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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Adipokines as Drug Targets in Diabetes and Underlying Disturbances

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Autor(es):
Andrade-Oliveira, Vincius [1] ; Camara, Niels O. S. [1, 2] ; Moraes-Vieira, Pedro M. [3]
Número total de Autores: 3
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Biomed Sci 4, Dept Immunol, Lab Transplantat Immunobiol, BR-05508 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Div Nephrol, Lab Clin & Expt Immunol, Sao Paulo, SP - Brazil
[3] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Med, Div Endocrinol Diabet & Metab, Cambridge, MA 02138 - USA
Número total de Afiliações: 3
Tipo de documento: Artigo de Revisão
Fonte: JOURNAL OF DIABETES RESEARCH; 2015.
Citações Web of Science: 72
Resumo

Diabetes and obesity are worldwide health problems. White fat dynamically participates in hormonal and inflammatory regulation. White adipose tissue is recognized as amultifactorial organ that secretes several adipose-derived factors that have been collectively termed ``adipokines.{''} Adipokines are pleiotropic molecules that gather factors such as leptin, adiponectin, visfatin, apelin, vaspin, hepcidin, RBP4, and inflammatory cytokines, including TNF and IL-1 beta, among others. Multiple roles in metabolic and inflammatory responses have been assigned to these molecules. Several adipokines contribute to the self-styled ``low-grade inflammatory state{''} of obese and insulin-resistant subjects, inducing the accumulation of metabolic anomalies within these individuals, including autoimmune and inflammatory diseases. Thus, adipokines are an interesting drug target to treat autoimmune diseases, obesity, insulin resistance, and adipose tissue inflammation. The aim of this review is to present an overview of the roles of adipokines in different immune and nonimmune cells, which will contribute to diabetes as well as to adipose tissue inflammation and insulin resistance development. We describe how adipokines regulate inflammation in these diseases and their therapeutic implications. We also survey current attempts to exploit adipokines for clinical applications, which hold potential as novel approaches to drug development in several immune-mediated diseases. (AU)

Processo FAPESP: 12/02270-2 - Novos mecanismos celulares, moleculares e imunológicos das lesões renais agudas e crônicas: busca por novas estratégias terapêuticas
Beneficiário:Niels Olsen Saraiva Câmara
Linha de fomento: Auxílio à Pesquisa - Temático