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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Epicardial and Pericardial Fat in Type 2 Diabetes: Favourable Effects of Biliopancreatic Diversion

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Autor(es):
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Junqueira Vasques, Ana Carolina [1, 2] ; Pareja, Jose Carlos [2, 3] ; Mattos Souza, Jose Roberto [4] ; Yamanaka, Ademar [2] ; de Oliveira, Maria da Saude [2] ; Novaes, Fernanda Satake [2] ; Chaim, Elinton Adami [3] ; Piccinini, Francesca [5] ; Dalla Man, Chiara [5] ; Cobelli, Claudio [5] ; Geloneze, Bruno [2]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Sch Appl Sci FCA, UNICAMP, Sao Paulo - Brazil
[2] Univ Estadual Campinas, Lab Invest Metab & Diabet LIMED, Fac Med Sci, Gastroctr, UNICAMP, BR-13081970 Campinas, SP - Brazil
[3] Univ Estadual Campinas, UNICAMP, Dept Surg, Diabet Surg Unit, Sao Paulo - Brazil
[4] Univ Estadual Campinas, UNICAMP, Fac Med Sci, Dept Cardiol, Sao Paulo - Brazil
[5] Univ Padua, Dept Informat Engn, Padua - Italy
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: OBESITY SURGERY; v. 25, n. 3, p. 477-485, MAR 2015.
Citações Web of Science: 4
Resumo

Purpose Ectopic fat is often identified in obese subjects who are susceptible to the development of type 2 diabetes mellitus (T2DM). The ectopic fat favours the decrease in insulin sensitivity (IS) and adiponectin levels. We aimed to evaluate the effect of biliopancreatic diversion (BPD) on the accumulation of ectopic fat, adiponectin levels and IS in obese with T2DM. Materials and Methods A nonrandomised controlled study was performed on sixty-eight women: 19 lean-control (23.0 +/- 2.2 kg/m(2)) and 18 obese-control (35.0 +/- 4.8 kg/m(2)) with normal glucose tolerance and 31 obese with T2DM (36.3 +/- 3.7 kg/m(2) ). Of the 31 diabetic women, 20 underwent BPD and were reassessed 1 month and 12 months after surgery. The subcutaneous adipose tissue, visceral adipose tissue, epicardial adipose tissue and pericardial adipose tissue were evaluated by ultrasonography. The IS was assessed by a hyperglycaemic clamp, applying the minimal model of glucose. Results One month after surgery, there was a reduction in visceral and subcutaneous adipose tissues, whereas epicardial and pericardial adipose tissues exhibited significant reduction at the 12-month assessment (p<0.01). Adiponectin levels and IS were normalised 1 month after surgery, resembling lean-control values and elevated above the obese-control values (p<0.01). After 12 months, the improvement in IS and adiponectin was maintained, and 17 of the 20 operated patients exhibited fasting glucose and glycated haemoglobin within the normal range. Conclusions After BPD, positive physiological adaptations occurred in grade I and II obese patients with T2DM. These adaptations relate to the restoration of IS and decreased adiposopathy and explain the acute (1 month) and chronic (12 months) improvements in the glycaemic control. (AU)

Processo FAPESP: 08/07312-0 - Capacidade secretória de insulina em pacientes saudáveis, em obesos, em obesos diabéticos tipo 2 e em obesos diabéticos tipo 2 submetidos à cirurgia bariátrica através do clamp hiperglicêmico
Beneficiário:Ana Carolina Junqueira Vasques
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 08/09451-7 - Capacidade secretória de insulina em pacientes saudáveis, em obesos, em obesos diabéticos tipo 2 e em obesos diabéticos tipo 2 submetidos à cirurgia bariátrica através do clamp hiperglicêmico.
Beneficiário:Bruno Geloneze Neto
Linha de fomento: Auxílio à Pesquisa - Regular