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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Fish Oil Decreases Hepatic Lipogenic Genes in Rats Fasted and Refed on a High Fructose Diet

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Autor(es):
de Castro, Gabriela S. [1, 2] ; Cardoso, Joao Felipe R. [3] ; Calder, Philip C. [2] ; Jordao, Alceu A. [1] ; Vannucchi, Helio [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Internal Med, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Southampton, Human Dev & Hlth Acad Unit, Fac Med, Southampton SO16 6YD, Hants - England
[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pathol, BR-14049900 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: NUTRIENTS; v. 7, n. 3, p. 1644-1656, MAR 2015.
Citações Web of Science: 9
Resumo

Fasting and then refeeding on a high-carbohydrate diet increases serum and hepatic triacylglycerol (TAG) concentrations compared to standard diets. Fructose is a lipogenic monosaccharide which stimulates de novo fatty acid synthesis. Omega-3 (n-3) fatty acids stimulate hepatic beta-oxidation, partitioning fatty acids away from TAG synthesis. This study investigated whether dietary n-3 fatty acids from fish oil (FO) improve the hepatic lipid metabolic response seen in rats fasted and then refed on a high-fructose diet. During the post-prandial (fed) period, rats fed a FO rich diet showed an increase in hepatic peroxisome proliferator-activated receptor alpha (PPAR-alpha) gene expression and decreased expression of carbohydrate responsive element binding protein (ChREBP), fatty acid synthase (FAS) and microsomal triglyceride transfer protein (MTTP). Feeding a FO rich diet for 7 days prior to 48 h of fasting resulted in lower hepatic TAG, lower PPAR-alpha expression and maintenance of hepatic n-3 fatty acid content. Refeeding on a high fructose diet promoted an increase in hepatic and serum TAG and in hepatic PPAR-alpha, ChREBP and MTTP expression. FO did not prevent the increase in serum and hepatic TAG after fructose refeeding, but did decrease hepatic expression of lipogenic genes and increased the n-3 fatty acid content of the liver. n-3 Fatty acids can modify some components of the hepatic lipid metabolic response to later feeding with a high fructose diet. (AU)

Processo FAPESP: 10/00408-1 - Efeitos dos ácidos graxos n-3 provenientes do óleo de peixe no metabolismo lipídico e expressão gênica de ratos alimentados com dieta rica em frutose
Beneficiário:Gabriela Salim Ferreira de Castro
Linha de fomento: Bolsas no Brasil - Doutorado