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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Postoperative analgesic effects of epidural administration of neostigmine alone or in combination with morphine in dogs undergoing orthopedic surgery of the pelvic limbs

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Autor(es):
Marucio, Rodrigo L. [1] ; Monteiro, Eduardo R. [2] ; Moroz, Ludmila R. [1] ; Fantoni, Denise T. [3]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Vet Med & Anim Sci, Dept Surg, BR-05508270 Sao Paulo - Brazil
[2] Univ Vila Velha, Fac Vet Med, BR-29102770 Vila Velha, ES - Brazil
[3] Univ Sao Paulo, Fac Med, Lab Med Invest LIM 08, BR-01246903 Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: AMERICAN JOURNAL OF VETERINARY RESEARCH; v. 75, n. 11, p. 956-963, NOV 2014.
Citações Web of Science: 4
Resumo

Objective-To evaluate the postoperative analgesic effects of epidural administration of morphine and neostigmine, either alone or in combination, in dogs. Animals-30 dogs undergoing orthopedic surgery on a pelvic limb. Procedures-Anesthetic protocols were standardized. At the end of surgery, 10 dogs each received 1 of 3 epidural treatments: morphine (0.1 mg/kg), neostigmine (5 mu g/kg), or morphine plus neostigmine (0.1 mg/kg and 5 mu g/kg, respectively). Postoperative pain scores and the need for rescue analgesia were evaluated for 24 hours. Results-Pain scores were higher in the neostigmine group, compared with scores for the morphine-neostigmine group, at 2 and 24 hours after surgery and higher in the morphine group than in the morphine-neostigmine group at 2 and 4 hours. During 24 hours, rescue analgesia was provided for 4, 7, and 2 of 10 dogs each in the morphine, neostigmine, and morphine-neostigmine groups, respectively. The number of dogs given rescue analgesia was significantly different among groups at 2, 3, 4, and 6 hours after surgery. Dogs in the morphine and morphine-neostigmine groups had a lower probability of receiving rescue analgesia within 24 hours than did dogs in the neostigmine group. Conclusions and Clinical Relevance-When administered epidurally, morphine alone or in combination with neostigmine provided effective postoperative analgesia in most dogs after orthopedic surgery, whereas neostigmine alone did not. Findings for this study suggested a potential role for neostigmine as an adjuvant for epidural analgesia in dogs undergoing orthopedic surgeries on the pelvic limbs. (AU)

Processo FAPESP: 07/57604-4 - Efeitos analgésicos da neostigmina e morfina, isoladas e associadas, pela via peridural em cães com fraturas ósseas nos membros posteriores
Beneficiário:Denise Tabacchi Fantoni
Linha de fomento: Auxílio à Pesquisa - Regular