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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Is there a role for leptin in the reduction of depression symptoms during weight loss therapy in obese adolescent girls and boys?

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Autor(es):
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de Carvalho-Ferreira, Joana Pereira [1] ; Landi Masquio, Deborah Cristina [2] ; da Silveira Campos, Raquel Munhoz [2] ; Netto, Barbara Dal Molin [2] ; Corgosinho, Flavia Campos [2] ; Sanches, Priscila L. [2] ; Tock, Lian [3] ; Tufik, Sergio [4] ; de Mello, Marco Tulio [4] ; Finlayson, Graham [5] ; Damaso, Ana R. [2, 1]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Postgrad Program Interdisciplinary Hlth Sci, BR-11060001 Santos, SP - Brazil
[2] Univ Fed Sao Paulo, Postgrad Program Nutr, Sao Paulo, SP - Brazil
[3] Weight Sci, Sao Paulo, SP - Brazil
[4] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo, SP - Brazil
[5] Univ Leeds, Inst Psychol Sci, Leeds, W Yorkshire - England
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: Peptides; v. 65, p. 20-28, MAR 2015.
Citações Web of Science: 8
Resumo

Several studies have sought to clarify the association between adolescent obesity and psychological distress. Recently, a biological link between leptin resistance and depression has been proposed. The aim of the present study was to examine changes in leptin concentrations as a potential predictor of reduced depression symptoms in obese adolescents during long-term interdisciplinary weight loss therapy. Seventy-five obese adolescents (age: 16.28 +/- 2.37 years; BMI: 35.65 +/- 4.64 kg/m(2)) engaged in a long-term interdisciplinary therapy for weight loss. They were evaluated at baseline and after 1 year of treatment for body composition, serum analyses and depression symptomatology. After therapy, body mass BMI, fat mass (% and kg), waist circumference, visceral, subcutaneous and visceral/subcutaneous fat and depression symptoms decreased and lean mass (%) increased significantly. There was an improvement in inflammatory profiles with a significant reduction in leptin and increase in adiponectin. Regression analyses showed that decreased leptin predicted amelioration in depression symptoms independent of age, gender and changes in visceral fat, body mass, fat mass (%) and leptin/adiponectin ratio. These associations appear stronger in girls than boys. The attenuation of hyperleptinemia appears to play an important role in the association between weight loss and depression, particularly in obese girls. (C) 2015 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 11/50414-0 - Influência da hiperleptinemia nas respostas inflamatórias e aterogênicas em adolescentes obesos
Beneficiário:Ana Raimunda Dâmaso
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 11/50356-0 - Análise de complemento protéico plasmático e de fatores de risco metabólicos em adolescentes obesos em tratamento no Centro de Recuperação e Educação Nutricional (CREN)
Beneficiário:Ana Raimunda Dâmaso
Linha de fomento: Auxílio à Pesquisa - Regular