Chronic Stress Improves NO- and Ca2+Flux-Dependent Vascular Function: A Pharmacological Study

Autor(es)

Bruder-Nascimento, Thiago ^{[1, 2]} ; Campos, Dijon Henrique Salome ^[1] ; Cicogna, Antonio Carlos ^[1] ; Cordellini, Sandra ^[2]

Afiliação do(s) autor(es)

^[1] Univ Estado Sao Paulo, UNESP, Dept Clin Med, Fac Med Botucatu, Botucatu, SP - Brazil

^[2] Univ Estado Sao Paulo, UNESP, Dept Farmacol, Inst Biociencias Botucatu, Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Arquivos Brasileiros de Cardiologia; v. 104, n. 3, p. 226-233, MAR 2015.
• Citações Web of Science: 3

Resumo

Background: Stress is associated with cardiovascular diseases. Objective: This study aimed at assessing whether chronic stress induces vascular alterations, and whether these modulations are nitric oxide (NO) and Ca2+ dependent. Methods: Wistar rats, 30 days of age, were separated into 2 groups: control (C) and Stress (St). Chronic stress consisted of immobilization for 1 hour/day, 5 days/week, 15 weeks. Systolic blood pressure was assessed. Vascular studies on aortic rings were performed. Concentration-effect curves were built for noradrenaline, in the presence of L-NAME or prazosin, acetylcholine, sodium nitroprusside and KCl. In addition, Ca2+ flux was also evaluated. Results: Chronic stress induced hypertension, decreased the vascular response to KCl and to noradrenaline, and increased the vascular response to acetylcholine. L-NAME blunted the difference observed in noradrenaline curves. Furthermore, contractile response to Ca2+ was decreased in the aorta of stressed rats. Conclusion: Our data suggest that the vascular response to chronic stress is an adaptation to its deleterious effects, such as hypertension. In addition, this adaptation is NO-and Ca2+-dependent. These data help to clarify the contribution of stress to cardiovascular abnormalities. However, further studies are necessary to better elucidate the mechanisms involved in the cardiovascular dysfunction associated with stressors. (AU)

• Processo FAPESP: 09/03771-2 - Alterações cardiovasculares em ratos expostos ou não ao estresse crônico durante a indução da obesidade
• Beneficiário: Thiago Bruder Do Nascimento
• Modalidade de apoio: Bolsas no Brasil - Mestrado