Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Visuospatial Memory Improvement after Gamma Ventral Capsulotomy in Treatment Refractory Obsessive-Compulsive Disorder Patients

Texto completo
Autor(es):
Mostrar menos -
Batistuzzo, Marcelo C. [1] ; Hoexter, Marcelo Q. [1] ; Taub, Anita [1] ; Gentil, Andre F. [1] ; Cesar, Raony C. C. [1] ; Joaquim, Marines A. [1] ; D'Alcante, Carina Chaubet [1] ; McLaughlin, Nicole C. [2, 3] ; Canteras, Miguel M. [4] ; Shavitt, Roseli G. [1] ; Savage, Cary R. [5] ; Greenberg, Benjamin D. [2, 3] ; Noren, Georg [6] ; Miguel, Euripedes C. [1] ; Lopes, Antonio C. [1]
Número total de Autores: 15
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Dept & Inst Psychiat, Sch Med, BR-01060970 Sao Paulo - Brazil
[2] Butler Hosp, Dept Psychiat & Behav Sci, Providence, RI 02906 - USA
[3] Brown Med Sch, Providence, RI - USA
[4] Hosp Santa Paula, Inst Neurol Radiosurg, Sao Paulo - Brazil
[5] Univ Kansas, Med Ctr, Ctr Hlth Behav Neurosci, Kansas City, KS 66103 - USA
[6] Brown Univ, Warren Alpert Med Sch, Dept Neurosurg, Providence, RI 02912 - USA
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: NEUROPSYCHOPHARMACOLOGY; v. 40, n. 8, p. 1837-1845, JUL 2015.
Citações Web of Science: 11
Resumo

Gamma ventral capsulotomy (GVC) radiosurgery is intended to minimize side effects while maintaining the efficacy of traditional thermocoagulation techniques for the treatment of refractory obsessive-compulsive disorder (OCD). Neuropsychological outcomes are not clear based on previous studies and, therefore, we investigated the effects of GVC on cognitive and motor performance. A double-blind, randomized controlled trial (RCT) was conducted with 16 refractory OCD patients allocated to active treatment (n = 8) and sham (n = 8) groups. A comprehensive neuropsychological evaluation including intellectual functioning, attention, verbal and visuospatial learning and memory, visuospatial perception, inhibitory control, cognitive flexibility, and motor functioning was applied at baseline and one year after the procedure. Secondary analysis included all operated patients: eight from the active group, four from the sham group who were submitted to surgery after blind was broken, and five patients from a previous open pilot study (n = 5), totaling 17 patients. In the RCT, visuospatial memory (VSM) performance significantly improved in the active group after GVC (p = 0.008), and remained stable in the sham group. Considering all patients operated, there was no decline in cognitive or motor functioning after one year of follow-up. Our initial results after 1 year of follow-up suggests that GVC not only is a safe procedure in terms of neuropsychological functioning but in fact may actually improve certain neuropsychological domains, particularly VSM performance, in treatment refractory OCD patients. (AU)

Processo FAPESP: 11/21357-9 - Investigação de circuitos neuronais e marcadores biológicos envolvidos no transtorno obsessivo-compulsivo por meio de paradigmas comportamentais de medo e ansiedade
Beneficiário:Eurípedes Constantino Miguel Filho
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 08/10257-0 - Capsulotomia ventro-capsular e ventro-estriatal por raios gama no transtorno obsessivo-compulsivo: um ensaio clínico randomizado
Beneficiário:Antonio Carlos Lopes
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 11/51485-9 - Potencialização de inibidores da recaptura de serotonina com N-acetilcisteína no tratamento do transtorno obsessivo-compulsivo resistente: um estudo duplo-cego controlado
Beneficiário:Roseli Gedanke Shavitt
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 09/09949-8 - Ativação cerebral associada à memória episódica verbal no Transtorno Obsessivo-Compulsivo (TOC): análise por ressonância magnética funcional
Beneficiário:Marcelo Camargo Batistuzzo
Linha de fomento: Bolsas no Brasil - Doutorado Direto