Histopathological alterations in the prostates of Mongolian gerbils exposed to a high-fat diet and di-n-butyl phthalate individually or in combination

Autor(es)

de Jesus, Mariana Marcielo ^[1] ; Negrin, Ana Carolina ^[1] ; Taboga, Sebastiao Roberto ^{[1, 2]} ; Pinto-Fochi, Maria Etelvina ^[2] ; Goes, Rejane Maira ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, UNICAMP, Inst Biol, Dept Funct & Struct Biol, Campinas, SP - Brazil

^[2] Univ Estadual Paulista, Dept Biol, Inst Biosci Humanities & Exact Sci, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: REPRODUCTIVE TOXICOLOGY; v. 52, p. 26-39, APR 2015.
• Citações Web of Science: 9

Resumo

Both high-fat diet and exposure to endocrine-disrupting chemicals have been implicated in susceptibility to pathological prostate lesions, but the consequences of combining the two have not yet been examined. We evaluated the effects of gestational and postnatal exposure to a high-fat diet (20% fat) and low doses of di-n-butyl phthalate (DBP; 5 mg/kg/day), individually or in combination, on the tissue response and incidence of pathological lesions in the ventral prostate of adult gerbils. Continuous intake of a high-fat diet caused dyslipidemia, hypertrophy, and promoted the development of inflammatory, premalignant and malignant prostate lesions, even in the absence of obesity. Life-time DBP exposure was obesogenic and dyslipidemic and increased the incidence of premalignant prostate lesions. Combined exposure to DBP and a high-fat diet also caused prostate hypertrophy, but the effects were less severe than those of individual treatments; combined exposure neither induced an inflammatory response nor altered serum lipid content. (C) 2015 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 09/16071-9 - Efeitos da obesidade materna e supernutrição pós-natal sobre o aparelho genital masculino de ratos: avaliação morfofuncional das células de leydig
• Beneficiário: Maria Etelvina Pinto Fochi
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 11/16406-0 - Efeitos combinados da exposição ao di-n-butil ftalato e do ambiente obesogênico sobre a estrutura e função testicular de gerbilos adultos
• Beneficiário: Ana Carolina Negrin
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 11/01612-4 - Efeitos da obesidade materna e supernutrição pós-natal sobre o aparelho genital masculino de ratos: avaliação morfofuncional das células de Leydig
• Beneficiário: Rejane Maira Góes
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/16316-1 - Efeitos combinados da exposição ao di-n-butil ftalato e do ambiente obesogênico sobre a resposta tecidual da próstata de gerbilos adultos
• Beneficiário: Mariana Marcielo de Jesus
• Modalidade de apoio: Bolsas no Brasil - Mestrado