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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Antiulcerogenic Activity and Toxicity of Bauhinia holophylla Hydroalcoholic Extract

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Autor(es):
Rozza, A. L. [1] ; Cesar, D. A. S. [1] ; Pieroni, L. G. [2] ; Saldanha, L. L. [2] ; Dokkedal, A. L. [3] ; De-Faria, F. M. [4] ; Souza-Brito, A. R. M. [4] ; Vilegas, W. [5] ; Takahira, R. K. [6] ; Pellizzon, C. H. [1]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista UNESP, Lab Experimentat Nat Prod, Dept Morphol, Inst Biosci, BR-18618970 Botucatu, SP - Brazil
[2] Univ Estadual Paulista UNESP, Inst Biosci, Bot Dept, BR-18618970 Botucatu, SP - Brazil
[3] Univ Estadual Paulista UNESP, Fac Sci, Dept Biol Sci, BR-17033360 Bauru, SP - Brazil
[4] Univ Campinas Unicamp, Inst Biol, Dept Struct & Funct Biol, BR-13083862 Campinas, SP - Brazil
[5] Univ Estadual Paulista UNESP, Expt Campus Paulista Coast, BR-11330900 Sao Vicente, SP - Brazil
[6] Univ Estadual Paulista UNESP, Sch Vet Med & Anim Sci, Clin Vet Dept, BR-18618970 Botucatu, SP - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: Evidence-based Complementary and Alternative Medicine; 2015.
Citações Web of Science: 7
Resumo

Several species of Bauhinia are used in traditional medicine for the treatment of gastrointestinal diseases, diabetes, and inflammation, among other conditions. The aim of this study was to investigate the antiulcer effect of a hydroalcoholic extract from the leaves of B. holophylla. The chemical profile of the extract was determined by HPLC-PAD-ESI-IT-MS. A dose-effect relation was constructed using the ethanol-induced gastric ulcer model in male Wistar rats. Histological analyses and studies of antioxidant and anti-inflammatory activities were performed in stomach samples. The involvement of SH compounds, NO, K-ATP(+) channels, and alpha(2)-adrenergic receptors in the gastroprotective effect was evaluated. A toxicity study was performed with a single oral dose of 5000 mg/kg. The extract was composed mainly of cyanoglucoside and flavonol-O-glycosides derivatives of quercetin and myricetin. SH compounds, NO release, K-ATP(+) channel activation, and presynaptic alpha(2)-adrenergic receptor stimulation each proved to be involved in the antiulcer effect. The levels of GSH and activity of GR and GPx were increased, and the levels of TNF-alpha, IL-6 and IL-10 were modulated. There was an antidiarrheal effect and there were no signs of toxicity. B. holophylla presents antiulcer activity mainly by decreasing oxidative stress and attenuating the inflammatory response, without inducing side effects. (AU)

Processo FAPESP: 09/52237-9 - Fitoterápicos padronizados como alvo para o tratamento de doenças crônicas
Beneficiário:Wagner Vilegas
Linha de fomento: Auxílio à Pesquisa - Programa BIOTA - Temático
Processo FAPESP: 12/05323-0 - Atividade gastroprotetora, antioxidante e antidiarreica dos extratos brutos etanólicos de Myrcia bella e Bauhinia holophylla
Beneficiário:Daniela Aparecida Silveira Cesar
Linha de fomento: Bolsas no Brasil - Iniciação Científica