanez Toreta |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |