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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Low Counts of Plasmacytoid Dendritic Cells after Engraftment Are Associated with High Early Mortality after Allogeneic Stem Cell Transplantation

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Autor(es):
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Goncalves, Matheus Vescovi [1] ; Yamamoto, Mihoko [1] ; Sugano Kimura, Eliza Yurico [1] ; Rensi Colturato, Vergilio Antonio [2] ; de Souza, Mair Pedro [2] ; Mauad, Marcos [2] ; Ikoma, Maura Valerio [2] ; Novis, Yana [3] ; Rocha, Vanderson [4, 5] ; Ginani, Valeria Cortez [6] ; Wanderley de Oliveira Felix, Olga Margareth [6] ; Seber, Adriana [7] ; Kerbauy, Fabio Rodrigues [8, 1] ; Hamerschlak, Nelson [8] ; Orfao, Alberto [9] ; Rodrigues, Celso Arrais [1, 3]
Número total de Autores: 16
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Disciplina Hematol & Hemoterapia, Sao Paulo, SP - Brazil
[2] Fundacao Dr Amaral Carvalho, Jau - Brazil
[3] Hosp Sirio Libanes, Ctr Oncol, Sao Paulo - Brazil
[4] Hop St Louis, Eurocord, Paris - France
[5] Oxford Univ Hosp, Churchill Hosp, Oxford - England
[6] Inst Oncol Pediat, Sao Paulo - Brazil
[7] Hosp Samaritano, Sao Paulo - Brazil
[8] Hosp Israelita Albert Einstein, Sao Paulo - Brazil
[9] Univ Salamanca, Ctr Invest Canc CIC I BMCC USAL CSIC, Serv Gen Citometria, Dept Med, IBSAL, E-37008 Salamanca - Spain
Número total de Afiliações: 9
Tipo de documento: Artigo Científico
Fonte: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION; v. 21, n. 7, p. 1223-1229, JUL 2015.
Citações Web of Science: 4
Resumo

Dendritic cells (DCs) are antigen-presenting cells that drive immune responses and tolerance and are divided in different subsets: myeloid DCs (mDCs: lineage; HLA-DR+, 11c+), plasmacytoid dendritic cells (pDCs: HLA-DR+, CD123+), and monocyte-derived DCs (moDC: lineage, 11c+, 16+). After hematopoietic stem cell transplantation (HSCT), low DC counts in the recipients' peripheral blood (PB) have been associated with worse outcomes, but the relevance of DC graft content remains unclear, and there are few data in the setting of unrelated donor HSCT. We evaluated the DC graft content and monitored DC recovery in PB from 111 HSCT recipients (median age, 17 years; range 1 to 74), who received bone marrow (46%), umbilical cord blood (32%), or PB (22%) from unrelated (81%) or related donors (19%). In 86 patients with sustained allogeneic recovery, patients with higher counts of all DC subsets (pDC, mDC, and moDC) 3 weeks after engraftment had lower incidence of nonrelapse mortality (NMR) and acute graft-versus-host disease (aGVHD) and better survival. pDC counts were associated with more striking results: patients with higher pDC counts had much lower incidences of NRM (3% versus 47%, P < .0001), lower incidence of aGVHD (24% versus 67%, P < .0001), and better overall survival (92% versus 45%, P < .0001). In contrast, higher pDC counts in the graft was associated with an increased risk of aGVHD (55% versus 26%, P = .02). Our results indicate that DC counts are closely correlated with HSCT outcomes and warrant further prospective evaluation and possible early therapeutic interventions to ameliorate severe aGVHD and decrease mortality. (C) 2015 American Society for Blood and Marrow Transplantation. (AU)

Processo FAPESP: 12/11730-7 - Estudo das subpopulações de células dendríticas e de linfócitos T e NK em receptores de transplante de sangue de cordão umbilical
Beneficiário:Celso Arrais Rodrigues da Silva
Linha de fomento: Auxílio à Pesquisa - Regular