Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Negative Energy Balance Induced by Paradoxical Sleep Deprivation Causes Multicompartmental Changes in Adipose Tissue and Skeletal Muscle

Texto completo
Autor(es):
Mostrar menos -
Monico-Neto, Marcos [1, 2] ; de Campos Giampa, Sara Quaglia [3, 2] ; Lee, Kil Sun [4] ; de Melo, Camila Maria [1, 2] ; Souza, Helton de Sa [1, 2] ; Dattilo, Murilo [1, 2] ; Minali, Paulo Alexandre [1, 2] ; Santos Prado, Pedro Henrique [2, 3] ; Tufik, Sergio [1, 2] ; de Mello, Marco Tulio [1, 2] ; Moreira Antunes, Hanna Karen [3, 2]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Psicobiol, BR-04024003 Sao Paulo, SP - Brazil
[2] Ctr Estudos Psicobiol & Exercicio, BR-04020060 Sao Paulo, SP - Brazil
[3] Univ Fed Sao Paulo, Dept Biociencias, BR-11015020 Santos, SP - Brazil
[4] Univ Fed Sao Paulo, Dept Bioquim, BR-04020060 Sao Paulo, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: INTERNATIONAL JOURNAL OF ENDOCRINOLOGY; 2015.
Citações Web of Science: 7
Resumo

Objective. Describe multicompartmental changes in the fat and various muscle fiber types, as well as the hormonal profile and metabolic rate induced by SD in rats. Methods. Twenty adult male Wistar rats were equally distributed into two groups: experimental group (EG) and control group (CG). The EG was submitted to SD for 96 h. Blood levels of corticosterone (CORT), total testosterone (TESTO), insulin like growth factor-1 (IGF-1), and thyroid hormones (T3 and T4) were used to assess the catabolic environment. Muscle trophism was measured using a cross-sectional area of various muscles (glycolytic, mixed, and oxidative), and lipolysis was inferred by the weight of fat depots from various locations, such as subcutaneous, retroperitoneal, and epididymal. The metabolic rate was measured using oxygen consumption (VO2) measurement. Results. SD increased CORT levels and decreased TESTO, IGF-1, and T4. All fat depots were reduced in weight after SD. Glycolytic and mixed muscles showed atrophy, whereas atrophy was not observed in oxidative muscle. Conclusion. Our data suggest that glycolytic muscle fibers are more sensitive to atrophy than oxidative fibers during SD and that fat depots are reduced regardless of their location. (AU)

Processo FAPESP: 98/14303-3 - Center for Sleep Studies
Beneficiário:Sergio Tufik
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 11/15962-7 - Efeitos do exercício físico resistido nas vias tróficas e atróficas da musculatura esquelética de ratos submetidos à privação de sono paradoxal
Beneficiário:Marcos Mônico Neto
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 13/00152-5 - Efeito do exercício físico resistido no músculo esquelético e cardíaco de ratos Wistar submetidos a privação de sono paradoxal
Beneficiário:Hanna Karen Moreira Antunes
Linha de fomento: Auxílio à Pesquisa - Regular