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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Unraveling the Biosynthesis of Pilocarpine in Pilocarpus microphyllus

Autor(es):
Christine, Alexandra [1] ; Sawaya, Helena Frankland [1] ; Costa, Yanna Dias [1] ; Mazzafera, Paulo [1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] State Univ Campinas UNICAMP, Inst Biol, Dept Plant Biol, BR-13083970 Campinas, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: NATURAL PRODUCT COMMUNICATIONS; v. 10, n. 5, p. 721-724, MAY 2015.
Citações Web of Science: 1
Resumo

Pilocarpine is found exclusively in species of Pilocarpus and the presence of other imidazole alkaloids has been reported in several species of the genus. Pilocarpine has several important pharmaceutical applications. Although several imidazole alkaloids related to pilocarpine have been reported in the previous years, little is still known about its biosynthetic route. At most, histidine has been reported as the precursor of pilocarpine. Based on our own previous reports and in an experiment where pilocarpine and related alkaloids (pilosine, trachyllophiline and anhydropilosine) were supplied to P. microphyllus leaves and the alkaloid profile analyzed by UPLC-MS, we suggest a biosynthesis pathway for pilocarpine. Further experiments using labeled precursors associated with transcriptome data may allow us to understand the whole biosynthesis pathway and its genetic control. (AU)

Processo FAPESP: 09/00773-4 - Isolamento e identificação de alcalóides imidazólicos do jaborandi (Pilocarpus microphyllus ) e avaliação de sua atividade biológica
Beneficiário:Alexandra Christine Helena Frankland Sawaya
Linha de fomento: Auxílio à Pesquisa - Regular