| Texto completo | |
| Autor(es): |
Lima Nascimento, Manuela Sales
[1]
;
Carregaro, Vanessa
[1]
;
Lima-Junior, Djalma Souza
[1]
;
Costa, Diego Luis
[1]
;
Ryffel, Bernhard
[2, 3]
;
Duthie, Malcolm S.
[4]
;
de Jesus, Amelia
[5]
;
de Almeida, Roque Pacheco
[5]
;
da Silva, Joao Santana
[1]
Número total de Autores: 9
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Biochem & Immunol, Aracaju - Brazil
[2] CNRS, F-45071 Orleans - France
[3] Univ Orleans, UMR6218, Orleans - France
[4] Infect Dis Res Inst, Seattle, WA - USA
[5] Univ Fed Sergipe, Ctr Biol & Hlth Sci, Aracaju - Brazil
Número total de Afiliações: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Infectious Diseases; v. 211, n. 6, p. 1015-1026, MAR 15 2015. |
| Citações Web of Science: | 42 |
| Resumo | |
Interleukin 17 (IL-17) is an inflammatory cytokine that plays a protective role against intracellular parasites. The role of IL-17 during Leishmania infection remains controversial and poorly defined. We evaluated whether IL-17 participates in the host immune response to Leishmania infantum. IL-17A is present in sera from patients with visceral leishmaniasis and decreases after successful treatment. In C57BL/6 infected mice, higher production of IL-17A coincided with the peak of parasitism gamma Il17ra(-/-) mice were more susceptible to infection and also exhibited reduced inflammatory infiltration and interferon gamma (IFN-gamma)-expressing CD4(+) T-cell frequencies than wild-type mice. The frequencies of FoxP3(+)CD4(+) T cells and interleukin 10 (IL-10)-expressing CD4(+) T cells were increased in Il17ra(-/-) mice. We also demonstrated that IL-17A acts synergistically with IFN-gamma to potentiate NO production and leishmanicidal activity in infected macrophages. Therefore, our results indicate that L. infantum induces IL-17A production, which promotes the control of parasite replication by strengthening T-helper type 1 responses and NO production and prevents regulatory T-cell and IL-10-expressing T-cell expansion. (AU) | |
| Processo FAPESP: | 13/01967-2 - Caracterização dos mecanismos intracelulares envolvidos na geração e modulação da resposta imunológica adaptativa celular protetora durante a infecção por Leishmania infantum |
| Beneficiário: | Manuela Sales Lima Nascimento |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 12/14524-9 - Modulação da diferenciação de linfócitos T em infecções por protozoários, fungos e bactérias |
| Beneficiário: | João Santana da Silva |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |