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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Effect of Melatonin Intake on Oxidative Stress Biomarkers in Male Reproductive Organs of Rats under Experimental Diabetes

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Autor(es):
Gobbo, Marina G. [1, 2] ; Pereira Costa, Carolina F. [1, 2] ; Humberto Silva, Danilo G. [1, 3] ; de Almeida, Eduardo A. [3] ; Goes, Rejane M. [2]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista UNESP, Dept Biol, Inst Biosci Humanities & Exact Sci, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
[2] State Univ Campinas UNICAMP, Inst Biol, Dept Cell Biol, BR-13083863 Campinas, SP - Brazil
[3] Univ Estadual Paulista UNESP, Dept Chem & Environm Sci, Inst Biosci Humanities & Exact Sci, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY; 2015.
Citações Web of Science: 15
Resumo

This study investigated the antioxidant system response of male reproductive organs during early and late phases of diabetes and the influence of melatonin treatment. Melatonin was administered to five-week-old Wistar rats throughout the experiment, in drinking water (10 mu g/kg b.w). Diabetes was induced at 13 weeks of age by streptozotocin (4.5 mg/100g b.w., i.p.) and animals were euthanized with 14 or 21 weeks old. Activities of catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidase (GPx), and lipid peroxidation were evaluated in prostate, testis, and epididymis. The enzymes activities and lipid peroxidation were not affected in testis and epididymis after one or eight weeks of diabetes. Prostate exhibited a 3-fold increase in GPx activity at short-term diabetes and at long-term diabetes there were 2- and 3-fold increase in CAT and GST, respectively (p <= 0.01). Melatonin treatment to healthy rats caused a 47% increase in epididymal GPx activity in 14-week-old rats. In prostate, melatonin administration normalized GST activity at both ages and mitigated GPx at short-term and CAT at long-term diabetes. The test is and epididymis were less affected by diabetes than prostate. Furthermore, melatonin normalized the enzymatic disorders in prostate demonstrating its effective antioxidant role, even at low dosages. (AU)

Processo FAPESP: 10/20756-4 - O papel da melatonina na atenuação dos danos testiculares causados pelo diabetes experimental
Beneficiário:Carolina Frandsen Pereira da Costa
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 11/19467-0 - Administração de melatonina durante a maturação sexual: influência na histofisiologia da próstata adulta e papel protetor contra os danos causados pelo diabetes experimental
Beneficiário:Marina Guimarães Gobbo
Linha de fomento: Bolsas no Brasil - Doutorado