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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Anti-androgenic activities of diuron and its metabolites in male Nile tilapia (Oreochromis niloticus)

Texto completo
Autor(es):
Boscolo Pereira, Thiago Scremin [1] ; Pereira Boscolo, Camila Nomura [1] ; Humberto da Silva, Danilo Gruenig [2] ; Batlouni, Sergio Ricardo [3] ; Schlenk, Daniel [4] ; de Almeida, Eduardo Alves [2]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista, Dept Anim Biol, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
[2] Univ Estadual Paulista, IBILCE, Dept Chem & Environm Sci, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
[3] Univ Estadual Paulista CAUNESP, Dept Aquaculture, BR-14884900 Jaboticabal, SP - Brazil
[4] Univ Calif Riverside, Dept Environm Sci, Riverside, CA 92521 - USA
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: AQUATIC TOXICOLOGY; v. 164, p. 10-15, JUL 2015.
Citações Web of Science: 14
Resumo

Diuron (3-(3,4-dichlorophenyl)-1,1-dimethylurea) is a widely used herbicide which has been frequently detected in surface waters throughout the world. In vivo bioassay guided fractionation studies indicated that diuron may have estrogenic activity augmented by biotransformation. This study evaluated the effects of diuron and three of its metabolites on plasma hormone concentrations and spermatogenesis of the freshwater fish Nile tilapia (Oreochromis niloticus). Sexually mature male fish were exposed for 25 days to diuron, as well to its metabolites 3,4-dichloroaniline (DCA), 3,4-dichlorophenylurea (DCPU) and 3,4-dichlorophenyl-N-methylurea (DCPMU), at concentrations of 200 ng/L. Testosterone levels were decreased by diuron, but had limited effects on gonadal histology. Diuron metabolites, however, caused significant decreases in testosterone and in 11-ketotestosterone, gonadosomatic index, diameter of seminiferous tubules and in the mean percentages of germ cells (spermatids and spermatozoa). We conclude that these metabolites have antiandrogenic activity to male Nile tilapia, potentially causing reproductive impairment in male fish. (C) 2015 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 11/52061-8 - Efeitos bioquímicos e estrogênicos do Diuron e seus metabólitos, isoladamente ou em combinação com alquilfenois em Tilápias do Nilo (Oreochromis niloticus)
Beneficiário:Eduardo Alves de Almeida
Linha de fomento: Auxílio à Pesquisa - Programa BIOEN - Regular